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排序方式: 共有831条查询结果,搜索用时 15 毫秒
81.
Pons D Monraats PS de Maat MP Pires NM Quax PH van Vlijmen BJ Rosendaal FR Zwinderman AH Doevendans PA Waltenberger J de Winter RJ Tio RA Frants RR van der Laarse A van der Wall EE Jukema JW 《Thrombosis and haemostasis》2007,98(6):1323-1328
Since activation of the haemostatic system is an important feature of the wound healing response triggered by arterial injury, variations in genes involved in thrombus formation may play a role in restenosis after percutaneous coronary interventions (PCI). Therefore, our aim was to examine the relationship between polymorphisms that are known to play a role in the haemostatic system and the risk of clinical restenosis in the GENetic DEterminants of Restenosis (GENDER) study, a multicenter prospective study design that enrolled 3,104 consecutive patients after successful PCI. Target vessel revascularization (TVR) was the primary endpoint. All patients were genotyped for six polymorphisms in the Factor II, Factor V, Factor VII and PAI-1 genes. The PAI-1 4G variant was associated with an increased risk of TVR. When compared to 5G/5G homozygotes, heterozygous patients were at higher risk for TVR (HR: 1.46, 95% CI: 1.05-2.03), whereas patients with the 4G/4G genotype had an even further increased risk (HR: 1.69, 95% CI: 1.19-2.41). In contrast, the factor V 506Gln (factor V Leiden) amino acid substitution was associated with a decreased risk of TVR (HR: 0.41, 95% CI: 0.19-0.86). Our findings indicate that polymorphisms in the factorV and PAI-1 genes may play a role in the process of restenosis. 相似文献
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Douwe Pons Pascalle S. Monraats Aeilko H. Zwinderman Moniek P. M. de Maat Pieter A. F. M. Doevendans Robbert J. de Winter René A. Tio Johannes Waltenberger J. Wouter Jukema 《Disease markers》2009,26(2):75-83
Variation in the NOS3 gene has been related to the development of restenosis. The Glu298Asp polymorphism has previously been investigated for its effect on NO levels and the development of restenosis. However, the variability of findings gave rise to the hypothesis that the functional significance of this polymorphism may only become manifest under conditions of endothelial dysfunction. Since patients with the metabolic syndrome are known to have endothelial dysfunction, we aimed to investigate if the significance of NOS3 polymorphisms may depend on the presence of the metabolic syndrome.We examined the impact of the -949 A/G, the -716 C/T and the Glu298Asp polymorphisms in the NOS3 gene on the risk of clinical restenosis in a previously described subpopulation of the GENDER-study, a multicenter prospective study design that enrolled consecutive patients after successful PCI. This subpopulation consisted of 901 patients of whom sufficient data were available to establish absence or presence of the metabolic syndrome. Of these patients, 448 had the metabolic syndrome. Clinical restenosis, defined as target vessel revascularization (TVR), was the primary endpoint.We demonstrated that the minor -949G, -716T and 298Asp alleles were associated with a significantly increased risk of TVR in patients with the metabolic syndrome (HR: 1.58 [95%CI: 1.04–2.40], HR: 1.95 [95%CI: 1.02–3.70] and HR: 1.67 [95%CI: 1.09–2.54], respectively). In the group without the metabolic syndrome we observed no association between the three polymorphisms and TVR. 相似文献
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Two-stage hepatectomy approach for initially unresectable colorectal hepatic metastases 总被引:2,自引:0,他引:2
Adam R Miller R Pitombo M Wicherts DA de Haas RJ Bitsakou G Aloia T 《Surgical Oncology Clinics of North America》2007,16(3):525-36, viii
Two-stage hepatectomy has been developed as a surgical strategy for extremely difficult cases of bilobar multinodular metastatic liver disease. This strategy is applied when it is impossible to resect all malignant lesions in a single procedure. The main principle of this approach is sequential resection by a two-staged hepatectomy. Its goal is to achieve a complete metastasectomy in those cases in which a complete resection with a single hepatectomy would have left a remnant postresection liver too small for patient survival. This article describes strategic surgical approaches to multinodular metastatic disease and provides decision guidelines for two-stage hepatectomies. 相似文献
88.
de Haas RJ Wicherts DA Hobbelink MG Borel Rinkes IH Schipper ME van der Zee JA van Hillegersberg R 《Annals of surgical oncology》2007,14(3):1070-1080
Background The primary role of sentinel lymph node (SLN) mapping in colon cancer is to increase the accuracy of nodal staging by identifying
those lymph nodes with the greatest potential for harbouring metastatic disease. Ultrastaging techniques aim to identify the
otherwise undetected metastases. Until now, no consensus exists as to the most optimal procedure in patients with colon cancer.
Methods A systematic literature search on the value of different SLN mapping techniques in patients with colon cancer was performed
using the electronic search engine PubMed. Prospective studies published before 1 December 2005 were included and further
articles were selected by cross-referencing. The results of different techniques using either blue dye or radiocolloid, were
investigated.
Results The literature search yielded 17 relevant articles. SLN mapping using blue dye was described in 15 studies. Two studies reported
the results of SLN mapping using a combination of blue dye and radiocolloid. The reported results on identification rate varied
between 71 and 100%. Accuracy rates were between 78 and 100%, sensitivity rates between 25 and 100% and true upstaging rates
between 0 and 26%. The results were not affected by the addition of radiocolloid to blue dye.
Conclusions Sentinel lymph node mapping in patients with colon cancer remains an experimental procedure with varying results. Further
evaluation may lead to a standardized technique that offers the potential for significant upstaging of stage II patients.
This may have important implications as to tailor adjuvant chemotherapeutic regimens in these patients.
Robbert J. de Haas and Dennis A. Wicherts have contributed equally and are mentioned alphabetically. 相似文献
89.