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71.
Yohei Sotomi Hiroki Tateishi Pannipa Suwannasom Jouke Dijkstra Jeroen Eggermont Shengnan Liu Erhan Tenekecioglu Yaping Zheng Mohammad Abdelghani Rafael Cavalcante Robbert J. de Winter Joanna J. Wykrzykowska Yoshinobu Onuma Patrick W. Serruys Takeshi Kimura 《The international journal of cardiovascular imaging》2016,32(6):871-883
The degree of stent/scaffold embedment could be a surrogate parameter of the vessel wall-stent/scaffold interaction and could have biological implications in the vascular response. We have developed a new specific software for the quantitative evaluation of embedment of struts by optical coherence tomography (OCT). In the present study, we described the algorithm of the embedment analysis and its reproducibility. The degree of embedment was evaluated as the ratio of the embedded part versus the whole strut height and subdivided into quartiles. The agreement and the inter- and intra-observer reproducibility were evaluated using the kappa and the interclass correlation coefficient (ICC). A total of 4 pullbacks of OCT images in 4 randomly selected coronary lesions with 3.0 × 18 mm devices [2 lesions with Absorb BVS and 2 lesions with XIENCE (both from Abbott Vascular, Santa Clara, CA, USA)] from Absorb Japan trial were evaluated by two investigators with QCU-CMS software version 4.69 (Leiden University Medical Center, Leiden, The Netherlands). Finally, 1481 polymeric struts in 174 cross-sections and 1415 metallic struts in 161 cross-sections were analyzed. Inter- and intra-observer reproducibility of quantitative measurements of embedment ratio and categorical assessment of embedment in Absorb BVS and XIENCE had excellent agreement with ICC ranging from 0.958 to 0.999 and kappa ranging from 0.850 to 0.980. The newly developed embedment software showed excellent reproducibility. Computer-assisted embedment analysis could be a feasible tool to assess the strut penetration into the vessel wall that could be a surrogate of acute injury caused by implantation of devices. 相似文献
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75.
Indira Tendolkar Guido van Wingen Maren Urner Robbert Jan Verkes Guill��n Fern��ndez 《Neuropsychopharmacology》2011,36(11):2266-2275
It is unknown how antidepressants reverse mood-congruent memory bias, a cognitive core factor causing and maintaining depression. Using a double-blind, placebo-controlled, cross-over design, we investigated the effect of a short-term treatment (14 days) with the dual reuptake inhibitor duloxetine on neural correlates of mood-congruent and mood-incongruent memory formation and retrieval in healthy volunteers who underwent a sad mood induction procedure. Duloxetine did not affect acute mood state or memory performance, but interacted with brain processes mediating mood-congruent memory. It decreased activity related to successful memory formation for mood-congruent and -incongruent items in a set of brain regions comprising the putamen and the middle frontal gyrus, as well as the middle and the anterior cingulate cortex. Duloxetine specifically increased amygdala activity related to successful memory retrieval for mood-incongruent items. Here we show that short-term administration of duloxetine affects the neural correlates of emotional memory formation and retrieval in a set of brain regions whose processing is related to affective state and its regulation. While duloxetine suppressed the neural correlates of emotional memory formation in general, it specifically enhanced amygdala processes associated with mood-incongruent memory retrieval. This pattern of results shows how an antidepressant may reduce emotional memory formation and reverse mood-congruent processing biases at retrieval. 相似文献
76.
Ghassemi AH van Steenbergen MJ Barendregt A Talsma H Kok RJ van Nostrum CF Crommelin DJ Hennink WE 《Pharmaceutical research》2012,29(1):110-120
Purpose
To investigate the in vitro release of octreotide acetate, a somatostatin agonist, from microspheres based on a hydrophilic polyester, poly(D,L-lactide-co-hydroxymethyl glycolide) (PLHMGA). 相似文献77.
Hagedoorn M Dagan M Puterman E Hoff C Meijerink WJ Delongis A Sanderman R 《Journal of behavioral medicine》2011,34(4):288-297
Based on attribution theory, this study hypthesized that past spousal supportiveness may act as a moderator of the link between
one partner’s current support behavior and the other partner’s relationship satisfaction. A sample of 88 patients with colorectal
cancer and their partners completed questionnaires approximately 3 and 9 months after diagnosis. The data were analyzed employing
dyadic data analytic approaches. In the short-term, spousal active engagement—which involved discussing feelings and engaging
in joint problem solving—was positively associated with relationship satisfaction in patients as well as in partners, but
only when past spousal support was relatively low. Spousal protective buffering—which involved hiding worries and fears and
avoiding talking about the disease—was negatively associated with relationship satisfaction in patients, again only when past
spousal support was relatively low. If past spousal support was high, participants rated the quality of their relationship
relatively high, regardless of their partner’s current support behavior. Over time, past spousal supportiveness was not found
to mitigate the negative association between spousal protective buffering and relationship satisfaction. Overall, our results
indicate that relationship satisfaction can be maintained if past spousal supportiveness is high even if the partner is currently
not very responsive to the individual’s needs, at least in the short-term. 相似文献
78.
Drury J A, Nik H, van Oppenraaij R H F, Tang A‐W, Turner M A & Quenby S (2011 Histopathology 59 , 1156–1162 Endometrial cell counts in recurrent miscarriage: a comparison of counting methods Aims: Studies of uterine natural killer (uNK) cells require reliable measurements of uNK cell density among diverse endometrial tissue. The aim of this study was to compare cell counting manually with two computer‐aided methods based on a public domain software package, ImageJ. Methods and results: Immunohistochemistry (IHC) of CD56+ uNK cells was performed on endometrium from recurrent miscarriage patients. Numbers of stromal cells per high‐power field (HPF) were counted by two observers using: (i) manual tally counter and graticule; (ii) ImageJ ‘point picker’ tool; and (iii) ImageJ ‘particle analysis’ tool. Coefficients of variation (CV) and Bland–Altman plots were used to evaluate interobserver differences. Evaluation of %uNK using ImageJ particle analysis for stromal cell counts and point picker tool for uNK counts was undertaken. Point picker and particle analysis were significantly better than manual counting [interobserver CVs mean (standard deviation) 6.1% (3.3%); 4.7% (3.9%), 8.2% (6.5%), respectively]. Mean inter‐ and intra‐observer CVs for %uNK were 10.3% (6.6%), 8.5% (4.9%) and 6.8% (4.3%), respectively. Bland–Altman analysis revealed no systematic differences in cell counts with the number of cells in the image for each method. Conclusions: Compared to manual cell counting, computer‐aided image analysis yields more reproducible results for the assessment of uNK cells density using IHC. 相似文献
79.
Carmen S. van der Zwaluw Ron H. J. Scholte Ad A. Vermulst Jan Buitelaar Robbert Jan Verkes Rutger C. M. E. Engels 《European child & adolescent psychiatry》2009,18(7):407-417
Background Remarkably, little attention has been paid to the role of intimate partners and their drinking behavior in relation to adolescent
alcohol use. In the current study, we examined associations between adolescent alcohol use and romantic partners’ drinking
behavior.
Methods A total of 428 families, consisting of both parents and two adolescents (aged 13.4 and 15.2 at Time 1) participated in a prospective
study with four annual waves. Correlations and multivariate regressions were used to examine (1) similarity in drinking behaviors
of adolescents and intimate partners, (2) whether alcohol use of partners prospectively predicts adolescent alcohol consumption,
and (3) whether adolescents who consume alcohol select partners over time who show similar drinking behaviors.
Results (1) Frequency of alcohol consumption of adolescents and of their romantic partners correlated significantly. (2) Alcohol use
of partners was not predictive of adolescent alcohol consumption over time, if previous levels of alcohol consumption were
taken into account. (3) Adolescents acquired partners with similar drinking behaviors. Gender effects were found; adolescent
girls, but not boys, were more likely to become involved with partners who also frequently consumed alcohol.
Conclusions Regarding alcohol consumption, adolescents and their intimate partners were relatively similar in alcohol use. This resemblance
is best explained by adolescents’ selection of future partner on the basis of alcohol consumption. Less indication was found
for influence effects, perhaps due to the transient nature of most adolescent romantic relationships.
相似文献
Carmen S. van der ZwaluwEmail: |
80.
Luttik ML Jaarsma T Veeger N Tijssen J Sanderman R van Veldhuisen DJ 《European journal of heart failure》2007,9(6-7):695-701
BACKGROUND: In complying with required life style changes Heart Failure (HF) patients often depend on their partners. However providing care may cause burden and affect the health of these partners. The aim of this study was to investigate determinants of caregiver burden in order to identify caregivers who are at risk. METHODS: Using a cross-sectional design, caregiver burden and potential determinants were measured in partners of HF patients. Demographic and clinical data were assessed in HF patients, partners completed questionnaires on caregiver burden (the Caregiver Reaction Assessment, CRA), caregiving tasks performed, physical and mental health status and quality of the marital relationship. RESULTS: In total 357 partners (75% female, mean age 67 years) participated. The physical health status of HF patients was only significantly associated with two domains of caregiver burden, 'disruption of daily schedule' (p<0.01) and 'loss of physical strength' (p<0.01). No associations were found with age, co-morbidity and LVEF. All domains of the CRA were mainly associated with the partner's own mental health (p<0.01) and with providing personal care to HF patients (p<0.01). Gender differences were only found with regard to the domain of 'feeling a lack of family support'. CONCLUSION: The assessment of caregiver burden should focus on the mental strength of partners. Furthermore when assistance in personal care is needed, additional support, either informal or professional, may be indicated. 相似文献