全文获取类型
收费全文 | 7116篇 |
免费 | 434篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 31篇 |
儿科学 | 143篇 |
妇产科学 | 121篇 |
基础医学 | 932篇 |
口腔科学 | 89篇 |
临床医学 | 970篇 |
内科学 | 1309篇 |
皮肤病学 | 86篇 |
神经病学 | 619篇 |
特种医学 | 319篇 |
外科学 | 836篇 |
综合类 | 44篇 |
一般理论 | 3篇 |
预防医学 | 856篇 |
眼科学 | 98篇 |
药学 | 532篇 |
中国医学 | 64篇 |
肿瘤学 | 508篇 |
出版年
2023年 | 45篇 |
2022年 | 59篇 |
2021年 | 136篇 |
2020年 | 98篇 |
2019年 | 124篇 |
2018年 | 179篇 |
2017年 | 142篇 |
2016年 | 151篇 |
2015年 | 211篇 |
2014年 | 264篇 |
2013年 | 379篇 |
2012年 | 571篇 |
2011年 | 630篇 |
2010年 | 330篇 |
2009年 | 296篇 |
2008年 | 530篇 |
2007年 | 538篇 |
2006年 | 490篇 |
2005年 | 473篇 |
2004年 | 411篇 |
2003年 | 351篇 |
2002年 | 363篇 |
2001年 | 56篇 |
2000年 | 45篇 |
1999年 | 61篇 |
1998年 | 67篇 |
1997年 | 51篇 |
1996年 | 41篇 |
1995年 | 41篇 |
1994年 | 36篇 |
1993年 | 32篇 |
1992年 | 23篇 |
1991年 | 25篇 |
1990年 | 22篇 |
1989年 | 15篇 |
1988年 | 17篇 |
1987年 | 18篇 |
1986年 | 24篇 |
1985年 | 15篇 |
1984年 | 12篇 |
1983年 | 14篇 |
1982年 | 11篇 |
1979年 | 13篇 |
1978年 | 8篇 |
1977年 | 12篇 |
1976年 | 10篇 |
1975年 | 9篇 |
1971年 | 8篇 |
1970年 | 9篇 |
1966年 | 12篇 |
排序方式: 共有7560条查询结果,搜索用时 0 毫秒
51.
52.
53.
Atypical MEN type 2B associated with two germline RET mutations on the same allele not involving codon 918. 总被引:1,自引:0,他引:1
Fred H Menko Rob B van der Luijt Irene A J de Valk Arno W F T Toorians Jan M Sepers Paul J van Diest Cornelis J M Lips 《The Journal of clinical endocrinology and metabolism》2002,87(1):393-397
A kindred was diagnosed with atypical MEN type 2B characterized by medullary thyroid cancer and mucosal neurilemmomas in multiple family members. Mutation analysis revealed a double RET germline mutation, Val804Met and Ser904Cys, in affected individuals. The clinical phenotype, the functional effect of the mutations, and the clinical implications of our findings are discussed. 相似文献
54.
Hermans MM Henry RM Dekker JM Nijpels G Heine RJ Stehouwer CD 《Journal of hypertension》2008,26(4):791-797
OBJECTIVE: Arterial remodeling aims to maintain a constant circumferential wall stress (sigmac). A failing remodeling process is associated with stroke. Data on the relationship between chronic kidney disease and arterial remodeling are scarce. METHODS: We investigated the association between a lower glomerular filtration rate (GFR) and microalbuminuria with arterial remodeling of the common carotid artery (CCA) in a population-based study of 806 patients. CCA properties including intima-media thickness and interadventitial diameter (IAD) were assessed. Lumen diameter, circumferential wall tension (CWT), and circumferential wall stress (sigmac) were calculated. GFR was estimated (eGFR) by the Modification of Diet in Renal Disease formula. Albuminuria was expressed as urinary albumin/creatinine ratio. RESULTS: Mean eGFR was 60.3 (+/-10.8) ml/min/1.73 m2; median urinary albumin/creatinine ratio was 0.57 (range 0.10-26.6 mg/mmol). After adjustment for age, sex, glucose tolerance status, and prevalent cardiovascular disease, eGFR was not independently associated with CCA properties. A greater urinary albumin/creatinine ratio (per quartile) was associated with a greater lumen diameter [regression coefficient beta with 95% confidence interval, 0.14 (0.08-0.20; P < 0.01)], IAD [0.15 (0.09-0.21; P < 0.01)], CWT [0.95 (0.52-1.38; P < 0.01)], and sigmac [1.7 (0.5-2.9; P < 0.01)] but not with a greater IMT [0.01 (-0.002-0.02; P = 0.12)]. Additional adjustments for mean arterial pressure, pulse pressure, and eGFR did not change the results. CONCLUSION: Greater albuminuria is independently associated with an increase in lumen diameter and IAD of the CCA. In addition, greater albuminuria is associated with a maladaptive carotid remodeling process as shown by an increase in CWT and sigmac. These findings may explain, why microalbuminuria is associated with a greater risk of cardiovascular disease and especially stroke. 相似文献
55.
Guido van Amerongen Kawita Kanhai Anne Catrien Baakman Jules Heuberger Erica Klaassen Tim L. Beumer Rob L.M. Strijers Joep Killestein Joop van Gerven Adam Cohen Geert Jan Groeneveld 《Clinical therapeutics》2018,40(9):1467-1482
Purpose
The aim of the present study was to evaluate the efficacy of an oral formulation of Δ9-tetrahydrocannabinol (ECP002A) in patients with progressive multiple sclerosis (MS).Methods
This accelerated proof-of-concept study consisted of 2 phases: a crossover challenge (dose-finding) phase and a 4-week, parallel, randomized, placebo-controlled treatment phase. Twenty-four patients with progressive MS and moderate spasticity were enrolled. During the treatment phase, biomarkers for efficacy and secondary pharmacodynamic effects were measured at baseline and after 2 and 4 weeks of treatment. Serum samples were collected to determine pharmacokinetic properties and perform population modeling. Safety and tolerability profiles were assessed based on adverse events and safety measurements.Findings
Pain was significantly reduced when measured directly after administration of ECP002A in the clinic but not when measured in a daily diary. A similar pattern was observed in subjective muscle spasticity. Other clinical outcomes were not significantly different between active treatment and placebo. Cognitive testing indicated that there was no decline in cognition after 2 or 4 weeks of treatment attributable to ECP002A compared with placebo.ImplicationsThis study specifically underlines the added value of thorough investigation of pharmacokinetic and pharmacodynamic associations in the target population. Despite the complex interplay of psychoactive effects and analgesia, the current oral formulation of Δ9-tetrahydrocannabinol may play a role in the treatment of spasticity and pain associated with MS because it was well tolerated and had a stable pharmacokinetic profile. 相似文献56.
57.
58.
59.
Metheny Nicholas Stephenson Rob Darbes Lynae A. Chavanduka Tanaka M. D. Essack Zaynab van Rooyen Heidi 《AIDS and behavior》2022,26(6):2003-2014
AIDS and Behavior - Despite having some of the world’s highest rates of HIV, there is a lack of knowledge on correlates of transmission risk among gay, bisexual and other men who have sex... 相似文献