全文获取类型
收费全文 | 13993篇 |
免费 | 797篇 |
国内免费 | 58篇 |
专业分类
耳鼻咽喉 | 91篇 |
儿科学 | 591篇 |
妇产科学 | 306篇 |
基础医学 | 2090篇 |
口腔科学 | 215篇 |
临床医学 | 1549篇 |
内科学 | 3167篇 |
皮肤病学 | 255篇 |
神经病学 | 1335篇 |
特种医学 | 388篇 |
外科学 | 1280篇 |
综合类 | 84篇 |
一般理论 | 9篇 |
预防医学 | 1122篇 |
眼科学 | 221篇 |
药学 | 957篇 |
中国医学 | 56篇 |
肿瘤学 | 1132篇 |
出版年
2023年 | 93篇 |
2022年 | 217篇 |
2021年 | 386篇 |
2020年 | 236篇 |
2019年 | 329篇 |
2018年 | 388篇 |
2017年 | 267篇 |
2016年 | 309篇 |
2015年 | 405篇 |
2014年 | 517篇 |
2013年 | 740篇 |
2012年 | 1057篇 |
2011年 | 1119篇 |
2010年 | 590篇 |
2009年 | 528篇 |
2008年 | 885篇 |
2007年 | 948篇 |
2006年 | 857篇 |
2005年 | 827篇 |
2004年 | 751篇 |
2003年 | 728篇 |
2002年 | 672篇 |
2001年 | 160篇 |
2000年 | 131篇 |
1999年 | 158篇 |
1998年 | 143篇 |
1997年 | 124篇 |
1996年 | 84篇 |
1995年 | 85篇 |
1994年 | 69篇 |
1993年 | 52篇 |
1992年 | 67篇 |
1991年 | 72篇 |
1990年 | 50篇 |
1989年 | 48篇 |
1988年 | 48篇 |
1987年 | 50篇 |
1986年 | 63篇 |
1985年 | 52篇 |
1984年 | 41篇 |
1983年 | 46篇 |
1982年 | 43篇 |
1981年 | 48篇 |
1980年 | 40篇 |
1979年 | 41篇 |
1978年 | 34篇 |
1977年 | 21篇 |
1975年 | 21篇 |
1974年 | 19篇 |
1970年 | 18篇 |
排序方式: 共有10000条查询结果,搜索用时 91 毫秒
41.
Antonio D'Andrilli Anna Maria Ciccone Federico Venuta Mohsen Ibrahim Claudio Andreetti Domenico Massullo Rita Formisano Erino A Rendina 《European journal of cardio-thoracic surgery》2008,33(3):440-443
OBJECTIVE: We report the long-term results of our 16-year experience with laryngotracheal resection for benign stenosis. METHODS: Between 1991 and 2006, 35 consecutive patients (19 males, 16 females) underwent laryngotracheal resection for subglottic postintubation (32) or idiopathic (3) stenosis. Mean age was 43 years (range 14-71). At the time of surgery 13 patients presented with tracheostomy and 7 with a Dumon stent. The upper limit of the stenosis was from 0.6 to 1.5 cm below the vocal cords. The length of airway resection ranged between 1.5 and 6 cm. Suprahyoid release was performed in two patients and pericardial release in one. Nine patients had psychiatric and/or neurological post-coma disorders. Mean follow-up is over 5 years (61 months; range 3-194). RESULTS: There was no perioperative mortality. Thirty patients (85.7%) had excellent or good anatomic and functional results. Four patients (11.4%) presented restenosis at a distance of 25-110 days from the operation. Restenosis was successfully treated by endoscopic procedures in all four patients. One patient (2.9%) presented anastomotic dehiscence that required temporary tracheostomy closed after 1 year with no sequelae. Three patients (8.4%) had wound infection. Long-term follow-up was uneventful also in patients who had early complications. CONCLUSIONS: Long-term follow-up confirms that laryngotracheal resection is the definitive curative treatment for benign subglottic stenosis. Surgical complications can be successfully managed by non-operative procedures. Despite the occurrence of early complications, excellent and stable results can still be obtained at long term. 相似文献
42.
Hintergrund.
Unter CRASH-Syndrom wird eine Gruppe von X-chromosomal vererbten Erkrankungen zusammengefasst, die eine Mutation im L1CAM-Gen vorweisen und nach dem Akronym CRASH folgende Symptome vorweisen k?nnen: Corpus-callosum-Hypoplasie, Retardierung, adduzierte Daumen, spastische Paraplegie und Hydrozephalus. Eine Erkrankung aus dieser Reihe ist der X-chromosomal gebundene Hydrozephalus, erstmals beschrieben von Bickers und Adams 1949 als Hydrozephalus mit ?quaduktstenose (HSAS). 相似文献43.
M Morcos B Fohr J Tafel F Pfisterer A Hamann P Humpert H Bode V Schwenger M Zeier C Becker C Kasperk T Schilling H P Hammes A Bierhaus P P Nawroth 《Experimental and clinical endocrinology & diabetes》2007,115(5):292-297
CONTEXT: Central Cushing's syndrome is not always curable by surgery or radiation of the pituitary. Medical treatment is often not possible or effective. Some studies revealed beneficial effects of the PPARgamma (Peroxisome-Proliferator-Activator- Receptor-gamma)-agonist rosiglitazone (RG) in in vitro studies, animal models and short term clinical studies. OBJECTIVE: of this study was to observe the long-term effects of RG-treatment on cortisol- and ACTH -secretion, clinical outcomes and morphological changes of the pituitary in patients with persistent ACTH-overproduction despite previous operation and radiation. DESIGN, SETTING AND PATIENTS: 14 patients with persistent central ACTH -production were included and monitored over a period up to 12 months. RG was administered daily and increased to a maximum dosage of 24 mg daily, according to the response of ACTH and cortisol secretion. ACTH and cortisol were measured at least every 4 weeks during RG treatment. RESULTS: Patients were treated between 4 and 12 months with RG (mean 6.8 months). Compared to baseline, ACTH- and cortisol levels dropped significantly (p<0.01) after 12, 16, 20, 24 and 28 weeks but thereafter rose again during the study period, despite continuous RG- treatment and dose increase up to the maximum dosage. This was paralleled by reocurrence of clinical symptoms. MRI-scans were performed in 6 patients because of persisting visible adenoma, but showed no morphological changes. CONCLUSION: RG seems not to be a long-term treatment option for patients with persistent central ACTH-evcess. Though, in order to reduce perioperative complications, short term treatment of patients could be an alternative. 相似文献
44.
Evaluation of a Commercial PCR Kit for Diagnosis of Cytomegalovirus Infection of the Central Nervous System 总被引:3,自引:2,他引:1
下载免费PDF全文
![点击此处可从《Journal of clinical microbiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Adriana Weinberg Debbie Spiers Guan-Yung Cai Christopher M. Long Rita Sun Vince Tevere 《Journal of clinical microbiology》1998,36(11):3382-3384
We evaluated the AMPLICOR cytomegalovirus (CMV) PCR kit for the diagnosis of neurologic CMV infections on 43 positive and 112 negative archived cerebrospinal fluid specimens originally tested by an in-house PCR method. The AMPLICOR kit showed sensitivity and specificity of 95 and 100%, respectively, versus the home-grown assay, indicating its utility in this clinical setting. 相似文献
45.
Rita M. Kesteven 《Canadian Medical Association journal》1992,146(11):1899-1900
46.
Eneida F. Vencio Rita C. Alencar Eduardo Zancope 《Journal of oral pathology & medicine》2007,36(2):120-122
A 13-year-old boy had complained of an asymptomatic swelling in the anterior maxilla for approximately 4 years. The patient reported no local trauma. The intra-oral examination revealed an exophytic lesion in the incisive papilla between the maxillary central and lateral incisor teeth. The radiographies detected no significant findings. Histopathologically, the lesion showed a dense fibrous tissue above the overlying mucosa. Bone ossification lay beneath a partially hypertrophic cartilage showing occasionally pleomorphic chondrocytes. Because of its microscopic aspects, heterotopic ossification may be mistaken for chondrosarcoma or other conditions involving periosteum, such as parosteal osteosarcoma. A case of heterotopic ossification in the anterior maxilla is presented, and clinicopathologic similarities with other osteochondromatous lesions are discussed. 相似文献
47.
Shahid Hussain Darren E Dreyfus Richard J Marcus Robert W W Biederman Rita L McGill 《Nephrology, dialysis, transplantation》2003,18(11):2364-2368
BACKGROUND: Spironolactone is useful in heart failure, but is not given to dialysis patients for fear of hyperkalaemia. This study evaluated the safety of spironolactone administration in haemodialysis patients. METHODS: Fifteen haemodialysis outpatients with mean serum potassium <5.6 mEq/l over the preceding 4 months were treated with spironolactone 25 mg daily for 28 days. Serum potassium was measured before every haemodialysis during the study. Aldosterone and renin were measured at the beginning and end of the study. Patients were monitored for side effects. Data were examined with a paired t-test, with patients serving as their own controls and P < 0.05 considered significant. A sample size of 14 was required to achieve a power of 0.8 and a P = 0.05 to detect a potassium difference of 0.5 +/- 0.6 mEq/l. All patients were analysed as intention-to-treat. RESULTS: The mean potassium level was 4.6 +/- 0.6 mEq/l at baseline and 4.9 +/- 0.9 mEq/l at study completion (P = 0.14). Thirteen patients completed the trial with no potassium levels >6.0 mEq/l. Four patients had potassium levels between 5.5 and 6.0 mEq/l. One patient was withdrawn at day 20 after developing hyperkalaemia (7.6 mEq/l). Another patient was withdrawn at day 25 after missing a dialysis treatment. There were no differences in either baseline or 28 day aldosterone or renin levels (16.8 +/- 28.8 vs 11.7 +/- 6.1 ng/dl and 3.5 +/- 3.9 vs 3.5 +/- 3.5 ng/ml/h, respectively). Infrequent side effects included dry mouth, nosebleed, pruritis, gynecomastia and diarrhoea. No significant leukopenia or anaemia was noted. CONCLUSIONS: Spironolactone may be considered as a treatment option for selected chronic haemodialysis patients with heart disease. 相似文献
48.
Jeffrey F. Waring Rita Ciurlionis Robert A. Jolly Matthew Heindel Gerry Gagne Jane A. Fagerland Roger G. Ulrich 《Toxicology in vitro》2003,17(5-6):693-701
In vitro human hepatocyte cultures are a key tool in the investigation of xenobiotic toxicity and metabolism. In most in vitro hepatocyte studies, the cells are allowed to adhere to an extracellular matrix, such as collagen. Unfortunately, the ability of freshly isolated hepatocytes to adhere to collagen varies from donor to donor. We used microarray analysis to determine what gene expression differences exist between hepatocytes in suspension and hepatocytes attached to collagen. Results from different donors showed a considerable difference in gene expression patterns between the two hepatocyte populations. In addition, we also compared the gene expression profiles of hepatocytes in culture with liver tissue. The results showed that both hepatocytes in suspension and hepatocytes attached to collagen display significant gene expression differences compared with liver tissue. Finally, we show that both populations of hepatocytes are responsive to dexamethasone and regulate some of the same genes. Overall, our results suggest that either significant gene expression changes occur in isolated hepatocytes or that suspended and attached cells represent different populations of hepatocytes found in intact livers. 相似文献
49.
Rita Shiang Stephen G. Ryan Ya-Zhen Zhu Thomas J. Fielder Richard J. Allen Alan Fryer Sumimasa Yamashita Peter O'Connell John J. Wasmuth 《Annals of neurology》1995,38(1):85-91
Hyperekplexia is a rare, autosomal dominant neurological disorder characterized by hypertonia, especially in infancy, and by an exaggerated startle response. This disorder is caused by mutations in the ?1 subunit of the inhibitory glycine receptor (GLRA1). We previously reported two GLRA1 point mutations detected in 4 unrelated hyperekplexia families; both mutations were at nucleotide 1192 and resulted in the replacement of Arg271 by a glutamine (R271Q) in one case and a leucine (R271L) in the other. Here, 5 additional hyperekplexia families are shown to have the most common G-to-A transition mutation at nucleotide 1192. Haplotype analysis using polymorphisms within and close to the GLRA1 locus suggests that this mutation has arisen at least twice (and possibly four times). In 2 additional families, a third mutation is also presented that changes a tyrosine at amino acid 279 to a cysteine (Y279C). Five patients with atypical clinical features and equivocal or absent family history of hyperekplexia and 1 patient with a classical presentation but no family history are presented in whom a mutation in the GLRA1 gene was not detected. Thus, only clinically typical hyperekplexia appears to be consistently associated with GLRA1 mutations, and these affect a specific extracellular domain of the protein. 相似文献
50.
Henry M. Goodgold M.D. Rita C. Gentilcore Lynn Hendershott James W. Fletcher Larry D. Samuels 《European journal of nuclear medicine and molecular imaging》1986,12(5-6):271-273
To assess the significance of diffuse cardiac activity (DCA) seen on In-111 labeled leukocyte scans, we reviewed 87 studies performed over the last 4 years. Inflammatory cardiac conditions were seen as frequently in patients with DCA (15%) as those without (7%, P=0.3). There was a higher ratio of RBC:WBC in the final WBC preparation in the false-positive DCA group than the true positive DCA and no DCA groups. False-positive studies showing DCA are most likely due to residual blood pool activity.Presented in part, 70th annual meeting, Radiological Society of North America, Washington D.C., 25 November 1984 相似文献