全文获取类型
收费全文 | 14011篇 |
免费 | 779篇 |
国内免费 | 58篇 |
专业分类
耳鼻咽喉 | 91篇 |
儿科学 | 591篇 |
妇产科学 | 306篇 |
基础医学 | 2090篇 |
口腔科学 | 215篇 |
临床医学 | 1549篇 |
内科学 | 3167篇 |
皮肤病学 | 255篇 |
神经病学 | 1335篇 |
特种医学 | 388篇 |
外科学 | 1280篇 |
综合类 | 84篇 |
一般理论 | 9篇 |
预防医学 | 1122篇 |
眼科学 | 221篇 |
药学 | 957篇 |
中国医学 | 56篇 |
肿瘤学 | 1132篇 |
出版年
2023年 | 93篇 |
2022年 | 217篇 |
2021年 | 386篇 |
2020年 | 236篇 |
2019年 | 329篇 |
2018年 | 388篇 |
2017年 | 267篇 |
2016年 | 309篇 |
2015年 | 405篇 |
2014年 | 517篇 |
2013年 | 740篇 |
2012年 | 1057篇 |
2011年 | 1119篇 |
2010年 | 590篇 |
2009年 | 528篇 |
2008年 | 885篇 |
2007年 | 948篇 |
2006年 | 857篇 |
2005年 | 827篇 |
2004年 | 751篇 |
2003年 | 728篇 |
2002年 | 672篇 |
2001年 | 160篇 |
2000年 | 131篇 |
1999年 | 158篇 |
1998年 | 143篇 |
1997年 | 124篇 |
1996年 | 84篇 |
1995年 | 85篇 |
1994年 | 69篇 |
1993年 | 52篇 |
1992年 | 67篇 |
1991年 | 72篇 |
1990年 | 50篇 |
1989年 | 48篇 |
1988年 | 48篇 |
1987年 | 50篇 |
1986年 | 63篇 |
1985年 | 52篇 |
1984年 | 41篇 |
1983年 | 46篇 |
1982年 | 43篇 |
1981年 | 48篇 |
1980年 | 40篇 |
1979年 | 41篇 |
1978年 | 34篇 |
1977年 | 21篇 |
1975年 | 21篇 |
1974年 | 19篇 |
1970年 | 18篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
171.
Yirajen Vuddamalay Mehdi Attia Rita Vicente Céline Pomié Geneviève Enault Bertrand Leobon Olivier Joffre Paola Romagnoli Joost P.M. van Meerwijk 《Immunology》2016,148(2):187-196
Regulatory T (Treg) lymphocytes play a central role in the control of immune responses and so maintain immune tolerance and homeostasis. In mice, expression of the CD8 co‐receptor and low levels of the co‐stimulatory molecule CD28 characterizes a Treg cell population that exerts potent suppressive function in vitro and efficiently controls experimental immunopathology in vivo. It has remained unclear if CD8+ CD28low Treg cells develop in the thymus or represent a population of chronically activated conventional T cells differentiating into Treg cells in the periphery, as suggested by their CD28low phenotype. We demonstrate that functional CD8+ CD28low Treg cells are present in the thymus and that these cells develop locally and are not recirculating from the periphery. Differentiation of CD8+ CD28low Treg cells requires MHC class I expression on radioresistant but not on haematopoietic thymic stromal cells. In contrast to other Treg cells, CD8+ CD28low Treg cells develop simultaneously with CD8+ CD28high conventional T cells. We also identified a novel homologous naive CD8+ CD28low T‐cell population with immunosuppressive properties in human blood and thymus. Combined, our data demonstrate that CD8+ CD28low cells can develop in the thymus of mice and suggest that the same is true in humans. 相似文献
172.
173.
174.
We have cloned and characterized a 2,778-kb XbaI segment of the mitochondrial genome of the locust, Locusta migratoria. It harbours portions of the ND4 and the ND1 genes, the entire genes for ND6, ND4L and cytochrome b, and the genes for three mitochondrial tRNAs. The genes are arranged in an order which is conserved between orthopteran and dipteran insects. The analysis of the cytochrome b sequence, and its comparison with other systems, supports the current model structure for this polypeptide. 相似文献
175.
Chalupníková R 《Acta medica (Hradec Králové). Supplementum Universitas Carolina, Facultas Medica Hradec Králové》2004,47(2):127-130
This article is aimed at developing of multimedia teaching programs. Authoring tool Authorware Professional for Windows is briefly described as a suited system for the developing of didactic applications. Author presents own application based on Authorware--Biophysics of perception of sound and light. At the end are also disscused benefits of multimedia teaching tools. 相似文献
176.
The Molecular Mechanism of B Cell Activation by toll-like
Receptor Protein RP-105 总被引:6,自引:1,他引:6 下载免费PDF全文
Vivien W.F. Chan Ingrid Mecklenbruker I-hsin Su Gemma Texido Michael Leitges Rita Carsetti Clifford A. Lowell Klaus Rajewsky Kensuke Miyake Alexander Tarakhovsky 《The Journal of experimental medicine》1998,188(1):93-101
The B cell–specific transmembrane protein RP-105 belongs to the family of Drosophila toll-like proteins which are likely to trigger innate immune responses in mice and man. Here we demonstrate that the Src-family protein tyrosine kinase Lyn, protein kinase C β I/II (PKCβI/II), and Erk2-specific mitogen-activated protein (MAP) kinase kinase (MEK) are essential and probably functionally connected elements of the RP-105–mediated signaling cascade in B cells. We also find that negative regulation of RP-105–mediated activation of MAP kinases by membrane immunoglobulin may account for the phenomenon of antigen receptor–mediated arrest of RP-105–mediated B cell proliferation. 相似文献
177.
Madalena Coutinho Cruz Rita Ilhão Moreira Ana Abreu Ana Teresa Timóteo Ramiro Sá Carvalho Lurdes Ferreira Rui Cruz Ferreira 《Revista portuguesa de cardiologia》2018,37(10):847-855
Introduction
Smoking is associated with atherosclerotic disease, but there is controversy about its protective nature after acute coronary syndrome (ACS).Objective
To determine the impact of smoking on the presentation, treatment and outcome of ACS.Methods
We analyzed all consecutive patients with ACS in a single center between 2005 and 2014. Current smokers and never-smokers were compared. Independent predictors of in-hospital mortality and of a composite of all-cause mortality, rehospitalization for cardiovascular causes, angiography, percutaneous coronary intervention and coronary artery bypass grafting were assessed by multivariate logistic regression.Results
A total of 2727 patients were included, 41.7% current smokers and 58.3% never-smokers. Current smokers were younger, more often male, had fewer comorbidities, a typical clinical presentation, lower heart rate, systolic blood pressure, Killip class, BNP/NT-pro-BNP and creatinine, better left ventricular systolic function and less severe coronary anatomy. ST-segment elevation myocardial infarction was more common in current smokers. Current smokers received more evidence-based treatments and had less in-hospital complications, in-hospital mortality and adverse outcomes at one year. More frequent percutaneous coronary intervention at one year was noted in current smokers. Smoking was not an independent predictor of outcome when the multivariate model was fully adjusted for baseline characteristics.Conclusion
The smoker's paradox was not observed in this population, since all differences in outcome were explained by smokers’ more benign baseline characteristics. 相似文献178.
179.
Outbreak of serogroup C meningococcal disease caused by a variant of Neisseria meningitidis serotype 2a ET-15 in a community of men who have sex with men 下载免费PDF全文
Tsang RS Kiefer L Law DK Stoltz J Shahin R Brown S Jamieson F 《Journal of clinical microbiology》2003,41(9):4411-4414
We describe an outbreak, in a community of men who have sex with men, of serogroup C meningococcal disease caused by a genetic variant of the serotype 2a ET-15 Neisseria meningitidis characterized by a point mutation in the gene coding for the serotype 2a antigen. A microbiological characterization of the outbreak strain is presented in this report. 相似文献
180.