全文获取类型
收费全文 | 47938篇 |
免费 | 2488篇 |
国内免费 | 280篇 |
专业分类
耳鼻咽喉 | 434篇 |
儿科学 | 903篇 |
妇产科学 | 798篇 |
基础医学 | 6110篇 |
口腔科学 | 1469篇 |
临床医学 | 3104篇 |
内科学 | 12420篇 |
皮肤病学 | 890篇 |
神经病学 | 3929篇 |
特种医学 | 2069篇 |
外科学 | 7597篇 |
综合类 | 180篇 |
一般理论 | 1篇 |
预防医学 | 1342篇 |
眼科学 | 930篇 |
药学 | 3103篇 |
中国医学 | 101篇 |
肿瘤学 | 5326篇 |
出版年
2023年 | 290篇 |
2022年 | 593篇 |
2021年 | 1086篇 |
2020年 | 575篇 |
2019年 | 806篇 |
2018年 | 1033篇 |
2017年 | 812篇 |
2016年 | 977篇 |
2015年 | 1019篇 |
2014年 | 1364篇 |
2013年 | 1673篇 |
2012年 | 2687篇 |
2011年 | 3016篇 |
2010年 | 1684篇 |
2009年 | 1501篇 |
2008年 | 2608篇 |
2007年 | 2648篇 |
2006年 | 2621篇 |
2005年 | 2623篇 |
2004年 | 2586篇 |
2003年 | 2401篇 |
2002年 | 2404篇 |
2001年 | 1128篇 |
2000年 | 1082篇 |
1999年 | 1139篇 |
1998年 | 601篇 |
1997年 | 492篇 |
1996年 | 425篇 |
1995年 | 383篇 |
1994年 | 341篇 |
1993年 | 312篇 |
1992年 | 763篇 |
1991年 | 686篇 |
1990年 | 682篇 |
1989年 | 674篇 |
1988年 | 563篇 |
1987年 | 515篇 |
1986年 | 520篇 |
1985年 | 459篇 |
1984年 | 338篇 |
1983年 | 294篇 |
1982年 | 141篇 |
1981年 | 145篇 |
1980年 | 141篇 |
1979年 | 266篇 |
1978年 | 174篇 |
1977年 | 158篇 |
1975年 | 120篇 |
1972年 | 120篇 |
1969年 | 116篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
993.
Takeshi Umazume Mamoru Morikawa Takahiro Yamada Kazutoshi Cho Nobuo Masauzi Hisanori Minakami 《Clinical Case Reports》2015,3(11):916-919
It is not clear that how long the affected fetuses can tolerate fetomaternal hemorrhage (FMH). Incidental serial measurements of the fetal peak systolic velocity of the middle cerebral artery and the retrospective analysis of stocked blood available incidentally indicated that our patient had suffered from FMH for at least 2 weeks prior to delivery. 相似文献
994.
Kinuyo Chikamatsu Akio Aono Hiroyuki Hata Yuriko Igarashi Akiko Takaki Hiroyuki Yamada Kentaro Sakashita Satoshi Mitarai 《Diagnostic microbiology and infectious disease》2018,90(1):35-39
We evaluated PyroMark Q24 (QIAGEN) pyrosequencing as a method for the identification of mycobacteria, with potential application in clinical practice. Sequence data from the hypervariable region A of the 16S rRNA gene (43 and 35 bp sequences) were obtained using PyroMark Q24, and a similarity search was performed automatically with PyroMark IdentiFire software. Of the 148 mycobacterial type strains tested, 138 (93.2%) were accurately identified to single or clade species level, including complex level. From the remaining 10 strains, 3 (Mycobacterium gilvum, Mycobacterium goodi, and Mycobacterium thermoresistible) showed poor sequencing quality of homopolymers. For 6 other strains (Mycobacterium cosmeticum, Mycobacterium flavescens, Mycobacterium pallens, Mycobacterium hodleri, Mycobacterium xenopi, and Mycobacterium crocinum), the sequences were unreadable from the middle, and Sanger sequencing indicated biallelic site. Finally, a 40 bp sequence for Mycobacterium gordonae could not be obtained despite repeated attempts. PyroMark Q24 provided accurate identification of multiple mycobacterial strains isolated from common clinical settings, but additional gene sequencing is required to distinguish species identified as a group or complex. 相似文献
995.
Yuichiro Yamada Yasuo Terauchi Hirotaka Watada Yasuhiko Nakatsuka Kazuhito Shiosakai Takuo Washio Takashi Taguchi 《Advances in therapy》2018,35(3):367-381
Introduction
G protein-coupled receptor 119 (GPR119) is a promising target for the treatment of type 2 diabetes mellitus (T2DM), as both insulin and glucagon-like peptide-1 secretion can be promoted with a single drug. We compared the efficacy and safety of the GPR119 agonist DS-8500a with placebo and sitagliptin 50 mg in Japanese patients with T2DM.Methods
This randomized, double-blind, parallel-group comparison study was conducted in Japan (trial registration NCT02628392, JapicCTI-153068). Eligible patients aged ≥ 20 years with T2DM and hemoglobin A1c (HbA1c) ≥ 7.0% and < 10.0% were randomized to receive placebo, DS-8500a (25, 50, or 75 mg), or sitagliptin 50 mg once daily for 12 weeks. The primary efficacy endpoint was change in HbA1c from baseline to week 12. Secondary endpoints included change in fasting plasma glucose (FPG), glucose AUC0–3h during a meal tolerance test, 2-hour postprandial glucose (2hr-PPG), and changes in lipid parameters (total, low-density lipoprotein (LDL-) and high-density lipoprotein (HDL-) cholesterol, and triglycerides) at week 12. Safety endpoints included adverse events, hypoglycemia, and clinical/laboratory variables.Results
DS-8500a demonstrated dose-dependent HbA1c lowering compared with placebo at week 12: change from baseline ? 0.23% (p = 0.0173), ? 0.37% (p = 0.0001), and ? 0.44% (p < 0.0001) in the 25-mg, 50-mg, and 75-mg groups, respectively. At 50- and 75-mg doses, DS-8500a significantly lowered FPG, glucose AUC0–3h, and 2hr-PPG compared with placebo. The glucose-lowering effect was maintained up to 12 weeks. DS-8500a did not lower any of the above parameters to a greater extent than sitagliptin. Compared with placebo and sitagliptin, DS-8500a 50 and 75 mg significantly reduced total cholesterol, LDL-cholesterol, and triglycerides, and significantly increased HDL-cholesterol. All DS-8500a doses were well tolerated. Two cases of clinically relevant drug-related hypoglycemia occurred in the DS-8500a 50-mg group.Conclusion
DS-8500a was well tolerated and demonstrated significant glucose-lowering effects and favorable changes in lipid profiles up to 12 weeks in Japanese patients with T2DM.Funding
Daiichi Sankyo Co. Ltd.996.
Yuka Yamada Ayako Wada Tomoyoshi Otsuka Kaori Muraoka Meigen Liu 《Disability and rehabilitation》2018,40(12):1421-1425
Purpose: Swallowing dysfunction has been reported in Duchenne muscular dystrophy (DMD), but has not been studied in Becker muscular dystrophy (BMD). The aims of this study were to report the characteristics of swallowing dysfunction in BMD compared with DMD.Materials and methods: The study participants were 18 patients with BMD and 18 patients with DMD. All the patients were examined using videofluorography during swallowing of 5?mL of fluid. The penetration–aspiration scale (P–A scale) and the videofluorographic dysphagia scale (VDS) were used to evaluate dysphagia.Results: Swinyard functional ability stage was not significantly different between the BMD and DMD groups. Rate of aspiration, P–A scale score, and total VDS score did not differ across groups, but the VDS item score for laryngeal elevation was lower in the BMD group than in the DMD group (median scores 4.5 and 9, respectively; p?0.001). In the BMD group, total VDS score significantly correlated with Swinyard stage (r?=?0.78, p?0.001), but not with age or lung function.Conclusion: Patients with BMD have swallowing problems similar to those observed in patients with DMD when matched according to physical functional status. These patients should be evaluated and followed-up for the duration of their disease.
- Implications for rehabiliation
Dysphagia is one of the most critical problems in patients with progressive neuromuscular disease but dysphagia in patients with Becker muscular dystrophy (BMD) was not well known.
Eighteen patients with BMD and 18 patients with Duchenne muscular dystrophy were examined with videofluorography.
Patients with BMD have swallowing problems similar to those observed in patients with DMD.
997.
998.
Ryo Kawasaki Yoko Akune Yoshimune Hiratsuka Shunichi Fukuhara Masakazu Yamada 《Ophthalmic epidemiology》2015,22(1):4-12
ABSTRACTPurpose: To evaluate the cost-effectiveness for a screening interval longer than 1 year detecting diabetic retinopathy (DR) through the estimation of incremental costs per quality-adjusted life year (QALY) based on the best available clinical data in Japan.Methods: A Markov model with a probabilistic cohort analysis was framed to calculate incremental costs per QALY gained by implementing a screening program detecting DR in Japan. A 1-year cycle length and population size of 50,000 with a 50-year time horizon (age 40–90 years) was used. Best available clinical data from publications and national surveillance data was used, and a model was designed including current diagnosis and management of DR with corresponding visual outcomes. One-way and probabilistic sensitivity analyses were performed considering uncertainties in the parameters.Results: In the base-case analysis, the strategy with a screening program resulted in an incremental cost of 5,147 Japanese yen (¥; US$64.6) and incremental effectiveness of 0.0054 QALYs per person screened. The incremental cost-effectiveness ratio was ¥944,981 (US$11,857) per QALY. The simulation suggested that screening would result in a significant reduction in blindness in people aged 40 years or over (?16%). Sensitivity analyses suggested that in order to achieve both reductions in blindness and cost-effectiveness in Japan, the screening program should screen those aged 53–84 years, at intervals of 3 years or less.Conclusions: An eye screening program in Japan would be cost-effective in detecting DR and preventing blindness from DR, even allowing for the uncertainties in estimates of costs, utility, and current management of DR. 相似文献
999.
Kohji Nagayama Katsutaro Morino Osamu Sekine Fumiyuki Nakagawa Atsushi Ishikado Hirotaka Iwasaki Takashi Okada Masashi Tawa Daisuke Sato Takeshi Imamura Yoshihiko Nishio Satoshi Ugi Atsunori Kashiwagi Tomio Okamura Hiroshi Maegawa 《Nutrients》2015,7(9):8112-8126
N-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have protective effects against atherosclerosis. Monocyte chemotactic protein (MCP)-1 is a major inflammatory mediator in the progression of atherosclerosis. However, little is known about the regulation of Mcp-1 by DHA and EPA in vessels and vascular smooth muscle cells (VSMCs). In this study, we compared the effect of DHA and EPA on the expression of Mcp-1 in rat arterial strips and rat VSMCs. DHA, but not EPA, suppressed Mcp-1 expression in arterial strips. Furthermore, DHA generated 4-hydroxy hexenal (4-HHE), an end product of n-3 polyunsaturated fatty acids (PUFAs), in arterial strips as measured by liquid chromatography-tandem mass spectrometry. In addition, 4-HHE treatment suppressed Mcp-1 expression in arterial strips, suggesting 4-HHE derived from DHA may be involved in the mechanism of this phenomenon. In contrast, Mcp-1 expression was stimulated by DHA, EPA and 4-HHE through p38 kinase and the Keap1-Nuclear factor erythroid-derived 2-like 2 (Nrf2) pathway in VSMCs. In conclusion, there is a dual effect of n-3 PUFAs on the regulation of Mcp-1 expression. Further study is necessary to elucidate the pathological role of this phenomenon. 相似文献
1000.
Serotonergic mechanisms are involved in antidepressant‐like effects of bisbenzylisoquinolines liensinine and its analogs isolated from the embryo of Nelumbo nucifera Gaertner seeds in mice
下载免费PDF全文
![点击此处可从《The Journal of pharmacy and pharmacology》网站下载免费的PDF全文](/ch/ext_images/free.gif)