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961.
Bioinformatics tools to understand human diseases 总被引:1,自引:0,他引:1
962.
963.
Ibañez J Arikan F Pedraza S Sánchez E Poca MA Rodriguez D Rubio E 《Journal of neurosurgery》2004,100(5):825-834
OBJECT: The aims of this study were to analyze the relevance of risk factors in mild head injury (MHI) by studying the possibility of establishing prediction models based on these factors and to evaluate the reliability of the clinical guidelines proposed for the management of MHI. METHODS: A series of 1101 patients with MHI were prospectively enrolled in this study. In all cases clinical data were collected and a computerized tomography (CT) scan was obtained. The relationship between clinical findings and the presence of intracranial lesions was studied to establish prediction models based on logistic regression and recursive partitioning analysis. Recently proposed guidelines and recommendations for the treatment of MHI were selected, calculating their diagnostic efficiency when applying each of them to our series. The incidence of acute intracranial lesions was 7.5% (83 patients). A Glasgow Coma Scale score of 14, loss of consciousness, vomiting, headache, signs of basilar skull fracture, neurological deficit, coagulopathies, hydrocephalus treated with shunt insertion, associated extracranial lesions, and patient age greater than 65 years were identified as independent risk factors. Prediction models built on clinical variables were able to indicate patients with clinically important lesions, but failed to achieve 100% sensitivity in the detection of all patients with CT scans positive for intracranial lesions within reasonable specificity limits. CONCLUSIONS: Clinical variables are insufficient to predict all cases of intracranial lesions following MHI, although they can be used to detect patients with relevant injuries. Avoiding systematic CT scan indication implies a rate of misdiagnosis that should be known and assumed when planning treatment in these patients by using guidelines based on clinical parameters. 相似文献
964.
Mosenthal AC Livingston DH Lavery RF Knudson MM Lee S Morabito D Manley GT Nathens A Jurkovich G Hoyt DB Coimbra R 《The Journal of trauma》2004,56(5):1042-1048
OBJECTIVE: Elderly patients (aged 60 years and older) have been demonstrated to have an increased mortality after isolated traumatic brain injury (TBI); however, the prognosis of those patients surviving their hospitalization is unknown. We hypothesized that surviving elderly patients would also have decreased functional outcome, and this study examined the functional outcome of patients with isolated TBI at discharge and at 6 months posthospitalization. METHODS: This was a multicenter prospective study of all patients with isolated moderate to severe TBI defined as Head Abbreviated Injury Scale score of 3 with an Abbreviated Injury Scale score in any other body area of 1. Patients surviving to discharge gave their consent and were enrolled. Data collected included demographics, Glasgow Coma Scale (GCS) score at admission, and neurosurgical interventions. Outcome data included discharge disposition and Glasgow Outcome Scale score and modified Functional Independence Measure (FIM) score at discharge and at 6 months. RESULTS: Two hundred thirty-five patients were enrolled, with 44 (19%) aged greater than or equal to 65 years. Mechanisms of injury were falls (34%), assaults (28%), motor vehicle collisions (14%), pedestrian (11%), and other (12%). Falls were more common in the older patients and assaults in the younger group. The mean admitting GCS score was 12.8 (95% confidence interval [CI], 12.4-13.3), with older patients having a higher mean GCS score, 14.1 (95% CI, 13.6-14.6) versus 12.5 (95% CI, 12.0-13.1; p = 0.03). There were no differences in the percentage of patients admitted to the intensive care unit or requiring neurosurgical intervention between younger and older patients. Because there were few elderly patients with low GCS scores who survived to discharge, outcome measures focused on those patients with GCS scores of 13 to 15. A greater percentage of elderly were discharged to rehabilitation (28% vs. 16%, p =0.08). The mean discharge FIM score was 10.4 (95% CI, 9.8-11.0) for the elderly versus 11.4 (95% CI, 11.1-11.7) for the young (p =0.001), with 68% elderly and 89% young discharged with total independent scores of 11 to 12. At 6 months, the difference narrowed, but the mean FIM score was still greater for the young group, 11.7 (95% CI, 11.6-11.9) versus 11.0 (95% CI, 10.6-11.4; p < 0.001). CONCLUSION: Functional outcome after isolated mild TBI as measured by the Glasgow Outcome Scale and modified FIM is generally good to excellent for both elderly and younger patients. Older patients required more inpatient rehabilitation and lagged behind their younger counterparts but continued to recover and improve after discharge. Although there were statistically significant differences in the FIM score at both discharge and 6 months, the clinical importance of these small differences in the mean FIM score to the patient's quality of life is less clear. Measurable improvement in functional status during the first 6 months after injury is observed in both groups. Aggressive management and care of older patients with TBI is warranted, and efforts should be made to decrease inpatient mortality. Continued follow-up is ongoing to determine whether these outcomes persist at 12 months. 相似文献
965.
The epidemiology of serious and fatal injury in San Diego County over an 11-year period 总被引:2,自引:0,他引:2
Potenza BM Hoyt DB Coimbra R Fortlage D Holbrook T Hollingsworth-Fridlund P;Trauma Research Education Foundation 《The Journal of trauma》2004,56(1):68-75
BACKGROUND: Analysis of the mechanism and severity of injury over time may permit a more focused planning of acute care and trauma prevention programs. METHODS: A retrospective, population-based study examining severe traumatic injury in a single county was undertaken. Three overlapping data sets were used to form a composite injury data set. RESULTS: There were 55,664 patients included in the study. A total of 40,897 (73.5%) patients survived and 14,767 (26.5%) died. Of those patients who died, 8,910 (60.3%) died in the field and were not transported to a trauma center. There was an increase in the mean age of all trauma victims (3 years) and an increase of 5 years in fatally injured patients. The mean Injury Severity Score decreased from 14.7 to 11.6 (p < 0.01); however, Injury Severity Score for fatal patients remained constant (39.7). The overall injury rate remained unchanged (195 per 10(5)), whereas the fatal injury rate decreased by 22% (45.9 per 10(5)) over the 11-year study period. The leading cause of injury was motor vehicle crash, followed by assault. The leading cause of fatal injury was suicide, followed by homicide. CONCLUSION: A combination of three independent injury data sources generated a composite data set of serious and fatal injury. This regional injury analysis was the most comprehensive overview of injury in our region. Important observations included the following: there has been no change in the overall incidence of severe injury within our county; the incidence of fatal traumatic injury has significantly decreased; the leading causes of nonfatal injury do not correlate with the rank order of fatal injury; intentional injury was the leading cause of injury deaths; and scene fatalities represent a poorly studied group of patients who may benefit from primary prevention and injury control research. 相似文献
966.
Comparison of the PFC Sigma fixed-bearing and rotating-platform total knee arthroplasty in the same patient: short-term results 总被引:7,自引:0,他引:7
Ranawat AS Rossi R Loreti I Rasquinha VJ Rodriguez JA Ranawat CS 《The Journal of arthroplasty》2004,19(1):35-39
This study compares the fixed-bearing PFC Sigma Total Knee Arthroplasty to the recently introduced rotating-platform version of the same design in 26 patients. At an average follow-up time of 46 months for the fixed-bearing side and 16 months for the rotating-platform side, no significant differences were found in terms of knee preference, knee pain, range of motion, overall satisfaction, or Knee Society scores (KSSs). No revisions, subluxations, dislocations, or infections were seen. Also no radiographic evidence of component loosening, osteolysis, or malalignment was found in any knee. The results of cementing the PFC Sigma rotating-platform, posterior-stabilized total knee show excellent patient satisfaction at 1 year and comparable clinical and radiographic results to the fixed-bearing version. 相似文献
967.
Hornero F Rodriguez I Buendía J Bueno M Dalmau MJ Canovas S Gil O Garcia R Montero JA 《Journal of cardiac surgery》2004,19(5):376-382
BACKGROUND: Mitral valve pathology is frequently associated with auricular dilatation and atrial fibrillation. Mitral surgery allows an immediate surgical auricular remodeling and besides in those cases in which sinus rhythm is reached, it is followed by a late remodeling. The aim of this study is to investigate the process of postoperative auricular remodeling in patients with permanent atrial fibrillation undergoing mitral surgery. METHODS: In a prospective randomized trial, 50 patients with permanent atrial fibrillation and dilated left atrium, submitted to surgical mitral repair, were divided into two groups: Group I contained 25 patients with left auricular reduction and mitral surgery, and Group II contained 25 patients with isolated valve surgery. Both groups were considered homogeneous in the preoperative assessment. RESULTS: After a mean follow-up of 31 months, 46% of patients included in Group I versus 18% of patients included in Group II restarted sinus rhythm (p = 0.06). An auricular remodeling with size regression occurred in those patients who recovered from sinus rhythm, worthy of remark in Group II (-10.8% of left auricular volume reduction in Group I compared to -21.5% in Group II; p < 0.05). A new atrial enlargement took place in those patients who remained with atrial fibrillation (+16.8% left auricular volume in Group I vs. +8.4% in Group II; p < 0.05). CONCLUSIONS: Mitral surgery produces an atrial postoperative volume that decrease especially when reduction techniques are employed. Late left atrial remodeling depended on the type of atrial rhythm and postoperative surgical volume. 相似文献
968.
Scott TE Mendez MV LaMorte WW Cupples LA Vokonas PS Garcia RI Menzoian JO 《Annals of vascular surgery》2004,18(4):459-464
Clinical observations suggest that varicose veins (VV) are less frequent in patients undergoing infrainguinal bypass surgery for femoral artery occlusive disease. While some previous studies support this relationship, others report that VV are more prevalent in coronary heart disease patients (CHD). This study used the Normative Aging Study (NAS) population to examine the association between VV and symptomatic CHD. The incidence of CHD over 35 years of follow-up was determined in the 2280 initially healthy male volunteers enrolled in the NAS. The incidence of CHD in the VV population and the subjects without VV were compared using Kaplan-Meier survival curves and the log-rank test. A time-dependent proportional hazards regression method was used to further explore the relationship between VV disease and subsequent development of CHD after adjusting for other cardiovascular risk factors. A total of 569 subjects (24.9%) were diagnosed with VV prior to the development of symptomatic CHD, and 1708 (75.1%) were not. Over 35 years of follow-up, 98 subjects with VV developed symptomatic CHD (17.2%), while 363 of those without VV subsequently developed symptomatic CHD (21.2%). Kaplan-Meier survival curves suggested a reduced risk of symptomatic CHD for subjects with VV (p = 0.0001). Further exploration of this relationship in a proportional hazards multivariate model showed VV to be associated with a 36% decreased risk of symptomatic CHD after adjusting for other recognized cardiovascular risk factors. In the NAS population, men with VV were less likely to develop symptomatic CHD over the 35+ years of follow-up than were subjects without VV. 相似文献
969.
Chousleb E Szomstein S Podkameni D Soto F Lomenzo E Higa G Kennedy C Villares A Arias F Antozzi P Zundel N Rosenthal R 《Obesity surgery》2004,14(9):1203-1207
Background: The authors reviewed the benefits of routine placement of closed drains in the peritoneal cavity following laparoscopic
Roux-en-Y gastric bypass (LRYGBP). The purpose of the study was to determine whether routine closed abdominal drainage provides
diagnostic and therapeutic advantages in the presence of complications such as bleeding and leaks. Materials and Methods:
The medical records of 593 consecutive patients who had undergone LRYGBP from July 2001 through May 2003 were retrospectively
reviewed. In all cases, antecolic antegastric LRYGBP was performed. Two 19-Fr Blake closed suction drains were left in place,
one at the gastrojejunostomy and the other at the jejunojejunostomy. The incidence of bleeding and leaks was reviewed, and
the utility of the drains relative to diagnosis and management was evaluated. Results: Bleeding presented in 24 patients (4.4%);
in 8, the diagnosis was based on increased sanguinous output from the drain and decreased hematocrit. None of the patients
with intraabdominal bleeding required reoperation. Of the 10 patients (1.68%) who presented with leaks, the diagnosis was
made within 48 hours postoperatively in 5 patients (50%), based on the characteristics of the drain output. Nonoperative management
with drainage and total parenteral nutrition was accomplished in 5 (50%) of the 10 patients with leaks. There was no mortality
in the series. Conclusion: The routine use of abdominal drains after LRYGBP appears to be beneficial. Drains allowed early
diagnosis of complications and in most cases, the successful treatment of leaks. When bleeding is suspected or documented,
appropriate volume replacement therapy is mandatory to maintain adequate hemodynamic parameters. Drain output may orient the
surgeon to take preventive measures such as discontinuing anticoagulation and early fluid resuscitation. In this series, in
most cases the bleeding spontaneously stopped and no further surgical management was required. 相似文献
970.
Background: Intra-operative pneumothorax (PTX) is an infrequent complication of laparoscopic surgery. Most cases are attributed
to CO2 diffusion across congenital diaphragmatic defects and resolve spontaneously. We report a case of PTX during a laparoscopic
Roux-en-Y gastric bypass (LRYGBP). When applied to this specific patient population, the current literature recommendations
for the management of intra-operative PTX are questioned. Material and Methods: A retrospective chart review of 400 consecutive
LRYGBP procedures performed over a 30-month period revealed 1 case of PTX (0.025%). Results: A bulging left diaphragm, hypotension,
bradycardia, decreased pO2, and elevated EtCO2 and airway pressures, were noted early in the case. She initially responded to conservative management but required multiple
subsequent hospital admissions for pulmonary complications. Conclusions: Pneumoperitoneum-induced PTX during laparoscopic
bariatric surgery is a rare complication. Its treatment must be based on the potential underlying cause, with consideration
of these patients' often delicate pulmonary status. In stable patients, where the PTX is attributed to diaphragmatic or hiatal
dissection, expectant treatment is appropriate. In all other situations, however, we believe that tube thoracostomy is indicated.
An algorithm for treatment of PTX in laparoscopic bariatric surgery is proposed. It follows the dictum of maintaining extreme
vigilance and a low threshold for aggressive intervention in this group of patients. 相似文献