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11.
Jin Woo Kim M.D. Ho Shik Kim M.D. In Kyung Kim M.D. Mee Ran Kim M.D. Eun Young Cho B.S. Heung Kee Kim M.D. Joon Mo Lee M.D. Sung Eun Namkoong M.D. 《Gynecologic oncology》1998,69(3):230-236
Transforming growth factor-β1 (TGF-β1) is known to be a potent growth inhibitor for many cell types, including most epithelial cells. In skin keratinocytes, TGF-β1 has been shown to inhibit growth and to rapidly reduce c-mycexpression. However, the molecular mechanism of TGF-β1 action on cell growth of cervical carcinoma has not yet been elucidated. We thus assessed the effect of TGF-β1 on the growth of cervical carcinoma cell lines. Two cervical squamous carcinoma cell lines, CUMC-3 and CUMC-6, were incubated with varying concentrations of TGF-β1, and growth inhibition was evaluated with tetrazolium-based colorimetric assay. After culture in TGF-β1 for 24 h, inhibition of growth was detected in a dose-dependent manner at concentrations of 0.1–10 ng/ml in both cell lines. This effect of TGF-β1 on cultured carcinoma cells was associated with apoptotic process including oligonucleosomal ladder DNA and apoptotic body formations. Northern blot analysis revealed c-mycmRNA expression was suppressed by 10 ng/ml of TGF-β1 following 3 h of treatment in both cell lines. Western blot analysis showed that the level of p27Kip1protein was increased after TGF-β1 treatment in both cell lines. These results suggest that the mechanisms by which TGF-β1 inhibits the growth of cervical carcinoma are complex and may include effects on down-regulation of c-mycgene, and overexpression of p27Kip1protein. 相似文献
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66例成人原发肾病综合征临床治疗与病理分析 总被引:1,自引:0,他引:1
本对66例原发肾病综合征患进行病理类型与临床疗效分析。最常见病理类型为系膜增殖性肾炎,占42.5%,其次为膜性肾病,占32.5%,IgA肾病占15.0%。微小病变型及系膜增殖性肾炎对激素及免疫抑制剂治疗效果好,膜性肾病治疗效果差。不同病理类型患病理损害程度与疗效相关。伴肾小管间质病变治疗效果差(P〈0.05)。NSⅠ型疗效明显优于NSⅡ型(P〈0.05)。50岁以下原发肾病综合征(PNS) 相似文献
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用硅胶层析及反相硅胶层析法,从大叶牛奶菜(MarsdeniakoiTsiang)抗生育活性的甲醇提取物中分离获得一孕甾四糖甙。经化学反应,波谱分析,酸碱降解及其水解产物的鉴定,确定其结构为12-0-cvnnamyl-dihydrosarcostin-3-0-β-D-glucopyranosyl(l→4)-0-3-0-methyl-6-deoxy-β-D-allopyranosyl(1→4)-0-β-D-oleandropyranosyl(1→4)-0-β-D-cymaropyranoside,命名为大叶牛奶菜甙庚(marsdekoisideG)。经系统文献检索证明其为首次自该植物中分离得到。 相似文献
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<正> 患者男性,52岁,突发上腹痛6 h来诊。疼痛呈持续性,无放射痛,无呕吐、腹泻、黄疸。既往有胃溃疡病史。查体:神清,T37.8℃,痛苦面容,平卧位,巩膜皮肤无黄染,心肺(-),上腹部压痛,轻度肌卫,无反跳痛,肝浊音界存在,移动性浊音(-),肠鸣音减弱。化验:WBC12.0×10~9/L、中性0.87。腹 相似文献
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Gal Ophir Ninette Amariglio Jasmine Jacob-Hirsch Ran Elkon Gideon Rechavi Daniel M. Michaelson 《Neurobiology of disease》2005,20(3):519-718
Apolipoprotein E4 (apoE4), the major genetic risk factor of Alzheimer's disease (AD), is associated with enhanced brain inflammation. Genome-wide gene expression profiling was employed to study the effects of apoE genotype on hippocampal gene expression in LPS-treated mice, transgenic for either apoE4 or the AD benign allele, apoE3. This revealed that the expression of inflammation-related genes following intracerebroventricular injection of LPS was significantly higher and more prolonged in apoE4 than in apoE3 transgenic mice. Clustering analysis revealed gene clusters which responded differently in apoE4 and apoE3 mice and were significantly enriched in NF-kappaB response elements. Direct measurement of NF-kappaB-regulated genes revealed that their extent of activation was greater in the apoE4 mice. Immunohistochemistry experiments revealed that microglial and NF-kappaB activation were more pronounced in apoE4 than in apoE3 mice. These findings suggest that the increased brain inflammation in apoE4 mice is related to disregulation of NF-kappaB signaling pathway. 相似文献
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s teaching was also significantly higher in the study group than in the control group(97.37% vs.64.71%,P<0.05).Conclusion Micro-teaching can effectively improve the quality of clinical teaching. 相似文献
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