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991.
同种异体肌腱移植的实验研究 总被引:6,自引:0,他引:6
采用淋巴细胞毒试验,淋巴细胞转化试验及吞噬细胞功能实验等多项细胞免疫学指标测定,以及组织形态学观察与生物力学测定,比较深低温冷冻与深低温冷冻干燥两种不同处理方式对同种异体肌腱移植的差异,并综合评价各种移植的效果。结果显示:(1)深低温冷冻移植组及深低温冷冻干燥移植组的淋巴细胞死亡率、转人弦及吞噬细胞吞噬率均低于未经处理的同种异体移植组(P〈0.05),而与自体肌腱移植组差异无显著性(P〉0.05) 相似文献
992.
多烯脂肪酸对脑血栓伴高脂血症病人降脂作用的疗效观察 总被引:2,自引:0,他引:2
目的:研究多烯脂肪酸胶囊对脑血栓伴高脂血症病人的降脂作用。选血脂康作对照。方法:60例脑血栓伴高脂血症病人随机分为二组:治疗组(n=31)及对照组(n=29)。服药前及服药后4周,8周查血脂。结果:⑴服药4周后TC和LDL-C分别降低21.02%和28.93%(多烯脂肪酸组)。⑵多烯脂肪酸组降低了34.06%的血清TG水平,效果显,结论:多烯脂肪酸胶囊降TG和LDL-C水平与血脂康作用相近,其降 相似文献
993.
Objective. To evaluate the results of operative treatment of spinal fracture-dislocation without neumlogic deficits. Metods. Eighteen patients with spinal fracture-dislocation were neurologically intact at the time of injury, and all were treated operatively. The fracture sites were:8 cases in cervical spine, 3 cases in thoracic spine, and 7 cases in lumbar spine. Eight patients with cervical injuries had variant degrees of forward slide and kyphotic deformity. Of the 10 thoracic and lumbar fractures, one had lateral dislocation, 4 cases with kyphotic deformities, 5 cases withspinal canal compromise averaged 50% (ranging from 40% to 70% ).Results. The aveiage period of follow-up was 4.4 years with a range of 11 months to 13 years. All the patients returned to full-time work. No patient developed neurologic deterioration. Kyphotic deformity was corrected in the 4 cases, and no progressive kyphosis was noted. There was no operation-related complication. The averaged post-opera-five hospitalization time was 13 days. Conclusions. Despite the rare incidence of spinal fracture-dislocation without neurologic deficits, we suggested that kind of fracture be considered unstable fracture because of its potential risk of delayed neurologic deterioration and kyphotic deformity, and be treated operatively to restore the sagittal alignment and the stability of the spine. 相似文献
994.
INTRODUCTION Themethodofcoldliverpreservationisacruciallimit ingfactorinthedurationofliverpreservation .Experimentalevidencehasshownthatnonparenchymalcellsaremorevulnerabletohypothermicstoragethanhepatocyte,indicatingthatprotectionofthemicrovasculatur… 相似文献
995.
Objective. To improve the localized diagnosis of insidious recurrent small intestinal hemorrhage. Methods. This retrospective analysis include 64 cases of such diseases, which were admitted from 1988 to 1998 toour hospital. Result. Ultrasonography, CT, small bowel pneumobariunlgraphy, diluted barium enema, isetopic examination, DSA and intraoperafive small-bowel endoscopy were used for diagnosis of hemonrrhagic site, and 37 cases got a defirfite location before operation, while 10 cases were confirmed the diagnosis during the operation. Forty-seven cases were treated surgically, while the other 17 cases had non-surgical treatment. Of the 47 cases,39 cases underwent partial en-terectomy, 5 cases had suture and ligature of vascular deformity, 2 cases had Whipple‘s operation, and one patient had ectomy of the end of ileum and right colon. Conclusion. DSA, Isotopic examination and intraoperafive enteroscopy are of considerable importance for the lo-cation judgement of recurrent small intestinal hemorrhage. 相似文献
996.
INHIBITORY EFFECT OF FLUVASTATIN ON AORTIC INTIMAL THICKENING IN NORMOCHOLESTEROLEMIC RABBITS 总被引:1,自引:0,他引:1
Objective, The anti-atherosclerotic effect of fluvastatin at doses insufficient to lower serum cholesterol on the catheter-induced intimal thickening and possible mechanism were investigated in abdominal aorta of rabbits. Methods. Fifty-six rabbits were randomly divided into eight groups( n = 7, each). Fluvastatin was given mixed with food at daily dose of 8mg/kg starting 5 days before catheterization. Light microscope, immanohistochemistry, transmis-sion electron microscope and RT-PCR assay were applied to assess vascular smooth muscle cell (VSMC) proliferation and apoptosis, as well as oncogene expression in vascular wall. Results. At day 10 and day 15 after catheter induced denudation intima/media( I/M) thickness ratio was obviously higher, and also the percentage of PCNA-positive cells and TUNEL-positive cells in media was significantly higher compared with controls. The intimal hyperplasia was mostly composed of α-SM-actin-pesitive cells. In rabbits given flu-vastatin I/M ratio and the percentage of these positive cells significantly decreased compared with those without fluvas-tatin.The overexpression of proto-oncogene H-ras mRNA and decreased expression of anti-oncogene p53 mRNA were found after vascular injury, whereas fluvastatin significantly reduced H-ras mRNA and increased p53 mRNA expres-sion. Conclusion. Proliferation of VSMC in the media and the migration to the intima can be inhibited, and apoptosis of VSMC be induced by short-term use of fluvastatin after balloon catheter denudation, independent of serum lipid change. The underlying mechanism is presumably associated With the influence of fluvastatin on oncogene expression in the injured vascular Wall. 相似文献
997.
Objective. To undertake the pilot experiments of prevention of disability (POD) in 14 different geographical areas to serve as examples for future development of rehabilitation work in China and in Asia. Mahods. According to the principles mid national criterion, 27 000 people affected by leprosy were selected and assessed using disability record forms at beginning and followed up regularly for observing changes of different indica-tors. Results. A total of 197 neuritis cases were detected and treated with prednisolone out of 1 407 new or active cas-es. Serf-care training of eyes, hands and feet were conducted for 10 500 disabled people affected by leprosy. Compre-hensive therapy was given to 1 804 cases having comphcated ulcers of which 1 055 cases have got their ulcers healed. Out of 706 prostheses, 613 were given to patients with satisfactory results. Surgical treatment was given to 269 cases and 251 have shown good progress. Conclusion. Most of patients have got benefit from the project in function or appearance which is very helpful for their going back to the society and agreed by foreign experts during the final evaluation. The experiences from the pro-ject can be implemented in the whole country. 相似文献
998.
999.
单用国产紫杉醇治疗乳腺癌 总被引:22,自引:2,他引:20
目的评价国产紫杉醇(特素)对乳腺癌的治疗效果和不良反应。方法自1995年3月至1995年7月,采用紫杉醇治疗乳腺癌22例。紫杉醇175mg/m2(170.9~210.8mg/m2),21天为1个周期,共1~4次(中位数3次)。结果紫杉醇近期客观疗效:完全缓解3例,部分缓解11例,总有效率63.6%(14/22),有效患者的病情已全部再度进展,缓解期2~7个月(中位3.5个月)。特素化疗的主要不良反应为白细胞下降(96.2%)、脱发(100%)和肌肉疼痛(84.9%)。结论国产紫杉醇治疗乳腺癌有效,不良反应可以耐受。 相似文献
1000.
胃癌细胞肿瘤坏死因子受体的研究 总被引:2,自引:0,他引:2
目的 探讨人胃癌细胞肿瘤坏死因子受体 ( TNFR)的数目与胃癌细胞分化程度以及与肿瘤坏死因子突变体 ( TNF- m)细胞毒效应之间的关系。方法 以12 5I- TNF- m为配体 ,用放射配体结合分析法 ,检测了高、中、低不同分化程度的体外培养胃癌细胞 ( MKN2 8、SGC790 1、MKN4 5)的 TNFR,同时用 MTT比色法研究了 TNF- m对三株胃癌细胞的细胞毒效应。结果 三株胃癌细胞 TNFR数目分别为每细胞 9.8× 10 -12 nmol、5.6× 10 -12 nmol、3.2× 10 -12 nmol,三者之间比较 ,TNFR数目差异有显著性 ( P<0 .0 5)。解离常数基本一致 ,同一温度时三株胃癌细胞 TNF- m的内化率几乎相等 ,且呈温度依赖关系。TNFR的半衰期大约为 90分钟 ,胞膜与胞浆 TNFR数目之比约为 1∶ 2 ,TNF- m对三株胃癌细胞的最大杀伤率分别为 86%、60 %、34 % ,差异有显著性 ( P<0 .0 5) ,且 39℃时的杀伤率高于37℃时的杀伤率。结论 胃癌细胞表面 TNFR数目与胃癌分化程度相关。 TNF- m的细胞毒效应与TNF数目及 TNF- m的内化量有关。 相似文献