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C R Reddy T R Rao C Ramulu 《Journal of oral surgery (American Dental Association : 1965)》1976,34(10):937-939
A case of malignant melanoma of the oral cavity is presented. The very high frequency of squamous cell carcinoma of the palate in Visakhapatnam, India, is compared to the rarity of malignant melanoma, even though pigmentation of the oral cavity is quite common in this geographical region. 相似文献
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Gliomas are devastating primary tumors of the central nervous system and tend to recur even after standard therapy. Celecoxib,
the selective COX-2 nonsteroidal anti-inflammatory drug, has anti-neoplastic activity against several malignancies. Accumulating
evidence suggests that several COX-2-independent mechanisms may also be involved in the anti-tumor effects of celecoxib. Deregulation
of the NF-κB signaling pathway contributes to enhanced glioma cell survival, proliferation, and chemoresistance. In this study,
we examined the efficacy of celecoxib in suppressing the growth of glioblastoma cell lines. We observed that treatment with
celecoxib significantly reduced the proliferation of a variety of GBM cell lines in a dose-dependent manner and also induced
apoptosis, which was evident from enhanced caspase-3 and 8 activity, PARP cleavage, and TUNEL positive cells. Celecoxib treatment
significantly down-regulated TNF-α induced NF-κB nuclear translocation, NF-κB DNA binding activity, and NF-κB-dependent reporter
gene expression in U373 and T98G cells in a dose-dependent manner. Furthermore, celecoxib suppressed IκBα degradation and
phosphorylation and reduced IKK activity in a dose-dependent manner. This study provides evidence that celecoxib suppresses
the growth of GBM cell lines partly by inhibiting the NF-κB signaling pathway. 相似文献
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C R Reddy V R Kameswari D Prahlad C Ramulu P G Reddy 《Journal of oral surgery (American Dental Association : 1965)》1975,33(6):435-438
Cytology smears from 325 oral carcinomas were studied; the false-negative rate was 37%. Cancers of the floor of mouth exfoliated most malignant cells and those of the gingiva exofoliated the least. There was no correlation between the histologic grading, location, sex of the patient, and the result of the cytology smear. Oral exfoliative cytology should only be used as an adjunctive measure and is not a substitute for biopsy. 相似文献
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PURPOSE: To report a case of conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma with presumed intraocular involvement. METHODS: Observational case report. RESULTS: A 73-year-old white man presented for a routine eye examination and was found to have a salmon-colored bulbar conjunctival mass of the left eye. Ultrasound showed a low-reflective mass with diffuse thickening of the ciliary body and choroid. Immunohistochemistry and flow cytometry of an incisional biopsy specimen suggested a polyclonal lesion. Treatment with topical steroids yielded no clinical improvement, and excisional biopsy was performed. A diagnosis of MALT lymphoma was made after polymerase chain reaction (PCR) analysis of the immunoglobulin heavy chain (IgH) locus revealed a clonal B-cell population. CONCLUSIONS: Conjunctival MALT lymphoma can present without symptoms and can extend intraocularly. PCR analysis of the IgH locus can identify lesion clonality when immunohistochemistry and flow cytometry fail to do so. 相似文献