A validated chiral HPLC method for the enantiomeric separation of tolterodine tartarate

An isocratic chiral HPLC method was developed for the separation of tolterodine tartarate enantiomers. The mobile phase consists of n-hexane and isopropyl alcohol in the ratio of 980:20 (v/v) with 1 ml diethylamine and 0.6 ml trifluoroacetic acid. Chiralcel OD-H (250 mm × 4.6 mm) column was used at constant room temperature. Flow rate was kept at 0.5 ml/min. This method is capable of detecting the S-isomer up to 0.1 μg/ml. The method was validated in terms of linearity, precision, limit of detection (LOD) and limit of quantification (LOQ).     

Real-time monitored photocatalytic activity and electrochemical performance of an rGO/Pt nanocomposite synthesized via a green approach

Herein, we have reported the real-time photodegradation of methylene blue (MB), an organic pollutant, in the presence of sunlight at an ambient temperature using a platinum-decorated reduced graphene oxide (rGO/Pt) nanocomposite. The photocatalyst was prepared via a simple, one-pot and green approach with the simultaneous reduction of GO and Pt using aqueous honey as a reducing agent. Moreover, the honey not only simultaneously reduced Pt ions and GO but also played a key role in the growth and dispersion of Pt nanoparticles on the surface of rGO. Various rGO/Pt nanocomposites with different percentages of Pt nanoparticles loaded on rGO were obtained by tuning the concentration of the Pt source. The high percentage of Pt nanoparticles with an average size of 2.5 nm dispersed on rGO has shown excellent electrochemical performance. The photocatalytic activity of the rGO/Pt composite was enhanced by increasing the weight percent of the Pt particles on rGO, which led to the formation of a highly efficient photocatalyst. The optimized photocatalyst exhibited remarkable photocatalytic activity and degraded 98% MB in 180 minutes; thus, it can be used for industrial and environmental applications.

Herein, we have reported the real-time photodegradation of methylene blue, an organic pollutant, in the presence of sunlight at an ambient temperature using a platinum-decorated reduced graphene oxide (rGO/Pt) nanocomposite.