全文获取类型
收费全文 | 1726篇 |
免费 | 92篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 100篇 |
妇产科学 | 18篇 |
基础医学 | 152篇 |
口腔科学 | 25篇 |
临床医学 | 128篇 |
内科学 | 306篇 |
皮肤病学 | 47篇 |
神经病学 | 72篇 |
特种医学 | 66篇 |
外国民族医学 | 1篇 |
外科学 | 178篇 |
综合类 | 306篇 |
预防医学 | 174篇 |
眼科学 | 43篇 |
药学 | 74篇 |
1篇 | |
中国医学 | 3篇 |
肿瘤学 | 122篇 |
出版年
2023年 | 7篇 |
2022年 | 11篇 |
2021年 | 37篇 |
2020年 | 24篇 |
2019年 | 23篇 |
2018年 | 35篇 |
2017年 | 18篇 |
2016年 | 32篇 |
2015年 | 62篇 |
2014年 | 80篇 |
2013年 | 73篇 |
2012年 | 84篇 |
2011年 | 106篇 |
2010年 | 109篇 |
2009年 | 86篇 |
2008年 | 97篇 |
2007年 | 92篇 |
2006年 | 96篇 |
2005年 | 70篇 |
2004年 | 96篇 |
2003年 | 62篇 |
2002年 | 61篇 |
2001年 | 44篇 |
2000年 | 44篇 |
1999年 | 37篇 |
1998年 | 29篇 |
1997年 | 34篇 |
1996年 | 31篇 |
1995年 | 24篇 |
1994年 | 23篇 |
1993年 | 13篇 |
1992年 | 16篇 |
1991年 | 8篇 |
1990年 | 12篇 |
1989年 | 19篇 |
1988年 | 11篇 |
1987年 | 9篇 |
1986年 | 16篇 |
1985年 | 16篇 |
1984年 | 10篇 |
1983年 | 4篇 |
1982年 | 7篇 |
1981年 | 6篇 |
1980年 | 4篇 |
1979年 | 3篇 |
1978年 | 9篇 |
1977年 | 6篇 |
1976年 | 4篇 |
1974年 | 3篇 |
1973年 | 3篇 |
排序方式: 共有1820条查询结果,搜索用时 15 毫秒
61.
M Gupta AK Lamba M Verma F Faraz S Tandon K Chawla DK Koli 《Australian dental journal》2013,58(1):41-49
Background
Traditional periodontal open flap debridement (OFD) results in reduced pocket depth (PD), clinical attachment loss (CAL), gingival recession (GR) and postoperative pain and discomfort. The quest to overcome these shortcomings has led to research into Er,Cr:YSGG laser assisted pocket therapy (ELAPT). This study was designed to compare the clinical outcomes of ELAPT versus OFD.Methods
Fifteen patients with a PD of ≥5 mm and ≤8 mm at two sites were selected. Test sites (Group 1) were treated by ELAPT and the control (Group 2) by OFD. Clinical parameters were recorded at baseline, 3 and 6 months and included Plaque Index (PI), Gingival Index (GI), modified Sulcular Bleeding Index (mSBI), PD, CAL and GR.Results
Both treatments produced a reduction in PI, GI, mSBI and PD, an increase in GR, and a gain in CAL at 3 and 6 months. The mean gain of CAL in Group 1 at 3 and 6 months (1.60 ± 0.78 and 1.80 ± 0.63) was similar (p > 0.05) to the value of Group 2 (1.93 ± 0.88 and 2.00 ± 0.54). GR increased significantly (p < 0.05) only in Group 2 at 3 and 6 months (1.80 ± 0.56 and 1.87 ± 0.64) compared to Group 1 (0.50 ± 0.68 and 0.60 ± 0.74).Conclusions
ELAPT compared with OFD results in similar CAL gains with less GR and significant reductions in PD, GI and mSBI, and may be considered as an alternative to surgical therapy. 相似文献62.
S Jegatheeswaran T Satyadas AJ Sheen T Treasure AK Siriwardena 《Annals of the Royal College of Surgeons of England》2013,95(2):140-143
Introduction
Distant metastases to liver and lung are not uncommon in colorectal cancer. Resection of metastases is accepted widely as the standard of care. However, there is no firm evidence base for this. This questionnaire survey was carried out to assess the current practice preferences of cardiothoracic surgeons in Great Britain and Ireland.Methods
An online questionnaire survey was emailed to cardiothoracic surgeons in Great Britain and Ireland. The survey was live for 12 weeks. Responses were collated with SurveyMonkey®.Results
Overall, there were 75 respondents. The majority (83%) indicated thoracic surgery as a specialist interest. Almost all (99%) used thoracic computed tomography (CT) for staging; 70% added liver CT and 51% added pelvic CT. Fluorodeoxyglucose positron emission tomography was used by 86%. The most frequent indication for pulmonary resection (97%) was solitary lung metastasis without extrathoracic disease. Video assisted thoracoscopic surgery (VATS) was used by 85%. In addition, thoracotomy was used by 96%. A third (33%) used radiofrequency ablation. Synchronous liver and lung resection was contraindicated for 83% of respondents. Over three-quarters (77%) thought that scientific equipoise exists presently for lung resection for colorectal lung metastases but only 21% supported a moratorium on this type of surgery until further evidence becomes available.Conclusions
The results confirm that the majority of respondents use conventional cross-sectional imaging and either VATS or formal thoracotomy for resection. The results emphasise the continuing need for formal randomised trials to provide evidence of any survival benefit from pulmonary metastasectomy for colorectal lung metastases. 相似文献63.
64.
65.
66.
Pawan Kumar Verma Rajinder Raina Mudasir Sultana Maninder Singh Pawan Kumar 《Renal failure》2016,38(1):142-150
The present study was aimed to determine the total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) of plasma and renal tissue in cisplatin (cDDP) induced nephrotoxic rats and its protection by treatments with floral extracts of Calendula officinalis Linn. Treatment with cDDP elevated (p?0.05) the levels of blood urea nitrogen, creatinine (CR), TOS, OSI and malondialdehyde (MDA) but lowered (p?0.05) total plasma proteins, TAS, total thiols (TTH), blood glutathione (GSH) and antioxidant enzymes compared to the control group. Pre- and post-treatments of ethanolic floral extract of C. officinalis along with cDDP restored (p?>?0.05) CR, albumin, TOS, GSH and activities of antioxidant enzymes in blood and renal tissue. Ethanolic extract treatments reduced (p?0.05) MDA level in renal tissue without restoring the erythrocyte MDA level following cDDP treatment. These observations were further supported by the histopathological findings in renal tissue. Observations of the present study have shown that treatments with ethanolic floral extract of C. officinalis protect cDDP induced nephrotoxicity by restoring antioxidant system of the renal tissue. 相似文献
67.
Chandraprakash Umapathy Amit Raina Shreyas Saligram Gong Tang Georgios I. Papachristou Mordechai Rabinovitz Jennifer Chennat Herbert Zeh Amer H. Zureikat Melissa E. Hogg Kenneth K. Lee Melissa I. Saul David C. Whitcomb Adam Slivka Dhiraj Yadav 《Journal of gastrointestinal surgery》2016,20(11):1844-1853
Background
Most studies of acute necrotizing pancreatitis (ANP) focus on short-term outcomes. We evaluated long-term survival and outcomes following ANP.Methods
Patients treated for ANP at the University of Pittsburgh Medical Center from 2001 to 2008 were studied. Data on presentation and course during initial hospitalization and follow-up (median 34 months) was extracted.Results
Mean age of patients (n?=?167) was 53?±?16 years; 70 % were male, 94 % white, 71 % transfers, 52 % biliary etiology, and 78 % had first-attack of acute pancreatitis. Majority had severe disease with high Acute Physiology and Chronic Health Evaluation II (APACHE-II) score (median 11), length of stay (median 26 days), intensive care unit (ICU) admission (87 %), presence of systemic inflammatory response syndrome (SIRS) (90 %), persistent organ failure (60 %), and infected necrosis (50 %). Intervention was needed in 74 %. Eighteen (10.8 %) patients died during index hospitalization, 9 (5.4 %) during the first year, and 13 (7.8 %) after 1 year. Median survival was significantly shorter when compared with age- and sex-matched US general population (9.1 vs. 26.1 years, p?<?0.001). Increasing age (HR 1.05), persistent organ failure (HR 4.5), and >50 % necrosis (HR 3.8) were independent predictors of death at 1 year. In eligible patients, new-onset diabetes, oral pancreatic enzyme replacement therapy, and disability were noted in 45, 25, and 53 %, respectively.Conclusion
ANP significantly impacts long-term survival. A high proportion of patients develop functional derangement and disability following ANP.68.
Manpreet K. Grewal Arul Mehta Ronith Chakraborty Rupesh Raina 《Seminars in dialysis》2020,33(2):109-119
Chronic kidney disease and end-stage renal disease (ESRD) in children are major health concerns worldwide with increasing incidence and prevalence. Renal replacement therapies and kidney transplants have remarkably improved the management of patients with ESRD in both adult and pediatric populations. Kidney transplant has the best patient outcomes, but many a time it has a considerable waiting period. In the meantime, the majority of patients with pediatric ESRD are dependent on dialysis. The conventionally utilized hemodialysis regimen is the three times weekly, in-center hemodialysis. Many studies have demonstrated the unfavorable long-term morbidity associated with the conventional regimen. Intensified dialysis programs, which include extended nocturnal hemodialysis or short daily hemodialysis, are being increasingly advocated over the past two decades. In addition to having much better clinical outcomes as compared with the conventional regimen, the flexibility to provide dialysis at home serves as a great incentive. PubMed/Medline, Embase and Cochrane databases for literature on nocturnal home hemodialysis in children with ESRD were extensively searched. Contrary to the noticeable literature available on adult home hemodialysis, a small number of studies exist in the pediatric population. In this review, the benefits, implementation and associated barriers of nocturnal home hemodialysis in children were addressed. 相似文献
69.
Antonio Suppa MD PhD Luca Marsili MD Flavio Di Stasio MD Anna Latorre MD AK. Parvez MBBS Carlo Colosimo MD Alfredo Berardelli MD 《Movement disorders》2014,29(1):97-104
In humans, intermittent and continuous theta‐burst stimulation (iTBS and cTBS) elicit long‐term changes in motor‐evoked potentials (MEPs) reflecting long‐term potentiation (LTP)‐ and depression (LTD)‐like plasticity in the primary motor cortex (M1). In this study, we used TBS to investigate M1 plasticity in patients with MSA. We also assessed whether responses to TBS reflect M1 excitability as tested by short‐interval intracortical inhibition (SICI), intracortical facilitation (ICF), short‐interval intracortical facilitation (SICF), and the input/output curves. We studied 20 patients with MSA and 20 healthy subjects (HS). Patients were clinically evaluated with the Unified Multiple System Atrophy Rating Scale. The left M1 was conditioned with TBS. Twenty MEPs were recorded from the right first dorsal interosseous muscle before TBS and 5, 15, and 30 minutes thereafter. In a subgroup of 10 patients, we also tested MEPs elicited by SICI, ICF, SICF, and input/output curves, before TBS. Between‐group analysis of variance showed that at all time points after iTBS MEPs increased, whereas after cTBS they decreased only in HS. In both subgroups tested, patients with predominant parkinsonian and cerebellar features, iTBS and cTBS left MEPs unchanged. MSA patients had reduced SICI, but normal ICF, SICF, and input/output curves. No correlation was found between patients' clinical features and responses to TBS and M1 excitability variables. These findings suggest impaired M1 plasticity in MSA. © 2013 International Parkinson and Movement Disorder Society 相似文献
70.
Raina Madhu Kaul Veenu 《Proceedings of the National Academy of Sciences, India. Section B.》2019,89(3):867-875
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - The stigma of Kigelia pinnata is spathulate, wet and sensitive to touch. Consisting of two flaps or folds,... 相似文献