全文获取类型
收费全文 | 3150篇 |
免费 | 165篇 |
国内免费 | 27篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 94篇 |
妇产科学 | 80篇 |
基础医学 | 527篇 |
口腔科学 | 38篇 |
临床医学 | 238篇 |
内科学 | 833篇 |
皮肤病学 | 41篇 |
神经病学 | 407篇 |
特种医学 | 88篇 |
外科学 | 237篇 |
综合类 | 9篇 |
预防医学 | 161篇 |
眼科学 | 33篇 |
药学 | 215篇 |
中国医学 | 10篇 |
肿瘤学 | 313篇 |
出版年
2024年 | 8篇 |
2023年 | 29篇 |
2022年 | 56篇 |
2021年 | 98篇 |
2020年 | 54篇 |
2019年 | 61篇 |
2018年 | 106篇 |
2017年 | 79篇 |
2016年 | 72篇 |
2015年 | 100篇 |
2014年 | 117篇 |
2013年 | 168篇 |
2012年 | 244篇 |
2011年 | 235篇 |
2010年 | 131篇 |
2009年 | 140篇 |
2008年 | 238篇 |
2007年 | 226篇 |
2006年 | 210篇 |
2005年 | 190篇 |
2004年 | 207篇 |
2003年 | 152篇 |
2002年 | 145篇 |
2001年 | 30篇 |
2000年 | 17篇 |
1999年 | 28篇 |
1998年 | 34篇 |
1997年 | 32篇 |
1996年 | 24篇 |
1995年 | 10篇 |
1994年 | 19篇 |
1993年 | 16篇 |
1992年 | 16篇 |
1991年 | 5篇 |
1990年 | 4篇 |
1989年 | 5篇 |
1988年 | 7篇 |
1987年 | 7篇 |
1986年 | 6篇 |
1985年 | 4篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1982年 | 1篇 |
1980年 | 1篇 |
1977年 | 1篇 |
1975年 | 1篇 |
排序方式: 共有3342条查询结果,搜索用时 31 毫秒
81.
Donaldson Kandace Huntington Alyssa De Vita Raffaella 《Annals of biomedical engineering》2021,49(8):1788-1804
Annals of Biomedical Engineering - The uterosacral ligaments (USLs) are important anatomical structures that support the uterus and apical vagina within the pelvis. As these structures are... 相似文献
82.
83.
84.
Patients with paroxysmal nocturnal hemoglobinuria have a high frequency of peripheral-blood T cells expressing activating isoforms of inhibiting superfamily receptors 总被引:4,自引:2,他引:4
下载免费PDF全文
![点击此处可从《Blood》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Poggi A Negrini S Zocchi MR Massaro AM Garbarino L Lastraioli S Gargiulo L Luzzatto L Notaro R 《Blood》2005,106(7):2399-2408
Patients with paroxysmal nocturnal hemoglobinuria (PNH) have a large clonal population of blood cells deriving from hematopoietic stem cells (HSCs) deficient in glycosylphosphatidylinositol (GPI)-anchored surface molecules. A current model postulates that PNH arises through negative selection against normal HSCs exerted by autoreactive T cells, whereas PNH HSCs escape damage. We have investigated the inhibitory receptor superfamily (IRS) system in 13 patients with PNH. We found a slight increase in the proportion of T cells expressing IRS. In contrast to what applies to healthy donors, the engagement of IRS molecules on T cells from patients with PNH elicited a powerful cytolytic activity in a redirected killing assay, indicating that these IRSs belong to the activating type. This was confirmed by clonal analysis: 50% of IRS+ T-cell clones in patients with PNH were of the activating type, while only 5% were of the activating type in healthy donors. Moreover, the ligation of IRS induces (1) production of tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) and (2) brisk cytolytic activity against cells bearing appropriate IRS counter-ligands. In addition, these IRS+ T cells show natural killer (NK)-like cytolytic activity to which GPI- cells were less sensitive than GPI+ cells. Thus, T cells with NK-like features, expressing the activating isoforms of IRS, may include effector cells involved in the pathogenesis of PNH. 相似文献
85.
86.
87.
Luca Masotti Grazia Panigada Giancarlo Landini Filippo Pieralli Francesco Corradi Salvatore Lenti Rino Migliacci Stefano Arrigucci Anna Frullini Maria Chiara Bertieri Stefano Tatini Alberto Fortini Irene Cascinelli Nicola Mumoli Stefano Giuntoli Alessandro De Palma Veronica De Crescenzo Michele Piacentini Giancarlo Tintori Alba Dainelli Giuseppa Levantino Plinio Fabiani Filippo Risaliti Roberta Mastriforti Michele Voglino Valentina Carli Simone Meini 《Journal of thrombosis and thrombolysis》2016,41(4):606-612
Prognostic stratification of acute pulmonary embolism (PE) remains a challenge in clinical practice. Simplified PESI (sPESI) score is a practical validated score aimed to stratify 30-day mortality risk in acute PE. Whether prognostic value of sPESI score differs according to sex has not been previously investigated. Therefore the aim of our study was to provide information about it. Data records of 452 patients, 180 males (39.8 %) and 272 females (60.2 %) discharged for acute PE from Internal Medicine wards of Tuscany (Italy) were analysed. sPESI was retrospectively calculated. Variables enclosed in sPESI score, all cause in-hospital mortality and overall bleedings were compared between sexes. Moreover, predictive ability of sPESI score as prognosticator of all cause in-hospital mortality was tested and compared between sexes. sPESI score 0 (low risk) was found in 17.7 % of males and 13.6 % of females (p = 0.2323). We didn’t find significant difference in sPESI scoring distribution. Age ≥80 years (51.4 vs. 33.8 %, p = 0.0003) and heart rate ≥110 bpm (23.5 vs. 14.4 %, p = 0.0219) were found significantly more prevalent in females, whereas active cancer (23.8 vs. 39.4 %, p = 0.0004) and cardio-respiratory diseases (19.8 vs. 27.7 %, p = 0.0416) were in males. All cause in-hospital mortality was 0 % in both genders for sPESI score 0, whereas it was 5.4 % in females and 13.6 % in males with sPESI score 1–2 (p = 0.0208) and 22 % in females and 19.3 % in males with sPESI score ≥3 (p = 0.7776). Overall bleedings were significantly more frequent in females compared with males (4.77 vs. 0.55 %, p = 0.0189). In females overall bleedings ranged from 2.7 % in sPESI score 0 to 6 % in sPESI score ≥3. Predictive ability of sPESI score as prognosticator of all cause in-hospital mortality was higher in females compared to males (AUC 0.72 vs. 0.67, respectively). In real life different co-morbidity burdens in females compared to males. Females seems to be at lower risk of all cause in-hospital mortality for sPESI score ≤2 but at higher risk of bleeding, irrespective from sPESI scoring. Predictive ability of sPESI score seems better in females. 相似文献
88.
89.
Raffaella Santi Alessandro Franchi Valeria Saladino Massimo Trovati Giovanna Cenacchi Massimo Squadrelli-Saraceno Gabriella Nesi 《Head and neck pathology》2015,9(2):300-304
Paragangliomas (PGs) of the head and neck region are typically benign, slow-growing neuroendocrine tumours. At times, they may exhibit unusual histological features, such as prominent stromal sclerosis (sclerosing PG), which may raise concerns of malignancy. We describe a case of sclerosing PG of the carotid body, emphasizing the value of immunohistochemical stains for differential diagnosis. A 43-year-old woman presented with a painless lump on the neck. A magnetic resonance imaging scan demonstrated a hypervascular lesion of the carotid body, which was surgically excised. Grossly, the lesion measured 1.8 cm at maximum diameter. On microscopic examination, irregular nests and tiny bundles of neoplastic cells were found between thick bands of fibrous tissue. Focal nuclear cytomegaly and marked pleomorphism were noted. Neoplastic cells proved to be immunoreactive for chromogranin, synaptophysin and neuron specific enolase, but negative for cytokeratins, smooth muscle actin and CD34. Ultrastructurally, numerous mitochondria, rough endoplasmic reticulum structures and endocrine granules were seen in the cytoplasm of the tumour cells. On consideration of the above-mentioned clinico-pathological and ultrastructural findings a diagnosis of sclerosing PG was established. Sclerosing PG is a rare entity which may mimic a malignant neoplasm. The recognition of this unusual morphological variant of PG, together with appropriate immunostains, leads to the correct diagnosis. 相似文献
90.
Maternal uniparental isodisomy (iUPD) of chromosome 4 in a subject with mild intellectual disability and speech delay
下载免费PDF全文
![点击此处可从《American journal of medical genetics. Part A》网站下载免费的PDF全文](/ch/ext_images/free.gif)