全文获取类型
收费全文 | 2268篇 |
免费 | 219篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 29篇 |
儿科学 | 74篇 |
妇产科学 | 45篇 |
基础医学 | 314篇 |
口腔科学 | 19篇 |
临床医学 | 296篇 |
内科学 | 484篇 |
皮肤病学 | 53篇 |
神经病学 | 242篇 |
特种医学 | 38篇 |
外科学 | 192篇 |
综合类 | 19篇 |
一般理论 | 1篇 |
预防医学 | 321篇 |
眼科学 | 43篇 |
药学 | 129篇 |
中国医学 | 1篇 |
肿瘤学 | 188篇 |
出版年
2024年 | 3篇 |
2023年 | 53篇 |
2022年 | 67篇 |
2021年 | 115篇 |
2020年 | 102篇 |
2019年 | 127篇 |
2018年 | 117篇 |
2017年 | 92篇 |
2016年 | 88篇 |
2015年 | 78篇 |
2014年 | 107篇 |
2013年 | 139篇 |
2012年 | 202篇 |
2011年 | 202篇 |
2010年 | 105篇 |
2009年 | 114篇 |
2008年 | 159篇 |
2007年 | 128篇 |
2006年 | 121篇 |
2005年 | 91篇 |
2004年 | 86篇 |
2003年 | 74篇 |
2002年 | 66篇 |
2001年 | 15篇 |
2000年 | 2篇 |
1999年 | 4篇 |
1998年 | 6篇 |
1997年 | 6篇 |
1996年 | 5篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1984年 | 1篇 |
1982年 | 2篇 |
1979年 | 1篇 |
排序方式: 共有2488条查询结果,搜索用时 46 毫秒
91.
92.
93.
Rachael I. Scahill Nicola Z. Hobbs Miranda J. Say Natalie Bechtel Susie M.D. Henley Harpreet Hyare Douglas R. Langbehn Rebecca Jones Blair R. Leavitt Raymund A.C. Roos Alexandra Durr Hans Johnson Stéphane Lehéricy David Craufurd Christopher Kennard Stephen L. Hicks Julie C. Stout Ralf Reilmann Sarah J. Tabrizi the TRACK‐HD investigators 《Human brain mapping》2013,34(3):519-529
TRACK‐HD is a multicentre longitudinal observational study investigating the use of clinical assessments and 3‐Tesla magnetic resonance imaging as potential biomarkers for future therapeutic trials in Huntington's disease (HD). The cross‐sectional data from this large well‐characterized dataset provide the opportunity to improve our knowledge of how the underlying neuropathology of HD may contribute to the clinical manifestations of the disease across the spectrum of premanifest (PreHD) and early HD. Two hundred and thirty nine gene‐positive subjects (120 PreHD and 119 early HD) from the TRACK‐HD study were included. Using voxel‐based morphometry (VBM), grey and white matter volumes were correlated with performance in four domains: quantitative motor (tongue force, metronome tapping, and gait); oculomotor [anti‐saccade error rate (ASE)]; cognition (negative emotion recognition, spot the change and the University of Pennsylvania smell identification test) and neuropsychiatric measures (apathy, affect and irritability). After adjusting for estimated disease severity, regionally specific associations between structural loss and task performance were found (familywise error corrected, P < 0.05); impairment in tongue force, metronome tapping and ASE were all associated with striatal loss. Additionally, tongue force deficits and ASE were associated with volume reduction in the occipital lobe. Impaired recognition of negative emotions was associated with volumetric reductions in the precuneus and cuneus. Our study reveals specific associations between atrophy and decline in a range of clinical modalities, demonstrating the utility of VBM correlation analysis for investigating these relationships in HD. Hum Brain Mapp, 2013. © 2011 Wiley Periodicals, Inc. 相似文献
94.
95.
Montgomery Lewis Chondrogianni Vicky Fletcher-Watson Sue Rabagliati Hugh Sorace Antonella Davis Rachael 《Journal of autism and developmental disorders》2022,52(8):3560-3573
Journal of Autism and Developmental Disorders - One factor that may influence how executive functions develop is exposure to more than one language in childhood. This study explored the impact of... 相似文献
96.
Rachael A. Cohen Jerome H. Check Michael P. Dougherty 《Journal of assisted reproduction and genetics》2016,33(2):221-229
Purpose
To determine if exposure to progesterone alone is sufficient to increase the production of the immunomodulatory protein known as the progesterone induced blocking factor (PIBF). Also to determine what method of progesterone delivery or form of P best stimulates PIBF secretion.Methods
Serum samples from patients with infertility and paid volunteers were evaluated for both PIBF and progesterone at various times during the follicular phase and the luteal phase in both natural cycles and cycles involving embryo transfer after endogenous and exogenous progesterone exposure and after various synthetic progestins. PIBF was measured by a non-commercial research ELISA assay. Comparisons were made of serum PIBF before and after exposure to progesterone, 17-hydroxyprogesterone, and oral contraceptives. PIBF was also measured before and after transfer of embryos.Results
Progesterone alone without exposure to the fetal allogeneic stimulus was able to produce a marked increase in serum PIBF. Neither a synthetic progestin (19-nortestosterone derivative) nor 17-hydroxyprogesterone caused an increase in PIBF. Some PIBF is generally detected even in the follicular phase.Conclusions
A previous concept considered that an allogeneic stimulus, e.g., from the fetal semi-allograft, was necessary to induce de novo progesterone receptors in gamma delta T cells, which, in turn, when exposed to a high concentration of progesterone, would secrete high levels of PIBF. These data show that exposure to an allogeneic stimulus is not needed to cause a marked rise in PIBF, merely progesterone alone is sufficient.97.
98.
99.
Rachael Hawley Jennie Brentnall Deborah Serratore Samantha Grant Inbal Luft 《Disability and rehabilitation》2016,38(23):2315-2323
100.
Gap junction protein expression and cellularity: comparison of immature and adult equine digital tendons 总被引:1,自引:0,他引:1
Stanley RL Fleck RA Becker DL Goodship AE Ralphs JR Patterson-Kane JC 《Journal of anatomy》2007,211(3):325-334
Injury to the energy-storing superficial digital flexor tendon is common in equine athletes and is age-related. Tenocytes in the superficial digital flexor tendon of adult horses appear to have limited ability to respond adaptively to exercise or prevent the accumulation of strain-induced microdamage. It has been suggested that conditioning exercise should be introduced during the growth period, when tenocytes may be more responsive to increased quantities or intensities of mechanical strain. Tenocytes are linked into networks by gap junctions that allow coordination of synthetic activity and facilitate strain-induced collagen synthesis. We hypothesised that there are reductions in cellular expression of the gap junction proteins connexin (Cx) 43 and 32 during maturation and ageing of the superficial digital flexor tendon that do not occur in the non-injury-prone common digital extensor tendon. Cryosections from the superficial digital flexor tendon and common digital extensor tendon of 5 fetuses, 5 foals (1-6 months), 5 young adults (2-7 years) and 5 old horses (18-33 years) were immunofluorescently labelled and quantitative confocal laser microscopy was performed. Expression of Cx43 and Cx32 protein per tenocyte was significantly higher in the fetal group compared with all other age groups in both tendons. The density of tenocytes was found to be highest in immature tissue. Higher levels of cellularity and connexin protein expression in immature tendons are likely to relate to requirements for tissue remodelling and growth. However, if further studies demonstrate that this correlates with greater gap junctional communication efficiency and synthetic responsiveness to mechanical strain in immature compared with adult tendons, it could support the concept of early introduction of controlled exercise as a means of increasing resistance to later injury. 相似文献