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排序方式: 共有922条查询结果,搜索用时 31 毫秒
31.
32.
Canan Ulusoy Eunmi Kim Erdem Tüzün Ruksana Huda Vuslat Yılmaz Konstantinos Poulas Nikos Trakas Lamprini Skriapa Athanasios Niarchos Richard T. Strait Fred D. Finkelman Selin Turan Paraskevi Zisimopoulou Socrates Tzartos Güher Saruhan-Direskeneli Premkumar Christadoss 《Clinical immunology (Orlando, Fla.)》2014,151(2):155-163
Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness associated with acetylcholine receptor (AChR), muscle-specific receptor kinase (MuSK) or low-density lipoprotein receptor-related protein 4 (LRP4)-antibodies. MuSK-antibodies are predominantly of the non-complement fixing IgG4 isotype. The MuSK associated experimental autoimmune myasthenia gravis (EAMG) model was established in mice to investigate immunoglobulin (Ig) and cytokine responses related with MuSK immunity. C57BL/6 (B6) mice immunized with 30 μg of recombinant human MuSK in incomplete or complete Freund's adjuvant (CFA) showed significant EAMG susceptibility (> 80% incidence). Although mice immunized with 10 μg of MuSK had lower EAMG incidence (14.3%), serum MuSK-antibody levels were comparable to mice immunized with 30 μg MuSK. While MuSK immunization stimulated production of all antibody isotypes, non-complement fixing IgG1 was the dominant anti-MuSK Ig isotype in both sera and neuromuscular junctions. Moreover, MuSK immunized IgG1 knockout mice showed very low serum MuSK-antibody levels. Sera and MuSK-stimulated lymph node cell supernatants of MuSK immunized mice showed significantly higher levels of IL-4 and IL-10 (but not IFN-γ and IL-12), than those of CFA immunized mice. Our results suggest that through activation of Th2-type cells, anti-MuSK immunity promotes production of IL-4, which in turn activates anti-MuSK IgG1, the mouse analog of human IgG4. These findings might provide clues for the pathogenesis of other IgG4-related diseases as well as development of disease specific treatment methods (e.g. specific IgG4 inhibitors) for MuSK-related MG. 相似文献
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Abdallah MA Abdullah HI Kang S Taylor DD Nakajima ST Gercel-Taylor C 《Fertility and sterility》2007,87(4):978-981
We describe our experience of over 300 cycles of preimplantation genetic diagnosis (PGD) and report clinical pregnancy rates (35%-67%) that support using this technology to screen for genetic disorders and chromosomal abnormalities. In clinical practice for over ten years, PGD offers couples the earliest form of genetic screening and may help improve ongoing pregnancy rates in poor-prognosis patients. 相似文献
35.
Diana H. Taft Zachery T. Lewis Nhu Nguyen Steve Ho Chad Masarweh Vanessa Dunne-Castagna Daniel J. Tancredi M. Nazmul Huda Charles B. Stephensen Katie Hinde Erika von Mutius Pirkka V. Kirjavainen Jean-Charles Dalphin Roger Lauener Josef Riedler Jennifer T. Smilowitz J. Bruce German Ardythe L. Morrow David A. Mills 《Nutrients》2022,14(7)
Bifidobacterium species are beneficial and dominant members of the breastfed infant gut microbiome; however, their health benefits are partially species-dependent. Here, we characterize the species and subspecies of Bifidobacterium in breastfed infants around the world to consider the potential impact of a historic dietary shift on the disappearance of B. longum subsp. infantis in some populations. Across populations, three distinct patterns of Bifidobacterium colonization emerged: (1) The dominance of Bifidobacterium longum subspecies infantis, (2) prevalent Bifidobacterium of multiple species, and (3) the frequent absence of any Bifidobacterium. These patterns appear related to a country’s history of breastfeeding, with infants in countries with historically high rates of long-duration breastfeeding more likely to be colonized by B. longum subspecies infantis compared with infants in countries with histories of shorter-duration breastfeeding. In addition, the timing of infant colonization with B. longum subsp. infantis is consistent with horizontal transmission of this subspecies, rather than the vertical transmission previously reported for other Bifidobacterium species. These findings highlight the need to consider historical and cultural influences on the prevalence of gut commensals and the need to understand epidemiological transmission patterns of Bifidobacterium and other major commensals. 相似文献
36.
Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy 总被引:13,自引:0,他引:13
Kumar A Thomas A Lavretsky H Yue K Huda A Curran J Venkatraman T Estanol L Mintz J Mega M Toga A 《The American journal of psychiatry》2002,159(4):630-636
OBJECTIVE: Neuroanatomical abnormalities have been identified in patients with late-life mood disorders by using magnetic resonance imaging. This study examined the biochemical correlates of late-life major depression in the frontal gray and white matter by using single-voxel proton spectroscopy. METHOD: Twenty elderly patients with major depression and 18 comparison subjects similar in age and gender to the patients were scanned on a 1.5-T magnetic resonance scanner with head coil. Voxels were placed in the left dorsolateral white matter and bilaterally in the anterior cingulate gray matter. Absolute levels of N-acetylaspartate, choline, myo-inositol, and creatine were estimated with the LC-Model algorithm. Ratios of metabolite to creatine levels were computed from the absolute values. RESULTS: myo-Inositol/creatine and choline/creatine ratios were significantly higher in the frontal white matter in the major depression group than in the comparison group. The groups had no significant differences in the metabolite ratios in the gray matter. CONCLUSIONS: Biochemical changes in the white matter may provide some of the neurobiological substrates to late-life major depression. 相似文献
37.
Won-Seok Lee Ismael Al-Ramahi Hyun-Hwan Jeong Youjin Jang Tao Lin Carolyn J. Adamski Laura A. Lavery Smruti Rath Ronald Richman Vitaliy V. Bondar Elizabeth Alcala Jean-Pierre Revelli Harry T. Orr Zhandong Liu Juan Botas Huda Y. Zoghbi 《The Journal of clinical investigation》2022,132(9)
Many neurodegenerative disorders are caused by abnormal accumulation of misfolded proteins. In spinocerebellar ataxia type 1 (SCA1), accumulation of polyglutamine-expanded (polyQ-expanded) ataxin-1 (ATXN1) causes neuronal toxicity. Lowering total ATXN1, especially the polyQ-expanded form, alleviates disease phenotypes in mice, but the molecular mechanism by which the mutant ATXN1 is specifically modulated is not understood. Here, we identified 22 mutant ATXN1 regulators by performing a cross-species screen of 7787 and 2144 genes in human cells and Drosophila eyes, respectively. Among them, transglutaminase 5 (TG5) preferentially regulated mutant ATXN1 over the WT protein. TG enzymes catalyzed cross-linking of ATXN1 in a polyQ-length–dependent manner, thereby preferentially modulating mutant ATXN1 stability and oligomerization. Perturbing Tg in Drosophila SCA1 models modulated mutant ATXN1 toxicity. Moreover, TG5 was enriched in the nuclei of SCA1-affected neurons and colocalized with nuclear ATXN1 inclusions in brain tissue from patients with SCA1. Our work provides a molecular insight into SCA1 pathogenesis and an opportunity for allele-specific targeting for neurodegenerative disorders. 相似文献
38.
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Gardner D Akil H Ascoli GA Bowden DM Bug W Donohue DE Goldberg DH Grafstein B Grethe JS Gupta A Halavi M Kennedy DN Marenco L Martone ME Miller PL Müller HM Robert A Shepherd GM Sternberg PW Van Essen DC Williams RW 《Neuroinformatics》2008,6(3):149-160
With support from the Institutes and Centers forming the NIH Blueprint for Neuroscience Research, we have designed and implemented
a new initiative for integrating access to and use of Web-based neuroscience resources: the Neuroscience Information Framework.
The Framework arises from the expressed need of the neuroscience community for neuroinformatic tools and resources to aid
scientific inquiry, builds upon prior development of neuroinformatics by the Human Brain Project and others, and directly
derives from the Society for Neuroscience’s Neuroscience Database Gateway. Partnered with the Society, its Neuroinformatics
Committee, and volunteer consultant-collaborators, our multi-site consortium has developed: (1) a comprehensive, dynamic,
inventory of Web-accessible neuroscience resources, (2) an extended and integrated terminology describing resources and contents,
and (3) a framework accepting and aiding concept-based queries. Evolving instantiations of the Framework may be viewed at
, , and other sites as they come on line. 相似文献