Reflex changes in respiration during a rise in pressure in the thoracic duct

Summary A rapid pressure rise in the thoracic duct following arrest of lymph outflow into the venous system or raising the pressure vessel in conditions of perfusion of thoracic duct leads to the reflex slowing and deepening of respiration. A slow rise in the lymph pressure in the duct following disturbance of its circulation may provoke pathological types of respiration.(Presented by Active Member AMN SSSR A. V. Lebedinskii) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 56, No. 7, pp. 20–24, July, 1963     

Changes in the mitochondrial oxidative enzyme activity in the skeletal muscles od rats during the recovery period after hypokinesia of varying duration

Enzyme activity was measured in 164 white rats exposed to hypokinesia of varying duration. NAD- and NADP-dependent isocitrate dehydrogenases (ICDH) decreased on hypokinesia day 7 and returned to normal on recovery days 4-5. Their enzyme activity was diminished on hypokinesia day 15. NAD- and NADP-dependent ICDH returned to normal on recovery days 11 and 7, respectively. Activity of alpha-ketoglutarate dehydrogenase (KGDH) and succinate dehydrogenase (SDH) decreased immediately after hypokinesia and remained lowered till day 18. Activity of pyruvate dehydrogenase (PDH) was decreased on recovery days 1-3 and increased on days 9-17. After 30-day hypokinesia PDH activity was lower than normal on recovery days 2-14. 30-day hypokinesia led to reduction of ICDH, KGDH, and SDH. NADP-dependent ICDH returned to normal on recovery day 12 and other enzymes during the third week of readaptation. These results suggest that during recovery the enzymes that are responsible for energy metabolism restoration are first to return to normal.