全文获取类型
收费全文 | 824篇 |
免费 | 50篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 45篇 |
妇产科学 | 6篇 |
基础医学 | 80篇 |
口腔科学 | 16篇 |
临床医学 | 101篇 |
内科学 | 159篇 |
皮肤病学 | 17篇 |
神经病学 | 31篇 |
特种医学 | 150篇 |
外科学 | 58篇 |
综合类 | 106篇 |
预防医学 | 55篇 |
眼科学 | 3篇 |
药学 | 26篇 |
中国医学 | 1篇 |
肿瘤学 | 30篇 |
出版年
2023年 | 3篇 |
2022年 | 4篇 |
2021年 | 8篇 |
2020年 | 5篇 |
2019年 | 9篇 |
2018年 | 16篇 |
2017年 | 12篇 |
2016年 | 11篇 |
2015年 | 22篇 |
2014年 | 28篇 |
2013年 | 24篇 |
2012年 | 36篇 |
2011年 | 23篇 |
2010年 | 41篇 |
2009年 | 41篇 |
2008年 | 47篇 |
2007年 | 37篇 |
2006年 | 22篇 |
2005年 | 17篇 |
2004年 | 22篇 |
2003年 | 17篇 |
2002年 | 13篇 |
2001年 | 19篇 |
2000年 | 11篇 |
1999年 | 21篇 |
1998年 | 47篇 |
1997年 | 40篇 |
1996年 | 35篇 |
1995年 | 22篇 |
1994年 | 29篇 |
1993年 | 24篇 |
1992年 | 8篇 |
1991年 | 13篇 |
1990年 | 12篇 |
1989年 | 19篇 |
1988年 | 15篇 |
1987年 | 26篇 |
1986年 | 9篇 |
1985年 | 12篇 |
1984年 | 4篇 |
1983年 | 8篇 |
1982年 | 14篇 |
1981年 | 6篇 |
1980年 | 7篇 |
1979年 | 4篇 |
1978年 | 8篇 |
1977年 | 4篇 |
1976年 | 8篇 |
1975年 | 5篇 |
1967年 | 2篇 |
排序方式: 共有890条查询结果,搜索用时 31 毫秒
141.
The study concerned the effect of repeated treatment with antidepressant drugs on the elevation of cyclic AMP levels in the rat cerebral cortex following electrical stimulation of the locus coeruleus. Some of the tricyclic and tetracyclic antidepressant drugs inhibited the cyclic AMP response. Desmethylimipramine was the most potent (effective when given 5 mg/kg/day for 2 weeks). Imipramine and nomifensine (daily dose 10 mg/kg for 2 weeks) produced slight decreases, while iprindol and clomipramine were ineffective. After 6 weeks of treatment (daily 10 mg/kg) iprindol, clomipramine and mianserin were without effect. The cyclic AMP response was suppressed by higher doses of the latter two drugs (2 weeks, 20 mg/kg/day). These results indicate that tricyclic and tetracyclic antidepressant drugs are able to decrease cerebral noradrenergic neurotransmission of locus coeruleus neurons, as far as this is mediated by cyclic AMP. It is not clear, however, whether such modification is related to the therapeutic action of antidepressant drugs. 相似文献
142.
Recently, Sloviter et al. reported that adrenalectomy (ADX) of young adult rats after 3 months led to a selective loss of granule neurons in the dentate gyrus (DG) and that this loss could be prevented by low doses of corticosterone. In the present study, the ADX-induced neuronal degeneration was investigated in Wistar rats, using a silver impregnation method for degenerating neurons. To examine the time course and distribution of the ADX-induced degeneration, young adult male rats were allowed to survive 2, 3, and 5 days and 1, 2, and 3 weeks after ADX. Argyrophilic neurons were present in the dentate granule cell layer on the second day following ADX. Three days after ADX, the number of argyrophilic granule neurons was much more abundant, and it increased gradually with longer post-ADX survival times. Argyrophilia was specifically confined to dentate granule cells and was accompanied by the occurrence of pyknotic nuclei as observed in adjacent cresyl violet-stained sections. There were significant differences between individual rats in quantity of argyrophilia. About one fifth of the ADX rats showed sporadic or no argyrophilia, in spite of plasma corticosterone levels below the detection limit (10 ng/mL). Sham-operated rats and ADX rats receiving corticosterone (10 mg/L) or dexamethasone (15 mg/L) in their drinking water did not display any argyrophilic neurons in the dentate gyrus. The distribution of the argyrophilia within the DG was highly characteristic with the highest number of degenerating cells in the hidden blade of the middle and the temporal thirds of the DG.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
143.
144.
Evidence for a direct relationship between phosphoinositide metabolism and airway smooth muscle contraction induced by muscarinic agonists 总被引:9,自引:0,他引:9
H Meurs A F Roffel J B Postema A Timmermans C R Elzinga H F Kauffman J Zaagsma 《European journal of pharmacology》1988,156(2):271-274
The relationship between bovine tracheal muscle contraction and phosphoinositide metabolism was studied with the muscarinic agonists, methacholine, oxotremorine, and McN-A-343. Analysis of the dose-response curves for contraction and inositol phosphates accumulation with these agonists demonstrated a direct relationship between the two parameters, with a considerable reserve of inositol phosphate production for the full contractile agonists, methacholine and oxotremorine, and no reserve for the partial agonist, McN-A-343. 相似文献
145.
146.
147.
148.
T Sinha PP Varma A Srivastava SC Karan AS Sandhu GS Sethi R Khanna R Talwar V Narang 《Medical Journal Armed Forces India》2006,62(3):236-238
Background
Laparoscopic donor nephrectomy (LDN) has been gaining popularity among kidney donors. There have been concerns about the safety and efficacy of the procedure as compared to open donor nephrectomy (ODN). We compare our results on LDN with ODN.Methods
We retrospectively analysed our data of LDN and ODN. Duration of surgery, blood loss, period of hospitalisation, per oral intake and analgesic requirements.Result
22 LDNs were done, the operation time ranged from 220-300 minutes, and blood loss from 100-150ml. In the first 10 laparoscopic operations four cases required conversion to open surgical dissection. Only one case was converted to open surgery in the subsequent 12 laparoscopic cases. Oral intake was started on the first postoperative day. Analgesic requirement in laparoscopy cases was less. Patients were mobilised on the first day after surgery. Patients were discharged by seventh day. There was no significant difference in the functioning of the graft after revascularisation in the recipient.Conclusion
Laparoscopic donor nephrectomy is a safe and effective technique of donor nephrectomy.Key Words: Laparoscopy, Laparoscopic donor nephrectomy, Living kidney donors, Kidney transplantation 相似文献149.
The three-dimensional treatment planning system developed at the Rhode Island Hospital visualizes the spatial interrelationships of the radiation beam, the tumor, and the adjacent organs within the patient. It is possible to rotate and vary the scale of the display to better comprehend the extent of these structures. By viewing the display as if from along the radiation beam, one can design shaped treatment fields which best suit the three-dimensional nature of the disease. With this system, it is possible to reduce the volume of normal tissue which would typically be irradiated if two-dimensional treatment planning techniques and assumptions were employed. 相似文献
150.