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排序方式： 共有2091条查询结果，搜索用时 15 毫秒
71.
Paulo Lisboa Bittencourt;Mateus Jorge Nardelli;Luísa Leite Barros;Guilherme Grossi Lopes Cançado;Eduardo Luiz Rachid Cançado;Débora Raquel Benedita Terrabuio;Cristiane Alves Villela-Nogueira;Maria Lucia Gomes Ferraz;Liana Codes;Vivian Rotman;Rodrigo Rocco;Guilherme Eduardo Felga;Diogo Delgado Dotta;Adrielly de Souza Martins;Liliana Sampaio Costa Mendes;Marlone Cunha da Silva;Elodie Bonfim Hyppolito;Geisa Perez Medina Gomide;Izabelle Venturini Signorelli;Maria Beatriz de Oliveira;Claudia Alexandra Pontes Ivantes;Maria Chiara Chindamo;Valéria Ferreira de Almeida e Borges;Luciana Costa Faria;Claudia Alves Couto; 《Clinical transplantation》2024,38(10):e70002
Primary sclerosing cholangitis (PSC) has been shown to recur after liver transplantation (LT). Some studies have identified certain clinical and laboratory variables associated with an increased risk for recurrent PSC (rPSC) in Caucasians. Furthermore, de novo cholangiocarcinoma (CCA) has been reported anecdotally in patients with rPSC. This study aims to assess the prevalence of rPSC, identify its associated risk factors, and investigate the occurrence of de novo CCA in a highly admixed population from Brazil. 相似文献
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73.
Carlos Franciney Moreira Vasconcelos Nívea Maria da Cunha Ferreira Nayanne Hardy Lima Pontes Thomas Dominik de Sousa dos Reis Ricardo Basto Souza Francisco Eduardo Arago Catunda Junior Lissiana Magna Vasconcelos Aguiar Rodrigo Maranguape Silva da Cunha 《Basic & clinical pharmacology & toxicology》2020,127(4):287-302
Parkinson's disease is a neurodegenerative disorder that affects the central nervous system and is mainly characterized by the loss of dopaminergic neurons and pro‐oxidant mechanisms. Eugenol has been widely studied due to its anti‐inflammatory and antioxidant activities, making it a promising neuroprotective agent. This study aimed to investigate the effects of eugenol and its combined action with levodopa in the 6‐hydroxydopamine‐induced Parkinson's disease model. Wistar rats were subjected to intrastriatal injection of 6‐hydroxydopamine (21 μg) and then treated with eugenol (0.1, 1, or 10 mg/kg), levodopa (25 mg/kg) or their combination (eugenol 10 mg/kg + levodopa 12.5 mg/kg) orally for 14 days. On the 14th day, the animals were subjected to behavioural tests, and after euthanization and dissection of the brain areas, neurochemical analyses were performed. The results showed that eugenol reduced the oxidative stress and behavioural disturbances induced by 6‐hydroxydopamine. The eugenol and levodopa combination was more effective in some behavioural parameters and body‐weight gain in addition to promoting an increase in reduced glutathione levels compared to levodopa alone. Thus, the neuroprotective activity of eugenol was observed against motor and neurochemical disorders. Additionally, the eugenol and levodopa combination was promising when compared to conventional treatment. 相似文献
74.
Luis Correia Daniel Lopes Joo Vítor Porto Yasmin F. Lacerda Vitor C. A. Correia Gabriela O. Bagano Bruna S. B. Pontes Milton Henrique Vitoria de Melo Thomaz E. A. Silva Andr C Meireles 《Arquivos brasileiros de cardiologia》2021,117(6):1061
Background:Multivariate prognostic analysis has been traditionally performed by regression models. However, many algorithms capable of translating an infinity of patterns into probabilities have emerged. The comparative accuracy of artificial intelligence and traditional statistical models has not been established in the medical field.Objective:To test the artificial intelligence as an accurate algorithm for predicting coronary disease in the scenario of acute chest pain and evaluate whether its performance is superior to traditional statistical model.Methods:A consecutive sample of 962 patients admitted with chest pain was analyzed. Two probabilistic models of coronary disease were built using the first two-thirds of patients: a machine learning algorithm and a traditional logistic model. The performance of these two predictive strategies were evaluated in the remaining third of patients. The final logistic regression model had significant variables only, at the 5% significance level.Results:The training sample had an average age of 59 ± 15 years, 58% males, and a 52% prevalence of coronary disease. The logistic model was composed of nine independent predictors. The machine learning algorithm was composed of all candidates for predictors. In the test sample, the area under the ROC curve for prediction of coronary disease was 0.81 (95% CI = 0.77 - 0.86) for the machine learning algorithm, similar to that obtained in logistic model (0.82; 95% CI = 0.77 - 0.87), p = 0.68.Conclusion:The present study suggests that an accurate machine learning prediction tool did not prove to be superior to the statistical model of logistic regression. 相似文献
75.
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77.
Anderson Mauricio Paiva e Costa Flvia Sirotheau Corrêa Pontes Lucas Lacerda de Souza Mrcio Ajudarte Lopes Alan Roger Santos-Silva Pablo Agustin Vargas Bruno Augusto Benevenuto de Andrade Kelly Tambasco Bezerra Mrio Jos Romaach Ricardo Santiago Gomez Rafael Ferreira e Costa Dcio dos Santos Pinto Júnior Danyel Elias da Cruz Perez Jurema Freire Lisboa de Castro 《Medicina oral, patología oral y cirugía bucal》2021,26(6):e738
78.
Mark P Maskery Christian Holscher Stephanie P Jones Christopher I Price W David Strain Caroline L Watkins David J Werring Hedley CA Emsley 《Journal of cerebral blood flow and metabolism》2021,41(1):14
Stroke mortality and morbidity is expected to rise. Despite considerable recent advances within acute ischemic stroke treatment, scope remains for development of widely applicable neuroprotective agents. Glucagon-like peptide-1 receptor agonists (GLP-1RAs), originally licensed for the management of Type 2 Diabetes Mellitus, have demonstrated pre-clinical neuroprotective efficacy in a range of neurodegenerative conditions. This systematic scoping review reports the pre-clinical basis of GLP-1RAs as neuroprotective agents in acute ischemic stroke and their translation into clinical trials. We included 35 pre-clinical studies, 11 retrospective database studies, 7 cardiovascular outcome trials and 4 prospective clinical studies. Pre-clinical neuroprotection was demonstrated in normoglycemic models when administration was delayed by up to 24 h following stroke induction. Outcomes included reduced infarct volume, apoptosis, oxidative stress and inflammation alongside increased neurogenesis, angiogenesis and cerebral blood flow. Improved neurological function and a trend towards increased survival were also reported. Cardiovascular outcomes trials reported a significant reduction in stroke incidence with semaglutide and dulaglutide. Retrospective database studies show a trend towards neuroprotection. Prospective interventional clinical trials are on-going, but initial indicators of safety and tolerability are favourable. Ultimately, we propose that repurposing GLP-1RAs is potentially advantageous but appropriately designed trials are needed to determine clinical efficacy and cost-effectiveness. 相似文献
79.
目的 观察及探究子宫内膜异位症患者血清及组织OPN、CA125、HMGB1、VEGF及其受体的变化状态.方法 选取2011年7月-2013年12月本院收治的75例子宫内膜异位症患者为观察组,并以同期的75例外伤手术患者为对照组,将两组OPN、CA125、HMGB1、VEGF及其受体的血清水平和组织阳性率进行比较,并比较观察组中不同r-AFS分期和分型者的血清水平及组织阳性率.结果 观察组OPN、CA125、HMGB1、VEGF及其受体的血清水平和组织阳性率均高于对照组,且分期较高及存在深部浸润病灶者的血清水平和组织阳性率高于分期较低及未伴有深部浸润病灶者（P＜0.05）,差异有统计学意义.结论 子宫内膜异位症患者血清及组织OPN、CA125、HMGB1、VEGF及其受体均呈现较高状态,且分期及是否存在深部浸润病灶对其有较大影响. 相似文献
80.