全文获取类型
收费全文 | 861篇 |
免费 | 57篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 35篇 |
妇产科学 | 9篇 |
基础医学 | 106篇 |
口腔科学 | 38篇 |
临床医学 | 107篇 |
内科学 | 215篇 |
皮肤病学 | 25篇 |
神经病学 | 49篇 |
特种医学 | 84篇 |
外科学 | 90篇 |
综合类 | 26篇 |
一般理论 | 1篇 |
预防医学 | 81篇 |
眼科学 | 3篇 |
药学 | 28篇 |
中国医学 | 1篇 |
肿瘤学 | 28篇 |
出版年
2023年 | 5篇 |
2021年 | 10篇 |
2020年 | 8篇 |
2019年 | 11篇 |
2018年 | 16篇 |
2017年 | 8篇 |
2016年 | 19篇 |
2015年 | 10篇 |
2014年 | 14篇 |
2013年 | 29篇 |
2012年 | 21篇 |
2011年 | 22篇 |
2010年 | 36篇 |
2009年 | 35篇 |
2008年 | 29篇 |
2007年 | 34篇 |
2006年 | 26篇 |
2005年 | 23篇 |
2004年 | 23篇 |
2003年 | 21篇 |
2002年 | 10篇 |
2001年 | 16篇 |
2000年 | 23篇 |
1999年 | 16篇 |
1998年 | 33篇 |
1997年 | 35篇 |
1996年 | 36篇 |
1995年 | 26篇 |
1994年 | 22篇 |
1993年 | 20篇 |
1992年 | 19篇 |
1991年 | 16篇 |
1990年 | 14篇 |
1989年 | 17篇 |
1988年 | 22篇 |
1987年 | 27篇 |
1986年 | 14篇 |
1985年 | 15篇 |
1984年 | 15篇 |
1983年 | 9篇 |
1982年 | 13篇 |
1981年 | 8篇 |
1979年 | 10篇 |
1978年 | 9篇 |
1977年 | 23篇 |
1976年 | 11篇 |
1975年 | 5篇 |
1974年 | 7篇 |
1970年 | 7篇 |
1968年 | 6篇 |
排序方式: 共有930条查询结果,搜索用时 15 毫秒
51.
52.
53.
Person B Sy F Holton K Govert B Liang A;National Center for Inectious Diseases/SARS Community Outreach Team 《Emerging infectious diseases》2004,10(2):358-363
Because of their evolving nature and inherent scientific uncertainties, outbreaks of emerging infectious diseases can be associated with considerable fear in the general public or in specific communities, especially when illness and deaths are substantial. Mitigating fear and discrimination directed toward persons infected with, and affected by, infectious disease can be important in controlling transmission. Persons who are feared and stigmatized may delay seeking care and remain in the community undetected. This article outlines efforts to rapidly assess, monitor, and address fears associated with the 2003 severe acute respiratory syndrome (SARS) epidemic in the United States. Although fear, stigmatization, and discrimination were not widespread in the general public, Asian-American communities were particularly affected. 相似文献
54.
55.
56.
Towndrow KM Jia Z Lo HH Person MD Monks TJ Lau SS 《Chemical research in toxicology》2003,16(3):312-319
Prostaglandins (PGs) act locally to maintain cellular homeostasis and stimulate stress response signaling pathways. These cellular effects are diverse and are tissue-dependent. PGE(2), and the synthetic analogue, 11-deoxy,16,16-dimethyl PGE(2) (DDM-PGE(2)), protect renal proximal tubular epithelial (LLC-PK1) cells against cellular injury induced by the potent nephrotoxic and nephrocarcinogenic metabolite of hydroquinone, 2,3,5-tris-(glutathion-S-yl)hydroquinone. Although this cytoprotective response (in LLC-PK1 cells) is mediated through a thromboxane or thromboxane-like receptor coupled to AP-1 signaling pathways, the mechanism of cytoprotection is unknown. In this study, we utilized HPLC-electrospray ionization tandem mass spectrometric (ESI MS/MS) and matrix-assisted laser desorption ionization time-of-flight mass spectrometric (MALDI TOF) analysis of proteins isolated from DDM-PGE(2)-stimulated LLC-PK1 cells to identify candidate cytoprotective proteins. DDM-PGE(2) selectively stimulated the synthesis of several proteins in LLC-PK1 cells. Peptide sequencing by ESI-MS/MS of in-gel tryptic protein digests revealed the identity of eight proteins: endothelial actin binding protein, myosin, elongation factor 2 (EF-2), elongation factor 1alpha-1 (EF-1alpha), heat shock protein 90beta (HSP90beta), glucose-regulated protein 78 (GRP 78), membrane-organizing extension spike protein, and actin. Both ESI-MS/MS and MALDI-MS analysis resulted in the same protein identification. Western analysis confirmed the temporal induction of the majority of these proteins, including EF-2, EF-1alpha, HSP90beta, GRP78, and actin. The collective expression of these proteins suggests that DDM-PGE(2)-mediated cytoprotection may involve alterations in cytoskeletal organization and/or stimulation of an endoplasmic reticulum (ER) stress response. The present studies provide insights into potential downstream targets of PG signaling. 相似文献
57.
Horwitz M Li FQ Albani D Duan Z Person RE Meade-White K Benson KF 《Cancer investigation》2003,21(4):579-587
Severe congenital neutropenia (SCN), a heterogeneous disorder that includes Kostmann syndrome, predisposes to myelodysplasia and acute myelogenous leukemia. Recently identified heterozygous mutations in the gene ELA2, encoding neutrophil elastase on human chromosome 19pter, account for the majority of autosomal dominant cases of SCN, including those demonstrating neoplastic progression. The involvement of the serine protease neutrophil elastase, localized to the granules of neutrophils and monocytes, implies an unexpected role for proteolytic regulation of hematopoiesis. Continued elucidation of the clinical features, molecular genetics, and biochemistry is likely to provide insight into novel pathways of leukemia induction with attendant prospects for new avenues of therapy. 相似文献
58.
Although the pursuit of Medicare certification has been one of the most controversial events in hospice history no study has examined its impact using data from a defined population of hospices before, during, and after federal legislation was enacted. This paper revisits the debate over the changing role of volunteers using such a longitudinal data source. Over time, as the patient population grew, aggregate levels of volunteers and professional staff increased. However, the ratios of professional staff and volunteers to patients reveal that regardless of certification status, hospices retained more professional staff per patient and fewer volunteers per patient over time. These data suggest hospices, particularly certified organizations, have transitioned from voluntary organizations to professionally staffed organizations with a strong volunteer component. The most important issue for future research is whether the observed changes have affected the quality of hospice care. 相似文献
59.