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71.
Twenty-nine young people aged 12-13 years considered to be at a high risk of substance abuse primarily because they no longer attend mainstream school participated in the study by completing a questionnaire designed to obtain information on their drug-using behaviours. The evidence in this paper suggests that many of them are already at a high risk for problem drug use compared with their peers in mainstream education. This is heightened by the fact they are excluded from school and are not accessing school-based prevention programmes delivered to their contemporaries at school. The paper concludes by suggesting that additional resources are needed to fully meet their requirements in relation to identifying and delivering appropriate drug prevention strategies. 相似文献
72.
Extrapyramidal dysfunction is poorly characterized in Rett's syndrome, a neurodegenerative disorder in girls. We studied the motor and behavioral findings in 32 Rett's syndrome patients, 21 months to 30 years old. In addition to the typical stereotyped movements and scoliosis, other motor disturbances included bruxism, sialorrhea, ocular deviations, parkinsonian findings, dystonia, myoclonus, and athetosis. The types of movement disorders seemed to be age-related, with the hyperkinetic disorders occurring in the younger patients and the bradykinetic disorders occurring more frequently in the older patients. 相似文献
73.
David?Lin Martin?Jacobs Thomas?Percy Yvonne?Dowdy Joseph?MantilEmail author 《Molecular imaging and biology》2005,7(3):201-202
Purpose The purpose of the study is to describe the rare tumor on 2-deoxy-2[F-18]fluoro-d-glucose (FDG) positron emission tomography (PET).Procedure A 33-year-old male was diagnosed with high uptake lesion on FDG-PET scanning, which was found to be hibernoma on excision.Results Hibernoma, originally confused with liposarcoma based on its PET and computed tomography presentation, was excised and correctly identified by pathology.Conclusion Although found to be benign, radiological and FDG-PET scanning results were indistinguishable from malignancy, and biopsy is required to exclude neoplasm. 相似文献
74.
75.
Percy Hintzen Elena Cyrus Mark Padilla Nelson Varas-Díaz 《Global public health》2019,14(11):1547-1556
ABSTRACTThis introduction presents a special issue of Global Public Health with a collection of articles that offer multidisciplinary perspectives on HIV/AIDS in the Caribbean. Since the 1990s, poverty, marginalisation, and social stigma have been strong foci of much social science research on HIV/AIDS in the region. These three interrelated phenomena have been offered as explanatory factors contributing to the high prevalence of cases observed in this region. Contributors to this special issue take these emphases in new directions, asking multi-level questions that require unique combinations of epidemiological, social scientific, theoretical, and policy-oriented perspectives and methodologies. Together, they identify several topical areas that intend to create dialogue across disciplines and dialectics, with the fundamental principle that the factors relevant to HIV/AIDS are broad and require intersectional lenses. The articles in this issue offer multi-level interventions into HIV/AIDS in the region, from the varied social circumstances that shape heightened risk factors to patient adherence programmes, with emphases on structural, social, and policy-level approaches. Collectively, this special issue establishes the importance of transdisciplinary approaches to HIV/AIDS that are macro-level in scope, but simultaneously attend to how large-scale dynamics are inflected in situated contexts and histories. 相似文献
76.
Fixing human factor IX (fIX): correction of a cryptic RNA splice enables the production of biologically active fIX in the mammary gland of transgenic mice.
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F Yull G Harold R Wallace A Cowper J Percy I Cottingham A J Clark 《Proceedings of the National Academy of Sciences of the United States of America》1995,92(24):10899-10903
Transgenic mice and sheep secrete only low levels of human factor IX in their milk because of an aberrant splicing of the transgene RNA in the mammary gland. Removal of the cryptic 3' splice site prevents this splicing and leads to the production of relatively high levels of factor IX. The purified protein is fully active showing that the mammary gland is capable of the efficient post-translational modification of this protein and that transgenic animals are a suitable means of its production. 相似文献
77.
Percy Wright MA Jose Nobrega PhD Ron Langevin PhD George Wortzman MD 《Sexual abuse : a journal of research and treatment》1990,3(3):319-328
Brain area and optical density were computed for each hemisphere and for 4 sections within the hemispheres at the level of the temporal horns for 18 pedophiles, 12 incest offenders, 34 sexually aggressive offenders of adult females and 12 nonviolent nonsex offender controls. Brain length and width was also computed, using the pineal gland as reference. From the width measures, an index of brain symmetry was computed. Results showed that the brains of sex offenders were relatively smaller in the left hemisphere compared to controls, but there were no significant group differences in optical density. There were no subgroup differences in brain area but the segments corresponding to the left frontal and temporal areas were smaller in sex offenders than controls. There were no significant differences in brain length but sex offenders had smaller widths in both hemispheres than controls. Analysis of symmetry showed that 66.7% of pedophiles and 53.1% of sexual aggressives had asymmetric brains compared to 8.3% of incest offenders and 20.0% of controls. Pedophiles showed smaller left hemispheres than right whereas sexual aggressives were equally split between left and right asymmetry. These results support earlier findings of temporal horn dilatation in pedophiles and sexual aggressives. 相似文献
78.
This study investigated adrenoreceptor-mediated responses of muscularis mucosae from the fundic and antral ends of the rabbit gastric corpus. Norepinephrine-induced fundic muscularis mucosae contractions were enhanced by propranolol and converted to relaxations by phentolamine. Methoxamine, but not clonidine, elicited large fundic contractions. Fundic muscle responded to low isoproterenol concentrations with atenolol- and butoxamine-resistant relaxations, and to high concentrations with atenolol-sensitive contractions. Norepinephrine evoked propranolol-resistant relaxations of antral muscularis mucosae that were enhanced by phentolamine. Methoxamine and clonidine elicited small antral contractions. Lower concentrations of isoproterenol caused atenolol-resistant antral relaxations that were enhanced by butoxamine; higher concentrations produced weak excitation. Fundic and antral relaxations to isoproterenol were abolished by cyanopindolol. Fundic muscularis mucosae possesses excitatory 1-, 1- and inhibitory 3-adrenoreceptors. Excitatory 2- and inhibitory 3-adrenoreceptors predominate in the antral region. The heterogeneous adrenoreceptor-mediated responses of the gastric muscularis mucosae suggest that adrenergic modulation of its motor activity is unlikely to be linked to acid secretion. 相似文献
79.
Khan MF Bennett MJ Jumper CC Percy AJ Silva LP Schriemer DC 《Journal of pharmaceutical and biomedical analysis》2011,55(4):1-841
Mass spectrometry is an important technology for mapping composition and flux in whole proteomes. Over the last 5 years in particular, impressive gains in the depth of proteome coverage have been realized, particularly for model organisms. This review will provide an update on advancements in the key analytical techniques, methods and informatics directed towards whole proteome analysis by mass spectrometry. Practical issues involving sample requirements, analysis time and depth of coverage will be addressed, to gauge how useful data-driven approaches are for solving biological problems. Targeted mass spectrometric methods, based on selected reaction monitoring, are presented as a powerful alternative to data-driven methods. They offer robust, transferable protocols for hypothesis-directed monitoring of limited yet biologically significant tracts of any proteome. 相似文献
80.
Katy S Orr Zhanzhong Shi W Mark Brown Kathleen A O'Hagan Terence R Lappin Perry Maxwell Melanie J Percy 《Journal of experimental & clinical cancer research : CR》2011,30(1):79