全文获取类型
收费全文 | 11340篇 |
免费 | 613篇 |
国内免费 | 61篇 |
专业分类
耳鼻咽喉 | 180篇 |
儿科学 | 228篇 |
妇产科学 | 220篇 |
基础医学 | 1472篇 |
口腔科学 | 1367篇 |
临床医学 | 688篇 |
内科学 | 2357篇 |
皮肤病学 | 256篇 |
神经病学 | 873篇 |
特种医学 | 222篇 |
外科学 | 1593篇 |
综合类 | 35篇 |
一般理论 | 7篇 |
预防医学 | 1012篇 |
眼科学 | 287篇 |
药学 | 685篇 |
中国医学 | 86篇 |
肿瘤学 | 446篇 |
出版年
2023年 | 103篇 |
2022年 | 212篇 |
2021年 | 432篇 |
2020年 | 269篇 |
2019年 | 315篇 |
2018年 | 456篇 |
2017年 | 314篇 |
2016年 | 321篇 |
2015年 | 451篇 |
2014年 | 570篇 |
2013年 | 643篇 |
2012年 | 1041篇 |
2011年 | 1142篇 |
2010年 | 570篇 |
2009年 | 458篇 |
2008年 | 792篇 |
2007年 | 804篇 |
2006年 | 692篇 |
2005年 | 565篇 |
2004年 | 527篇 |
2003年 | 436篇 |
2002年 | 376篇 |
2001年 | 58篇 |
2000年 | 42篇 |
1999年 | 53篇 |
1998年 | 47篇 |
1997年 | 26篇 |
1996年 | 23篇 |
1995年 | 11篇 |
1994年 | 16篇 |
1993年 | 13篇 |
1992年 | 20篇 |
1991年 | 19篇 |
1990年 | 13篇 |
1989年 | 14篇 |
1988年 | 17篇 |
1987年 | 14篇 |
1985年 | 7篇 |
1984年 | 7篇 |
1983年 | 10篇 |
1982年 | 13篇 |
1981年 | 10篇 |
1980年 | 11篇 |
1979年 | 8篇 |
1978年 | 6篇 |
1976年 | 5篇 |
1975年 | 6篇 |
1973年 | 6篇 |
1969年 | 5篇 |
1965年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 250 毫秒
101.
Emphysema induced by elastase enhances acute inflammatory pulmonary response to intraperitoneal LPS in rats 下载免费PDF全文
Lídia Maria Carneiro da Fonseca Maycon Moura Reboredo Leda Marília Fonseca Lucinda Thaís Fernanda Fazza Maria Aparecida Esteves Rabelo Adenilson Souza Fonseca Flavia de Paoli Bruno Valle Pinheiro 《International journal of experimental pathology》2016,97(6):430-437
Abnormalities in lungs caused by emphysema might alter their response to sepsis and the occurrence of acute lung injury (ALI). This study compared the extension of ALI in response to intraperitoneal lipopolysaccharide (LPS) injection in Wistar rats with and without emphysema induced by elastase. Adult male Wistar rats were randomized into four groups: control, emphysema without sepsis, normal lung with sepsis and emphysema with sepsis. Sepsis was induced, and 24 h later the rats were euthanised. The following analysis was performed: blood gas measurements, bronchoalveolar lavage (BAL), lung permeability and histology. Animals that received LPS showed significant increase in a lung injury scoring system, inflammatory cells in bronchoalveolar lavage (BAL) and IL‐6, TNF‐α and CXCL2 mRNA expression in lung tissue. Animals with emphysema and sepsis showed increased alveolocapillary membrane permeability, demonstrated by higher BAL/serum albumin ratio. In conclusion, the presence of emphysema induced by elastase increases the inflammatory response in the lungs to a systemic stimulus, represented in this model by the intraperitoneal injection of LPS. 相似文献
102.
Hellen Silva Cintra Juliana Castro Dourado Pinezi Graziella Dias Pinheiro Machado Gustavo Moura de Carvalho Ana Terra Silva Carvalho Thalles Eduardo Dias dos Santos Ricardo Duarte Marciano Renata de Bastos Ascen?o Soares 《Disease markers》2013,35(6):701-710
The purpose of this study was to evaluate the association between ATM, TP53 and MDM2 polymorphisms in prostate cancer patients and morbidity after radiotherapy. The presence of ATM (rs1801516), TP53 (rs1042522, rs1800371, rs17878362, rs17883323, and rs35117667), and MDM2 (rs2279744) polymorphisms was assessed by direct sequencing of PCR fragments from 48 patients with histologically proven prostate adenocarcinoma and treated with external beam radiation. The side effects were classified according to the Radiation Therapy Oncology Group (RTOG) score. The results showed no association between clinical characteristics and the development of radiation toxicities (P > 0.05). The C>T transition in the position 16273 (intron 3) of TP53 (rs35117667) was significantly associated with the risk of acute skin toxicity (OR: 0.0072, 95% CI 0.0002–0.227, P = 0.003). The intronic TP53 polymorphism at position 16250 (rs17883323) was associated with chronic urinary toxicity (OR: 0.071, 95%CI 0.006–0.784, P = 0.032). No significant associations were found for the remaining polymorphisms (P > 0.05). The results show that clinical characteristics were not determinant on the developing of radiation sensitivity in prostate cancer patients, and intronic TP53 polymorphisms would be associated with increased acute and chronic radiation toxicities. These observations corroborate the importance of investigating the genetic profile to predict adverse side effects in patients undergoing radiotherapy. 相似文献
103.
Bruna Leonel Carlos Jéssica Suzuki Yamanaka Gabriela Rezende Yanagihara Ana Paula Macedo Plauto Christopher Aranha Watanabe João Paulo Mardegan Issa 《Journal of biomaterials science. Polymer edition》2013,24(14):1291-1307
AbstractNatural latex extracted from Hevea brasiliensis is one of the materials pointed out as potential tissue regenerators. The use of latex-based membranes in bone regeneration might be an alternative to stimulate bone formation. The aim of this study was to evaluate the effects of latex membranes in guided bone regeneration of defects produced in long bones of rats. Sixty rats were equally divided into latex and control groups, and each group was subdivided into two subgroups according to treatment duration of 1 and 4 weeks. Bone defects with 2.5?mm in diameter were surgically made in the left tibia. In the animals of the latex group, a latex membrane was placed over the bone defect. The samples underwent quantitative histological analysis of bone formation and collagen matrix, immunohistochemical analysis of osteogenic protein markers, assessment of bone mechanical properties and bone densitometry, and radiological assessment. The osteocalcin immunostaining data were submitted to the generalized linear model test with two independent factors. For the other data, the multivariate ANOVA with two independent factors was performed. The use of the latex membrane significantly improved (p?<?0.005) the volume of newly formed bone, collagen type I matrix, expression of osteopontin, and bone stiffness, both in the early and late stages of regeneration. In conclusion, the latex membrane was able to promote bone regeneration in long bones. 相似文献
104.
105.
Bisphenol A release from orthodontic adhesives measured in vitro and in vivo with gas chromatography
106.
Telma M. Santos-Machado Maria C. Zerbini Lillian M. Cristofani Paula Maria Azevedo Maria T. A. Almeida Paulo T. Maluf Jr. 《Pediatric hematology and oncology》2013,30(2):129-135
The authors report the case of a 4-year-old boy with a diagnosis of stage IV neuroblastoma (NB), who had been treated with 6 cycles of cyclophosphamide, doxorubicin, cisplatin, and etoposide for 12 months. The patient reached partial remission and presented a diagnosis of acute myelomonocytic leukemia (M4 AML), confirmed by immunophenotyping. After 2 months of therapy for leukemia, the child died with both malignancies in activity. A necropsy histologically confirmed the simultaneity of the two diseases. The authors review the possibilities of this association. The review leads to the conclusion that AML can occur as a secondary malignancy after the onset of the neuroblastoma, or be suggested by a misdiagnosis. The simultaneous occurrence of both as described here is not, however, found in the literature, to the best of the authors' knowledge. 相似文献
107.
Criado PR de Carvalho JF Ayabe LA Brandt HR Romiti R Maruta CW 《Rheumatology international》2012,32(8):2551-2555
Adult-onset Still’s disease (AOSD) patients typically present with arthralgia, fever, lymphadenopathy and a transient salmon maculopapular rash. Only approximately 25 cases of AOSD with urticaria were described in the literature. In this article, the authors report three additional cases of AOSD with urticarial and dermographic lesions who had a good clinical response to glucocorticoid and antihistamines. A review of the literature concerning this issue is also herein written. 相似文献
108.
109.