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991.
Zimmer EZ Lowenstein L Bronshtein M Goldsher D Aharon-Peretz J 《Archives of gynecology and obstetrics》2007,276(5):487-490
Objective The prevalence and clinical significance of isolated mega cisterna magna in both fetuses and adults is not yet well defined.
It is therefore difficult to provide reliable parental counseling in cases of a fetal sonographic diagnosis of this anomaly.
The aim of the present study was to, determine the cognitive profile of adults with isolated mega cisterna magna.
Methods We reviewed 19,301 consecutive CT/MRI of the brain. Isolated mega cisterna magna was observed in 49 cases. A battery of neuropsychological
tests was performed in 18 adults with this anomaly and in 18 controls who had no brain anomaly on CT/MRI.
Results Subjects with isolated mega cisterna magna had a lower performance on memory tasks [RAVLT saving score (0.8 ± 0.2 vs. 1.02 ± 0.2,
P = 0.003)] and verbal fluency [phonemic fluency (9.4 ± 4.5 vs. 13.6 ± 5.3, P = 0.02), semantic fluency (19.8 ± 5.8 vs. 24.4 ± 7.5, P = 0.05)]. They did not differ from controls in regard to the Raven similarity tests indicating that this brain anomaly is
not associated with impairment of general cognitive abilities.
Conclusion Adults with isolated mega cisterna have an overall normal cognitive functioning but may score inferior to controls on some
parameters of memory and verbal fluency. Although application of adult cases to the fetuses is not well established, this
information might be of value in parental counseling in cases of a fetus with this anomaly. 相似文献
992.
Prevalence of pathology in women attending colposcopy for postcoital bleeding with negative cytology
Objective To determine the frequency of cervical pathology and the incidence of cervical neoplasia in women presenting with PCB at the
colposcopy clinic with negative cytology.
Design A retrospective study.
Setting A district general hospital.
Population Eighty-seven women with postcoital bleeding and negative cytology were seen in the colposcopy unit during 1 January 2003 to
31 December 2005.
Methods Women were identified from computer records and details were extracted from the case notes.
Main outcome measure Histopathological diagnosis.
Results Six women (6.9%) had cervical intraepithelial neoplasia. There were no cases of invasive cancer. Thus in our study 6.9% women
with postcoital bleeding had abnormal histology even though they had normal smears. Other identifiable causes were cervical
polyp (12.5%), ectopy (33.6%) and Chlamydia (2.3%). No pathology was found in 50% of women.
Conclusion Women with postcoital bleeding even with normal smears appear to be at much greater risk of cervical neoplasia than the general
population. Unfortunately there is no general consensus for management of these patients. Hence further research is needed
to standardise the management of women with PCB. Patients should be reassured that in vast majority of cases no serious pathology
is detected. 相似文献
993.
Hermans C 《Archives of gynecology and obstetrics》2007,276(3):271-276
Backgroud Hereditary angioedema (HAE) is a rare genetic disorder caused by a deficiency of the plasma protein C1 inhibitor (C1-INH).
HAE is characterised by the onset of angioedema, which may develop in one or several organs, and may last from a few hours
to several days. Oedema of the upper airway can be life-threatening. As a result of hormonal changes, some women experience
more frequent angioedema attacks during pregnancy. During pregnancy, antifibrinolytic agents should only be used with caution,
and attenuated androgens are contraindicated; therefore, replacement therapy with C1-INH concentrate represents one of few
therapeutic options, but it is not widely documented.
Case study We report the first case study of the successful management with regular infusions of C1-INH concentrate, of two successive
pregnancies in a patient with HAE. During the second half of the first pregnancy, C1-INH was administered on demand at home.
For the second pregnancy, on demand treatment was intensified to prophylactic therapy, with once or twice weekly infusions
from the middle of the second trimester in order to efficiently control the frequent attacks.
Conclusions This report illustrates that HAE can be successfully managed during pregnancy with C1-INH infusions at home. Since the number
of crises may vary between pregnancies, the treatment regimen must be adapted to the patient’s need. 相似文献
994.
Srivastava G Pilkington A Nallala D Polson DW Holt E 《Archives of gynecology and obstetrics》2007,276(5):555-557
Objective Ogilvies syndrome (OS) is a rare condition in obstetrics but occurs most commonly after caesarean section. Mortality rates
from OS can be as high as 36–50% when bowel perforation or ischemia develops which highlights the early recognition of this
condition. Early diagnosis is therefore essential to prevent serious morbidity and mortality.
Conclusion We, therefore report a case of OS after caesarean section in which early detection by senior clinicians resulted in successful
management of the condition and an excellent outcome. 相似文献
995.
Objective Case report of a rare combination of a trisomy 18 and 21 in a dizygotic twin pregnancy in a woman with a history of recurrent
miscarriage, a neonatal death, no living offspring and Graves disease.
Methods Case report and literature search.
Results Only one other report in the literature of a combined trisomy 18 and 21 twin pregnancy was found.
Conclusion The combination of a trisomy 18 and 21 in a dizygotic twin pregnancy is very rare. Despite the high frequency and clinical
importance of aneuploidy, very little is known about the factors that may modulate meiotic non-disjunction. 相似文献
996.
Araujo Júnior E Guimarães Filho HA Saito M Pires AB Pontes AL Nardozza LM Moron AF 《Archives of gynecology and obstetrics》2007,275(2):141-144
Context
The cervical teratomas are rare, benign tumors, they are formed by the three embryonic layers, and they represent only 6%
of teratomas. The prognosis depends mainly on the size and location of the lesion, on the tumor growth rate, and on the level
of tracheal compression. Prenatal diagnosis is usually reached with the aid of a two-dimensional ultrasonography (2DUS) after
the 15th week of gestation, which shows a large heterogeneous mass in the cervical region, plus a polyhydramnios, on the Doppler
mode which also shows the vascularization of the tumor.
Case report
We report a case of cervical teratoma diagnosed on the 31st week of gestation with the aid of a 2DUS and color Doppler mode.
We focus on the main findings obtained with the three-dimensional ultrasonography in surface mode, and we highlight the importance
of this methodology for the indirect evaluation of the neonatal prognosis. 相似文献
997.
Wiwanitkit V 《Archives of gynecology and obstetrics》2007,276(6):629-631
Background Consequences of syphilis in mother, pregnancy, fetus and child are considerable, but preventable. Serological screening must
be offered at the first prenatal visit. Presently, the diagnosis of syphilis is dependent mainly on serological tests. The
most widely used screening tests for syphilis are the VDRL and the rapid plasma reagin (RPR) and for confirmation the fluorescent
treponemal antibody (FTA) and the treponema pallidum hemagglutination (TPHA) tests.
Method The four alternative nodes for diagnosis of can be a) VDRL + FTA, b) VDRL + TPHA, c) RPR + FTA and d) RPR + TPHA. Here the
author reports an evaluation of cost utility of those tests in obstetrical practice. According to this study, it can be shown
that the cost per accurate diagnosis for VDRL + TPHA is the least expensive choice and for RPR + FTA is the most expensive
choice.
Conclusion Therefore, this alternative is the best method for serological diagnosis of syphilis, based on medical laboratory economics
principles. 相似文献
998.
Staboulidou I Soergel P Schmidt P Steinborn A Hillemanns P Scharf A 《Archives of gynecology and obstetrics》2007,276(1):35-42
Introduction
The proper function of the fetal heart is indispensable for the fetal development and the normal fetal growth. For prenatal medicine, Doppler sonography offers the possibility of a non-invasive method to examine the fetal cardiovascular function under normal and pathological circumstances. The role of the Doppler sonography is to identify those fetuses who have a high risk factor for developing a pre- or intrapartual asphyxia and therefore have to be delivered promptly. This study aimed at evaluating the clinical value of the intracardiac Doppler sonography (IDS) and at scrutinizing its usefulness during the supervision of the pregnancy of intrauterine growth restricted (IUGR) fetuses.Materials and methods
In a prospective research at the Medical School of Hanover, fetal IDS was applied to 174 pregnant women between the 21 and 37 weeks of gestation (WG). The e-wave and the a-wave, the E/A ratio, and the TVI (time velocity integral) were measured at the atrioventricular (AV) valves. The PV (peak velocity) as well as the TVI were determined at both the aortic and the pulmonary valve. Normal range curves were compiled for all measured parameters.Results
Alongside a control group with untroubled gravidity, which consisted of 153 patients, IUGR fetuses, who formed a collective of 21 patients, were Doppler sonographically examined.While the gestational age advanced, an increase of both the e-wave and the a-wave above the AV-valves could be ascertained, which lead to an E/A ratio <1. Above the semilunar valves there was indicated a slight steady increase of the TPV, the PV as well as the TVI. Normal range curves, which largely correspond to those described in the literature, were compiled for the collective of the pregnancies without pathological findings (n = 153). In comparison to the standard collective, there were no significant differences from the collective of the growth restricted fetuses (n = 21).Conclusion
A temporal informational advantage of pathological intracardiac Doppler values for high risk pregnancies (IUGR) could not be retraced in the examined collective.Doppler sonography traces acute and chronic deficits, which are indicated by hemodynamic changes of the fetus’s blood supply. The clinical importance of IDS as regards dystrophic fetuses has to be ascertained in continuative studies: In the stage of compensatory placental insufficiency (IUGR, arterial Doppler without ARED-flow, venous Doppler without pathological findings) the IDS cannot provide an informational advantage. Contrastingly, the diagnostic potential of the IDS as a screening method of fetal cardiac insufficiency during decompensative placental insufficiency (IUGR, arterial Doppler with ARED-flow, venous Doppler normal or pathological) remains indistinct and should therefore be prospectively evaluated within this high risk group and contrastingly compared to the significance of the venous Doppler sonography (informational advantage?).999.
Successful pregnancy in Noonan’s syndrome and balanced Robertsonian translocation women is extremely rare. This is because
pregnancies in these women usually end in spontaneous miscarriage or termination before 24 weeks gestation due to severe congenital
anomaly. In this article, we report the case of a 41-years-old woman with Noonan’s syndrome and balanced Robertsonian translocation.
She was delivered by an elective caesarean section at 38 weeks of a live male infant following a second attempt of in vitro
fertilisation (IVF) and embryo transfer from donor oocytes. The use of donor eggs and IVF in these women means more of them
will achieve successful term pregnancy as in this case. It is therefore important that Obstetricians understand this rare
condition and optimise care. This case highlights some of the medical problems encountered by Obstetricians in managing patients
in this high risk group. 相似文献
1000.
Makedos G Papanicolaou A Hitoglou A Kalogiannidis I Makedos A Vrazioti V Goutzioulis M 《Archives of gynecology and obstetrics》2007,275(2):121-124
Objective Elevated plasma homocysteine has been implicated in vascular changes compatible with atherosis and endothelial dysfunction
similar to the vascular changes of the placenta in preeclampsia. Previous reports have indicated an increased incidence of
hyperohomocysteinemia in preeclamptic patients. The aim of this study was to examine the association of homocysteine levels
and preeclampsia in our patients.
Study design Prospective study of 28 preeclamptic patients that were matched with 26 normal controls of the same gestational age.
Results The preeclamptic group had an increased incidence of cesarean sections (75%), of growth retarded fetuses (50%), intrauterine
deaths (7%) and placental abruptions (7%). Mean levels of homocysteine were significantly elevated in the preeclamptic than
in control group (11.11 vs. 6.40 μmol/l, P < 0.001). There were no differences between the groups regarding the levels of folic acid (11.12 vs. 9.73 ng/ml, P = 0.55) and vitamin B12 (295.76 vs. 356.15 pg/ml, P = 0.43).
Conclusion It is concluded that in our study homocysteine levels are significantly elevated in patients with preeclampsia compared with
control group, while no vitamin deficiencies were observed. 相似文献