全文获取类型
收费全文 | 4337925篇 |
免费 | 352598篇 |
国内免费 | 15454篇 |
专业分类
耳鼻咽喉 | 61514篇 |
儿科学 | 134781篇 |
妇产科学 | 112824篇 |
基础医学 | 662252篇 |
口腔科学 | 119898篇 |
临床医学 | 393659篇 |
内科学 | 786812篇 |
皮肤病学 | 103818篇 |
神经病学 | 371735篇 |
特种医学 | 172179篇 |
外国民族医学 | 913篇 |
外科学 | 659577篇 |
综合类 | 127082篇 |
现状与发展 | 23篇 |
一般理论 | 2686篇 |
预防医学 | 367881篇 |
眼科学 | 102286篇 |
药学 | 306257篇 |
25篇 | |
中国医学 | 11508篇 |
肿瘤学 | 208267篇 |
出版年
2021年 | 56300篇 |
2020年 | 35847篇 |
2019年 | 59170篇 |
2018年 | 74054篇 |
2017年 | 56541篇 |
2016年 | 62932篇 |
2015年 | 76202篇 |
2014年 | 111220篇 |
2013年 | 176945篇 |
2012年 | 122178篇 |
2011年 | 125899篇 |
2010年 | 124594篇 |
2009年 | 127483篇 |
2008年 | 112613篇 |
2007年 | 119607篇 |
2006年 | 128742篇 |
2005年 | 123933篇 |
2004年 | 124550篇 |
2003年 | 114989篇 |
2002年 | 105527篇 |
2001年 | 154687篇 |
2000年 | 150767篇 |
1999年 | 139908篇 |
1998年 | 71638篇 |
1997年 | 68008篇 |
1996年 | 65852篇 |
1995年 | 61684篇 |
1994年 | 55767篇 |
1993年 | 51769篇 |
1992年 | 103744篇 |
1991年 | 99101篇 |
1990年 | 94188篇 |
1989年 | 91839篇 |
1988年 | 85464篇 |
1987年 | 83898篇 |
1986年 | 79576篇 |
1985年 | 78046篇 |
1984年 | 66080篇 |
1983年 | 58973篇 |
1982年 | 48279篇 |
1981年 | 44984篇 |
1980年 | 42260篇 |
1979年 | 57931篇 |
1978年 | 47116篇 |
1977年 | 41663篇 |
1976年 | 38721篇 |
1975年 | 37907篇 |
1974年 | 42499篇 |
1973年 | 40632篇 |
1972年 | 38083篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
991.
992.
L. Dvorakova J. Sikora M. Hrebicek H. Hulkova M. Bouckova L. Stolnaja M. Elleder 《Journal of inherited metabolic disease》2006,29(4):591
Summary We present the third case of Niemann–Pick disease type C without neurological symptoms. The patient was a 53-year-old woman
without significant prior health problems who died of acute pulmonary embolism. Autopsy findings of hepatosplenomegaly, lymphadenopathy
and ceroid-rich foam cells raised the suspicion of the visceral form of acid sphingomyelinase deficiency (Niemann–Pick disease
type B; NPB) or a much rarer disorder, variant adult visceral form of Niemann–Pick disease type C (NPC). To verify the histopathological
findings, SMPD1, NPC1 and NPC2 genes were analysed. Two novel sequence variants, c.1997G>A (S666N) and c.2882A>G (N961S) were detected in the NPC1 gene. No pathogenic sequence variants were found either in the SMPD1 gene mutated in NPB or in NPC2 gene. The pathogenicity of both NPC1 variants was supported by their location in regions important for the protein function. Both variations were not found in
more than 300 control alleles. Identified sequence variations confirm the diagnosis of the extremely rare adult visceral form
of Niemann–Pick disease type C, which is otherwise dominated by neurovisceral symptoms. Although only three patients have
been reported, this (most probably underdiagnosed) form of NPC should be considered in differential diagnosis of isolated
hepatosplenomegaly with foam cells in adulthood.
Electronic supplementary material Supplementary material is available for this article at 相似文献
993.
Neetu Radhakrishnan M.D. Chong. H. Park M.D. Barry M. Kaplan M.D. F.A.C.C. Rajiv Jauhar M.D. F.A.C.C. 《The International journal of angiology》2006,15(1):37-42
A 65-year-old man developed acute limb ischemia, severe abdominal wall and lower limb livedo reticularis following a coronary
angiogram. The differential diagnoses of acute limb ischemia and multiple cholesterol emboli syndrome (MCES) are discussed.
This work was performed at Long Island Jewish Medical Center, 270-05, 76th Avenue, New Hyde Park, NY 11040. 相似文献
994.
Light emitting diodes for auramine O fluorescence microscopic screening of Mycobacterium tuberculosis. 总被引:1,自引:0,他引:1
R M Anthony A H J Kolk S Kuijper P R Klatser 《The international journal of tuberculosis and lung disease》2006,10(9):1060-1062
We describe the simple adaptation of a standard fluorescent microscope for illumination using a 'Royal Blue' Luxeon light emitting diode (LED) and demonstrate that this form of illumination is suitable for the detection of auramine O stained Mycobacterium spp. The low cost, low power consumption, safety and reliability of LEDs makes them attractive alternatives to mercury vapour lamps. 相似文献
995.
996.
997.
精神分裂症首次发病患者的磁共振弥散张量显像研究 总被引:1,自引:0,他引:1
目的探讨从未用过药的精神分裂症首次发病(以下简称首发)患者的重要白质及部分灰质区的磁共振弥散张量显像(DTI)的特点。方法选取9例首发精神分裂症患者(患者组)及9名年龄、性别、受教育程度与患者组相配对的健康者,应用DTI成像技术检测脑额颞交界处、内囊等白质区和颞中回灰质、中央前回、中央后回等灰质区的各向异性(FA)、表观扩散系数(ADC)及双侧海马体积。结果患者组及对照组组内左右两侧兴趣区FA值及ADC值的差异无统计学意义(P>0.05);患者组与对照组各感兴趣区FA值差异无统计学意义(P>0.05),但患者组颞中回灰质(8.655×10-9)、中央前回(7.816×10-9)、中央后回(7.855×10-9)ADC值高于对照组(分别为7.428×10-9,6.921×10-9,7.013×10-9;P=0.049,0.009,0.005);两组内及组间双侧海马体积比较,差异均无统计学意义(P>0.05)。结论首发精神分裂症患者与健康者DTI参数之间没有明显区别。 相似文献
998.
999.
OBJECTIVE: Gelastic seizures are a frequent and well established manifestation of the epilepsy associated with hypothalamic hamartomas. The scalp EEG recordings very seldom demonstrate clear spike activity and the information about the ictal epilepsy dynamics is limited. In this work, we try to isolate epileptic rhythms in gelastic seizures and study their generators. METHODS: We extracted rhythmic activity from EEG scalp recordings of gelastic seizures using decomposition in independent components (ICA) in three patients, two with hypothalamic hamartomas and one with no hypothalamic lesion. Time analysis of these rhythms and inverse source analysis was done to recover their foci of origin and temporal dynamics. RESULTS: In the two patients with hypothalamic hamartomas consistent ictal delta (2-3 Hz) rhythms were present, with subcortical generators in both and a superficial one in a single patient. The latter pattern was observed in the patient with no hypothalamic hamartoma visible in MRI. The deep generators activated earlier than the superficial ones, suggesting a consistent sub-cortical origin of the rhythmical activity. CONCLUSIONS: Our data is compatible with early and brief epileptic generators in deep sub-cortical regions and more superficial ones activating later. SIGNIFICANCE: Gelastic seizures express rhythms on scalp EEG compatible with epileptic activity originating in sub-cortical generators and secondarily involving cortical ones. 相似文献
1000.
目的 探讨术中电生理监护对椎管神经鞘瘤显微手术中的作用及意义,提高对椎管内神经鞘瘤的治疗水平。方法 回顾性分析65例术中电生理动态监护下,显微手术切除椎管内神经鞘瘤。结果 治愈60例(占92.3%),好转5例(占7.7%),无死亡;肿瘤全切62例,次全切除3例,全切率95.4%。结论 常规动态电生理监测下显微手术切除椎管神经鞘瘤,能保全脊髓神经的功能,减少副损伤,提高手术安全性;显微手术有助于提高肿瘤全切率,可有效减少术后复发。对影响脊柱稳定性的行脊柱融合内固定。 相似文献