全文获取类型
收费全文 | 1507篇 |
免费 | 84篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 42篇 |
妇产科学 | 24篇 |
基础医学 | 136篇 |
口腔科学 | 7篇 |
临床医学 | 173篇 |
内科学 | 331篇 |
皮肤病学 | 7篇 |
神经病学 | 194篇 |
特种医学 | 54篇 |
外科学 | 260篇 |
综合类 | 13篇 |
预防医学 | 146篇 |
眼科学 | 13篇 |
药学 | 64篇 |
中国医学 | 2篇 |
肿瘤学 | 113篇 |
出版年
2023年 | 10篇 |
2022年 | 17篇 |
2021年 | 15篇 |
2020年 | 12篇 |
2019年 | 35篇 |
2018年 | 35篇 |
2017年 | 28篇 |
2016年 | 30篇 |
2015年 | 26篇 |
2014年 | 56篇 |
2013年 | 65篇 |
2012年 | 90篇 |
2011年 | 131篇 |
2010年 | 71篇 |
2009年 | 61篇 |
2008年 | 116篇 |
2007年 | 85篇 |
2006年 | 105篇 |
2005年 | 106篇 |
2004年 | 75篇 |
2003年 | 85篇 |
2002年 | 78篇 |
2001年 | 32篇 |
2000年 | 29篇 |
1999年 | 30篇 |
1998年 | 24篇 |
1997年 | 14篇 |
1996年 | 12篇 |
1995年 | 9篇 |
1994年 | 2篇 |
1993年 | 7篇 |
1992年 | 5篇 |
1991年 | 3篇 |
1990年 | 7篇 |
1989年 | 5篇 |
1988年 | 9篇 |
1987年 | 9篇 |
1986年 | 11篇 |
1985年 | 13篇 |
1984年 | 5篇 |
1983年 | 6篇 |
1982年 | 7篇 |
1981年 | 4篇 |
1980年 | 3篇 |
1978年 | 2篇 |
1975年 | 2篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1969年 | 4篇 |
1961年 | 1篇 |
排序方式: 共有1598条查询结果,搜索用时 15 毫秒
51.
52.
Addison Poppy Carsky Katie Patti Mary Elizabeth Roslin Mitchell 《Obesity surgery》2022,32(5):1681-1688
Obesity Surgery - With the increasing performance of bariatric surgery, rare complications are becoming prevalent. We review the diagnosis and treatment of dysautonomia after bariatric surgery and... 相似文献
53.
Ashley N. Cabacungan Matthew J. Ellis Debra Sudan Tara S. Strigo Iris Pounds Jennie A. Riley Margaret Falkovic Aviel N. Alkon Sarah B. Peskoe Clemontina A. Davenport Jane F. Pendergast Patti L. Ephraim Dinushika Mohottige Clarissa J. Diamantidis Jennifer St. Clair Russell Nicole DePasquale L. Ebony Boulware 《Clinical transplantation》2020,34(3):e13799
We studied associations between perceived adequacy of live donor kidney transplant (LDKT) information or knowledge with pursuit of LDKT or receipt of live donor inquiries among 300 African American kidney transplant candidates. Participants reported via questionnaire how informed or knowledgeable they felt regarding LDKT. Participants also reported their pursuit of LDKT, categorized as “low” (no discussion with family or friends about LDKT and no identified donor), “intermediate” (discussed LDKT with family but no identified donor) or “high” (discussed LDKT with family and identified a potential donor). We reviewed participants' electronic health records to identify potential donors' transplant center inquiries on participants' behalves. A minority of participants reported they felt “very” or “extremely” well informed about LDKT (39%) or had “a great deal” of LDKT knowledge (38%). Participants perceiving themselves as “very” or “extremely” (vs “not” or “slightly”) well informed about LDKT had statistically significantly greater odds of intermediate or high (vs low) pursuit of LDKT (odds ratio [95% confidence interval] 2.71 [1.02-7.17]). Perceived LDKT knowledge was not associated with pursuit of LDKT. Neither perceived information adequacy nor knowledge was associated with living donor inquiries. Efforts to better understand the role of education in the pursuit of LDKT among African American transplant candidates are needed. 相似文献
54.
55.
56.
57.
Elvira Isganaitis Melissa Woo Huijuan Ma Michael Chen Wen Kong Aristides Lytras Vicencia Sales Jennifer DeCoste-Lopez Kyung-Ju Lee Cianna Leatherwood Deborah Lee Connor Fitzpatrick Walter Gall Steven Watkins Mary-Elizabeth Patti 《Diabetes》2014,63(2):688-700
Maternal obesity and gestational diabetes mellitus (GDM) are associated with obesity and diabetes risk in offspring. We tested whether maternal insulin resistance, which frequently coexists with GDM and obesity, could independently contribute to dysregulation of offspring metabolism. Female mice haploinsufficient for insulin receptor substrate-1 (IRS1-het) are hyperinsulinemic and insulin resistant during pregnancy, despite normal plasma glucose and body weight, and thus serve as a model of isolated maternal insulin resistance. Wild-type (WT) offspring of IRS1-het dams insulin resistance-exposed [IR-exposed] were compared with WT offspring of WT dams. Despite no differences in adiposity, male IR-exposed pups were glucose intolerant (P = 0.04) and hyperinsulinemic (1.3-fold increase, P = 0.02) by 1 month of age and developed progressive fasting hyperglycemia. Moreover, male IR-exposed pups challenged with high-fat diet exhibited insulin resistance. Liver lipidomic analysis of 3-week-old IR-exposed males revealed increases in the 16:1n7 fraction of several lipid classes, suggesting increased Scd1 activity. By 6 months of age, IR-exposed males had increased lipid accumulation in liver as well as increased plasma refed fatty acids, consistent with disrupted lipid metabolism. Our results indicate that isolated maternal insulin resistance, even in the absence of hyperglycemia or obesity, can promote metabolic perturbations in male offspring. 相似文献
58.
Simonetta Viviani Arabella Mazzocchi Chiara Pavoni Francesca Taverna Andrea Rossi Caterina Patti Alessandra Romano Livio Trentin Roberto Sorasio Anna Guidetti Daniela Gottardi Corrado Tarella Michele Cimminiello Roberta Zanotti Lucia Farina Andrés José Maria Ferreri Marina Galbiati Paolo Corradini Alessandro Massimo Gianni Andrea Gallamini Alessandro Rambaldi 《Hematological oncology》2020,38(4):501-508
Among patients with advanced-stage classical Hodgkin lymphoma (cHL) receiving ABVD chemotherapy, PET performed after the first two treatment cycles (PET-2) has prognostic value. However, 15% of patients with a negative PET-2 will experience treatment failure. Here we prospectively evaluated serum thymus and activation-regulated chemokine (TARC) levels, to improve risk assessment in patients treated according to HD0607 PET-driven trial (#NCT00795613). In 266 patients with available serum samples, who have agreed to participate in a sub-study for assessment of the role of TARC monitoring, serum TARC levels were measured at baseline and at time of PET-2 by commercially available ELISA test kits. The primary end-point was to evaluate the association between TARC after 2 ABVD cycles and PFS. Median TARC-2 values were significantly higher in PET-2-positive patients compared to PET-2-negative patients (P = .001), and in patients with treatment failure compared to those in continuous CR (P = .01). The 4-year PFS significantly differed between patients with TARC-2 >800 pg/mL vs ≤800 pg/mL (64% vs 86%, P = .0001). Moreover, among PET-2-negative patients, elevated TARC-2 identified those with a worse prognosis (74% vs 89%; P = .01). In multivariable analysis, TARC-2 >800 pg/mL was a significant independent predictor of PFS in the whole study population (HR 2.39, P = .004) and among the PET-2-negative patients (HR 2.49, P = .02). In conclusion, our results indicate that TARC-2 serum levels above 800 pg/mL suggest the need for a stringent follow-up in PET-2-negative patients, and the evaluation of new drugs in PET-2-positive, who will likely fail to respond to intensification with escalated BEACOPP. 相似文献
59.
Sergio Berti Luigi Emilio Pastormerlo Gennaro Santoro Elvis Brscic Matteo Montorfano Luigi Vignali Paolo Danna Claudio Tondo Marco Rezzaghi Gianpiero D’Amico Amerigo Stabile Salvatore Saccà Giuseppe Patti Antonio Rapacciuolo Arnaldo Poli Paolo Golino Paolo Magnavacchi Francesco Meucci Giuseppe Tarantini 《JACC: Cardiovascular Interventions》2018,11(11):1086-1092
Objectives
This study sought to evaluate the feasibility, safety, and efficacy of intracardiac echocardiography (ICE)–guided versus transesophageal echocardiography (TEE)–guided left atrial appendage occlusion (LAAO) by the use of Amplatzer Cardiac Plug or Amulet devices included in a large Italian registry.Background
TEE is widely used for LAAO procedure guidance. ICE may be a potential alternative imaging modality in LAAO.Methods
Data from 604 LAAO procedures performed in 16 Italian centers were reviewed. ICE-guided LAAO was performed in 187 patients, whereas TEE was used in 417 patients. Procedural success was defined as LAAO without occurrence of pericardial tamponade, stroke, systemic embolism with end organ damage, major bleeding, and device embolization. Stroke, transient ischemic attack, major bleeding, overall and cardiovascular death were analyzed.Results
CHA2DS2-VASc (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, prior stroke or transient ischemic attack or thromboembolism, vascular disease, age 65 to 74 years, sex category) and HAS-BLED (hypertension, abnormal renal and liver function, stroke, bleeding, labile international normalized ratio, elderly, drugs or alcohol) scores were similar between the ICE and TEE groups. TEE implied lower procedural (delta 12 min) and fluoroscopy time (delta 5 min) when compared with ICE. Procedural success was similarly high (≥94%) between the TEE and ICE groups with a complication rate of 6.5% for TEE versus 4.2% for ICE (odds ratio: 1.468; 95% confidence interval: 0.681 to 3.166; p = 0.327). At median follow-up of 451 days (interquartile range: 162 to 899 days), the rate of cerebral ischemic events was similar between TEE-guided and ICE-guided procedures.Conclusions
ICE-guided LAAO by means of Amplatzer devices may represent a second alternative imaging modality after an appropriate learning curve and bearing in mind that pre-procedural computed tomography imaging is mandatory. When comparing ICE with TEE, TEE remains the gold standard. 相似文献60.
Accumulated Clonal Genetic Alterations in Familial and Sporadic Colorectal Carcinomas with Widespread Instability in Microsatellite Sequences 总被引:16,自引:3,他引:16
下载免费PDF全文
![点击此处可从《The American journal of pathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)