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排序方式: 共有2075条查询结果,搜索用时 15 毫秒
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Gabriel Courties Timo Heidt Matthew Sebas Yoshiko Iwamoto Derrick Jeon Jessica Truelove Benoit Tricot Greg Wojtkiewicz Partha Dutta Hendrik B. Sager Anna Borodovsky Tatiana Novobrantseva Boris Klebanov Kevin Fitzgerald Daniel G. Anderson Peter Libby Filip K. Swirski Ralph Weissleder Matthias Nahrendorf 《Journal of the American College of Cardiology》2014
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Partha Sardar Ramez Nairooz Saurav Chatterjee Savi Mushiyev Gerald Pekler Ferdinand Visco 《Journal of thrombosis and thrombolysis》2014,38(1):1-10
Cangrelor is a new parenteral adenosine diphosphate P2Y12 receptor inhibitor with rapid, profound and reversible inhibition of platelet activity. The aim of this meta-analysis was to evaluate efficacy and safety of this new agent in patients undergoing percutaneous coronary intervention (PCI). We searched PubMed, Cochrane Library, EMBASE, Web of Science and CINAHL databases from the inception through April 2013. Randomized controlled trials (RCTs) comparing cangrelor with control (clopidogrel/placebo) were selected. We used the random-effects models to calculate the risk ratio. The primary efficacy outcome was risk of myocardial infarction, and the primary safety outcome was TIMI major bleeding at 48 h. Three RCTs included a total of 25,107 participants. Effects of Cangrelor were not different against comparators for myocardial infarction (MI) (Risk ratio [RR] 0.94, 95 % confidence interval [CI] 0.78–1.13) and all-cause mortality (RR 0.72, 95 % CI 0.36–1.43). However, cangrelor significantly reduced the risk of ischemia-driven revascularization (RR 0.72, 95 % CI 0.52–0.98), stent thrombosis (RR 0.60, 95 % CI 0.44–0.82) and Q wave MI (RR 0.53, 95 % CI 0.30–0.92) without causing extra major bleeding (Thrombolysis in Myocardial infarction criteria) and severe or life-threatening bleeding (Global utilization of streptokinase and tissue plasminogen activator for occluded coronary arteries criteria). Separate analysis against only clopidogrel also showed similar findings except Q wave MI outcome. Use of cangrelor during PCI might reduce the risk of ischemia-driven revascularization and stent thrombosis, without causing extra major bleeding. 相似文献
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Mukherjee Partha Sarathi Ghosh Sujoy Mukhopadhyay Pradip Das Kausik Das Dipesh Kr. Sarkar Pabak Bhattacharya Debdoot Mazumdar Saibal Chatterjee Kajal 《International journal of diabetes in developing countries.》2020,40(4):612-618
International Journal of Diabetes in Developing Countries - Type 2 diabetes is a pandemic in India, yet studies regarding knowledge, attitude, and practices in diabetes in various Indian... 相似文献
66.
Loss of Gsα Early in the Osteoblast Lineage Favors Adipogenic Differentiation of Mesenchymal Progenitors and Committed Osteoblast Precursors
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Partha Sinha Piia Aarnisalo Rhiannon Chubb Noriaki Ono Keertik Fulzele Martin Selig Hamid Saeed Min Chen Lee S Weinstein Paola Divieti Pajevic Henry M Kronenberg Joy Y Wu 《Journal of bone and mineral research》2014,29(11):2414-2426
In humans, aging and glucocorticoid treatment are associated with reduced bone mass and increased marrow adiposity, suggesting that the differentiation of osteoblasts and adipocytes may be coordinately regulated. Within the bone marrow, both osteoblasts and adipocytes are derived from mesenchymal progenitor cells, but the mechanisms guiding the commitment of mesenchymal progenitors into osteoblast versus adipocyte lineages are not fully defined. The heterotrimeric G protein subunit Gsα activates protein kinase A signaling downstream of several G protein‐coupled receptors including the parathyroid hormone receptor, and plays a crucial role in regulating bone mass. Here, we show that targeted ablation of Gsα in early osteoblast precursors, but not in differentiated osteocytes, results in a dramatic increase in bone marrow adipocytes. Mutant mice have reduced numbers of mesenchymal progenitors overall, with an increase in the proportion of progenitors committed to the adipocyte lineage. Furthermore, cells committed to the osteoblast lineage retain adipogenic potential both in vitro and in vivo. These findings have clinical implications for developing therapeutic approaches to direct the commitment of mesenchymal progenitors into the osteoblast lineage. © 2014 American Society for Bone and Mineral Research 相似文献
67.
Rani Singh Rajib Deb Umesh Singh Rani Alex Sushil Kumar Soumendu Chakraborti Sheetal Sharma Gyanendra Sengar Rupali Singh 《Archives of virology》2014,159(12):3385-3389
ITGB6 is known to be one of the major receptor components involved in host tropism of foot-and-mouth disease (FMD) virus in cattle. A competitive PCR technique called ARMS PCR was adapted to identify a single-nucleotide polymorphism (SNP), G29A, db SNP Id: rs109075046, in the 5′ untranslated region (5′UTR) of the bovine ITGB6 gene. Genotype profiling identified three kinds of genetic variation within the targeted SNP among Frieswal crossbred cattle. The occurrence of FMD in the three genotypes was further evaluated, revealing a clear role in the incidence of FMD in the studied population. 相似文献
68.
R Deb U Singh S Kumar R Singh G Sengar A Sharma 《Majallah-i ta?qīqāt-i dāmpizishkī-i īrān》2014,15(4):406-408
The aim of the present study was to screen the genotype profile of bovine kappa-casein gene among Frieswal (HF × Sahiwal) crossbred cattle developed in India. A total number of two hundred Frieswal cows were evaluated for HinfI RFLP based genotyping of kappa-casein gene. We observed that only two genotypes (AA and AB) exist among the studied population with the genotype frequency of 0.58 (n=117) and 0.42 (n=83), respectively. The calculated allele frequency for A and B was 0.79 and 0.21, respectively. Association of genotypes with certain milk production traits revealed that AB had significant (P<0.05) effect on total milk yield, peak yield, yield at 300 days and SNF% as compared to AA.Key Words: Kappa-casein, Polymorphism, Frieswal, RFLP, Milk production traits 相似文献
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Raj Pallavi Desai Sadhana K. Roy Partha Guha Kania Prema 《Journal of obstetrics and gynaecology of India》2020,70(3):234-236
The Journal of Obstetrics and Gynecology of India - 相似文献