全文获取类型
收费全文 | 1089篇 |
免费 | 81篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 17篇 |
妇产科学 | 30篇 |
基础医学 | 108篇 |
口腔科学 | 76篇 |
临床医学 | 88篇 |
内科学 | 168篇 |
皮肤病学 | 25篇 |
神经病学 | 165篇 |
特种医学 | 14篇 |
外科学 | 191篇 |
综合类 | 16篇 |
预防医学 | 185篇 |
眼科学 | 1篇 |
药学 | 47篇 |
肿瘤学 | 39篇 |
出版年
2024年 | 4篇 |
2023年 | 17篇 |
2022年 | 12篇 |
2021年 | 27篇 |
2020年 | 27篇 |
2019年 | 42篇 |
2018年 | 26篇 |
2017年 | 23篇 |
2016年 | 26篇 |
2015年 | 37篇 |
2014年 | 30篇 |
2013年 | 48篇 |
2012年 | 89篇 |
2011年 | 79篇 |
2010年 | 40篇 |
2009年 | 27篇 |
2008年 | 60篇 |
2007年 | 70篇 |
2006年 | 55篇 |
2005年 | 54篇 |
2004年 | 54篇 |
2003年 | 44篇 |
2002年 | 45篇 |
2001年 | 22篇 |
2000年 | 12篇 |
1999年 | 19篇 |
1998年 | 10篇 |
1997年 | 6篇 |
1996年 | 6篇 |
1995年 | 5篇 |
1994年 | 10篇 |
1993年 | 8篇 |
1992年 | 15篇 |
1991年 | 10篇 |
1990年 | 12篇 |
1989年 | 8篇 |
1988年 | 6篇 |
1987年 | 6篇 |
1986年 | 6篇 |
1985年 | 9篇 |
1982年 | 3篇 |
1979年 | 4篇 |
1978年 | 7篇 |
1971年 | 3篇 |
1965年 | 2篇 |
1964年 | 2篇 |
1962年 | 5篇 |
1961年 | 2篇 |
1942年 | 2篇 |
1914年 | 3篇 |
排序方式: 共有1171条查询结果,搜索用时 31 毫秒
21.
Intra-articular glucocorticoid injections are often used in patients with rheumatoid arthritis, either as bridging therapy or in periods with increased disease activity. We present a case of local skin depigmentation that occurred at the site of injection in a dark-skinned patient. Depigmentation is a rare complication of such therapy but may have important implications for dark-skinned patients.Abbreviations DMARD Disease-modifying anti-rheumatic drugs - RA Rheumatoid arthritis 相似文献
22.
K Thorsteinsson S Ladelund S Jensen-Fangel MV Larsen IS Johansen TL Katzenstein G Pedersen M Storgaard N Obel AM Lebech 《Scandinavian journal of infectious diseases》2012,44(10):766-775
Abstract Background: Gender differences in the risk of AIDS-defining illness (ADI) and mortality have been reported in the HIV-1-infected (HIV-positive) population, with conflicting findings. We aimed to assess the impact of gender on the risk of ADI and death in HIV-positive patients infected sexually. Methods: This was a population-based, nationwide cohort study of incident Danish HIV-positive individuals infected by sexual contact. Outcomes were progression to AIDS and death. We used Cox proportional hazards models and Poisson regression analyses to calculate the risk of progression to AIDS and mortality rate ratios (MRR) between risk groups and compared these with the general Danish population. Results: We identified 587 heterosexually infected women, 583 men who have sex with women (MSW), and 1089 men who have sex with men (MSM). The total follow-up time was 13,708 person-y. At the time of HIV diagnosis MSM had a lower prevalence of AIDS compared to MSW. Women and MSW presented more often with tuberculosis and less often with AIDS-defining cancers compared to MSM. In the adjusted analyses we observed no differences in progression to AIDS. In the adjusted analyses of risk of death, there were no differences between the 3 risk groups, although we saw a trend towards a higher risk of death in older MSW. MSM had a lower risk of death compared to the background population than women and MSW. Conclusions: In the Danish HIV population, gender has no major impact on progression to AIDS or mortality. Differences in these factors between women, MSW, and MSM are mainly due to confounding from race and CD4 + cell count at diagnosis. 相似文献
23.
24.
Background
Computed tomography (CT) scans often identify postoperative fluid collections of uncertain clinical relevance.Methods
Consecutive adult patients undergoing colorectal resection and postoperative CT scan from January 1, 2000 to December 31, 2008, at a university teaching hospital were identified from a prospective database. A host of clinical and CT findings were recorded. Fisher's exact test and logistic regression with univariate and multivariate analysis were used to assess the predictive value of clinical and radiologic variables.Results
Nine hundred six patients had a colon resection during the study period. Fifty-four patients had a postoperative fluid collection, of which 36 were found to be abscesses. Only high clinical suspicion of an abscess predicted the presence of an abscess (P = .009); of the radiologic criteria, only proximity to the anastomosis was predictive (P = .05).Conclusions
Clinical judgment is superior to radiologic and individual clinical parameters. This finding has the potential to prevent many unnecessary procedures. 相似文献25.
Hjorthøj CR Fohlmann A Larsen AM Arendt M Nordentoft M 《Addiction (Abingdon, England)》2012,107(6):1123-1131
Aims To assess correlations and agreement between timeline follow‐back (TLFB)‐assisted self‐report and blood samples for cannabis use. Design Secondary analysis of a randomized trial. Setting Copenhagen, Denmark. Participants One hundred and three patients from the CapOpus trial with cannabis use disorder and psychosis, providing 239 self‐reports of cannabis use and 88 valid blood samples. Measurements Delta‐9‐tetrahydrocannabinol (THC), 11‐hydroxy‐delta‐9‐tetrahydrocannabinol (11‐OH‐THC) and 11‐nor‐delta‐9‐tetrahydrocannabinol‐9‐carboxylic acid (THC‐COOH) detected in plasma using high‐performance liquid chromatography with tandem mass spectrometry detection. Self‐report of cannabis‐use last month by TLFB. Pearson's r, sensitivity and specificity calculated as measures of correlation or agreement. Findings Correlations were strong; r = 0.75 for number of days and r = 0.83 for number of standard joints in the preceding month when excluding outliers. Including outliers, coefficients were moderate to strong (r = 0.49). There were differences in subgroups, mainly inconsistent, depending on inclusion or exclusion of outliers. Sensitivity and specificity for TLFB detecting the presence or absence of cannabis use were 95.7% [95% confidence interval (CI) 88.0–99.1%) and 72.2% (95% CI 46.5–90.3%), respectively. Using 19 days as cut‐off on TLFB, they were 94.3% (95% CI 86.0–98.4%) and 94.4% (95% CI 72.2–99.9%), respectively. Area under the receiver operating characteristic (ROC) curve was 0.96. Conclusions Timeline follow‐back (TLFB)‐assisted self‐report of cannabis use correlates highly with plasma‐delta‐9‐tetrahydrocannabinol in patients with comorbid cannabis use disorder and psychosis. Sensitivity and specificity of timeline follow‐back appear to be optimized with 19 days as the cut‐off point. As such, timeline follow‐back may be superior to analysis of blood when going beyond 19 days of recall. 相似文献
26.
27.
Torstein Husby Jan-Ragnar Haugstvedt Merete Brandt Inger Holm Harald Steen 《Acta orthopaedica》2013,84(4):408-414
In a randomized prospective study, we selected 15 patients for arthroscopic subacromial decompression (ASD) and 19 patients for open subacromial decompression (OSD). All had impingement syndrome (Neer grade II), and had been unsuccessfully treated without surgery for more than 6 months. The UCLA Shoulder Rating Scale, Visual Analogue Scales for pain and satisfaction, isokinetic dynamometer recordings and physical testing were assessed preoperatively and at 1 (except isokinetic testing), 3, 6, and 12 months, and, finally, 8 years after surgery. We found essentially no differences in the clinical tests between the groups during this period. The use of ASD or OSD seems to be a matter of cosmesis and personal preference. 相似文献
28.
Merete Nordentoft Ping Qin Karin Helweg-Larsen Knud Juel 《Nordic journal of psychiatry》2013,67(2):97-106
Restriction of means for suicide is an important part of suicide preventive strategies in different countries. All suicides in Denmark between 1970 and 2000 were examined with regard to method used for suicide. Overall suicide mortality and method-specific suicide mortality was compared with official information about availability of medical compounds (barbiturates, benzodiazepines, analgesics, antidepressants) and carbon monoxide in vehicle exhaust and household gas. Restrictions on the availability of carbon monoxide, barbiturates and dextropropoxyphen was associated with a decline in the number of suicides by self-poisoning with these compounds. Restricted access occurred concomittantly with a 55% decrease in suicide rate. 相似文献
29.
Tina R. Kilburn Merete Juul Sørensen Mikael Thastum Ronald M. Rapee Charlotte Ulrikka Rask Kristian Bech Arendt 《Nordic journal of psychiatry》2013,67(4-5):273-280
AbstractPurpose: Autism spectrum disorder (ASD) includes core symptoms that affect general and social development. High risk of developing comorbid disorders such as anxiety is prominent. Up to 60% of children with ASD suffer from anxiety disorders which can negatively influence educational, social and general development together with quality of life. This study is the first to investigate the feasibility of the manualised cognitive behavioural therapy (CBT) group programme 'Cool Kids ASD' for anxiety adapted for children with ASD in a general hospital setting.Methods: Nine children, aged 9–13 years, with ASD and anxiety recruited from a public child psychiatric health clinic were enrolled in the study. Outcome measures were collected from both child and parent pre- and post-treatment and at 3-month follow-up and included scores from a semi-structured anxiety interview, together with questionnaires on anxiety symptoms, life interference, children's automatic thoughts and satisfaction with the programme.Results: Eight out of nine families found the programme useful and would recommend it to other families in a similar situation. Six families attended all 12 sessions in the programme, two missed one session and one family only managed to attend eight sessions. At follow-up, five children were free of all anxiety diagnoses and a further two out of the nine children no longer met the criteria for their primary anxiety diagnosis.Conclusions: This study suggests that the transition of the group programme 'Cool Kids ASD' from University Clinics to standard child psychiatric clinical settings is feasible. Further randomised studies are needed to confirm the efficacy of the programme in a larger sample. 相似文献
30.
Trine Madsen Esben Agerbo Preben B. Mortensen Merete Nordentoft 《Social psychiatry and psychiatric epidemiology》2013,48(9):1481-1489