全文获取类型
收费全文 | 462篇 |
免费 | 19篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 10篇 |
妇产科学 | 13篇 |
基础医学 | 56篇 |
临床医学 | 29篇 |
内科学 | 70篇 |
皮肤病学 | 22篇 |
神经病学 | 24篇 |
特种医学 | 2篇 |
外科学 | 50篇 |
综合类 | 1篇 |
预防医学 | 163篇 |
眼科学 | 8篇 |
药学 | 13篇 |
中国医学 | 1篇 |
肿瘤学 | 16篇 |
出版年
2024年 | 1篇 |
2023年 | 8篇 |
2022年 | 16篇 |
2021年 | 19篇 |
2020年 | 5篇 |
2019年 | 19篇 |
2018年 | 20篇 |
2017年 | 6篇 |
2016年 | 9篇 |
2015年 | 10篇 |
2014年 | 17篇 |
2013年 | 21篇 |
2012年 | 48篇 |
2011年 | 50篇 |
2010年 | 37篇 |
2009年 | 26篇 |
2008年 | 19篇 |
2007年 | 28篇 |
2006年 | 24篇 |
2005年 | 24篇 |
2004年 | 19篇 |
2003年 | 22篇 |
2002年 | 13篇 |
2001年 | 2篇 |
2000年 | 1篇 |
1992年 | 6篇 |
1991年 | 2篇 |
1986年 | 2篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1979年 | 1篇 |
1973年 | 3篇 |
排序方式: 共有481条查询结果,搜索用时 31 毫秒
61.
Essais O Bouzid C Ouni Z Ibrahim H Ouertani H Machghoul S Zidi B 《La Tunisie médicale》2006,84(5):279-281
Previous studies have suggested that hyperhomocysteinaemia (Hcy) could be a strong and independent cardiovascular risk factor. Many factors could influence the serum concentration of Hcy such as vitamin B 12, folic acid, renal failure, hypothyroid status, ovarian failure and cancers. So the aim of our study was to evaluate the prevalence of hyperhomocysteinaemia among 54 type 2 diabetic patients and to study, its relationship with vitamin B12, folic acid and Metformin. Were excluded all patients with an evident cause of hyperhomocysteinaemia. Mean age of patients was 52.8 years. Mean Hcy was 11.7 + 6.9 micromol/l. The prevalence of hyperhomocysteinaemia was 27.8% in our group. There were eight (14%) patients with vitamin B12 deficiency and three among them had hyperhomocysteinaemia. There was no folic acid deficiency and no relationship with Metformin treatment. We suggest a wide screening of hyperhomocysteinaemia in type 2 diabetic patients and folic acid or vitamin B12 supplements if necessary. 相似文献
62.
11 beta-hydroxylase deficiency is a rare recessive autosomal disorder. The aim of this report was to describe among a retrospective study of seven cases, different clinical pictures, problems in diagnosis and management. Results: the frequency of 11 beta-hydroxylase deficiency was 17.5% of congenital adrenal hypererplasia etiology in our study. Consanguinity was found in all cases. The sex ratio was 5 boys/2 girls. Median age on diagnosis was 4.3 years. Five cases were revealed with precocious puberty associated with hypertension. One patient had sexual ambiguity, Prader IV stage, hypertension appears later. One patient developed heterosexual precocious puberty and hypertension at five years of age. One patient had bilateral testicular adrenal rests. Hypertension was diagnosed early in 4 cases and secondarly in the other 3 cases. Hypertension was severe complicated by convulsions, facial paralysis and epistaxis. Hypo kaliemia was identified in six cases. Hormonal investigations confirmed diagnosis in all cases. The secondary sexual characteristics were controled by glucocorticoid substitution. Antihypertensive treatment was necessary initially and prolonged only in three cases. Prognosis of final height of patients with late diagnosis was particularly compromised. 相似文献
63.
Ayadi-Kaddour A Abid L Braham E Saïji E Ismail O Smati B Kilani T El Mezni F 《La Tunisie médicale》2006,84(3):205-208
Inflammatory pseudotumors are uncommon benign lesions of the lung of unknown origin, that may show aggressive behavior. Although pseudotumors constitute less than 1% of all lung tumors, they are reported to be the most common cause of solitary lung masses in children. Complete resection, when possible, is safe and leads to excellent survival. The case presented here highlights difficulties in clinical and histologic diagnosis. 相似文献
64.
Chaabane NB Mansour IB Hellara O Loghmeri H Bdioui F Safer L Saffar H 《Presse medicale (Paris, France : 1983)》2011,40(3):239-247
Anemia induced by digestive diseases refers to anemia due to iron deficiency. Conventional gastrointestinal diagnostic workup fails to establish the cause of iron deficiency in about one third of patients. Abnormal iron absorption is increasingly recognized as an important cause of unexplained iron deficiency. The importance of coeliac disease as a possible cause of iron deficiency anemia refractory to oral iron treatment, without other manifestations of malabsorption syndrome, is increasingly being recognized. In addition, Helicobacter pylori (HP) has been implicated in several recent studies as a cause of iron deficiency anemia (IDA) refractory to oral iron treatment. Cure of previously refractory IDA by HP eradication provides strong evidence supporting a cause-and-effect relationship. In order to establish a cause-and-effect relationship between HP gastritis and IDA, prospective randomized studies comparing the effects of iron administration with or without H. pylorieradication are highly recommended. 相似文献
65.
66.
Braham Jmili N Omri H Senana Sendi H Fekih S Hizem S Sriha B Khelif A Saad A Kortas M 《Clinical laboratory》2006,52(3-4):125-130
We report a case of a patient aged about 53 years, who initially presented with hematological disorders (WBC: 44000/mm3, Hb: 11g/dl, Pit: 127000/mm3) without tumoral syndrome. The Wright-Giemsa stained bone marrow and peripheral blood smears showed a population of blast cells characterized by cells with high N/C and strongly basophilic cytoplasm without granules. The nuclei were predominantly round. Nuclear chromatin was fine and contained small nucleoli. Cytochemisty was positive for peroxidase activity. Immunophenotyping showed myeloid typical markers of granulocytic lineage (MP0+, CD13+, CD33+, CD117+, CD34-). The karyotype revealed the expression of t(15;17) chromosomal translocation. The diagnosis of acute myeloid leukaemia (AML) was then evoked initially. The cytological features corresponded closely to the M1 subtype as defined in the FAB classification. The patient was treated with induction therapy according to the 7/3 protocol. One month later, he was discharged from hospital on hematological and cytogenetic remission. He died at home because of a heart attack. From the biological findings the patient was retrospectively diagnosed as having promyelocytic leukemia (hyperbasophilic form). 相似文献
67.
Ines Omrane Olfa Baroudi Nadia Kourda Yves-Jean Bignon Nancy Uhrhammer Alexis Desrichard Imen Medimegh Hager Ayari Nejla Stambouli Amel Mezlini Hssan Bouzayenne Raja Marrakchi Amel Benammar-Elgaaid Karim Bougatef 《Tumour biology》2014,35(1):545-551
Toll-like receptors (TLRs) are considered as major endotoxin-signaling receptor and as crucial sensors of innate immunity. TLRs recognize pathogen-associated molecular patterns; induce effectors genes involving inflammatory cytokines and therefore initiation of adaptative immune responses against pathogens. Recently, it has been shown that TLRs are involved in tumor progression. In fact, increased level of TLR4 is associated with progression of colon malignancies. Even, TLR4 polymorphism has been shown associated with susceptibility to have colorectal cancer. Our study aimed to investigate an association between TLR4 Asp299Gly (D299G) and Thr399Ile (T399I) polymorphisms in Tunisian patients with colorectal cancer. Using a primer extension method (SNaPshot), we genotyped two variants of TLR4 D299G and T399I in 100 patients with colorectal cancer and 140 healthy controls in Tunisian population. Interesting, we noted a significant association between T399I polymorphism and tumor differentiation (p?=?0.027) and tumor architecture (p?=?0.02) in colorectal cancer (CRC) patients. We also showed a significant association of D299G with an increased risk of advanced stage (p?=?0.03). Finally, we observed a positive link between D299G and T399I polymorphisms and CRC patients with lymph node (p?=?0.00024; p?=?0.0005, respectively) and metastasis (p?=?0.001; p?=?0.002, respectively). However, we found no evidence to support a significant association between TLR4 D299G and T399I polymorphisms and colorectal cancer susceptibility. Our findings suggest that TLR4 D299G and T399I polymorphisms are significantly associated with clinical features variables. TLR4 polymorphisms may serve as biomarker of disease progression. Therefore, our results need confirmation in even larger studies. 相似文献
68.
69.
70.