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81.
Yeon Ju Bae Jae-Cheal Yoo Nammi Park Dawon Kang Jaehee Han Eunmi Hwang Jae-Yong Park Seong-Geun Hong 《The Korean journal of physiology & pharmacology》2013,17(1):57-64
Cells can resist and even recover from stress induced by acute hypoxia, whereas chronic hypoxia often leads to irreversible damage and eventually death. Although little is known about the response(s) to acute hypoxia in neuronal cells, alterations in ion channel activity could be preferential. This study aimed to elucidate which channel type is involved in the response to acute hypoxia in rat pheochromocytomal (PC12) cells as a neuronal cell model. Using perfusing solution saturated with 95% N2 and 5% CO2, induction of cell hypoxia was confirmed based on increased intracellular Ca2+ with diminished oxygen content in the perfusate. During acute hypoxia, one channel type with a conductance of about 30 pS (2.5 pA at -80 mV) was activated within the first 2~3 min following onset of hypoxia and was long-lived for more than 300 ms with high open probability (Po, up to 0.8). This channel was permeable to Na+ ions, but not to K+, Ca+, and Cl- ions, and was sensitively blocked by amiloride (200 nM). These characteristics and behaviors were quite similar to those of epithelial sodium channel (ENaC). RT-PCR and Western blot analyses confirmed that ENaC channel was endogenously expressed in PC12 cells. Taken together, a 30-pS ENaC-like channel was activated in response to acute hypoxia in PC12 cells. This is the first evidence of an acute hypoxia-activated Na+ channel that can contribute to depolarization of the cell. 相似文献
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Influence of coexistent Hashimoto's thyroiditis on the extent of cervical lymph node dissection and prognosis in papillary thyroid carcinoma
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Yu-Syuan Wang Tsai-Wei Hung Eun-Kyung Bae Kuo-Jen Wu Wei Hsieh Seong-Jin Yu 《CNS Neuroscience & Therapeutics》2021,27(7):831-841
AimsNaltrexone is a mu opioid receptor (MOR) antagonist used to treat drug dependence in patients. Previous reports indicated that MOR antagonists reduced neurodegeneration and inflammation after brain injury. The purpose of this study was to evaluate the neuroprotective effect of naltrexone in cell culture and a mouse model of traumatic brain injury (TBI).MethodsThe neuroprotective effect of naltrexone was examined in primary cortical neurons co‐cultured with BV2 microglia. Controlled cortical impact (CCI) was delivered to the left cerebral cortex of adult male MOR wild‐type (WT) and knockout (KO) mice. Naltrexone was given daily for 4 days, starting from day 2 after lesioning. Locomotor activity was evaluated on day 5 after the CCI. Brain tissues were collected for immunostaining, Western, and qPCR analysis.ResultsGlutamate reduced MAP2 immunoreactivity (‐ir), while increased IBA1‐ir in neuron/BV2 co‐culture; both responses were antagonized by naltrexone. TBI significantly reduced locomotor activity and increased the expression of IBA1, iNOS, and CD4 in the lesioned cortex. Naltrexone significantly and equally antagonized the motor deficits and expression of IBA1 and iNOS in WT and KO mice. TBI‐mediated CD4 protein production was attenuated by naltrexone in WT mice, but not in KO mice.ConclusionNaltrexone reduced TBI‐mediated neurodegeneration and inflammation in MOR WT and KO mice. The protective effect of naltrexone involves non‐MOR and MOR mechanisms. 相似文献
86.
Features of papillary thyroid microcarcinoma associated with lateral cervical lymph node metastasis
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Sung Man Bae 《Stress and health》2020,36(1):51-58
This study aimed to examine causal relationships between bicultural identity, acculturative stress, and subjective well‐being among multicultural adolescents. Secondary longitudinal data that were obtained from 1,635 multicultural adolescents were analysed. The results showed that bicultural identity had a positive effect on psychological well‐being and a negative impact on acculturative stress; in addition, greater acculturative stress was associated with lower psychological well‐being. Finally, bicultural identity indirectly affected psychological well‐being by mediating the effects of acculturative stress. These findings underscore the need to facilitate the adaptation of multicultural adolescents by reducing acculturative stress and promoting bicultural acceptance in educational institutions. 相似文献
90.
Predicting pre‐ and post‐resectional histologic discrepancies in gastric low‐grade dysplasia: A comparison of white‐light and magnifying endoscopy
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