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31.
EO Ajani PD Shallie BO Adegbesan B A Salau M Adesanya 《African journal of traditional, complementary, and alternative medicines》2008,5(2):180-186
This study was carried out to investigate the cardiovascular effect of administration of antimalarial drugs amodiaquine and artesunate and the efficacy of Garcinia kola extract (kolaviron) in protecting against such possible effect. Thirty (30) adult male albino rats divided into six (6) groups were used in this study. Groups D, E and F were treated with 100 mg/Kg b. w of the extract twice daily for the first one week and 200 mg/Kg b. w. /day for the subsequent three (3) weeks. Amodiaquine (10mg/Kg. b. w. /day) was administered orally for four (4) days into rats in groups A and E while rats in groups B and F were treated with artesunate (5mg/Kg b. w. /day) for four (4) days. Group C rats (normal control) were treated with normal saline. All the rats were sacrificed after four (4) weeks treatment period. Blood was withdrawn by cardiac puncture while the liver, kidney, stomach and heart were removed, cleansed and weigh. Total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides were measured in the serum, while total fibrinogen, platelet count, red blood cell and white blood cell count were measured in the whole blood. The artherogenic and coronary risk index were also determined. Results indicate that both amodiaquine and artesunate predispose to cardiovascular disease, however the effect was more pronounced with artesunate than amodiaquine. The result also suggests that both drugs could increase the risk of coronary and artherogenic diseases and that Garcinia kola do not prevent the cardiotoxicity and coronary risk effect. 相似文献
32.
AS Aktürk† N Bilen† D Bayrämgürler† EO Demirsoy† S Erdogan‡ R Kiran† 《Journal of the European Academy of Dermatology and Venereology》2007,21(8):1086-1090
BACKGROUND: It is a common opinion that expansion and darkening in melanocytic nevi may occur during pregnancy. The main problem is that whether it is a usual finding, or it is a condition that requires suspicion about melanoma. OBJECTIVES: It was aimed to find the changes that might occur in the sizes and structures of melanocytic nevi during pregnancy. METHODS: Ninety-seven nevi of the 56 pregnant women in the first trimester were evaluated in the study. The localization and size of the nevi were recorded on a standard body diagram. After clinical examination, dermoscopic analyses were applied. Pattern analyses were done, and total dermoscopy scores (TDS) were calculated by applying ABCD scoring system. All subjects were seen again during the third trimester. RESULTS: There was a statistically significant difference between the mean diameters of nevi in the first and third trimester (P = 0.001). Of nevi whose diameters increased, 10 (50.00%) were localized on the front of body, 6 (30.00%) on the face and neck, 3 (15.00%) on the legs, and 1 (5.00%) on the back. The enlargement in diameters was more significant on the front of the body, but there was no statistically significant difference. Compared according to the pattern analysis, new dot formation was observed only on the structure of six nevi during the last trimester. Four of them were localized on the front of the body. There was statistically significant increase in mean TDS in comparison between the first and third trimesters (P = 0008). CONCLUSIONS: During the pregnancy, widening in diameters and structure changes of nevi may be seen especially on the front of the body. We also think that these findings might be connected with expansion of the skin during pregnancy. Dermoscopic controls are the first choice of method to analyse the nevi since the patient may not recognize these changes. 相似文献
33.
Expression of mutated glucocerebrosidase alleles in human cells 总被引:1,自引:1,他引:1
Pasmanik-Chor M; Madar-Shapiro L; Stein EO; Aerts H; Gatt S; Horowitz M 《Human molecular genetics》1997,6(6):887-895
Gaucher disease is a heterogeneous disease characterized by impaired
activity of the lysosomal enzyme glucocerebrosidase. This heterogeneity is
attributed to a large number of mutations in the corresponding gene. In
order to test the biochemical properties of some mutations prevalent among
Israeli populations, the normal human glucocerebrosidase cDNA and cDNAs
carrying mutations N370S, L444P, D409H, recTL, recNcil, P415R and 84GG were
coupled to the T7 RNA polymerase promoter in a vaccinia virus- derived
expression vector (pTM-1). Recombinant viruses were produced and used to
infect human tissue culture cells. RNA and protein stability, recognition
by anti-glucocerebrosidase monoclonal antibodies and intracellular
enzymatic activity were measured. The results demonstrated that the D409H
allele directed synthesis of cytoplasmic RNA with decreased stability
compared with its normal counterpart or other mutated forms. The D409H and
L444P mutated proteins had lower stability than that of their normal
counterpart, while the recNcil- mutated protein was more stable. Only
glucocerebrosidase forms harboring leucine at position 444 were recognized
by the anti- glucocerebrosidase monoclonal antibodies used (8E4 and 2C7).
Measurements of enzymatic activity of the recombinant proteins in cells
loaded with a fluorescent glucosylceramide demonstrated that the N370S
mutated enzyme had activity similar to that of the normal enzyme. The other
mutated enzymes exhibited varying degrees of activities, generally
corresponding to the phenotypes with which they are associated. The results
presented demonstrate the use of the vaccinia virus-derived expression
system and of loading living cells with fluorescent substrate as efficient
tools for studying mutants in Gaucher disease and in other lysosomal
diseases.
相似文献
34.
35.
Injuries in a modern dance company: effect of comprehensive management on injury incidence and time loss 总被引:1,自引:0,他引:1
BACKGROUND: Professional dancers experience high rates of musculoskeletal injuries. OBJECTIVE: To analyze the effect of comprehensive management (case management and intervention) on injury incidence, time loss, and patterns of musculoskeletal injury in a modern dance organization. STUDY DESIGN: Retrospective/prospective cohort study. METHODS: Injury data were analyzed over a 5-year period, 2 years without intervention and 3 years with intervention, in a modern dance organization (42 dancers). The number of workers' compensation cases and number of dance days missed because of injury were compared across a 5-year period in a factorial design. RESULTS: Comprehensive management significantly reduced the annual number of new workers' compensation cases from a high of 81% to a low of 17% and decreased the number of days lost from work by 60%. The majority of new injuries occurred in younger dancers before the implementation of this program. Most injuries involved overuse of the lower extremity, similar to patterns reported in ballet companies. Benefits of comprehensive management included early and effective management of overuse problems before they became serious injuries and triage to prevent overutilization of medical services. CONCLUSIONS: This comprehensive management program effectively decreased the incidence of new cases and lost time. Both dancers and management strongly support its continuance. 相似文献
36.
全复配食用菌提取物对C26荷瘤小鼠的抑瘤作用和免疫功能影响 总被引:1,自引:0,他引:1
背景与目的:食用真菌在医疗保健领域的研究展现出强大的应用潜力.该课题探讨全复配食用菌提取物的抗肿瘤作用及对荷瘤小鼠免疫功能的影响.方法:小鼠随机编号分组,其中预防组预先给予全复配食用菌提取物灌胃2周,每天1次,之后各组均接种C26细胞建立荷瘤小鼠模型,接种后第2天给小鼠予以不同制剂灌胃(空白组灌0.9%氯化钠溶液,治疗组、预防阻灌复配食用菌提取物,CTX阳性组腹腔注射CTX)每天1次,观察记录小鼠一般状态,2周后处死小鼠无菌取脾脏、取瘤称重.MTT法检测小鼠脾淋巴细胞转化功能,乳酸脱氢酶(LDH)法检测NK细胞杀伤活性.结果:复配食用菌提取物预防组对小鼠C26肿瘤有30.4%的抑制率;小鼠脾淋巴细胞在ConA刺激下的增殖能力和NK细胞杀伤功能均显著高于空白组.结论:复配食用菌提取物预防性摄入对再接种C26小鼠有抑瘤和免疫增强作用. 相似文献
37.
Background
Development of “combination” assays detecting in parallel, within a single test, Hepatitis C Virus (HCV) antigens and antibodies, not only reduces the window period in HCV-infection but also costs. Reduction of costs is important for developing countries where money and personal resources are limited.Methods
We compared the Monolisa® HCV Antigen-Antibody Ultra (Bio-Rad Laboratories Limited, Marnes La Coquette, France) with the AXSYM HCV version 3.0 (Abbot Diagnostics, Germany)-the latter assay detecting only antibodies to HCV. Seventy three HCV-PCR positive and negative samples were tested.Results
Although the two assays showed comparable results, two samples from a bone marrow transplant (BMT) patient of viral loads 7.8 × 105 and 8.9 × 106 IU/mL could not be detected by the Monolisa® HCV Antigen-Antibody Ultra assay. Failure to detect the two samples with viral loads considered above threshold of detection for antigen proteins suggested a lack of sensitivity by this assay to discover viral capsid protein in patient samples. Genotyping of these samples revealed genotype 1b, a HCV-subtype which is widespread and should thus be easily detected.Conclusion
We conclude that although this assay depicts high sensitivity and specificity in detecting antibodies to HCV, it seems not to add further benefit in our study population to detect HCV infections by enhanced sensitivity due the potential contingency to trace viral capsid antigens. 相似文献38.
39.
40.
BACKGROUND: Data on enteral feeding management of premature infants are limited and often not the subject of randomized clinical trials. Several small studies suggest benefits from the early initiation of feeding, but do not assess the combined effects of time of initiation of feeding, tube-feeding method, and type of milk used. Either singly or in combination, these treatments may affect growth, bone mineralization, biochemical measures of nutritional status, and feeding tolerance, and, ultimately, the duration of hospitalization. METHODS: A total of 171 premature infants, stratified by gestational age (26 to 30 weeks) and diet (human milk or preterm formula) were assigned randomly among four treatment combinations in a balanced two-way design comparing the presence or absence of gastrointestinal (GI) priming for 10 days and continuous infusion versus intermittent bolus tube-feeding. RESULTS: The major outcome, time required for infants to attain full oral feeding, was similar among treatments. GI priming was not associated with any measured adverse effect and was associated with better calcium and phosphorus retention, higher serum calcium and alkaline phosphatase activity, and shorter intestinal transit times. The bolus tube-feeding method was associated with significantly less feeding intolerance and greater rate of weight gain than the continuous method. In addition, the greater the quantity of human milk fed, the lower the morbidity. CONCLUSIONS: Early GI priming with human milk, using the bolus tube-feeding method, may provide the best advantage for the premature infant. 相似文献