Gute Compliance mit Buccaltablette Oropharyngeale Candidose

Bei einer oropharyngealen Candidose reicht meist eine topische Therapie aus.     

Angiographic assessment of atherosclerotic load at the lower extremity in patients with diabetic foot and charcot neuro-arthropathy

Background

The aim of this study was to investigate atherosclerotic load at the lower extremity in patients with diabetic foot and charcot neuro-arthropathy and compare them with patients with diabetic foot without charcot neuro-arthropathy.

Treatment of taxane acute pain syndrome (TAPS) in cancer patients receiving taxane-based chemotherapy—a systematic review

Background

Taxane acute pain syndrome (TAPS) is characterized by myalgias and arthralgias starting 1–3 days and lasting 5–7 days after taxane-based chemotherapy. Despite negatively impacting patient’s quality of life, little is known about the optimal TAPS management. A systematic review of treatment strategies for TAPS across all tumor sites was performed.

Methods

Embase, Ovid MEDLINE(R), and the Cochrane Central Register of Controlled Trials were searched from 1946 to October 2014 for trials reporting the effectiveness of different treatments of TAPS in cancer patients receiving taxane-based chemotherapy. Two individuals independently screened citations and full-text articles for eligibility. Outcome measures included type of treatment and response of myalgias, arthralgias, pain, and quality of life (QoL).

Results

Of 1614 unique citations initially identified, five studies met the pre-specified eligibility criteria. Two were randomized placebo-controlled trials (225 patients), two were randomized open-label trials 76 patients), and one was a retrospective study (10 patients). The agents investigated included gabapentin, amifostine, glutathione, and glutamine. Study sizes ranged from 10 to 185 patients. Given the heterogeneity of study designs, a narrative synthesis of results was performed. Neither glutathione (QoL, p = 0.30, no 95 % CI reported) nor glutamine (mean improvement in average pain was 0.8 in both treatment arms, p = 0.84, no 95 % CI reported) were superior to placebo. Response to amifostine (pain response) and gabapentin (reduction in taxane-induced arthralgias and myalgias) was 36 % (95 % CI, 16–61 %) and 90 % (no 95 % CI data reported), respectively.

Conclusions

Despite its prevalence in patients receiving taxane-based chemotherapies, TAPS remains poorly researched and few studies evaluate its optimal management. If the management of patients is to be improved, more prospective trials are needed.

     

Idiotypic vaccination against human B-cell lymphoma. Rescue of variable region gene sequences from biopsy material for assembly as single-chain Fv personal vaccines

Idiotypic determinants on neoplastic B cells could provide tumor antigens for vaccination of patients with B-cell tumors. Because this approach requires an individual vaccine for each patient, simple methods for obtaining idiotypic antigen are desirable. Using polymerase chain reaction (PCR) with family-based V-gene and J-region primers, the variable region genes of heavy and light chains (VH and VL) of Ig have been obtained from biopsy material from 13 patients with B-cell tumors. In each case, analysis of random clones derived from the PCR product showed repeated, clonally-related sequences, whereas normal lymphoid tissue generated no repeated sequences. In 3/3 cases, the repeated sequences were found to be the same as those in a tumor-derived hybridoma. Mutational patterns in the V-genes differed among the tumors, with follicular lymphoma tending to be more highly mutated. The individual VH and VL sequences have been assembled with a flexible linker sequence to encode single-chain Fv (scFv). The scFv sequences can be cloned into bacterial expression vectors to produce protein, or into vectors suitable for direct vaccination using naked DNA. In a model system, expressed scFv protein retained all idiotypic determinants defined by a panel of five anti-idiotypic monoclonal antibodies (MoAbs). Similarly, expressed scFv proteins from two patients were shown to react with anti-idiotypic antibodies. This approach allows production of potential vaccines from surgical biopsies within 2 to 3 weeks.     

多巴胺和维生素B12球后注射治疗儿童弱视

目的：探讨多巴胺和维生素B12球后注射治疗儿童弱视的疗效。方法：80例屈光参差性和斜视性弱视儿童随机分为两组：治疗组，应用小剂量（2～4mg）多巴胺和维生素B12进行球后注射；对照组，采用综合疗法如光栅、后像及精细作业等训练。两组均遮盖主导眼，观察3～24个月，平均15.8个月。结果：治疗组基本治愈率为72.5%，47.5%恢复完善的立体视觉，27人P-VFP潜时缩短。对照组基本治愈率为27.5%。立体视觉恢复率为15%，8人P-VFP潜时缩短，两级差异具有非常显著性意义。结论：多巴胺和维生素B12治疗儿童弱视安全有效。     

Anaemia in haemodialysis patients of five European countries: association with morbidity and mortality in the Dialysis Outcomes and Practice Patterns Study (DOPPS)

Nephrol Dial Transplant 2004; 19:     

Histological and epidemiological profile of oral cancer in Congo (Zaire).

From the files of the Department of Pathology at Kinshasa University Hospital, D.R. Congo, we have studied the histological and epidemiological profile of oral cancer in Congo. The relative frequency of oral cancer in Congo is 2.1%. The palate is the most common site (28.8%) and the squamous cell carcinoma the most frequent histological type (57.6%). People between 50 and 59 years old (27%) (Means: 48.39 +/- 15.43 years) and females (M/F = 0.47/1 are more affected).     

Pathology of Burkitt's lymphoma in Zaire

A study was made of 527 cases of lymphoma diagnosed over the period 1960-1980 in the Department of Pathology of the University of Kinshasa. Of these cases, 115 were found to be Burkitt's lymphoma, the maxilla being the most frequently affected site. Most of the cases (74%) were diagnosed during the first decade of life and the majority (75%) of the cases of maxillary BL occurred in young children. The results show that the disease is quite common in Zaire and occurs in all the Provinces of the country and among all ethnic groups.