全文获取类型
收费全文 | 6725篇 |
免费 | 552篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 68篇 |
儿科学 | 188篇 |
妇产科学 | 154篇 |
基础医学 | 886篇 |
口腔科学 | 66篇 |
临床医学 | 818篇 |
内科学 | 1245篇 |
皮肤病学 | 143篇 |
神经病学 | 847篇 |
特种医学 | 112篇 |
外科学 | 780篇 |
综合类 | 65篇 |
一般理论 | 9篇 |
预防医学 | 743篇 |
眼科学 | 145篇 |
药学 | 516篇 |
中国医学 | 6篇 |
肿瘤学 | 504篇 |
出版年
2024年 | 15篇 |
2023年 | 141篇 |
2022年 | 175篇 |
2021年 | 398篇 |
2020年 | 204篇 |
2019年 | 319篇 |
2018年 | 324篇 |
2017年 | 218篇 |
2016年 | 281篇 |
2015年 | 285篇 |
2014年 | 345篇 |
2013年 | 404篇 |
2012年 | 633篇 |
2011年 | 602篇 |
2010年 | 290篇 |
2009年 | 267篇 |
2008年 | 405篇 |
2007年 | 393篇 |
2006年 | 381篇 |
2005年 | 315篇 |
2004年 | 281篇 |
2003年 | 214篇 |
2002年 | 189篇 |
2001年 | 19篇 |
2000年 | 22篇 |
1999年 | 12篇 |
1998年 | 19篇 |
1997年 | 21篇 |
1996年 | 11篇 |
1995年 | 12篇 |
1994年 | 8篇 |
1993年 | 8篇 |
1992年 | 9篇 |
1991年 | 9篇 |
1990年 | 7篇 |
1989年 | 2篇 |
1987年 | 2篇 |
1986年 | 3篇 |
1985年 | 3篇 |
1984年 | 5篇 |
1983年 | 4篇 |
1982年 | 6篇 |
1981年 | 5篇 |
1980年 | 6篇 |
1975年 | 3篇 |
1974年 | 5篇 |
1972年 | 2篇 |
1964年 | 2篇 |
1963年 | 2篇 |
1925年 | 1篇 |
排序方式: 共有7295条查询结果,搜索用时 15 毫秒
61.
62.
Gabija Krutkyte Leyla Wenk Jonas Odermatt Philipp Schuetz Zeno Stanga Natalie Friedli 《Nutrients》2022,14(14)
Malnutrition is one of the most frequent metabolic challenges in the population of chronically ill patients. This results in increased administration of nutritional therapy in inpatient settings, which poses the risk of side effects, in particular, the development of refeeding syndrome. If not managed accordingly, it leads to a significant rise in morbidity and mortality. However, despite its importance, evidence-based recommendations on the management of refeeding syndrome are largely lacking, and only a few randomized controlled trials have been conducted. In light of this, the aim of this review is to raise awareness of refeeding syndrome in chronically ill patients by critically reviewing recent literature and providing a short overview as well as diagnosis and treatment algorithms of this underreported metabolic condition. In summary, recent findings suggest undergoing risk assessment and stratification for every patient receiving nutritional therapy. According to this, adaptation of energy and fluid support during the replenishment phase should be implemented in the nutritional therapy for patients at high risk. Additionally, continuous monitoring should take place, and appropriate actions should be initiated when necessary. 相似文献
63.
Marielle E. Yohe Christine M. Heske Elizabeth Stewart Peter C. Adamson Nabil Ahmed Cristina R. Antonescu Eleanor Chen Natalie Collins Alan Ehrlich Rene L. Galindo Berkley E. Gryder Heidi Hahn Sharon Hammond Mark E. Hatley Douglas S. Hawkins Madeline N. Hayes Andrea Hayes‐Jordan Lee J. Helman Simone Hettmer Myron S. Ignatius Charles Keller Javed Khan David G. Kirsch Corinne M. Linardic Philip J. Lupo Rossella Rota Jack F. Shern Janet Shipley Sivasish Sindiri Stephen J. Tapscott Christopher R. Vakoc Leonard H. Wexler David M. Langenau 《Pediatric blood & cancer》2019,66(10)
Overall survival rates for pediatric patients with high‐risk or relapsed rhabdomyosarcoma (RMS) have not improved significantly since the 1980s. Recent studies have identified a number of targetable vulnerabilities in RMS, but these discoveries have infrequently translated into clinical trials. We propose streamlining the process by which agents are selected for clinical evaluation in RMS. We believe that strong consideration should be given to the development of combination therapies that add biologically targeted agents to conventional cytotoxic drugs. One example of this type of combination is the addition of the WEE1 inhibitor AZD1775 to the conventional cytotoxic chemotherapeutics, vincristine and irinotecan. 相似文献
64.
Steven B. Tillis Jillian M. Josimovich Melissa A. Miller Laura L. Hoon-Hanks Arik M. Hartmann Natalie M. Claunch Marley E. Iredale Tracey D. Logan Amy A. Yackel Adams Ian A. Bartoszek John S. Humphrey Bryan M. Kluever Mark D. Stenglein Robert N. Reed Christina M. Romagosa James F. X. Wellehan Jr. Robert J. Ossiboff 《Viruses》2022,14(12)
65.
66.
Elaine C. Khoong Natalie A. Rivadeneira Lucia Pacca Dean Schillinger David Lown Palav Babaria Neha Gupta Rajiv Pramanik Helen Tran Tyler Whitezell Ma Somsouk Urmimala Sarkar 《Journal of general internal medicine》2023,38(1):21
BackgroundInequitable follow-up of abnormal cancer screening tests may contribute to racial/ethnic disparities in colon and breast cancer outcomes. However, few multi-site studies have examined follow-up of abnormal cancer screening tests and it is unknown if racial/ethnic disparities exist.ObjectiveThis report describes patterns of performance on follow-up of abnormal colon and breast cancer screening tests and explores the extent to which racial/ethnic disparities exist in public hospital systems.DesignWe conducted a retrospective cohort study using data from five California public hospital systems. We used multivariable robust Poisson regression analyses to examine whether patient-level factors or site predicted receipt of follow-up test.Main MeasuresUsing data from five public hospital systems between July 2015 and June 2017, we assessed follow-up of two screening results: (1) colonoscopy after positive fecal immunochemical tests (FIT) and (2) tissue biopsy within 21 days after a BIRADS 4/5 mammogram.Key ResultsOf 4132 abnormal FITs, 1736 (42%) received a follow-up colonoscopy. Older age, Medicaid insurance, lack of insurance, English language, and site were negatively associated with follow-up colonoscopy, while Hispanic ethnicity and Asian race were positively associated with follow-up colonoscopy. Of 1702 BIRADS 4/5 mammograms, 1082 (64%) received a timely biopsy; only site was associated with timely follow-up biopsy.ConclusionDespite the vulnerabilities of public-hospital-system patients, follow-up of abnormal cancer screening tests occurs at rates similar to that of patients in other healthcare settings, with colon cancer screening test follow-up occurring at lower rates than follow-up of breast cancer screening tests. Site-level factors have larger, more consistent impact on follow-up rates than patient sociodemographic traits. Resources are needed to identify health system–level factors, such as test follow-up processes or data infrastructure, that improve abnormal cancer screening test follow-up so that effective health system–level interventions can be evaluated and disseminated.Supplementary InformationThe online version contains supplementary material available at 10.1007/s11606-022-07657-4.KEY WORDS: safety-net system, cancer screening, colon cancer, breast cancer, cancer disparities 相似文献
67.
Chongliang Luo Md Nazmul Islam Natalie E Sheils John Buresh Martijn J Schuemie Jalpa A Doshi Rachel M Werner David A Asch Yong Chen 《J Am Med Inform Assoc》2022,29(8):1366
ObjectiveTo develop a lossless distributed algorithm for generalized linear mixed model (GLMM) with application to privacy-preserving hospital profiling.Materials and MethodsThe GLMM is often fitted to implement hospital profiling, using clinical or administrative claims data. Due to individual patient data (IPD) privacy regulations and the computational complexity of GLMM, a distributed algorithm for hospital profiling is needed. We develop a novel distributed penalized quasi-likelihood (dPQL) algorithm to fit GLMM when only aggregated data, rather than IPD, can be shared across hospitals. We also show that the standardized mortality rates, which are often reported as the results of hospital profiling, can also be calculated distributively without sharing IPD. We demonstrate the applicability of the proposed dPQL algorithm by ranking 929 hospitals for coronavirus disease 2019 (COVID-19) mortality or referral to hospice that have been previously studied.ResultsThe proposed dPQL algorithm is mathematically proven to be lossless, that is, it obtains identical results as if IPD were pooled from all hospitals. In the example of hospital profiling regarding COVID-19 mortality, the dPQL algorithm reached convergence with only 5 iterations, and the estimation of fixed effects, random effects, and mortality rates were identical to that of the PQL from pooled data.ConclusionThe dPQL algorithm is lossless, privacy-preserving and fast-converging for fitting GLMM. It provides an extremely suitable and convenient distributed approach for hospital profiling. 相似文献
68.
Poor pain assessment is cited as one barrier to the adequate treatment of cancer pain. The identification of relevant psychosocial factors may improve the assessment of chronic cancer pain. This article presents: 1) a critical review of the evidence for an association between chronic cancer pain and psychological distress, social support, and coping; 2) clinical implications of the findings; and 3) recommendations for future research. Fourteen of the 19 reviewed studies on psychological distress found a significant association between increased pain and increased distress. Seven of the eight studies on social support found significant association between higher levels of pain and decreased levels of social activities and social support. Three of the four studies that examined coping strategies found that increased catastrophizing was significantly associated with more intense pain. Based on several criteria, the evidence is considered Strong for psychological distress, Moderate for social support, and Inconclusive for coping. This review suggests that comprehensive chronic pain assessment should include routine screening for psychological distress. 相似文献
69.
Roda Matilde Pazzaglia Alberto Guaraldi Fabio Taroni Leonardo Natalie di Geronimo Fresina Michela Schiavi Costantino 《Indian journal of ophthalmology》2022,70(2):673
A 41-year-old man presented to the emergency department complaining of decrease of vision in his left eye. Initial examination was consistent with retrobulbar optic neuritis, and an intravenous drip of methylprednisolone was started. On the third day, the fundus examination revealed the appearance of multiple Purtscher-like cotton-wool spots in the posterior pole and nasally to the optic disc, slight retinal whitening around the fovea, and cherry-red spot. The patient reported flu-like symptoms, and he tested positive at PCR (polymerase chain reaction) test for 2019-nCoV (2019 novel coronavirus) infection. Assuming possible 2019-nCoV-related vascular damage, we prescribed low-molecular-weight heparin. The lesions were regressing at follow-up, and we registered a complete visual recovery. 相似文献
70.