全文获取类型
收费全文 | 573篇 |
免费 | 46篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 13篇 |
妇产科学 | 32篇 |
基础医学 | 52篇 |
口腔科学 | 17篇 |
临床医学 | 59篇 |
内科学 | 100篇 |
皮肤病学 | 12篇 |
神经病学 | 44篇 |
特种医学 | 21篇 |
外科学 | 58篇 |
综合类 | 19篇 |
预防医学 | 59篇 |
眼科学 | 29篇 |
药学 | 52篇 |
中国医学 | 7篇 |
肿瘤学 | 38篇 |
出版年
2024年 | 1篇 |
2023年 | 5篇 |
2022年 | 14篇 |
2021年 | 32篇 |
2020年 | 22篇 |
2019年 | 33篇 |
2018年 | 48篇 |
2017年 | 31篇 |
2016年 | 25篇 |
2015年 | 26篇 |
2014年 | 31篇 |
2013年 | 42篇 |
2012年 | 64篇 |
2011年 | 56篇 |
2010年 | 38篇 |
2009年 | 16篇 |
2008年 | 26篇 |
2007年 | 27篇 |
2006年 | 11篇 |
2005年 | 18篇 |
2004年 | 12篇 |
2003年 | 14篇 |
2002年 | 10篇 |
2001年 | 3篇 |
2000年 | 2篇 |
1999年 | 2篇 |
1998年 | 2篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 3篇 |
1990年 | 1篇 |
1988年 | 1篇 |
1984年 | 1篇 |
排序方式: 共有622条查询结果,搜索用时 15 毫秒
11.
12.
Li Ping Wong Haridah Alias Nasrin Aghamohammadi I-ching Sam Sazaly AbuBakar 《Journal of community health》2017,42(5):854-864
The aims of this study were to explore the differences in (1) the perception of severity towards ZIKV infection and dengue fever, and (2) mosquito control practices before and after the ZIKV outbreak were declared a Public Health Emergency of International Concern (PHEIC). Data were collected between Feb to May 2016 using a computer-assisted telephone interviewing system. The median scale score for perceived severity of ZIKV was 3 (interquartile range [IQR] 1–5) versus 4 (IQR 3–5) for dengue (P?<?0.001). The scores for mosquito control practices before and after ZIKV was declared a PHEIC were similar, at 4 (IQR 3–5). Multivariate analysis revealed that participants with a higher score for perception of severity of ZIKV were more likely to report greater mosquito control practices after the declaration of the PHEIC (OR 1.822 [95% CI 1.107–2.998]). The emerging ZIKV pandemic requires concerted efforts to enhance mosquito control practices among the Malaysian public. Efforts to improve public mosquito control practices should focus on enhancing the perception of the severity of ZIKV. 相似文献
13.
Manoel Antonio De Paiva Neto Alexander Vandergrift Nasrin Fatemi Alessandra A. Gorgulho Antonio A. DeSalles Pejman Cohan Christina Wang Ronald Swerdloff Daniel F. Kelly 《Clinical endocrinology》2010,72(4):512-519
Objective Giant pituitary adenomas (≥40 mm) pose a major management challenge. We describe the experience of a single surgeon and a dedicated neuro‐endocrine team with multimodality treatment of these tumours in three specialized institutions. Design Retrospective data set analyses. Patients Fifty‐one consecutive patients with a giant adenoma (39 endocrine‐inactive, 12 endocrine‐active; mean tumour diameter 45 mm) treated over 10 years by an endonasal transsphenoidal approach were included. All patients had surgical resection followed by radiotherapy and/or medical therapy as judged necessary. Measurements Hormonal and visual status, extent of resection, tumour control rates, complications and use of medical and radiotherapy were evaluated. Results Surgery resulted in gross total, near total and subtotal removal in21 (41%), 10 (20%) and 20 (39%) patients respectively. Complete tumour removal was associated with absence of cavernous sinus invasion (P < 0·001). Long‐term endocrine function improved in 49% of patients and new endocrinopathy occurred in 14·6%; 76% required long‐term hormone replacement therapy. Vision improved in 81·5% of the patients and there was no visual worsening. At the last follow up (median 30 months), tumour control was achieved in 96% of patients: 59% with surgery alone, 20% with surgery plus focussed radiotherapy, 18% with surgery and medical therapy and two with all three modalities. Conclusions Endonasal surgery provides effective initial treatment for patients with giant adenomas. Multimodality therapy was needed in almost 50% of patients and this rate will likely increase with longer follow up. Close collaboration of neurosurgeons with endocrinologists and radiation oncologists is essential for optimal treatment of patients with these challenging tumours. 相似文献
14.
15.
Brain tissue cells have been shown to use two predominant pathways for energy production. The first of these is the pentose
phosphate shunt, and the second is glycolysis, followed by the TCA cycle. Inhibition of these pathways can result in a reduction
of ATP, and changes in the concentration of various metabolites. In the present study, the acute and chronic effect of 6-aminonicotinamide
(6-AN) (0.01, 0.02, and 0.03 mg/ml) was examined on astrocytes and C6-glioma cells. Following this treatment, glucose, lactate,
glutamate, ATP, and PCr were assayed according to the procedures of Lowry and Passonneau. Our data indicated that following
15 minutes treatment of astrocytes and C6-glioma with 6AN there was no significant difference in the concentration of metabolites
measured. However, following 24 hours treatment there was a significant increase in glucose concentration and significant
reduction in the concentration of ATP, PCr, lactate and glutamate in both cell types. Morphological changes appeared later
following 48 hours treatment with 6-AN in both cell types. Glucose accumulation can be explained by the fact that it is the
precursor to both glycolysis and the pentose phosphate shunt. If these processes are inhibited, glucose will obviously accumulate
and products like ATP, PCr, lactate and glutamate will decrease. Additionally, there was significant differences in concentration
of glucose and lactate between astrocytes and C6-glioma cells. The significance of these differences has been discussed. 相似文献
16.
Purpose
The evidence has suggested that resveratrol has anti-inflammatory effect; however, the results are inconsistent and inconclusive. The aim of this study was to assess the effect of resveratrol supplementation on the levels of inflammatory markers through a systematic review and meta-analysis of available randomized controlled trials (RCTs).Methods
A search strategy was completed using Medline, ISI Web of Science, Directory of Open Access Journal, SID, ProQuest, Cochrane Library, Scopus, and EMBASE up to May 2017, to identify placebo-controlled RCTs that assessed resveratrol effects on circulating (serum and plasma) inflammatory markers (interleukin [IL]-6, tumor necrosis factor–α [TNF-α], and high-sensitivity C-reactive protein [hs-CRP]) among adult participants aged 17 years and older in 17 RCTs with a total of 736 subjects. The evaluation of study quality was performed using the Jadad scale. Weighted mean difference (WMD) was calculated for evaluating the changes in the inflammatory markers using fixed-effects or random-effects models. We performed subgroup and sensitivity analyses to evaluate the heterogeneity of the studies.Findings
Seventeen RCTs, including 736 subjects, fulfilled the eligibility criteria and were selected for analyses. The results of meta-analysis found significant reductions in the level of TNF-α (WMD, –0.44; 95% CI, –0.71 to –0.164; P?=?0.002; Q statistic?=?21.60; I2?=?49.1%; P?=?0.02) and hs-CRP (WMD, –0.27; 95% CI, –0.5 to –0.02; P?=?0.033; Q statistic?=?26.95; I2?=?51.8%; P?=?0.013) after supplementation with resveratrol. Resveratrol supplementation had no significant effect on the level of IL-6 (WMD, –0.16; 95% CI, –0.53 to 0.20; P?=?0.38; Q statistic?=?36.0; I2?=?72.3%; P?=?0.001). Statistically significant heterogeneity was observed for the type of sample in IL-6 and study duration in inflammatory markers IL-6, TNF-α, and hs-CRP.Implications
Available evidence from RCTs suggests that resveratrol supplementation significantly reduced TNF-α and hs-CRP levels. Significant improvement in inflammatory markers support resveratrol as an adjunct to pharmacologic management of metabolic diseases. 相似文献17.
18.
Brianna Lindsay Joe Oundo M. Anowar Hossain Martin Antonio Boubou Tamboura Alan W. Walker Joseph N. Paulson Julian Parkhill Richard Omore Abu S.G. Faruque Suman Kumar Das Usman N. Ikumapayi Mitchell Adeyemi Doh Sanogo Debasish Saha Samba Sow Tamer H. Farag Dilruba Nasrin Shan Li Sandra Panchalingam Myron M. Levine Karen Kotloff Laurence S. Magder Laura Hungerford Halvor Sommerfelt Mihai Pop James P. Nataro O. Colin Stine 《Emerging infectious diseases》2015,21(2):242-250
Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 moderate-to-severe diarrheal) from the Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal specimens had a higher number of enteropathogens (diarrheal mean 1.4, nondiarrheal mean 0.95; p<0.0001). Rotavirus showed a negative association with Shigella spp. in cases of diarrhea (odds ratio 0.31, 95% CI 0.17–0.55) and had a large combined effect on moderate-to-severe diarrhea (odds ratio 29, 95% CI 3.8–220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, the association between pathogen and disease was decreased, which is consistent with the possibility that Lactobacillus spp. are protective against Shigella spp.–induced diarrhea. Bacterial diversity of gut microbiota was associated with diarrhea status, not high levels of the Shigella spp. ipaH gene. 相似文献
19.
Since 1990 and the invention of the very first generation of ordered mesoporous silica materials, several innovative methodologies have been applied to synthesize, characterize, and modify silica/non-silica mesoporous materials. The growth of the mesoporous materials field has generated significant environmental and economic advantages compared to various other industrial developments. According to the literature, there are several key synthesis approaches and parameters that can affect the structural, textural and morphological characteristics of mesoporous materials. To date, huge attempts have been made to maximize the activities and selectivities of these materials through either the in situ or post-synthesis functionalization of the large interior surface areas and internal mesostructured frameworks in the presence of specific organic/inorganic components. However, the main challenge is to provide good control over the incorporation and distribution of multiple guest components within the mesostructured hosts. Mesostructured materials have received great attention for various applications, such as being used in electronics, medicine, photocatalysis, catalyst supports, catalysis, absorbers, sensors, gas separation, etc. In the current paper, several recent developments have been highlighted and reviewed regarding the fabrication and characterization of siliceous/non-siliceous mesoporous materials via various synthetic approaches. Furthermore, the availability of diverse functionalization methods has been reviewed to provide comprehensive approaches for synthesizing new generations of suitably modified mesoporous materials with superior structural, physicochemical, and textural characteristics.Since 1990 and the invention of the very first generation of ordered mesoporous silica materials, several innovative methodologies have been applied to synthesize, characterize, and modify silica/non-silica mesoporous materials. 相似文献
20.
The impact of hemodialysis on retinal and choroidal thickness in patients with chronic renal failure
Shoshtari Fariba Shaikhi Biranvand Sasan Rezaei Leila Salari Nader Aghaei Nasrin 《International ophthalmology》2021,41(5):1763-1771
International Ophthalmology - Patients with chronic renal failure are commonly cared using a blood filtration mechanism like hemodialysis. Little information is available regarding ocular changes... 相似文献