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101.
Malek Mahdavi Aida Khalili Afshin Alihosseini Samin Jaberinezhad Mehran Esalatmanesh Kamal Hajialilo Mehrzad Seyedmardani Seyedmostafa Khabbazi Alireza 《Clinical rheumatology》2021,40(10):3941-3949
Clinical Rheumatology - Adult-onset Still’s disease (AOSD) characterized by a high spiking fever, skin rash, arthritis, and leukocytosis. The aim of the present study was considering the... 相似文献
102.
Prognostic Impact of Serum Growth Differentiation Factor 15 Level in Acute Myeloid Leukemia Patients
Hany Mohamed Hegab Amro Mohamed Sedky El-Ghammaz Mostafa Kamal El-Razzaz Reham Ali Ali Helal 《Indian journal of hematology & blood transfusion》2021,37(1):37
Growth differentiation factor 15 (GDF15) plays an important role in cancer pathophysiology and prognosis. However, limited studies analyzed its level and prognostic value in acute myeloid leukemia (AML) patients. This study included 56 adult AML patients. Serum GDF15 level was measured at diagnosis in all patients by enzyme-linked immunosorbent assay. Remission and survival statuses were assessed at 90 days following treatment. GDF15 level was significantly higher in patients than in controls (P < 0.001). GDF15 level correlated positively with age (P < 0.001), hemoglobin level (P = 0.027), and platelet count (P = 0.024). High GDF15 above the median level was associated with inferior OS (P = 0.044) together with high platelet count (P = 0.006) and high bone marrow blast percent (P = 0.038). There was no statistically significant difference between patients with GDF15 above and below the median level regarding DFS (P = 0.881). On multivariate analysis for OS, GDF15 level was an independent risk factor (P = 0.047). In conclusion, serum GDF15 level is significantly elevated in AML patients and high GDF15 level is associated with inferior OS. 相似文献
103.
Mohammed Al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Yasser El-Sawaf 《World journal of gastroenterology : WJG》2021,27(16):1716-1727
The coronavirus disease 2019 (COVID-19) pandemic is a threat worldwide for individuals of all ages, including children. Gastrointestinal manifestations could be the initial presenting manifestation in many patients, especially in children. These symptoms are more common in patients with severe disease than in patients with non-severe disease. Approximately 48.1% of patients had a stool sample that was positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA. Children typically form 1%-8% of all laboratory-confirmed cases of SARS-CoV-2. Gastrointestinal manifestations of COVID-19 in children are not rare, with a prevalence between 0 and 88%, and a wide variety of presentations, including diarrhoea, vomiting, and abdominal pain, can develop before, with or after the development of respiratory symptoms. Atypical manifestations such as appendicitis or liver injury could also appear, especially in the presence of multisystem inflammatory disease. In this review, we discussed the epidemiology of COVID-19 gastrointestinal diseases in children as well as their implications on the diagnosis, misdiagnosis, prognosis, and faecal-oral transmission route of COVID-19 and the impact of gastrointestinal diseases on the gut microbiome, child nutrition, and disease management. 相似文献
104.
Nabil Salhab M.D. Mr. David J. Jones F.R.C.S. Johannes L. Bos Ph.D. Ann Kinsella Ph.D. Philip F. Schofield M.D. F.R.C.S. 《Diseases of the colon and rectum》1989,32(8):659-664
DNA extracted from 31 primary colorectal carcinomas was analyzed for the presence ofras gene amplification and mutations. Nine carcinomas had Ha-ras amplification and seven Ki-ras amplification. Nine carcinomas had codon 12 Ki-ras mutations. Immunohistochemical staining forras proteins revealed a normal membrane association in normal mucosa and benign polyps but an abnormal cytoplasmic distribution
in carcinomas. Amplification, mutations, and immunohistochemical staining were independent of histologic differentiation,
Duke's stage, or DNA ploidy status. This study demonstrates that abnormalities ofras genes are a common finding in colorectal carcinomas. They are potentially important biologic changes associated with malignancy,
although they do not appear to be related to clinical behavior.
Supported by The Cancer Research Campaign and the North West Regional Health Authority. 相似文献
105.
Exhaled nitric oxide is age-dependent in asthma 总被引:1,自引:0,他引:1
Avital A Uwyyed K Berkman N Bar-Yishay E Godfrey S Springer C 《Pediatric pulmonology》2003,36(5):433-438
We determined whether the exhaled nitric oxide (eNO) level in asthmatics is age-dependent. Eighty-seven asthmatic patients aged 2-41 years were studied. Hyperreactivity to adenosine 5'-monophosphate (AMP) was used to confirm asthma (= 200 mg/ml). In the younger group of children (2-5 years), AMP challenge was performed by the provocation concentration causing wheeze (PCW) method, while in the older groups of patients (6-41 years), regular spirometry was used. Exhaled NO was measured in the younger group by the tidal breathing method (TBm) and in the older subjects by the slow vital capacity method (SVCm). TBm and SVCm were compared in 21 other subjects, and there was a significant correlation between the two values (r = 0.96, P < 0.0001). The equation of correlation between the two methods was eNOTBm = 0.78eNOSVCm - 0.51. Within asthmatic patients, we found a significant increase in eNO with age (P < 0.0001), while there was no significant difference in AMP reactivity (P = 0.35). We conclude that eNO in asthmatic patients is age-dependent, with lower values in young children. 相似文献
106.
Maliha?Khan Tariq?Muzzafar Hagop?Kantarjian Ifra?Badar Nicholas?Short Xuemei?Wang Kamal?Chamoun Preetesh?Jain Courtney?DiNardo Naveen?Pemmaraju Prithviraj?Bose Gautam?Borthakur Jorge?Cortes Srdan?Verstovsek Guillermo?Garcia-Manero Zeev?EstrovEmail author 《Annals of hematology》2018,97(7):1183-1191
The impact of bone marrow fibrosis grade on the prognosis of patients with chronic myelomonocytic leukemia (CMML) remains controversial. Therefore, we examined the records of 82 patients diagnosed with CMML at our institution and summarized baseline characteristics and molecular profiles by subgroups of absent or mild (grades 0/1) and moderate (grade 2) fibrosis. Cox proportional hazards models were constructed to assess the prognostic significance of fibrosis grade. Grade 2 fibrosis was identified in 63 patients (76.8%), grade 1 in 16 patients (19.5%), and grade 0 in 3 patients (3.7%). Grade 2 fibrosis was associated with reduced hemoglobin levels (median 9.75 vs 11.0 g/dL in grade 0/1; p?=?0.04) and increased percentages of ringed sideroblasts (7.5 vs 0%; p?=?0.008). In multivariable analysis, grade 2 fibrosis was an independent predictor of poor overall survival (OS; 95% CI 1.32–6.35; HR 2.90; p?=?0.008), but not event-free survival (EFS; 95% CI 0.62–2.67; HR 1.28; p?=?0.50). Absolute neutrophil count (ANC) was found to impact OS (95% CI 1.01–1.09; HR 1.05; p?=?0.009), while both ANC (95% CI 1.00–1.07; HR 1.04; p?=?0.04) and peripheral blood blast percentage (95% CI 1.02–1.32; HR 1.16; p?=?0.02) impacted EFS. These results implicate fibrosis grade is an important indicator of prognosis, with high-grade fibrosis predicting inferior survival. Given the prevalence of marrow fibrosis in CMML, fibrosis grading should be incorporated into prognostic assessment and therapeutic decision-making. 相似文献
107.
Intramuscular gold decreases cytokine expression and macrophage numbers in the rheumatoid synovial membrane. 总被引:11,自引:6,他引:11 下载免费PDF全文
G Yanni M Nabil M R Farahat R N Poston G S Panayi 《Annals of the rheumatic diseases》1994,53(5):315-322
OBJECTIVES--Cytokines, released from mononuclear cells (MNC) are mediators of joint destruction in rheumatoid arthritis (RA). The mechanisms of action of gold salts used in the treatment of RA are unknown. The aim of this study was to investigate cytokine expression and intensity of MNC infiltrate in the RA synovial membrane (SM) following treatment with sodium aurothiomalate (SAT). METHODS--Sequential blind needle biopsies were obtained at entry into the study and at two and 12 weeks after the start of SAT therapy in 10 patients with active RA. SMs were stained with a panel of monoclonal antibodies to assess cytokine expression (IL-1 alpha, IL-1 beta, TNF-alpha, IL-6, and GM-CSF). RESULTS--There was a significant decrease in IL-1 alpha, IL-1 beta, IL-6 and TNF-alpha expression 12 weeks after treatment (p < 0.004, p < 0.002, p < 0.009 and p < 0.004 respectively). This was noted in the lining layer, the perivascular aggregates and the connective tissue areas. Detailed examination of the MNC infiltrate showed a significant reduction in inflammatory monocytes (MONO) in the lining layer at two weeks (p < 0.03). A decrease in the number of CD68+ macrophages (MAC) was noted in the perivascular and connective tissue areas at 12 weeks. No significant changes were observed in the number of T and B cells and blood vessels. CONCLUSION--The results suggest that gold may suppress RA disease activity by diminishing MONO and MAC numbers and consequently monokine production in the SM. 相似文献
108.
Paul F. Lebeau Hanny Wassef Jae Hyun Byun Khrystyna Platko Brandon Ason Simon Jackson Joshua Dobroff Susan Shetterly William G. Richards Ali A. Al-Hashimi Kevin Doyoon Won Majambu Mbikay Annik Prat An Tang Guillaume Par Renata Pasqualini Nabil G. Seidah Wadih Arap Michel Chrtien Richard C. Austin 《The Journal of clinical investigation》2021,131(2)
Individuals harboring the loss-of-function (LOF) proprotein convertase subtilisin/kexin type 9 Gln152His variation (PCSK9Q152H) have low circulating low-density lipoprotein cholesterol levels and are therefore protected against cardiovascular disease (CVD). This uncleavable form of proPCSK9, however, is retained in the endoplasmic reticulum (ER) of liver hepatocytes, where it would be expected to contribute to ER storage disease (ERSD), a heritable condition known to cause systemic ER stress and liver injury. Here, we examined liver function in members of several French-Canadian families known to carry the PCSK9Q152H variation. We report that PCSK9Q152H carriers exhibited marked hypocholesterolemia and normal liver function despite their lifelong state of ER PCSK9 retention. Mechanistically, hepatic overexpression of PCSK9Q152H using adeno-associated viruses in male mice greatly increased the stability of key ER stress-response chaperones in liver hepatocytes and unexpectedly protected against ER stress and liver injury rather than inducing them. Our findings show that ER retention of PCSK9 not only reduced CVD risk in patients but may also protect against ERSD and other ER stress–driven conditions of the liver. In summary, we have uncovered a cochaperone function for PCSK9Q152H that explains its hepatoprotective effects and generated a translational mouse model for further mechanistic insights into this clinically relevant LOF PCSK9 variant. 相似文献
109.
Meenakshi Hegde Malini Mukherjee Zakaria Grada Antonella Pignata Daniel Landi Shoba A. Navai Amanda Wakefield Kristen Fousek Kevin Bielamowicz Kevin K.H. Chow Vita S. Brawley Tiara T. Byrd Simone Krebs Stephen Gottschalk Winfried S. Wels Matthew L. Baker Gianpietro Dotti Maksim Mamonkin Malcolm K. Brenner Jordan S. Orange Nabil Ahmed 《The Journal of clinical investigation》2021,131(13)
110.