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991.
Checkpoint kinase 1 is cleaved in a caspase-dependent pathway during genotoxic stress-induced apoptosis 总被引:1,自引:0,他引:1
Checkpoint kinase 1 (Chk1) plays important roles in genotoxic stress-induced cell cycle checkpoint and in normal cell cycle progression. Here, we show that Chk1 is cleaved in the treatment of apoptotic dose of etoposide (ETP) or cisplatin (CIS) but not of viable dose in HeLa S3 cells. The cleavage of Chk1 was completely inhibited by an irreversible and cell-permeable pan-caspase inhibitor, N-benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (z-VAD-fmk). These results identify Chk1 as a novel substrate that is cleaved by a caspase-dependent manner during genotoxic stress-induced apoptosis. Our data may also indicate the existence of a novel Chk1-regulated apoptotic pathway. 相似文献
992.
Kanayama G Amiaz R Seidman S Pope HG 《Experimental and clinical psychopharmacology》2007,15(6):529-538
Several lines of accumulating evidence suggest that testosterone might be effective for the treatment of depression, especially in older men who exhibit low testosterone levels. However, despite the potential promise of this approach, the available literature of controlled studies of testosterone in depression remains extremely limited. Therefore, testosterone treatment of depression must still be considered an experimental procedure. At the present state of research, it appears that testosterone might most likely show benefit as an augmentation strategy in men who exhibit low or borderline testosterone levels and who show only a partial response to conventional antidepressants. In this article, we provide some suggested practical guidelines for the treatment of such individuals. However, it should be recognized that these suggestions are tentative and will likely require revision as additional data become available. 相似文献
993.
Taue R Izaki H Nakanishi R Yamaguchi K Nakatzuji H Kishimoto T Oka N Hukumori T Takahashi M Nishitani MA Kanayama HO 《Hinyokika kiyo. Acta urologica Japonica》2007,53(7):497-500
A 56-year-old man was diagnosed with a right testicular tumor. Orchiectomy with high ligation of the spermatic cord was performed. Histological examination revealed leiomyosarcoma of the spermatic cord. Distant metastases were not found. The patient was treated with adjuvant radiation therapy to control the disease, since a high incidence of local recurrence has been reported. The patient had no evidence of disease 24 months postoperatively. 相似文献
994.
Inagaki M Obara M Suzuki S Ishizaki A Takahashi K Matsumoto K Haneda M Tokusashi Y Miyokawa N Kasai S 《Journal of Hepato-Biliary-Pancreatic Surgery》2007,14(5):518-521
We report a case of mucinous carcinoma of Vater's ampulla with a unique extension along only the main pancreatic duct (MPD)
and microinvasion to the pancreas. A 52-year-old man was referred to our hospital for the evaluation and treatment of acute
pancreatitis. Abdominal computed tomography (CT) demonstrated swelling in the head of the pancreas with a mass in the duodenum.
Hypotonic duodenography and endoscopic examination revealed a well-defined mass, measuring about 25 mm in size, in Vater's
ampulla. A biopsy specimen of the tumor showed moderately differentiated adenocarcinoma. A pylorus-preserving pancreaticoduodenectomy
with a regional lymphadenectomy was performed, under a preoperative diagnosis of adenocarcinoma of Vater's ampulla with direct
invasion into the head of the pancreas. The resected specimen of the duodenum confirmed the presence of the mass, which measured
22 × 15 mm in size, in Vater's ampulla. Microscopically, the tumor consisted of two components: moderately differentiated
adenocarcinoma in the peripheral region of the tumor Vater's papilla and mucinous carcinoma in the central region of the tumor.
The mucinous carcinoma component uniquely extended along only the MPD with microinvasion to the pancreas. Immunohistochemically,
both the moderately differentiated adenocarcinoma and the mucinous carcinoma were positive for cytokeratin 20 (CK20) and negative
for cytokeratin 7 (CK7) which is the pattern of intestinal-type carcinoma of Vater's ampulla. We concluded that the original
site of this tumor may have been the duodenal epithelium of Vater's ampulla originally moderately differentiated adenocarcinoma—which
subsequently changed to mucinous carcinoma that extended along only the MPD with microinvasion to the pancreas. 相似文献
995.
Inagaki M Obara M Kino S Goto J Suzuki S Ishizaki A Tanno S Kohgo Y Tokusashi Y Miyokawa N Kasai S 《Journal of Hepato-Biliary-Pancreatic Surgery》2007,14(3):264-269
Background/Purpose Total pancreatectomy (TP) is rarely performed to treat invasive ductal carcinoma of the pancreas, due to the associated markedly
impaired quality of life and poor prognosis after the resection. Intraductal papillary-mucinous neoplasm (IPMN) of the pancreas
is characterized by extensive intraductal spread and a favorable outcome even when presenting at an invasive stage. We herein
reappraise the role of pylorus-preserving total pancreatectomy (PPTP) as a viable alternative pancreatic resection modality
for borderline and malignant IPMN.
Methods A total of five patients with IPMN underwent PPTP and their clinical follow-up data were reviewed.
Results TP was performed due to recurrent IPMN in the remnant pancreas after distal pancreatectomy in three patients and due to massive
involvement of the entire pancreas in the others. All patients were treated by the pylorus-preserving method, while the spleen
was also preserved in one patient. The surgical margins were negative and no metastasis to the resected lymph nodes was evident,
based on histological examinations. One patient underwent a re-operation due to postoperative intraabdominal bleeding, while
another patient required tubedrainage for left pleural effusion. Three of the four patients who underwent PPTP with a splenectomy
experienced postoperative gastric ulcer, which were controlled by medication. One patient died due to suicide 16 months after
the PPTP. All the others were doing well without recurrence at periods of 62 to 127 months after the PPTP.
Conclusions PPTP is therefore considered to be indicated as an effective treatment for borderline or malignant IPMN with extensive involvement,
when the patient's condition permits, in order to achieve complete resection of the IPMN. 相似文献
996.
997.
Saito Y Katori N Soyama A Nakajima Y Yoshitani T Kim SR Fukushima-Uesaka H Kurose K Kaniwa N Ozawa S Kamatani N Komamura K Kamakura S Kitakaze M Tomoike H Sugai K Minami N Kimura H Goto Y Minami H Yoshida T Kunitoh H Ohe Y Yamamoto N Tamura T Saijo N Sawada J 《Pharmacogenetics and genomics》2007,17(7):461-471
998.
Matthew R Cooperberg Shiro Hinotsu Michael B Chancellor Yukio Homma Peter S Nelson Hideyasu Matsuyama Mani Menon Omer Kucuk Isao Hara Shin Egawa Robert G Uzzo Hiro‐omi Kanayama Akihiko Okuyama Hideyuki Akaza 《International journal of urology》2009,16(8):703-708
Preface: We are heartily grateful for the warm support of all of the people concerned, including the moderators and panelists of both societies for giving us the opportunity to hold the 4th American Urological Association/Japanese Urological Association (AUA/JUA) Joint Meeting, held once again at the 104th Annual Meeting of the American Urological Association (25–30 April 2009, Chicago, Illinois, USA).
2009 is a memorable year, being the start of new collaborations between AUA and JUA. The JUA in collaboration with AUA is promoting an academic exchange program whereby outstanding and promising Japanese and American junior faculty members will be given the opportunity to work in the USA and Japan for one month. The program not only allows the sharing of knowledge and experience, but is designed to foster a closer alliance between the AUA and JUA, and assists in identifying future leaders within both organizations.
The JUA will have an exhibit booth at the AUA annual meeting, promoting our new joint activities. The Journal of Urology and International Journal of Urology will share reviewers. The JUA will participate in developing AUA guidelines. With all of these activities, the JUA hopes it will provide greater opportunities to young Japanese urologists to participate in educational projects in the US.
We would like to thank Professor Robert C. Flanigan, the Secretary General of AUA, Professor Glenn M. Preminger, the Chairman of the AUA Office of Education and the staff of AUA and JUA for supporting our program. We hope to keep holding the joint meeting and have plenty of ideas on themes and forums. We believe that this international program helps to establish a closer relationship between JUA and AUA in the scientific field.
Akihiko Okuyama md , President of JUA
Hideyuki Akaza md , Chairman of the International Committee of JUA 相似文献
2009 is a memorable year, being the start of new collaborations between AUA and JUA. The JUA in collaboration with AUA is promoting an academic exchange program whereby outstanding and promising Japanese and American junior faculty members will be given the opportunity to work in the USA and Japan for one month. The program not only allows the sharing of knowledge and experience, but is designed to foster a closer alliance between the AUA and JUA, and assists in identifying future leaders within both organizations.
The JUA will have an exhibit booth at the AUA annual meeting, promoting our new joint activities. The Journal of Urology and International Journal of Urology will share reviewers. The JUA will participate in developing AUA guidelines. With all of these activities, the JUA hopes it will provide greater opportunities to young Japanese urologists to participate in educational projects in the US.
We would like to thank Professor Robert C. Flanigan, the Secretary General of AUA, Professor Glenn M. Preminger, the Chairman of the AUA Office of Education and the staff of AUA and JUA for supporting our program. We hope to keep holding the joint meeting and have plenty of ideas on themes and forums. We believe that this international program helps to establish a closer relationship between JUA and AUA in the scientific field.
Akihiko Okuyama md , President of JUA
Hideyuki Akaza md , Chairman of the International Committee of JUA 相似文献
999.
Wako Urano Takefumi Furuya Eisuke Inoue Atsuo Taniguchi Tomohiko Urano Shigeru Kotake Chieko Sekita Satoshi Inoue Masako Hara Shigeki Momohara Naoyuki Kamatani Hisashi Yamanaka 《Journal of bone and mineral metabolism》2009,27(5):574-583
Several case reports have described associations between pathological nonvertebral fractures and low-dose methotrexate (MTX)
in rheumatoid arthritis (RA) patients. Furthermore, a significant association between the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene and incident fractures has been reported in postmenopausal women. We attempted to determine whether MTX use and MTHFR polymorphisms are associated with incident fracture risk in Japanese female RA patients. DNA samples, laboratory data, and
clinical data were obtained from 731 female RA patients more than 50 years old as part of the Institute of Rheumatology Rheumatoid
Arthritis (IORRA) observational cohort study. Genotyping of the MTHFR polymorphisms C677T and A1298C was performed using TaqMan SNP Genotyping Assays. MTX use, MTHFR polymorphisms, and other potential risk factors predictive of fracture were analyzed by Cox proportional hazards regression
models, including time-dependent covariates. During 78 months from October 2000 to March 2007, 25 and 90 patients developed
vertebral and nonvertebral fractures, respectively. Patients with nonvertebral fractures were more likely to take MTX (P = 0.011; odds ratio, 1.77; 95% confidence interval, 1.13–2.76) compared to patients without fractures. Although the C677T
and A1298C polymorphisms were not significantly associated with incident fracture risk, MTX use, age, disease duration, and
Japanese health assessment questionnaire score were significantly (P < 0.05) and independently associated with nonvertebral fracture incidence. Our results suggest that MTX use is associated
with a nonvertebral fracture risk, whereas MTHFR polymorphism status does not appear to be a clinically useful marker for predicting fracture risk in Japanese female RA patients. 相似文献
1000.
Akira Kabashima Naoyuki Ueda Yusuke Yonemura Kojiro Mashino Kyuzo Fujii Tetsuo Ikeda Hideya Tashiro Hisanobu Sakata 《Surgery today》2009,39(11):1002-1005
Glanzmann’s thrombasthenia (GT) is a rare inherited platelet disorder with no specific treatment. Prophylactic and therapeutic
platelet transfusions work only as supportive treatments. To date, there has been no report of surgical treatment for malignant
disease in GT patients. We herein report the case of a 43-year-old woman presenting with cecal cancer with accompanying GT.
The patient underwent a laparotomic procedure under general anesthesia for resection of the tumor. A good perioperative course
was achieved by the transfusion of ABO-identical and antihistocompatibility locus antigen-matched platelets, without causing
any accidental bleeding. 相似文献