全文获取类型
收费全文 | 3890篇 |
免费 | 174篇 |
国内免费 | 34篇 |
专业分类
耳鼻咽喉 | 30篇 |
儿科学 | 38篇 |
妇产科学 | 99篇 |
基础医学 | 502篇 |
口腔科学 | 84篇 |
临床医学 | 271篇 |
内科学 | 1108篇 |
皮肤病学 | 31篇 |
神经病学 | 287篇 |
特种医学 | 143篇 |
外科学 | 555篇 |
综合类 | 10篇 |
预防医学 | 79篇 |
眼科学 | 208篇 |
药学 | 212篇 |
中国医学 | 2篇 |
肿瘤学 | 439篇 |
出版年
2023年 | 22篇 |
2022年 | 38篇 |
2021年 | 57篇 |
2020年 | 44篇 |
2019年 | 62篇 |
2018年 | 87篇 |
2017年 | 73篇 |
2016年 | 64篇 |
2015年 | 79篇 |
2014年 | 103篇 |
2013年 | 130篇 |
2012年 | 250篇 |
2011年 | 285篇 |
2010年 | 138篇 |
2009年 | 150篇 |
2008年 | 251篇 |
2007年 | 275篇 |
2006年 | 259篇 |
2005年 | 272篇 |
2004年 | 256篇 |
2003年 | 229篇 |
2002年 | 210篇 |
2001年 | 50篇 |
2000年 | 55篇 |
1999年 | 75篇 |
1998年 | 42篇 |
1997年 | 26篇 |
1996年 | 31篇 |
1995年 | 31篇 |
1994年 | 29篇 |
1993年 | 23篇 |
1992年 | 37篇 |
1991年 | 25篇 |
1990年 | 30篇 |
1989年 | 39篇 |
1988年 | 20篇 |
1987年 | 37篇 |
1986年 | 34篇 |
1985年 | 40篇 |
1984年 | 17篇 |
1983年 | 20篇 |
1982年 | 16篇 |
1981年 | 8篇 |
1979年 | 21篇 |
1978年 | 7篇 |
1975年 | 6篇 |
1971年 | 6篇 |
1970年 | 6篇 |
1968年 | 5篇 |
1967年 | 5篇 |
排序方式: 共有4098条查询结果,搜索用时 15 毫秒
41.
Shin-Ichiro Sugiyama Naoyuki Shimada Hiroyuki Miyoshi Kiyoshi Yamauchi 《Toxicological sciences》2005,88(2):367-374
We developed a thyroid hormone (TH) inducible primary screening assay for the identification and assessment of man-made chemicals that interfere with the TH-signalling pathway within target cells. The assay was developed in a Xenopus laevis cell line that was transduced with a self-inactivating (SIN) lentivirus vector (LV) containing a luciferase gene. The luciferase activation in this cell line was TH-specific: 3,3',5-L-triiodothyronine (T(3)) > 3,3'5-L-triiodothyroacetic acid (Triac) > 3,3',5-D-triiodothyronine (D-T(3)), > L-thyroxine (T(4)) > 3,3',5'-L-triiodothyronine (rT(3)). The application of the ligand-dependent luciferase assay for screening for thyroid system-disrupting chemicals revealed that three phthalates (dicyclohexyl phthalate, n-butylbenzyl phthalate, and di-n-butyl phthalate), two herbicides (ioxynil and pentachlorophenol) and a miticide (dicofol) had 3,3',5-L-triiodothyronine- T(3)- antagonist activity at concentrations ranging from 10(-6) to 10(-5) M. These chemicals also inhibited the expression of the endogenous primary T(3)-response TH nuclear receptor beta (TRbeta) gene. The inhibitory characteristics of these chemicals were similar for both assays performed, although the assay for T(3)-dependent activation of TRbeta gene was more sensitive than the luciferase assay. These results indicate that the luciferase assay was a rapid method with a small intra-assay variation for the primary screening of thyroid system-disrupting chemicals. Of the six chemicals, only n-butylbenzyl phthalate and pentachlorophenol exhibited T(3)-antagonist activity in an in vivo metamorphosis-based assay. It should be noted that chemicals elicited thyroid system-disrupting activity in the luciferase assay did not always interfere with the thyroid system in vivo. 相似文献
42.
Satoshi Hojo Mio Hanaoka Ai Anami Naoyuki Nakanami Kazuhiro Kotoh 《Hypertension in pregnancy》2013,32(1):23-29
We report a case of preeclampsia associated with hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome and concomitant nonbiliary acute pancreatitis and cholecystitis in the first postpartum day. A thorough investigation ruled out known etiologies of both pancreatitis and cholecystitis. Following conservative treatment, the patient's HELLP syndrome, pancreatitis, and cholecystitis resolved on the third postpartum day. Preeclampsia is associated with microvascular abnormalities that may involve the splanchnic circulation. These abnormalities may cause not only HELLP syndrome but also pancreatitis and cholecystitis. Recognizing that ischemia can damage not only the liver but also the pancreas and gallbladder, could result in improvements in the diagnosis and management of pancreatitis in patients with preeclampsia. 相似文献
43.
Yosuke Ando Takahiro Hayashi Kaori Ito Eri Suzuki Naoyuki Mine Ayumi Miyamoto Miyuki Oya Hidezo Matsuda Ami Isaji Toru Nakanishi Kazuyoshi Imaizumi Tomoyuki Shibata Tatsuyoshi Okada Kazuo Sakurai Kensei Naito Ichiro Uyama Kenji Kawada Hiroshi Takahashi Shigeki Yamada 《Supportive care in cancer》2016,24(2):871-878
44.
Kyoko Kanno Masako Minami‐Hori Akemi Ishida‐Yamamoto Keiji Komura Kensuke Oikawa Naoyuki Miyokawa Hajime Iizuka 《The Journal of dermatology》2014,41(8):736-738
We report a 38‐year‐old male patient who presented with cutaneous lesions mimicking widespread discoid lupus erythematosus with high‐grade fever, arthralgia and lymphadenopathy. Additional lymph node and skin biopsies, however, revealed karyorrhectic debris without neutrophils and numerous CD68‐positive cells, a characteristic finding of Kikuchi's disease (KD). Comparing skin biopsies on different occasions, we could see different forms of histopathology. The histopathology of skin lesions of KD may vary during the clinical course, which may reflect the stage of the disease. 相似文献
45.
46.
Therapeutic efficacy of intense pulsed light in patients with refractory meibomian gland dysfunction
Purpose
To evaluate the efficacy and safety of intense pulsed light (IPL) combined with meibomian gland expression (MGX) for treatment of refractory meibomian gland dysfunction (MGD).Methods
Ninety eyes of 45 patients were randomly assigned to receive either the combination of IPL and MGX or MGX alone (control). Each eye underwent eight treatment sessions at 3-week intervals. Parameters were evaluated before and during treatment as well as at 3–11 weeks after the last treatment session. Measured parameters included the Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire score, noninvasive breakup time (NIBUT), fluorescein breakup time (BUT), lipid layer grade, lipid layer thickness (LLT), lid margin abnormalities, corneal and conjunctival fluorescein staining (CFS) score, meibum grade, and meiboscore.Results
A significant improvement in lipid layer grade was apparent in the IPL-MGX group from 6 to 32 weeks after treatment onset (adjusted P?<?0.001) but was not observed in the control group. The IPL-MGX group also showed significant improvements in LLT, NIBUT, BUT, lid margin abnormalities, and meibum grade compared with the control group at 24 and 32 weeks (adjusted P?<?0.001) as well as significant improvements in the SPEED score at 32 weeks (adjusted P?=?0.044) and in CFS score at 24 (adjusted P?=?0.015) and 32 (adjusted P?=?0.006) weeks.Conclusions
The combination of IPL and MGX improved homeostasis of the tear film and ameliorated ocular symptoms in patients with refractory MGD and is thus a promising modality for treatment of this condition. 相似文献47.
48.
49.
50.
Hiroyuki MATSUMOTO Rie YAKO Osamu MASUO Katsuhisa HIRAYAMA Yuji UEMATSU Naoyuki NAKAO 《Neurologia medico-chirurgica》2014,54(2):139-144
We report a patient''s case of slow progressive in-stent restenosis 10 years after bare-metal stent implantation to his carotid artery. We treated the patient with an additional stent placement under a distal filter protection device. Optical coherence tomographic assessment and plaque histology during the carotid artery stenting (CAS) revealed atheromatous change at in-stent neointima, which contained lipid-rich plaque and calcification deposits. These findings suggest that in-stent neoatherosclerosis may play an important role in the pathogenesis of very late stent restenosis after CAS. 相似文献