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21.
Samira Rostom Karima Benbouaaza Bouchra Amine Rachid Bahiri Yousra Ibn Yacoub Sanae Ali Ou Alla Redouane Abouqal Najia Hajjaj-Hassouni 《Clinical rheumatology》2010,29(7):781-788
The objectives of this study are to translate, adapt in the Moroccan cultural context, and validate in patients with ankylosing
spondylitis (AS) the Bath Ankylosing Spondylitis Functional Index (BASFI) and Bath Ankylosing Spondylitis Disease Activity
Index (BASDAI). The cross-cultural adaptation of the BASFI and BASDAI was obtained in accordance with the guidelines for translation
of the health status measures. Eighty-five patients with AS were included in the study. The test–retest reliability and the
internal consistency were analyzed, and both questionnaires were assessed for external construct validity. Structural validity
was analyzed with correlation matrix. Twenty-four-hour test–retest reliability was good: BASFI intraclass correlation coefficient
(ICC) = 0.96 (confidence interval (CI) at 95%, 0.93–0.97), BASDAI ICC = 0.93 (CI at 95%, 0.90–0.95). Cronbach’s alpha was
0.90 for the BASFI and 0.86 for BASDAI. The construct validity of the instruments was evaluated. The BASFI showed a strong
validity when correlating its results with Schober’s test (r = −0.56), occipital wall distance (r = 0.46), chest expansion (r = −0.46), BASDAI (r = 0.54), Bath Ankylosing Spondylitis Metrology Index (r = 0.70), Bath Ankylosing Spondylitis Global Score (BAS-G; r = 0.58), Bath Ankylosing Spondylitis Radiology Index (r = 0.61), and the radiological changes in sacroiliac joints (r = 0.54). A good correlation was observed between the BASDAI and the spinal pain (r = 0.53), the number of nocturnal awakenings (r = 0.57), the morning stiffness (r = 0.65), the enthesic index (r = 0.47), the BAS-G (r = 0.53), the BASFI (r = 0.54), and the erythrocyte sedimentation rate (r = 0.41; for all p < 0.001). The correlation matrix showed an intermediate correlation between items. The Moroccan version of the BASFI and
the BASDAI showed adequate reliability and validity. These instruments can be used in the clinical evaluation of Moroccan
and Arabic-speaking patients with AS. 相似文献
22.
Harzy T Allali F Amine B Rahmouni R Hajjaj-Hassouni N 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2005,26(5):386-392
BACK GROUND: The aim of our study is to describe the more common cardiac manifestations of idiopathic hypereosinophilic syndrome representing the major cause of mortality. MAIN POINTS: Current therapy consists of corticosteroid, hydroxyurea and interferon alpha. Recent publications confirm the activity of imatinib mesylate, a selective tyrosine kinase inhibitor, in patients with idiopathic hypereosinophilic syndrome. In cases with marked valvular compromise or with endomyocardial thrombosis or fibrosis, cardiac surgery can provide substantial benefits. PERSPECTIVES: A better understanding of the pathophysiology of this syndrome could lead to the development of new therapeutic agents. 相似文献
23.
Najlaa Srifi Rachid Bahiri Samira Rostom Imad Bendeddouche Noufissa Lazrek Najia Hajjaj-Hassouni 《Rheumatology international》2013,33(1):179-183
The Revised Fibromyalgia Impact Questionnaire (FIQ-R) is an updated version of the FIQ attempts to address the limitations of the Fibromyalgia Impact Questionnaire (FIQ). As there is no Moroccan version of the FIQ-R available, we aimed to investigate the validity and reliability of a Moroccan translation of the FIQR in Moroccan fibromyalgia (FM) patients. After translating the FIQR into Moroccan, it was administered to 80 patients with FM. All of the patients filled out the questionnaire together with Arabic version of short form-36 (SF-36). The tender-point count was calculated from tender points identified by thumb palpation. Three days later, FM patients filled out the Moroccan FIQR at their second visit. The test–retest reliability of the Moroccan FIQR questions ranged from 0.72 to 0.87. The test and retest reliability of total FIQR score was 0.84. Cronbach’s alpha was 0.91 for FIQR visit 1 (the first assessment) and 0.92 for FIQR visit 2 (the second assessment), indicating acceptable levels of internal consistency for both assessments. Significant correlations for construct validity were obtained between the Moroccan FIQ-R total and domain scores and the subscales of the SF-36 (FIQR total versus SF-36 physical component score and mental component score were r = ?0.69, P < 0.01 and r = ?0.56, P < 0.01, respectively). The Moroccan FIQ-R showed adequate reliability and validity. This instrument can be used in the clinical evaluation of Moroccan and Arabic-speaking patients with FM. 相似文献
24.
Amine B Rostom S Benbouazza K Abouqal R Hajjaj-Hassouni N 《Rheumatology international》2009,29(3):275-279
This study aimed to investigate the proxy-reported Health related quality of life (HRQOL) and its determinants in patients
with juvenile idiopathic arthritis (JIA). It was hypothesized that HRQOL would decrease with worsening disease and disability.
Data were available in cross-sectional study on children and adolescents with JIA according to the ILAR criteria. Patient
demographics, type of JIA, clinical determinants and laboratory parameters relating to JIA were obtained for each patient.
Functional disability was assessed using the parent’s or children’s version of the child health assessment questionnaire (CHAQ).
The HRQOL was evaluated using the juvenile arthritis quality of life questionnaire (JAQQ). These questionnaires were previously
translated and validated in Moroccan children. A total of 80 participants were enrolled with mean age of 11 [6–17 years],
and female predominance (59%). Many patients (42.5%) had oligoarticular subtype; 31.3% polyarticular subtypes and 26.2% systemic
form. The mean global score of JAQQ was 2.6 ± 1.3 (1–6). Patients with persistant oligoarticular had better gross motor function
(P < 0.0001), better fine motor function (P < 0.0001), less psychosocial impact (P = 0.001), and less symptoms (P = 0.001) in comparison with polyarticular and systemic subtypes. The HRQOL assessed by the JAQQ was worse in adolescent patients
in comparison with children except for symptoms (P = 0.15). The gender (P = 0.95), age at onset of JIA (P = 0.81), and evolution duration (P = 0.34) were not correlated with global score of JAQQ. The diagnosis delay was significantly associated with decrease of
HRQOL (P = 0.001). The decrease of HRQOL was correlated with disease activity [pain (VAS), painful and swollen joints, erythrocyte
sedimentation rate (for P < 0.0001)], with disability index (CHAQ) (P = 0.001) and presence of hip involvement (P = 0.01). This study suggests that JIA can have a significant adverse effect on the HRQOL of moroccan patients, particularly
adolescents with polyarticular and systemic subtypes. Disease duration, disability score (CHAQ) and pain were the strongest
determinants of poorer HRQOL. 相似文献
25.
Ibn Yacoub Y Amine B Laatiris A Wafki F Znat F Hajjaj-Hassouni N 《Rheumatology international》2012,32(10):3143-3148
In this case-control study, our first aim was to evaluate the bone mineral density (BMD) in women with systemic sclerosis (SSc) and its correlates. Secondarily, we aimed to evaluate 25-hydroxyvitamin D3 status and its relationships with disease parameters and BMD. Sixty patients with SSc and 60 age-and gender-matched controls were included in the absence of confounding factors that interfere with bone metabolism. Body mass index, menopausal status, familial history of osteoporosis and/or fractures; personal fracture history; exercise activity and laboratory parameters of bone metabolism were assessed in patients and controls. BMD was measured by using a dual-energy X-ray absorptiometry in lumbar spine (L1-L4) and femoral neck. The 25-hydroxyvitamin D3 was measured in a subgroup of 30 patients and in a subgroup of 30 matched controls. Systemic manifestations of SSc, biological inflammatory parameters, functional disability (scleroderma health assessment questionnaire (S-HAQ)) and immunological status of disease were collected in patients' group. The mean age of patients was 49.44?±?13.07?years versus 49.55?±?12.11 in controls. The mean disease duration was 9.63?±?5.9?years. SSc patients had a significantly earlier age and longer duration of menopause than controls (P?=?0.003). Phosphocalcic metabolism parameters were within normal ranges in both groups. BMD was significantly lower in SSc patients than in controls both in lumbar spine (-2.97?±?0.25 in patients vs. 0.46?±?0.11 in controls) and femoral neck (-1.93?±?0.32 in patients vs. -0.81?±?0.69 in controls) (P?0.01). Thirty-six (60%) patients versus 15 (25%) controls had osteoporosis and 19 (31.7%) patients versus 13 (21.7%) controls had osteopenia (P?0.01). In correlation analysis and in multiple regression models, there were significant correlations between BMD and longer duration of SSc, severe joint involvement (severe joint pain and erosive arthropathy), malabsorption syndrome and the positivity of anti-DNA topoisomerase I antibodies. Also, we found very low levels of vitamin D (10.88?±?2.68?ng/ml) comparing to controls (57.41?±?4.18?ng/ml) (P?=?0.001). Vitamin D levels were correlated with the severity of joint pain, with immunological status and with BMD in lumbar spine and femoral neck (P?0.01). In our sample, we state the importance of decreased BMD in Moroccan women with SSc with a high frequency of osteoporosis comparing to healthy controls. Bone loss seems to be associated with prolonged disease duration, severe joint involvement, malabsorption syndrome and immunological status. Also, SSc patients had lower levels of 25-hydroxyvitamin D3 than controls. Larger studies are needed to confirm those findings. 相似文献
26.
Hakkou J Rostom S Aissaoui N Berrada Ghezioul K Bahiri R Abouqal R Hajjaj-Hassouni N 《Clinical rheumatology》2012,31(3):441-445
The BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) is the most widely used instrument for the assessment of disease
activity in ankylosing spondylitis (AS). Objective. The aims to investigate whether the alternative BASDAI, here termed as the miniBASDAI [(Question (Q) 1 fatigue + Q2 spinal
pain) + mean of (Q5 strength morning stiffness + Q6 duration morning stiffness)] / 3], measures disease activity more accurately
in the subgroup of AS patients without peripheral manifestations. One hundred and ten patients were included in this cross-sectional
study according to the modified New York criteria for AS. Clinical and biological parameters were evaluated. The disease activity
was evaluated by the BASDAI. We calculated the miniBASDAI by omitting both the peripheral joints and the enthesitis questions:
questions 3 and 4. Patients were dichotomized into a “P+” group if peripheral manifestations were present (at least arthritis
or enthesitis) and a “P−” group, the subgroup without peripheral involvement (with either arthritis or enthesitis). Correlation
of the BASDAI and miniBASDAI with other disease parameters were examined with the Spearman's rank correlation analysis. One
hundred and ten patients were recruited. The percentage of patients with pure axial disease manifestation without peripheral
involvement “P − group” was 42.7%. We found a similarly good correlation of the miniBASDAI with patient global, physician
on disease activity, BASFI, ESR and CRP if compared to the correlation of the original BASDAI with these disease parameters,
also in the group without peripheral involvement. Our study suggests that the BASDAI remains valid in assessing disease activity
in AS patients with and without peripheral manifestations. 相似文献
27.
We aimed to evaluate the immunological status and its relationships with disease-related parameters of activity, severity
and quality of life in Moroccan patients with rheumatoid arthritis (RA). Two hundred forty-five consecutive patients with
RA were recruited. The following data were collected: demographic characteristics, disease duration (years), disease activity
(evaluated by the disease activity score, DAS28), structural damage (evaluated by Sharp's method as modified by van der Heijde),
functional disability (assessed by using the Moroccan version of the Health Assessment Questionnaire, HAQ) and quality of
life (by using the Arabic version of the Medical Outcomes Study Short Form 36 Health Survey: the SF-36). Immunological status
(rheumatoid factor rate, RF) and antibodies against citrullinated peptides rate (ACPAs) by the Elisa method were examined.
ACPAs were detected in 75.1% of patients with a mean rate of 79.2 ± 43.8 UI. RF was detected in 80.8% of patients with a mean
rate of 80.1 ± 50.6 UI. Patients with positive RF and ACPAs had higher disease activity, impaired functional ability, severe
structural damage, more ocular symptoms and altered aspects of quality of life. In univariate analysis, higher levels of ACPAs
were significantly correlated with the age at onset (r = 0.307), disease duration (r = 0.520), disease activity (DAS28) (r = 0.531), Sharp score (r = 0.431), and with the deterioration of all domains of SF-36 (for all p ≤ 0.01). RF levels were correlated with disease duration (r = 0.517), disease activity (r = 0.470), functional disability (r = 0.521), and the alteration of physical domains of SF-36 (for all p ≤ 0.01). In multivariate analysis, the main factors associated to ACPAs and RF levels were functional disability, structural
damage and impaired QoL. Furthermore, using the SF-36 scores as dependent variables, the impairment of physical domains and
the domain of vitality were significantly associated with ACPA levels while the decrease of the domain of physical function
was associated with the level of RF. Our study suggests that the presence and the levels of ACPAs and RF in our RA patients
are associated with more active disease, more severe joint damage, worst functional disability and altered aspects of quality
of life. 相似文献
28.
Abourazzak FE Benbouazza K Amine B Bahiri R Lazrak N Bzami F Jroundi I Abouqal R Guillemin F Hajjaj-Hassouni N 《Rheumatology international》2008,28(12):1197-1203
Objective of the study is to test the reliability and validity of a translated version of health assessment questionnaire (HAQ) on Moroccan patients with rheumatoid arthritis (RA). We led a prospective study from July 2004 to September 2005. A total of 100 Moroccan patients were recruited. After translation to dialect Arabic, back translation, expert committee review and pretesting of the questionnaire, it was administered to the selected patients and tested for construct validity, reliability and internal consistency. The construct validity was evaluated by correlating the yield of the questionnaire with other disease activity and severity parameters. The questionnaire was administered again after a time interval of between 2 and 10 days for evaluation of the reliability of this test. All the items were tested for their loyalty to the principal component. The adapted questionnaire showed a good internal consistency. Cronbach's alpha test was 0.994. The test-retest showed a strong reliability with a kappa test ranging from 0.70 to 0.92 for all domains. Intraclass correlation coefficient for the total score was 0.987. The Moroccan HAQ showed a strong validity. It correlates significantly with disease activity and severity parameters. The unidimentionality has been demonstrated. About 71.5% of all variabilities was accounted for by the first principal component. The Moroccan Arabic dialect version of HAQ is a reliable and valid instrument that can be self-administered by Moroccan RA patients to assess their functional disability. 相似文献
29.
30.
Rawasia WF Sridaran S Patel JC Abdallah J Ghanchi NK Barnwell JW Escalante AA Udhayakumar V Beg MA 《Infection, genetics and evolution》2012,12(2):278-281
Chloroquine (CQ) resistance in Plasmodium falciparum has been associated with point mutations in the P. falciparum CQ resistance transporter gene (pfcrt). Previous studies have shown 4-5 independent origins for CQ resistant pfcrt alleles globally, two in South America, one each in Southeast Asia, Papua New Guinea (PNG) and Philippines. In Asia, at least two different alleles corresponding to amino acids 72-76 (CVIET and SVMNT) have been found. The CVIET allele originated in Southeast Asia and then spread to Asia and Africa as well. The SVMNT allele, originating from PNG, has been found in India. This study was undertaken to investigate the genetic background of the CQ resistant pfcrt haplotypes in Pakistan. We genotyped microsatellite markers surrounding the pfcrt gene (six different markers at -12.3, -4.8, -1, 1.5, 3.9, 18.8 kb) in 114 clinical isolates of P. falciparum collected from different regions in Pakistan. Microsatellite analysis showed a significant reduction in genetic variation among the mutant SVMNT pfcrt alleles when compared to wild type alleles. The predominant SVMNT haplotype found in this study shared the same microsatellite haplotype found in both PNG and India. Two isolates with CVIET haplotypes showed similar microsatellite background to those found in Africa and Asia. In conclusion, this study suggests that CQ resistant SVMNT haplotypes in India and Pakistan have a common ancestral origin similar to that of Papua New Guinean isolates. 相似文献