全文获取类型
收费全文 | 409篇 |
免费 | 49篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 18篇 |
妇产科学 | 20篇 |
基础医学 | 68篇 |
口腔科学 | 8篇 |
临床医学 | 32篇 |
内科学 | 76篇 |
皮肤病学 | 24篇 |
神经病学 | 6篇 |
特种医学 | 2篇 |
外科学 | 22篇 |
综合类 | 23篇 |
预防医学 | 71篇 |
眼科学 | 6篇 |
药学 | 40篇 |
中国医学 | 31篇 |
肿瘤学 | 10篇 |
出版年
2023年 | 1篇 |
2022年 | 12篇 |
2021年 | 19篇 |
2020年 | 7篇 |
2019年 | 11篇 |
2018年 | 21篇 |
2017年 | 17篇 |
2016年 | 18篇 |
2015年 | 9篇 |
2014年 | 18篇 |
2013年 | 24篇 |
2012年 | 44篇 |
2011年 | 32篇 |
2010年 | 25篇 |
2009年 | 21篇 |
2008年 | 30篇 |
2007年 | 18篇 |
2006年 | 13篇 |
2005年 | 18篇 |
2004年 | 26篇 |
2003年 | 19篇 |
2002年 | 15篇 |
2001年 | 5篇 |
2000年 | 9篇 |
1999年 | 5篇 |
1998年 | 2篇 |
1997年 | 3篇 |
1996年 | 3篇 |
1995年 | 4篇 |
1994年 | 1篇 |
1992年 | 3篇 |
1991年 | 4篇 |
1990年 | 1篇 |
1987年 | 1篇 |
1973年 | 1篇 |
排序方式: 共有460条查询结果,搜索用时 15 毫秒
91.
Cytotoxicity of the Roots of Trillium govanianum Against Breast (MCF7), Liver (HepG2), Lung (A549) and Urinary Bladder (EJ138) Carcinoma Cells 下载免费PDF全文
Kashif M. Khan Lutfun Nahar Afaf Al‐Groshi Alexandra G. Zavoianu Andrew Evans Nicola M. Dempster Jean D. Wansi Fyaz M. D. Ismail Abdul Mannan Satyajit D. Sarker 《Phytotherapy research : PTR》2016,30(10):1716-1720
Trillium govanianum Wall. (Melanthiaceae alt. Trilliaceae), commonly known as ‘nag chhatri’ or ‘teen patra’, is a native species of the Himalayas. It is used in various traditional medicines containing both steroids and sex hormones. In folk medicine, the rhizomes of T. govanianum are used to treat boils, dysentery, inflammation, menstrual and sexual disorders, as an antiseptic and in wound healing. With the only exception of the recent report on the isolation of a new steroidal saponin, govanoside A, together with three known steroidal compounds with antifungal property from this plant, there has been no systematic pharmacological and phytochemical work performed on T. govanianum. This paper reports, for the first time, on the cytotoxicity of the methanol extract of the roots of T. govanianum and its solid‐phase extraction (SPE) fractions against four human carcinoma cell lines: breast (MCF7), liver (HEPG2), lung (A549) and urinary bladder (EJ138), using the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazoliumbromide cytotoxicity assay and liquid chromatography and electrospray ionization quadrupole time‐of‐flight mass spectrometry analysis of the SPE fractions. The methanol extract and all SPE fractions exhibited considerable levels of cytotoxicity against all cell lines, with the IC50 values ranging between 5 and 16 µg/mL. Like other Trillium species, presence of saponins and sapogenins in the SPE fractions was evident in the liquid chromatography mass spectrometry data. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
92.
93.
94.
95.
M Al-Azemi G Jones F Sirkeci S Walters M Houdmont W Ledger 《BJOG : an international journal of obstetrics and gynaecology》2009,116(12):1646-1656
Objective To assess the safety and efficacy of long-term use of long-acting GnRH agonist in women with chronic cyclical pelvic pain using immediate versus delayed add-back hormonal replacement therapy (HRT).
Design A prospective randomised trial.
Setting Reproductive and Developmental Medicine, Academic Unit, University Teaching Hospital and NHS Hospitals.
Population Thirty-eight premenopausal women with chronic cyclical pelvic pain were recruited.
Methods Women were given Zoladex 10.8 mg over 18 months and randomised to receive HRT (tibolone 2.5 mg) either immediately or after 6 months. Follow up was 12-month post-treatment.
Main outcome measures Bone mineral density at 6 months, the end of treatment (18 months), and 12 months later, pain and quality of life.
Results Women treated with immediate HRT add-back showed less bone mineral density loss at 6 months and less vasomotor symptoms compared with those who had delayed HRT add-back treatment. Long-term follow up showed both groups experienced equivalent bone mineral density loss. Pain and health-related quality-of-life assessment showed improvement in both groups but there was evidence of a return to baseline levels after ending treatment.
Conclusion Long-term use of GnRH agonist plus immediate add-back HRT is a safe and acceptable approach to intractable cyclical pelvic pain. Given the delay in reactivation of the hypothalamo-pituitary-ovarian axis after long-term suppression, an intermittent dose regime with GnRH agonist might warrant investigation. 相似文献
Design A prospective randomised trial.
Setting Reproductive and Developmental Medicine, Academic Unit, University Teaching Hospital and NHS Hospitals.
Population Thirty-eight premenopausal women with chronic cyclical pelvic pain were recruited.
Methods Women were given Zoladex 10.8 mg over 18 months and randomised to receive HRT (tibolone 2.5 mg) either immediately or after 6 months. Follow up was 12-month post-treatment.
Main outcome measures Bone mineral density at 6 months, the end of treatment (18 months), and 12 months later, pain and quality of life.
Results Women treated with immediate HRT add-back showed less bone mineral density loss at 6 months and less vasomotor symptoms compared with those who had delayed HRT add-back treatment. Long-term follow up showed both groups experienced equivalent bone mineral density loss. Pain and health-related quality-of-life assessment showed improvement in both groups but there was evidence of a return to baseline levels after ending treatment.
Conclusion Long-term use of GnRH agonist plus immediate add-back HRT is a safe and acceptable approach to intractable cyclical pelvic pain. Given the delay in reactivation of the hypothalamo-pituitary-ovarian axis after long-term suppression, an intermittent dose regime with GnRH agonist might warrant investigation. 相似文献
96.
Nurul Ain Azizan Angeliki Papadaki Tin Tin Su Muhammad Yazid Jalaludin Shooka Mohammadi Maznah Dahlui Mohd Nahar Azmi Mohamed Hazreen Abdul Majid 《Nutrients》2021,13(9)
This study evaluated implementing a school-based intervention to promote healthier dietary habits in the school environment among Malaysian adolescents using qualitative methods. This qualitative study was conducted in four secondary schools in Perak and Selangor (two urban and two rural schools) that received the intervention (either training or training and food subsidy). A total of eight focus groups (68 students aged 15 years old) and 16 in-depth interviews were conducted with canteen operators, school convenience shop operators, school teachers and school principals in each school. Thematic analysis was used to analyse the qualitative data to identify suitable themes. We found several initiatives and changes by the schools’ stakeholders to change to a healthy school canteen programme. The stakeholders also noticed the students’ food preferences that influence healthy food intake in canteens and convenience shops. The food vendors and school administrators also found that subsidising healthy meals might encourage healthy eating. Among barriers to implementing healthy school initiatives were the student’s perception of healthy food and their eating habits, which also affect the food vendors’ profit if they want to implement a healthy canteen. The school-based intervention has the potential to promotes healthier eating among school adolescents. Continuous training and monitoring of canteen operators and convenience shops are needed, including building partnerships and educating the students on healthy eating to cultivate healthy eating habits. 相似文献
97.
Paul Muscat Mika Lidov MD Tammana Nahar MD Stanley Tuhrim MD Jesse Weinberger MD 《Journal of neuroimaging》2001,11(1):50-54
Aortic artery dissection is a rare but well-recognized complication of Turner's syndrome. Isolated carotid or vertebral artery dissection has not previously been reported. The authors report the clinical and magnetic resonance imaging findings in a 30-year-old woman with Turner's syndrome who developed a high cervical spinal cord infarction with a Brown-Sequard syndrome owing to bilateral vertebral artery dissection. The diagnosis and management of the case is reviewed. 相似文献
98.
B Nahar MI Hossain JD Hamadani T Ahmed S Grantham-McGregor LA Persson 《BMC public health》2012,12(1):622
ABSTRACT: BACKGROUND: Parenting programmes are effective in enhancing parenting practices and child development. This study evaluated the effects of a intervention with psychosocial stimulation (PS) on the quality of the home environment and mothers' child-rearing practices in a community-based trial with severely malnourished Bangladeshi children. METHOD: Severely underweight children (n = 507), 6-24 months of age, were randomly assigned to five groups: PS; food supplementation (FS); PS + FS; clinic-control (CC); and, hospital-control (CH). PS included fortnightly follow-up visits for six months at community clinics where a play leader demonstrated play activities and gave education on child development and child rearing practices. FS comprised cereal-based supplements (150-300 kcal/day) for three months. All groups received medical care, micronutrient supplements and growth monitoring. Mothers were given the Home Observation for Measurement of the Environment (HOME) inventory and a questionnaire on parenting at baseline and after six months to assess the outcome. RESULTS: 322 children completed the study. After six months of intervention the PS + FS and PS groups benefitted in the total HOME score (depending on the comparison group, effect sizes varied from 0.66 to 0.33 SD) The PS + FS and PS groups also benefitted in two HOME subscales: maternal involvement (effect sizes: 0.8 to 0.55 SD) and play materials, (effect sizes: 0.46 to 0.6 SD), and child-rearing practices scores (effect size: 1.5 to 1.1 SD). The PS + FS group benefitted 4.0 points in total HOME score compared with CH, 4.8 points compared with CC and 4.5 points compared with FS (p < 0.001 for all). The PS group benefitted 2.4 points compared with CH (p = 0.035), 3.3 points compared with CC (p = 0.004), and 2.9 points compared with FS (p = 0.006). Child-rearing practice scores of the PS + FS group improved 7.7, 6.4 and 6.6 points and the PS group improved 8.5, 7.2 and 7.4 points more than CH, CC and FS, respectively (p < 0.001 for all). CONCLUSIONS: Child-rearing practices of mothers of severely malnourished children and the quality of their home environment can be improved through community-based psychosocial stimulation with or without food supplementation. This may be of importance to promote child development. 相似文献
99.
Shaden A. M. Khalifa Mohamed H. Elashal Nermeen Yosri Ming Du Syed G. Musharraf Lutfun Nahar Satyajit D. Sarker Zhiming Guo Wei Cao Xiaobo Zou Aida A. Abd El-Wahed Jianbo Xiao Hany A. Omar Mohamed-Elamir F. Hegazy Hesham R. El-Seedi 《Nutrients》2021,13(6)
Bee pollen is a combination of plant pollen and honeybee secretions and nectar. The Bible and ancient Egyptian texts are documented proof of its use in public health. It is considered a gold mine of nutrition due to its active components that have significant health and medicinal properties. Bee pollen contains bioactive compounds including proteins, amino acids, lipids, carbohydrates, minerals, vitamins, and polyphenols. The vital components of bee pollen enhance different bodily functions and offer protection against many diseases. It is generally marketed as a functional food with affordable and inexpensive prices with promising future industrial potentials. This review highlights the dietary properties of bee pollen and its influence on human health, and its applications in the food industry. 相似文献
100.
Md Abid Hossain Mollah Probhat Ranjan Dey S. A. Tarafdar Sohela Akhter Shakil Ahmed Tariq Hassan Nargis Ara Begum Nazmun Nahar 《Indian journal of pediatrics》2002,69(11):859-861
Objective : This prospective study was carried out from July-December 1999 to see the status of zinc in CSF of children with febrile
convulsion and to compare this to that of control.Methods : Forty-two cases of febrile convulsion and 30 controls (fever without convulsion) were enrolled into the study. CSF zinc
was estimated by atomic absorption spectrophotometry (AAS) in Atomic Energy Center, Dhaka and compared between the two groups.Results : The mean zinc level in CSF in the study sample was 40.19mgm/L and that in control was 74.98mgm/L This difference was statistically
significant (p<0.001).Conclusion : The study concludes that a significantly lower of zinc exists in CSF of children with febrile. However no relationship
was found between CSF zinc status with age, sex, degree & duration of fever and time of lumbar puncture after convulsion. 相似文献