全文获取类型
收费全文 | 4446篇 |
免费 | 329篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 46篇 |
儿科学 | 104篇 |
妇产科学 | 86篇 |
基础医学 | 769篇 |
口腔科学 | 65篇 |
临床医学 | 553篇 |
内科学 | 870篇 |
皮肤病学 | 81篇 |
神经病学 | 528篇 |
特种医学 | 136篇 |
外科学 | 412篇 |
综合类 | 34篇 |
一般理论 | 2篇 |
预防医学 | 389篇 |
眼科学 | 29篇 |
药学 | 261篇 |
中国医学 | 25篇 |
肿瘤学 | 396篇 |
出版年
2024年 | 4篇 |
2023年 | 54篇 |
2022年 | 93篇 |
2021年 | 157篇 |
2020年 | 94篇 |
2019年 | 150篇 |
2018年 | 150篇 |
2017年 | 117篇 |
2016年 | 150篇 |
2015年 | 162篇 |
2014年 | 183篇 |
2013年 | 259篇 |
2012年 | 402篇 |
2011年 | 406篇 |
2010年 | 217篇 |
2009年 | 198篇 |
2008年 | 292篇 |
2007年 | 296篇 |
2006年 | 300篇 |
2005年 | 256篇 |
2004年 | 212篇 |
2003年 | 206篇 |
2002年 | 203篇 |
2001年 | 15篇 |
2000年 | 13篇 |
1999年 | 20篇 |
1998年 | 34篇 |
1997年 | 19篇 |
1996年 | 13篇 |
1995年 | 10篇 |
1994年 | 18篇 |
1993年 | 15篇 |
1992年 | 8篇 |
1991年 | 7篇 |
1990年 | 5篇 |
1989年 | 5篇 |
1988年 | 3篇 |
1987年 | 2篇 |
1986年 | 6篇 |
1985年 | 2篇 |
1984年 | 6篇 |
1983年 | 7篇 |
1982年 | 7篇 |
1981年 | 1篇 |
1976年 | 2篇 |
1974年 | 5篇 |
1970年 | 1篇 |
1894年 | 1篇 |
排序方式: 共有4786条查询结果,搜索用时 15 毫秒
101.
Michelle Nadine Servaas Harriëtte Riese Johan Ormel André Aleman 《Human brain mapping》2014,35(9):4303-4315
The tendency to worry is a facet of neuroticism that has been shown to mediate the relationship between neuroticism and symptoms of depression and anxiety. The aim of the current study was to investigate the neural correlates of state worry in association with neuroticism. One‐hundred twenty participants were selected from an initially recruited sample of 240 women based on their neuroticism score. First, participants completed a questionnaire to assess the excessiveness and uncontrollability of pathological worry. Second, we measured brain activation with functional magnetic resonance imaging (fMRI) while participants were randomly presented with 12 worry‐inducing sentences and 12 neutral sentences in a mood induction paradigm. Individuals scoring higher on neuroticism reported to worry more in daily life and to have generated more worry‐related thoughts after the presentation of a worry‐inducing sentence. Furthermore, imaging results showed the involvement of default mode and emotional brain areas during worry, previously associated with self‐related processing and emotion regulation. Specifically, cortical midline structures and the anterior insula showed more activation during worry, when individuals indicated to have generated more worry‐related thoughts. Activation in the retrosplenial and visual cortex was decreased in individuals scoring higher on neuroticism during worry, possibly suggesting reduced autobiographical specificity and visual mental imagery. In the literature, both these processes have been related to the cognitive avoidance of emotional distress. Excessive worry features in a number of emotional disorders and results from studies that elucidate its neural basis may help explain how and why neuroticism contributes to vulnerability for psychopathology. Hum Brain Mapp 35:4303–4315, 2014. © 2014 Wiley Periodicals, Inc . 相似文献
102.
103.
104.
Nadine Berndt Catherine Bolman Erika Sivarajan Froelicher Aart Mudde Math Candel Hein de Vries Lilian Lechner 《Journal of behavioral medicine》2014,37(4):709-724
Smoking cessation interventions for cardiac patients need improvement given their weak effects on long-term abstinence rates and low compliance by nurses to implementation. This study tested the effectiveness of two smoking cessation interventions against usual care in cardiac patients, and conditional effects for patients’ motivation to quit and socio-economic status (SES). An experimental study was conducted from 2009 to 2012 for which Dutch cardiac patient smokers were assigned to: usual care (UC; n = 245), telephone counseling (TC; n = 223) or face-to-face counseling (FC; n = 157). The three groups were comparable at baseline and had smoked on average 21 cigarettes a day before hospitalization. After six months, interviews occurred to assess self-reported smoking status. Patients in the TC and FC group had significantly higher smoking abstinence rates than patients in the UC group (p ≤ 0.05 at all times). Regression analysis further revealed significant conditional effects of the interventions on smoking abstinence in patients with lower SES, with a larger effect for TC than FC when compared to UC. These findings suggest that intensive counseling is effective in increasing short-term abstinence rates, particularly in patients with lower SES. Future studies need to investigate how patients with higher SES can profit equally from these type of interventions. 相似文献
105.
106.
Sixteen Nuremberg war criminals' (NWC) Rorschach records were compared to those of Antisocial Personality Disordered (APD) incarcerated males procured by Gacono and Meloy (1988). The Meloy (1988) set of hypotheses for psychopathy was applied to the NWCs' Rorschachs. The NWCs did not match Meloy's hypotheses, and neither did the antisocial personality disordered inmates. However, individually and as a group, the NWC Rorschach variables indicated less psychopathy, according to the hypotheses, than those of the APD inmates. Unlike most previous studies, variance in type and degree of psychopathology precluded the application of a mental disorder, character structure, or trait to all, or to the majority, of NWCs. Nevertheless, common features, such as avoidance of responsibility, low self-esteem, and capacity for affection, were revealed. 相似文献
107.
108.
Leonie Konczalla Daniel R. Perez Nadine Wenzel Gerrit Wolters-Eisfeld Clarissa Klemp Johanna Lüddeke Annika Wolski Dirk Landschulze Chris Meier Anika Buchholz Dichao Yao Bianca T. Hofmann Julia K. Graß Sarah L. Spriestersbach Katharina Grupp Udo Schumacher Christian Betzel Svetlana Kapis Theresa Nuguid Pablo Steinberg Klaus Püschel Guido Sauter Maximillian Bockhorn Faik G. Uzunoglu Jakob R. Izbicki Cenap Güngör Alexander T. El Gammal 《International journal of cancer. Journal international du cancer》2020,146(6):1618-1630
MALT1 is a key mediator of NF-κB signaling and a main driver of B-cell lymphomas. Remarkably, MALT1 is expressed in the majority of pancreatic ductal adenocarcinomas (PDACs) as well, but absent from normal exocrine pancreatic tissue. Following, MALT1 shows off to be a specific target in cancer cells of PDAC without affecting regular pancreatic cells. Therefore, we studied the impact of pharmacological MALT1 inhibition in pancreatic cancer and showed promising effects on tumor progression. Mepazine (Mep), a phenothiazine derivative, is a known potent MALT1 inhibitor. Newly, we described that biperiden (Bip) is a potent MALT1 inhibitor with even less pharmacological side effects. Thus, Bip is a promising drug leading to reduced proliferation and increased apoptosis in PDAC cells in vitro and in vivo. By compromising MALT1 activity, nuclear translocation of c-Rel is prevented. c-Rel is critical for NF-κB-dependent inhibition of apoptosis. Hence, off-label use of Bip or Mep represents a promising new therapeutic approach to PDAC treatment. Regularly, the Anticholinergicum Bip is used to treat neurological side effects of Phenothiazines, like extrapyramidal symptoms. 相似文献
109.
Kloth Nadine Lemke Jolene Wiendl Heinz Meuth Sven G. Duning Thomas Johnen Andreas 《Journal of neurology》2020,267(4):975-983
Journal of Neurology - A significant proportion of patients with behavioural variant frontotemporal dementia (bvFTD) show memory impairments similar to patients with Alzheimer’s disease (AD),... 相似文献
110.
Nadine Schlichting Tatiana Kartashova Michael Wiesing Eckart Zimmermann 《Journal of vision》2022,22(2)
Complex, goal-directed and time-critical movements require the processing of temporal features in sensory information as well as the fine-tuned temporal interplay of several effectors. Temporal estimates used to produce such behavior may thus be obtained through perceptual or motor processes. To disentangle the two options, we tested whether adaptation to a temporal perturbation in an interval reproduction task transfers to interval reproduction tasks with varying sensory information (visual appearance of targets, modality, and virtual reality [VR] environment or real-world) or varying movement types (continuous arm movements or brief clicking movements). Halfway through the experiments we introduced a temporal perturbation, such that continuous pointing movements were artificially slowed down in VR, causing participants to adapt their behavior to sustain performance. In four experiments, we found that sensorimotor adaptation to temporal perturbations is independent of environment context and movement type, but modality specific. Our findings suggest that motor errors induced by temporal sensorimotor adaptation affect the modality specific perceptual processing of temporal estimates. 相似文献