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目的:介绍B-Twin可膨胀式融合器系统及相关B-Twin椎间融合术的开展情况。方法:应用计算机检索“B-Twin expandable cage,lumbar interbody space fusion,lumbar disc degenerative disease,minimal invasive spinal fusion”;中文期刊检索词“B-Twin、腰椎融合术”。检索工具:Pubmed,google,CNKI中文期刊网。同时有部分国外会议资料。结果:腰椎间盘退行性疾病是临床上引起腰腿痛及功能障碍的一类疾病,目前常用的治疗方法包括保守治疗、微创手术以及外科手术治疗。传统的腰椎融合术多为开放性手术,创伤大,恢复时间长,近年来,可膨胀的B-Twin融合器的应用使经皮腰椎融合术成为可能,并且具有创伤小、恢复快、操作简便、安全性高的特点。结论:可膨胀的B-Twin融合器的应用,使得经皮腰椎融合术成为可能,具有广阔的前景。 相似文献
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Background
Bias against individuals who are overweight is well documented. However, little is known about biased perceptions of men and women at varying specified degrees of overweight.Methods
Men and women (N = 308) rated male and female figures (low normal weight, overweight, obese, extremely obese) on measures of dislike, personality characteristics, and functional limitations.Results
Little or no bias was observed against overweight figures (BMI approximately 25 kg/m2); however, strong bias was observed against obese and extremely obese figures. Men''s ratings of extremely obese females were more negative than those of comparable males. However, for other weight categories, participants evidenced similar or greater weight bias against overweight and obese men than against female targets of corresponding weight. Furthermore, male participants tended to perceive heavier females as having more functional deficits and disliked them somewhat more than female participants.Conclusion
By using targets of known BMI categories, the current study enhances our understanding of who is likely to be impacted by weight bias. As individuals with a BMI < 30 kg/m2 are typically not the targets of weight-related bias, research and efforts regarding weight-related bias should focus more specifically on those individuals who are obese or extremely obese.Key Words: Weight bias, Gender differences, Body size, Attitudes, Overweight 相似文献775.
Novel PRKD gene rearrangements and variant fusions in cribriform adenocarcinoma of salivary gland origin 下载免费PDF全文
Ilan Weinreb Lei Zhang Laxmi MS Tirunagari Yun‐Shao Sung Chun‐Liang Chen Bayardo Perez‐Ordonez Blaise A Clarke Alena Skalova Simion I Chiosea Raja R Seethala Daryl Waggott Paul C Boutros Christine How Fei‐Fei Liu Jonathan C Irish David P Goldstein Ralph Gilbert Nasir ud Din Adel Assaad Jason L Hornick Lester DR Thompson Cristina R Antonescu 《Genes, chromosomes & cancer》2014,53(10):845-856
Polymorphous low‐grade adenocarcinoma (PLGA) and cribriform adenocarcinoma of minor salivary gland (CAMSG) are low‐grade carcinomas arising most often in oral cavity and oropharynx, respectively. Controversy exists as to whether these tumors represent separate entities or variants of one spectrum, as they appear to have significant overlap, but also clinicopathologic differences. As many salivary carcinomas harbor recurrent translocations, paired‐end RNA sequencing and FusionSeq data analysis was applied for novel fusion discovery on two CAMSGs and two PLGAs. Validated rearrangements were then screened by fluorescence in situ hybridization (FISH) in 60 cases. Histologic classification was performed without knowledge of fusion status and included: 21 CAMSG, 18 classic PLGA, and 21 with “mixed/indeterminate” features. The RNAseq of 2 CAMSGs showed ARID1A‐PRKD1 and DDX3X‐PRKD1 fusions, respectively, while no fusion candidates were identified in two PLGAs. FISH for PRKD1 rearrangements identified 11 additional cases (22%), two more showing ARID1A‐PRKD1 fusions. As PRKD2 and PRKD3 share similar functions with PRKD1 in the diacylglycerol and protein kinase C signal transduction pathway, we expanded the investigation for these genes by FISH. Six additional cases each showed PRKD2 and PRKD3 rearrangements. Of the 26 (43%) fusion‐positive tumors, there were 16 (80%) CAMSGs and 9 (45%) indeterminate cases. A PRKD2 rearrangement was detected in one PLGA (6%). We describe novel and recurrent gene rearrangements in PRKD1–3 primarily in CAMSG, suggesting a possible pathogenetic dichotomy from “classic” PLGA. However, the presence of similar genetic findings in half of the indeterminate cases and a single PLGA suggests a possible shared pathogenesis for these tumor types. © 2014 Wiley Periodicals, Inc. 相似文献
776.
Electro-encephalogram disturbances in different sleep-wake states following exposure to high environmental heat 总被引:5,自引:0,他引:5
Sinha RK 《Medical & biological engineering & computing》2004,42(3):282-287
In this study, cerebral electrical activity or electro-encephalogram (EEG) was studied following exposure to high environmental
heat, in three different age groups of freely moving rats. Each age group was subdivided into three groups: the acute heat
stress group, subjected to a single exposure of 4h at 38°C in the biological oxygen demand incubator; the chronic heat stress
group, exposed for 21 days, for 1 h each day, at 38°C in the incubator; and the handling control group. The polygraphic sleep-wake
recordings involved simultaneous recordings of cortical EEG, electrooculogram (EOG), and electromyogram (EMG), on paper and
in digital form on computer hard disk, just after the heat exposure for the acute stressed rats and on the 22nd day for the
chronic stressed rats. The power spectrum was calculated for 2s epochs of the EEG signals. Quantitative analyses of EEG (qEEG)
showed that, in all three age groups, changes in higher-frequency components (β2) were significant in all sleep-wake states following both acute and chronic heat stress conditions. The power of β2 activity in all three age groups after acute heat exposure was significantly decreased during slow wave sleep (SWS) (p<0.05)
and rapid eye movement sleep (p<0.05), whereas the reverse was observed in the awake state (p<0.05). Following chronic heat
exposure, β2 activity was found to increase in all three sleep-wake stages in all groups of rats (p<0.01 for SWS in the weaning group
and p<0.05 for other data). Thus the study demonstrated that the cortical EEG is sensitive to environmental heat, and alterations
in EEG frequencies in different states of mental consciousness due to high heat can be differentiated efficiently by EEG power
spectrum analysis. 相似文献
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