全文获取类型
收费全文 | 1193篇 |
免费 | 71篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 29篇 |
儿科学 | 23篇 |
妇产科学 | 18篇 |
基础医学 | 136篇 |
口腔科学 | 31篇 |
临床医学 | 123篇 |
内科学 | 309篇 |
皮肤病学 | 42篇 |
神经病学 | 67篇 |
特种医学 | 19篇 |
外科学 | 226篇 |
综合类 | 18篇 |
预防医学 | 54篇 |
眼科学 | 37篇 |
药学 | 87篇 |
中国医学 | 10篇 |
肿瘤学 | 53篇 |
出版年
2023年 | 28篇 |
2022年 | 57篇 |
2021年 | 81篇 |
2020年 | 43篇 |
2019年 | 68篇 |
2018年 | 67篇 |
2017年 | 50篇 |
2016年 | 53篇 |
2015年 | 45篇 |
2014年 | 87篇 |
2013年 | 85篇 |
2012年 | 101篇 |
2011年 | 99篇 |
2010年 | 40篇 |
2009年 | 45篇 |
2008年 | 50篇 |
2007年 | 58篇 |
2006年 | 47篇 |
2005年 | 42篇 |
2004年 | 33篇 |
2003年 | 17篇 |
2002年 | 14篇 |
2001年 | 13篇 |
2000年 | 7篇 |
1999年 | 6篇 |
1998年 | 5篇 |
1997年 | 11篇 |
1996年 | 2篇 |
1995年 | 6篇 |
1993年 | 3篇 |
1991年 | 1篇 |
1989年 | 3篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1984年 | 1篇 |
1982年 | 2篇 |
1980年 | 3篇 |
1976年 | 2篇 |
1974年 | 1篇 |
1971年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有1282条查询结果,搜索用时 15 毫秒
41.
Histopathology of surgically treated renal tumours in young adults: a developing country perspective
Mubarak M Kazi JI Mohsin R Hashmi A Naqvi SA Ul Hassan Rizvi SA 《Journal of cancer research and clinical oncology》2012,138(2):189-194
Background
There is no data on the histopathological characteristics of renal tumours in young adults in Pakistan. 相似文献42.
Bozdogan ST Unsal C Erkman H Genc A Yuregir OO Muslumanoglu MH Aslan H 《Hemoglobin》2012,36(3):283-288
Thalassemias are genetically heterogeneous group of disorders with reduced or absent production of globin. β-Thalassemia major can be caused by homozygosity or compound heterozygosity for β-globin gene mutation. Here we report, for the first time in Turkey, three cases who carry the nonsense β-thalassemia (β-thal) mutation at codon 37 (TGG>TGA; Trp→Stop) causing premature stop codon. 相似文献
43.
Anupom Borah Rajib Paul Muhammed Khairujjaman Mazumder Nivedita Bhattacharjee 《神经科学通报》2013,29(5):655-660
While the cause of dopaminergic neuronal cell death in Parkinson's disease(PD)is not yet understood,many endogenous molecules have been implicated in its pathogenesis.β-phenethylamine(β-PEA),a component of various food items including chocolate and wine,is an endogenous molecule produced from phenylalanine in the brain.It has been reported recently that long-term administration ofβ-PEA in rodents causes neurochemical and behavioral alterations similar to that produced by parkinsonian neurotoxins.The toxicity ofβ-PEA has been linked to the production of hydroxyl radical(.OH)and the generation of oxidative stress in dopaminergic areas of the brain,and this may be mediated by inhibition of mitochondrial complex-I.Another significant observation is that administration ofβ-PEA to rodents reduces striatal dopamine content and induces movement disorders similar to those of parkinsonian rodents.However,no reports are available on the extent of dopaminergic neuronal cell death after administration ofβ-PEA.Based on the literature,we set out to establishβ-PEA as an endogenous molecule that potentially contributes to the progressive development of PD.The sequence of molecular events that could be responsible for dopaminergic neuronal cell death in PD by consumption ofβ-PEA-containing foods is proposed here.Thus,long-term over-consumption of food items containingβ-PEA could be a neurological risk factor having significant pathological consequences. 相似文献
44.
Binali Çakur DDS PhD Muhammed Akif Sümbüllü DDS PhD Doğan Durna DDS 《Clinical implant dentistry and related research》2013,15(1):83-87
Background: Osseo‐integrated implants are increasingly being used to restore functional dentition; however, in the posterior region, implant placement can be problematic because of inadequate bone height. In this condition, maxillary sinus floor elevation surgery has become the treatment of choice. The presence of anatomic variations within the maxillary sinus such as Underwood's septa and thin schneiderian membrane decreases the success of the sinus floor elevation. Purpose: In this study, we tried to determine the relationship between the anatomic variations of the maxillary sinus: Underwood's septa, schneiderian membrane thickness, and the cortical thickness of the inferior border of the maxillary sinus. Material and Methods: The left and right maxillary sinus images of 74 patients were obtained by using dental computed tomography (CT). The schneiderian membrane and the cortical thickness of the inferior border of the maxillary sinus were measured on the coronal images of dental CT scans at the deepest portion of the sinus cavity. The presence of Underwood's septa was identified on the axial images. The correlations between these variables were assessed. Results: We found that there was only a negative correlation between the schneiderian membrane thickness and the presence of Underwood's septa (r = –0.168 p = .042). Conclusion: It is suggested that Underwood's septa may be the reason for the thinness of the schneiderian membrane. However, future studies among larger groups are necessary for confirming the finding by using well‐designed clinical studies. 相似文献
45.
46.
Cemal Firat Emine Samdancı Serkan Erbatur Ahmet Hamdi Aytekin Muharrem Ak Muhammed Gokhan Turtay Yusuf Kenan Coban 《Burns : journal of the International Society for Burn Injuries》2013
Saving the zone of stasis is one of the major goals of burn specialists. Increasing the tissue tolerance to ischaemia and inhibiting inflammation have been proposed to enable salvage of this zone. After a burn, excessive inflammation, including increased vascular permeability, local tissue oedema and neutrophil activation, causes local tissue damage by triggering vascular thrombosis and blocking capillaries, resulting in tissue ischaemia and necrosis. Oxygen radicals also contribute to tissue damage after a burn. However, macrophages play a pivotal role in the response to burn. We studied β-glucan because of its many positive systemic effects that are beneficial to burn healing, including immunomodulatory effects, antioxidant effects (free-radical scavenging activity) and effects associated with the reduction of the inflammatory response. 相似文献
47.
Muhammed Allami Peter Giannoudis Laura Piñeiro Esteban Mocetti Ana Morandi Francisco Piccaluga 《Acta orthopaedica》2013,84(6):771-772
No Abstract available 相似文献
48.
Murtaza Emre Durakoğlugil MD Yüksel Çiçek MD Sinan Altan Kocaman MD Mehmet Sabri Balik MD Serkan Kirbaş MD Mustafa Çetin MD Turan Erdoğan MD Aytun Çanga MD 《Muscle & nerve》2013,47(6):872-877
Introduction: Carpal tunnel syndrome (CTS) is associated with cardiovascular risk factors. The aim of our study was to determine whether carotid intima–media thickness (CIMT) and carotid–femoral pulse wave velocity (cf-PWV), as surrogates of cardiovascular disease and arterial stiffness, are increased in patients with carpal tunnel syndrome. Methods: Forty patients with CTS and 40 gender- and age-matched controls underwent cf-PWV assessment, CIMT measurement, and nerve conduction study. Results: CIMT and cf-PWV were increased significantly in patients with CTS. They correlated positively with median sensory and motor nerve distal latency. Whereas both CIMT and PWV related to CTS, only CIMT independently predicted CTS. Conclusions: There is both increased pulse wave velocity and CIMT and a positive correlation between these parameters and median nerve sensory distal latency in patients with CTS. CTS appears to be associated with arterial stiffness and atherosclerotic burden, but the underlying mechanisms require further study. Muscle Nerve 47: 872–877, 2013 相似文献
49.
Nusret Soylu Ahmet Hamdi Alpaslan Muhammed Ayaz Selcen Esenyel Mücahit Oruç 《Research in developmental disabilities》2013,34(12):4334-4342
The purpose of this study was to compare sexually abused children and adolescents, with and without intellectual disabilities (ID), in terms of post-abuse psychiatric disorders, features of the sexual abuse, and sociodemographic characteristics. The study included sexually abused children aged 6–16 years, who were sent to three different child mental health units for forensic evaluation; there were 102 cases (69 girls and 33 boys) with ID and 154 cases (126 girls and 28 boys) without ID. Researchers retrospectively examined the files, social examination reports, and the judicial reports of the cases. It was determined that in the group with ID, sexual abuse types including penetration and contact had higher rates, they were exposed to more frequent repeated abuses, the abuses were revealed with their own reports at a later period and lower rates, and post-abuse pregnancies were more frequent. It was also determined that the abuser was a familiar person and a family member at lower rates and more than one abuser was encountered more frequently, compared to the group without ID. While no difference was determined between the two groups in terms of the frequency of post-abuse post-traumatic stress disorder (PTSD) and major depressive disorder (MDD), conduct disorder (CD) was observed more frequently in the group with ID. This study emphasizes that sexual abuse, which is an important problem in individuals with ID, has different features and effects. 相似文献
50.
Renson Thomas Forkert Nils D. Amador Kimberly Miettunen Paivi Parsons Simon J. Dhalla Muhammed Johnson Nicole A. Luca Nadia Schmeling Heinrike Stevenson Rebeka Twilt Marinka Hamiwka Lorraine Benseler Susanne 《Pediatric rheumatology online journal》2023,21(1):1-2
To characterize the clinical features and outcomes of childhood-onset primary Sjögren’s syndrome (pSS). Patients less than 18 years old who were diagnosed with pSS by paediatric rheumatologists were included, and all patients were applied the 2002 American-European Consensus Group (ACEG) criteria, the 2016 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria for pSS, or the 1999 proposed juvenile pSS criteria. The electronic medical records of patients with pSS from 2013 to 2020 were collected and analysed. Thirty-nine patients were included. Of them, 27 (69.2%), 38 (97.4%) and 35 (89.7%) patients fulfilled the AECG criteria, ACR/EULAR criteria and proposed juvenile pSS criteria, respectively. The female:male ratio was 3.9:1. The median ages at first signs or symptoms and at diagnosis were 9.2 (4.7, 14.5) years and 10.9 (6.3, 15.0) years, respectively. The main clinical manifestations were rash or purpura (20, 51.3%), followed by fever (12, 30.8%), glandular enlargement/recurrent parotitis (10, 25.6%), and dry mouth and/or dry eyes (9, 23.1%). Twenty-eight (56.4%) patients had systemic damage, the most common of which was haematological involvement (14, 35.9%), followed by hepatic (13, 33.3%) and renal involvement (8, 20.5%). Thirty-eight (97.4%) patients underwent labial minor salivary gland biopsy, and all exhibited focal lymphocytic sialadenitis. All patients had a global ESSDAI score ≥ 1 at diagnosis, and the median total score at diagnosis was 8 (2, 31). Thirty-six (92.3%) patients were followed up for a median time of 23.6 (7.9, 79.5) months, and three patients developed systemic lupus erythematosus (SLE) at follow-up times of 13.3, 38.8 and 63.8 months. The presentation of childhood-onset pSS is atypical, and extraglandular manifestations and systemic involvement are more common than in adult-onset pSS. Labial salivary gland biopsy is vital for patients with probable pSS. Some patients may develop SLE over time. 相似文献