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Acute gastrointestinal hemorrhage of small-bowel origin 总被引:2,自引:0,他引:2
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云南省恶性疟原虫多药抗性基因Asn86Tyr多态性调查 总被引:1,自引:0,他引:1
目的检测云南恶性疟原虫多药抗性基因(Pfmdr1)Asn86Tyr的多态性,探索其与氯喹敏感性表现型的关系.方法用等位基因特异PCR和限制性酶切片段长度分析技术(AS-PCR/RFLP).结果在86%(19/22)的氯喹抗性分离株中检测到Pfmdr1基因的Asn86Tyr两种多态性,携带编码86Tyr多态变异的占50%,而含编码Asn86多态的也是50%.结论在云南氯喹抗性高度流行区,Pfmdr1基因Asn86Tyr的多态性是普遍存在的. 相似文献
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A new flexible, spiral-shaped biliary endoprosthesis is described. This spiral endoprosthesis can negotiate acute angles, can be cut to any length, and has been specifically designed to deal with the problem of stent migration. The authors report their initial experience with this endoprosthesis in 14 patients. 相似文献
47.
KV Sarkissyan IS Aslibekyan BV Shabalkin 《Indian Journal of Thoracic and Cardiovascular Surgery》1989,6(1):55-57
One-hundred and seven patients with unstable angina were treated between 1981 and 1987. Platelet dysfunction and elevation
of fibrinogen was observed. The efficacy of aspirin, dipyridamole and heparin on coagulation profile is compared. Left main
disease was seen in 11.4 per cent. Left anterior descending was occluded in 90.7 per cent. Aortocoronary bypass graft using
saphenous vein graft was carried out on all patients. On an average, each patients received 3.5 grafts. Emergency surgery
was done in nineteen. Associated ventricular aneurysm was resected in nine. Thirteen patients died. Operative mortality decreased
to nil in 1986–1987. Perioperative infarction was seen in five patients.
Clinical improvement was seen in 80.3 per cent and 48.9 per cent were asymptomatic. Actuarial survival was 92 per cent after
six years. Postoperative coronary angiography in 28 patients showed patency of grafts in 18, partial patency in six and occlusion
in four. Aspirin was found useful after surgery to relieve angina. Spiroergometry and Thallium201 scintigraphy was useful to assess medical and surgical treatment. 相似文献
48.
We present the case of a 50-year-old man who underwent kidney biopsy for nephrotic syndrome. In addition to a membranous pattern, anti-glomerular basement membrane (anti-GBM) staining was noted before manifestations of anti-GBM disease. Hematuria and renal failure ensued 2 weeks later. In addition, he had simultaneous circulating levels of anti-GBM antibody and both perinuclear (P-) and cytoplasmic (C-) antineutrophil cytoplasmic antibody (ANCA). 相似文献
49.
Cary B Aarons Skandan Shanmugan Joshua IS Bleier 《World journal of gastroenterology : WJG》2014,20(43):16178-16183
Colon cancer remains a significant clinical problem worldwide and in the United States it is the third most common cancer diagnosed in men and women.It is generally accepted that most malignant neoplasms of the colon arise from precursor adenomatous polyps.This stepwise progression of normal epithelium to carcinoma,often with intervening dysplasia,occurs as a result of multiple sequential,genetic mutations-some are inherited while others are acquired.Malignant polyps are defined by the presence of cancer cells invading through the muscularis mucosa into the underlying submucosa(T1).They can appear benign endoscopically but the presence of malignant invasion histologically poses a difficult and often controversial clinical scenario.Emphasis should be initially focused on the endoscopic assessment of these lesions.Suitable polyps should be resected en-bloc,if possible,to facilitate thorough evaluation by pathology.In these cases,proper attention must be given to the risks of residual cancer in the bowel wall or in the surrounding lymph nodes.If resection is not feasible endoscopically,thenthese patients should be referred for surgical resection.This review will discuss the important prognostic features of malignant polyps that will most profoundly affect this risk profile.Additionally,we will discuss effective strategies for their overall management. 相似文献
50.
A multinational observational investigation of illness perceptions and quality of life among patients with a Fontan circulation
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Christina E. Holbein PhD Nicholas D. Fogleman MS Kevin Hommel PhD Silke Apers PhD Jessica Rassart MSc Philip Moons PhD RN Koen Luyckx PhD Maayke A. Sluman MD Junko Enomoto PhD Bengt Johansson MD PhD Hsiao‐Ling Yang PhD RN Mikael Dellborg MD PhD Raghavan Subramanyan MD Jamie L. Jackson PhD Werner Budts MD PhD Adrienne H. Kovacs PhD Stacey Morrison PsyD Martha Tomlin Cnp Kathy Gosney Mssw Alexandra Soufi MD Katrine Eriksen MSc Corina Thomet MSc Malin Berghammer PhD Luis Alday MD Edward Callus PhD Susan M Fernandes PA‐C Maryanne Caruana MD Samuel Menahem MD Stephen C. Cook MD Gwen R. Rempel PhD RN Kamila White PhD Paul Khairy MD PhD Shelby Kutty MD Gruschen Veldtman MBChB Frcp APPROACH‐IS consortium the International Society for Adult Congenital Heart Disease 《Congenital heart disease》2018,13(3):392-400
Objective: First, to compare QOL and illness perceptions between patients with a Fontan circulation and patients with anatomically simple defects (ie, atrial septal defects [ASD] or ventricular
septal defects [VSD]). Second, to explore illness perceptions as a mediator of the association
between congenital heart disease (CHD) diagnosis and QOL.
Design: Cross-sectional observational study.
Setting: Twenty-four cardiology centers from 15 countries across five continents.
Patients: Four hundred thirty-five adult patients with congenital heart disease (177 Fontan and 258 ASD/VSD) ages 18-83 years.
Outcome Measures: QOL and illness perceptions were assessed by the Satisfaction With Life Scale and the Brief Illness Perceptions Questionnaire, respectively.
Results: Patients with a Fontan circulation reported lower QOL (Wald Z = -3.59, p 5 <.001) and more negative perceptions of their CHD (Wald Z = -7.66, p < .001) compared with patients with ASD/VSD. After controlling for demographics, anxiety, depressive symptoms, and New York Heart Association functional class, path analyses revealed a significant mediation model, αβ = 0.15, p = .002, 95% CI = 0.06-0.25, such that CHD diagnosis was indirectly related to QOL through illness perceptions.
Conclusions: The Fontan sample’s more negative perceptions of CHD were likely a reflection of life with a more complex defect. Illness perceptions appear to account for unique differences in QOL between groups of varying CHD complexity. Psychosocial screening and interventions may be important treatment components for patients with CHD, particularly those with Fontan circulations. 相似文献
Design: Cross-sectional observational study.
Setting: Twenty-four cardiology centers from 15 countries across five continents.
Patients: Four hundred thirty-five adult patients with congenital heart disease (177 Fontan and 258 ASD/VSD) ages 18-83 years.
Outcome Measures: QOL and illness perceptions were assessed by the Satisfaction With Life Scale and the Brief Illness Perceptions Questionnaire, respectively.
Results: Patients with a Fontan circulation reported lower QOL (Wald Z = -3.59, p 5 <.001) and more negative perceptions of their CHD (Wald Z = -7.66, p < .001) compared with patients with ASD/VSD. After controlling for demographics, anxiety, depressive symptoms, and New York Heart Association functional class, path analyses revealed a significant mediation model, αβ = 0.15, p = .002, 95% CI = 0.06-0.25, such that CHD diagnosis was indirectly related to QOL through illness perceptions.
Conclusions: The Fontan sample’s more negative perceptions of CHD were likely a reflection of life with a more complex defect. Illness perceptions appear to account for unique differences in QOL between groups of varying CHD complexity. Psychosocial screening and interventions may be important treatment components for patients with CHD, particularly those with Fontan circulations. 相似文献