全文获取类型
收费全文 | 1998篇 |
免费 | 94篇 |
国内免费 | 76篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 114篇 |
妇产科学 | 20篇 |
基础医学 | 156篇 |
口腔科学 | 22篇 |
临床医学 | 238篇 |
内科学 | 393篇 |
皮肤病学 | 74篇 |
神经病学 | 164篇 |
特种医学 | 326篇 |
外国民族医学 | 1篇 |
外科学 | 233篇 |
综合类 | 35篇 |
预防医学 | 119篇 |
眼科学 | 82篇 |
药学 | 101篇 |
中国医学 | 4篇 |
肿瘤学 | 63篇 |
出版年
2023年 | 7篇 |
2022年 | 6篇 |
2021年 | 17篇 |
2020年 | 15篇 |
2019年 | 19篇 |
2018年 | 29篇 |
2017年 | 31篇 |
2016年 | 23篇 |
2015年 | 27篇 |
2014年 | 30篇 |
2013年 | 39篇 |
2012年 | 74篇 |
2011年 | 76篇 |
2010年 | 57篇 |
2009年 | 86篇 |
2008年 | 62篇 |
2007年 | 105篇 |
2006年 | 62篇 |
2005年 | 66篇 |
2004年 | 41篇 |
2003年 | 57篇 |
2002年 | 45篇 |
2001年 | 50篇 |
2000年 | 70篇 |
1999年 | 35篇 |
1998年 | 92篇 |
1997年 | 77篇 |
1996年 | 62篇 |
1995年 | 62篇 |
1994年 | 54篇 |
1993年 | 49篇 |
1992年 | 51篇 |
1991年 | 44篇 |
1990年 | 48篇 |
1989年 | 59篇 |
1988年 | 63篇 |
1987年 | 51篇 |
1986年 | 53篇 |
1985年 | 59篇 |
1984年 | 29篇 |
1983年 | 22篇 |
1982年 | 19篇 |
1981年 | 12篇 |
1980年 | 14篇 |
1979年 | 13篇 |
1978年 | 13篇 |
1977年 | 22篇 |
1976年 | 15篇 |
1975年 | 17篇 |
1969年 | 6篇 |
排序方式: 共有2168条查询结果,搜索用时 15 毫秒
51.
Corzo D; Yunis JJ; Salazar M; Lieberman JA; Howard A; Awdeh Z; Alper CA; Yunis EJ 《Blood》1995,86(10):3835-3840
Genes of the major histocompatibility complex (MHC) have been associated with susceptibility to drug-induced adverse reactions. We previously found that clozapine-induced agranulocytosis (CA) is associated with the HLA-DRB1*0402, DRB4*0101, DQB1*0302, DQA1*0301 haplotype in Ashkenazi Jewish patients and with the HLA-DRB1*1601, DRB5*02, DQB1*0502, DQA1*0102 haplotype in non-Jewish patients. In the present study, we tested the hypothesis that the variants of the heat- shock protein 70 (HSP-70) encoded by the HSP-70 loci located within the MHC region and known to be involved in apoptosis and regulation of cell proliferation could play an important role in molecular mechanisms of CA. First, we analyzed HSP70-2 polymorphism in risk-associated haplotypes from HLA homozygous cells and normal individuals and confirmed that the HSP70-2 9-kb variant was associated invariably with DR4 (HLA-DRB1*0402, DQB1*0302) and DR2 (HLA-DRB1*01601, DQB1*0502, DQA1*0102 and HLA-DRB1*1501, DQB1*0602) haplotypes, which were the haplotypes found increased in Jewish and non-Jewish patients with CA, respectively. The 9.0-kb variant was also found to be associated with HLA-B44, DRB1*0401 and HLA-B44, DRB1*07 haplotypes. Second, in patients with CA (12 Ashkenazi Jewish and 20 non-Jewish patients), HSP70-1 A and HSP70-2 9.0-kb variants were associated with the MHC haplotypes found by us to be markers of susceptibility to CA. The clozapine-treated control group had an excess number of HSP70-1 C and HSP70-2 8.5-kb variants, consistent with genetic resistance to CA associated with those variants. This finding supports our hypothesis that a dominant gene within the MHC region (marked by HSP70-1 and HSP70-2), but not necessarily HLA, is associated with CA in two different ethnic groups. 相似文献
52.
S Wurtzer V Marechal JM Mouchel Y Maday R Teyssou E Richard JL Almayrac L Moulin 《Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin》2020,25(50)
IntroductionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease (COVID-19). People infected with SARS-CoV-2 may exhibit no or mild non-specific symptoms; thus, they may contribute to silent circulation of the virus among humans. Since SARS-CoV-2 RNA can be detected in stool samples, monitoring SARS-CoV-2 RNA in waste water (WW) has been proposed as a complementary tool to investigate virus circulation in human populations.AimTo test if the quantification of SARS-CoV-2 genomes in WW correlates with the number of symptomatic or non-symptomatic carriers.MethodWe performed a time-course quantitative analysis of SARS-CoV-2 by RT-qPCR in raw WW samples collected from several major WW treatment plants in Greater Paris. The study period was 5 March to 23 April 2020, including the lockdown period in France (from 17 March).ResultsWe showed that the increase of genome units in raw WW accurately followed the increase of human COVID-19 cases observed at the regional level. Of note, the viral genome could be detected before the epidemic grew massively (around 8 March). Equally importantly, a marked decrease in the quantities of genome units was observed concomitantly with the reduction in the number of new COVID-19 cases, 29 days following the lockdown.ConclusionThis work suggests that a quantitative monitoring of SARS-CoV-2 genomes in WW could generate important additional information for improved monitoring of SARS-CoV-2 circulation at local or regional levels and emphasises the role of WW-based epidemiology. 相似文献
53.
54.
Florian Grahammer Nora Haenisch Frederic Steinhardt Lukas Sandner Malte Roerden Frederic Arnold Tomke Cordts Nicola Wanner Wilfried Reichardt Dontscho Kerjaschki Markus A. Ruegg Michael N. Hall Pierre Moulin Hauke Busch Melanie Boerries Gerd Walz Ferruh Artunc Tobias B. Huber 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(27):E2817-E2826
55.
A Mocroft B Neesgard R Zangerle A Rieger A Castagna V Spagnuolo A Antinori FC Lampe M Youle JJ Vehreschild C Mussini V Borghi J Begovac C Duvivier HF Gunthard A Rauch J Tiraboschi N Chkhartishvili N Bolokadze F Wit JC Wasmuth S De Wit C Necsoi C Pradier V Svedhem C Stephan K Petoumenos H Garges F Rogatto L Peters L Ryom 《HIV medicine》2020,21(9):599-606
56.
Vincent JJ Odekerken Teus van Laar Michiel J Staal Arne Mosch Carel FE Hoffmann Peter CG Nijssen Guus N Beute Jeroen PP van Vugt Mathieu WPM Lenders M Fiorella Contarino Marieke SJ Mink Lo J Bour Pepijn van den Munckhof Ben A Schmand Rob J de Haan P Richard Schuurman Rob MA de Bie 《Lancet neurology》2013,12(1):37-44
57.
Mayrand D Laforce-Lavoie A Larochelle S Langlois A Genest H Roy M Moulin VJ 《Angiogenesis》2012,15(2):199-212
During wound healing, angiogenesis plays a crucial role in inducing adequate perfusion of the new tissue, thereby allowing
its survival. This angiogenic process contributes to the formation of granulation tissue, alongside myofibroblasts. Myofibroblasts
are cells specialized in wound contraction and synthesis of new extracellular matrix. Fibroblasts, considered by some to be
at the origin of myofibroblasts, have already been shown to promote neovascularization. Thus, we hypothesized that myofibroblasts
play a key role during angiogenic development in wound healing. We isolated myofibroblasts from normal human skin wounds and
dermal microvascular endothelial cells (HDMVEC) and fibroblasts from skin. Using an in vitro fibrin-based model, we compared
the proangiogenic activity of wound myofibroblasts to that of fibroblasts in the presence of HDMVEC. By immunostaining with
collagen IV antibodies, we observed the formation of a capillary network significantly more developed when HDMVEC were cultured
with myofibroblasts compared to the network formed in the presence of fibroblasts. The differences between these cell types
did not result from a differential secretion of Vascular Endothelial Growth Factor or basic Fibroblast Growth Factor. However,
in the presence of myofibroblasts, a significant decrease in matrix metalloproteinase activity was observed. This finding
was correlated with a significant increase in Tissue Inhibitor of MetalloProteinase (TIMP)-1 and TIMP-3. Furthermore, inhibition
of TIMP-1 secretion using shRNA significantly decreased myofibroblasts induced angiogenesis. These results led to the hypothesis
that normal wound myofibroblasts contribute to the vascular network development during wound healing. Our data emphasize the
critical role of wound myofibroblasts during healing. 相似文献
58.
59.
P. Perrin S. Caillard R. M. Javier L. Braun F. Heibel C. Borni‐Duval C. Muller J. Olagne B. Moulin 《American journal of transplantation》2013,13(10):2653-2663
The risk of fractures after kidney transplantation is high. Hyperparathyroidism frequently persists after successful kidney transplantation and contributes to bone loss, but its impact on fracture has not been demonstrated. This longitudinal study was designed to evaluate hyperparathyroidism and its associations with mineral disorders and fractures in the 5 posttransplant years. We retrospectively analyzed 143 consecutive patients who underwent kidney transplantation between August 2004 and April 2006. The biochemical parameters were determined at transplantation and at 3, 12 and 60 months posttransplantation, and fractures were recorded. The median intact parathyroid hormone (PTH) level was 334 ng/L (interquartile 151–642) at the time of transplantation and 123 ng/L (interquartile 75–224) at 3 months. Thirty fractures occurred in 22 patients. The receiver operating characteristic (ROC) curve analysis for PTH at 3 months (area under the ROC curve = 0.711, p = 0.002) showed that a good threshold for predicting fractures was 130 ng/L (sensitivity = 81%, specificity = 57%). In a multivariable analysis, independent risk factors for fracture were PTH >130 ng/L at 3 months (adjusted hazard ratio [AHR] = 7.5, 95% CI 2.18–25.50), and pretransplant osteopenia (AHR = 2.7, 95% CI 1.07–7.26). In summary, this study demonstrates for the first time that persistent hyperparathyroidism is an independent risk factor for fractures after kidney transplantation. 相似文献
60.