全文获取类型
收费全文 | 2305篇 |
免费 | 109篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 142篇 |
妇产科学 | 34篇 |
基础医学 | 266篇 |
口腔科学 | 75篇 |
临床医学 | 163篇 |
内科学 | 451篇 |
皮肤病学 | 26篇 |
神经病学 | 306篇 |
特种医学 | 172篇 |
外科学 | 303篇 |
综合类 | 39篇 |
预防医学 | 97篇 |
眼科学 | 41篇 |
药学 | 185篇 |
中国医学 | 2篇 |
肿瘤学 | 116篇 |
出版年
2023年 | 8篇 |
2022年 | 25篇 |
2021年 | 56篇 |
2020年 | 25篇 |
2019年 | 53篇 |
2018年 | 47篇 |
2017年 | 31篇 |
2016年 | 33篇 |
2015年 | 34篇 |
2014年 | 39篇 |
2013年 | 63篇 |
2012年 | 96篇 |
2011年 | 125篇 |
2010年 | 66篇 |
2009年 | 79篇 |
2008年 | 107篇 |
2007年 | 118篇 |
2006年 | 115篇 |
2005年 | 103篇 |
2004年 | 76篇 |
2003年 | 80篇 |
2002年 | 80篇 |
2001年 | 80篇 |
2000年 | 87篇 |
1999年 | 75篇 |
1998年 | 51篇 |
1997年 | 56篇 |
1996年 | 40篇 |
1995年 | 37篇 |
1994年 | 35篇 |
1993年 | 25篇 |
1992年 | 37篇 |
1991年 | 34篇 |
1990年 | 39篇 |
1989年 | 56篇 |
1988年 | 46篇 |
1987年 | 46篇 |
1986年 | 31篇 |
1985年 | 26篇 |
1984年 | 18篇 |
1983年 | 20篇 |
1982年 | 11篇 |
1981年 | 14篇 |
1980年 | 11篇 |
1979年 | 8篇 |
1978年 | 8篇 |
1977年 | 8篇 |
1975年 | 6篇 |
1971年 | 6篇 |
1930年 | 6篇 |
排序方式: 共有2430条查询结果,搜索用时 31 毫秒
61.
Gerónimo Fernández Ana Moraga María I. Cuartero Alicia García-Culebras Carolina Peña-Martínez Jesús M. Pradillo Macarena Hernández-Jiménez Silvia Sacristán M. Irene Ayuso Rafael Gonzalo-Gobernado David Fernández-López M. Elena Martín María A. Moro Victor M. González Ignacio Lizasoain 《Molecular therapy》2018,26(8):2047-2059
62.
63.
Induction of clinical and colonoscopic remission of mild–to–moderate ulcerative colitis with budesonide MMX 9 mg: pooled analysis of two phase 3 studies
下载免费PDF全文
![点击此处可从《Alimentary pharmacology & therapeutics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
64.
65.
66.
Left ventricular false tendons (or anomalous bands) have been described in several anatomic studies. Recently the echocardiographic features of such false tendons have been reported also. We have found a prevalence of 36 cases in 1,600 consecutive patients examined (2.2%). False tendons represent a rather common and benign phenomenon. Echocardiography is the most useful tool in the detection of false tendons. 相似文献
67.
J. F. San Miguel M. Gonzáalez A. Gascón Ma J. Moro J. M. Hernáandez F. Ortega R. Jimenez L. Guerras M. Romero F. Casanova M. A. Sanz J. Sáanchez J. A. Portero A. Orfao 《British journal of haematology》1991,77(2):185-190
In 112 untreated myeloma patients we have analysed the immunophenotype of plasma cells both by immunofluorescence (IF) and immunocytochemistry (APAAP). Both techniques yielded similar results pointing to an important degree of heterogeneity in antigenic expression not only between different patients but also within the same patient. The expression of CD38 and Han-PC1 antigens (Ags) was almost constant (greater than 90% positive cases), while CD9 was detected in 66% of the cases. On the other hand, less than one third of patients were positive for CD10, CD20 and HLA-DR and generally with a weak expression (less than 30% positive plasma cells). In occasional cases plasma cells were weakly positive for the myelomonocytic markers CD13 (9%), CD15 (25%) and CD14 (6%). The possibility that this heterogeneity might be the result of different stages of differentiation of the neoplastic clone is suggested both by the positive correlation in the expression of some of these antigens (CD10, CD9, CD20, HLA-DR) and by the relationship between CD10 and myeloid antigens with immature plasma cell morphology. Finally, the cALLA antigen does not seem to be of significant value in predicting survival. Moreover, none of the other markers explored showed a clear influence in the course of the disease, although the tendency towards a lower survival found for the CD20+ cases as well as the association of the expression of some antigens and advanced clinical stage, may warrant further studies in a larger series of patients. 相似文献
68.
Hervé Lefèvre Chantal Stheneur Charlotte Cardin Lola Fourcade Christine Fourmaux Elise Tordjman Marie Touati Flore Voisard Sevan Minassian Pauline Chaste Marie Rose Moro Jonathan Lachal 《Journal of pain and symptom management》2021,61(2):416-422
The coronavirus disease 2019 pandemic presents unprecedented challenges for the health care system. The pressure on health care staff continues to intensify, accentuated by the confinement (lockdown) of the population and the unprecedented duration of this emergency. Separately and especially together, overwork, degraded conditions of care because of the never-ending emergency, and the risk of exposure to the virus can lead to acute psychological distress or signs of burnout.This original program was developed at Cochin Hospital in Paris, France to prevent these potentially dramatic psychological consequences, support the medical staff, and identify those most affected to offer them specific care. A program and a space for relaxation and support for hospital caregivers by hospital caregivers, the Port Royal Bulle (the Bubble) offers these workers help in decompression and relaxation. It combines a warm and caring welcome that promotes attention, listening, conversations, and exchanges as needed, empathetic support, and the ability to participate in soothing, relaxing, or low-impact physical activities. It takes care of caregivers. The Bubble is a program that is simple to set up and that appears to meet professionals' expectations. Making it permanent and enlarging its scale, as a complement to existing programs, might help to support health care personnel in their work. 相似文献
69.
Takao Sudo Yasutaka Motomura Daisuke Okuzaki Tetsuo Hasegawa Takafumi Yokota Junichi Kikuta Tomoka Ao Hiroki Mizuno Takahiro Matsui Daisuke Motooka Ryosuke Yoshizawa Takashi Nagasawa Yuzuru Kanakura Kazuyo Moro Masaru Ishii 《The Journal of experimental medicine》2021,218(5)
The cell-cycle status of hematopoietic stem and progenitor cells (HSPCs) becomes activated following chemotherapy-induced stress, promoting bone marrow (BM) regeneration; however, the underlying molecular mechanism remains elusive. Here we show that BM-resident group 2 innate lymphoid cells (ILC2s) support the recovery of HSPCs from 5-fluorouracil (5-FU)–induced stress by secreting granulocyte-macrophage colony-stimulating factor (GM-CSF). Mechanistically, IL-33 released from chemo-sensitive B cell progenitors activates MyD88-mediated secretion of GM-CSF in ILC2, suggesting the existence of a B cell–ILC2 axis for maintaining hematopoietic homeostasis. GM-CSF knockout mice treated with 5-FU showed severe loss of myeloid lineage cells, causing lethality, which was rescued by transferring BM ILC2s from wild-type mice. Further, the adoptive transfer of ILC2s to 5-FU–treated mice accelerates hematopoietic recovery, while the reduction of ILC2s results in the opposite effect. Thus, ILC2s may function by “sensing” the damaged BM spaces and subsequently support hematopoietic recovery under stress conditions. 相似文献
70.
NA Hanchard DR Murdock PL Magoulas M Bainbridge D Muzny YQ Wu M Wang AL McGuire JR Lupski RA Gibbs CW Brown 《Clinical genetics》2013,83(5):457-461
The advent of whole‐exome next‐generation sequencing (WES) has been pivotal for the molecular characterization of Mendelian disease; however, the clinical applicability of WES has remained relatively unexplored. We describe our exploration of WES as a diagnostic tool in a 3½‐year old female patient with a 2‐year history of episodic muscle weakness and paroxysmal dystonia who presented following a previous extensive but unrevealing diagnostic work‐up. WES was performed on the proband and her two parents. Parental exome data was used to filter potential de novo genomic events in the proband and suspected variants were confirmed using di‐deoxy sequencing. WES revealed a de novo non‐synonymous mutation in exon 21 of the calcium channel gene CACNA1S that has been previously reported in a single patient as a rare cause of atypical hypokalemic periodic paralysis. This was unexpected, as the proband's original differential diagnosis had included hypokalemic periodic paralysis, but clinical and laboratory features were equivocal, and standard clinical molecular testing for hypokalemic periodic paralysis and related disorders was negative. This report highlights the potential diagnostic utility of WES in clinical practice, with implications for the approach to similar diagnostic dilemmas in the future. 相似文献