全文获取类型
收费全文 | 9955篇 |
免费 | 607篇 |
国内免费 | 43篇 |
专业分类
耳鼻咽喉 | 56篇 |
儿科学 | 368篇 |
妇产科学 | 163篇 |
基础医学 | 1461篇 |
口腔科学 | 195篇 |
临床医学 | 690篇 |
内科学 | 2431篇 |
皮肤病学 | 271篇 |
神经病学 | 769篇 |
特种医学 | 375篇 |
外科学 | 1294篇 |
综合类 | 44篇 |
现状与发展 | 1篇 |
一般理论 | 1篇 |
预防医学 | 456篇 |
眼科学 | 186篇 |
药学 | 784篇 |
中国医学 | 35篇 |
肿瘤学 | 1025篇 |
出版年
2023年 | 81篇 |
2022年 | 156篇 |
2021年 | 277篇 |
2020年 | 168篇 |
2019年 | 211篇 |
2018年 | 277篇 |
2017年 | 216篇 |
2016年 | 264篇 |
2015年 | 278篇 |
2014年 | 386篇 |
2013年 | 434篇 |
2012年 | 679篇 |
2011年 | 725篇 |
2010年 | 376篇 |
2009年 | 345篇 |
2008年 | 636篇 |
2007年 | 635篇 |
2006年 | 527篇 |
2005年 | 551篇 |
2004年 | 535篇 |
2003年 | 511篇 |
2002年 | 528篇 |
2001年 | 173篇 |
2000年 | 146篇 |
1999年 | 129篇 |
1998年 | 113篇 |
1997年 | 73篇 |
1996年 | 80篇 |
1995年 | 49篇 |
1994年 | 48篇 |
1993年 | 56篇 |
1992年 | 92篇 |
1991年 | 75篇 |
1990年 | 97篇 |
1989年 | 77篇 |
1988年 | 70篇 |
1987年 | 78篇 |
1986年 | 59篇 |
1985年 | 64篇 |
1984年 | 28篇 |
1983年 | 17篇 |
1981年 | 21篇 |
1979年 | 40篇 |
1978年 | 18篇 |
1977年 | 16篇 |
1976年 | 14篇 |
1975年 | 19篇 |
1974年 | 17篇 |
1973年 | 21篇 |
1971年 | 20篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
82.
83.
Okuda R Kinoshita M Morikawa J Jotoku T Abe M 《Clinical orthopaedics and related research》2002,(396):173-178
The results of a dome-shaped osteotomy of the proximal third of the fifth metatarsal in patients with symptomatic bunionette deformity were reviewed. The series was comprised of eight patients (10 feet; mean age of patients, 21 years). The average followup was 30 months. All patients were free from pain at the fifth metatarsophalangeal joint and were satisfied with the results of this procedure. The mean angle between the longitudinal axes of the fifth metatarsal and the proximal phalanx was 18.9 degrees before surgery and 2.6 degrees after surgery. The mean angle between the longitudinal axes of the fourth and fifth metatarsals was 12.2 degrees before surgery and 4.8 degrees after surgery. The overall results were good in all 10 feet. Three feet had delayed union at the osteotomy site, but union was obtained in all feet. The osteotomy site of the fifth metatarsal in feet with delayed union was more proximal than that of the other feet. Therefore, proximal osteotomy of the fifth metatarsal should be done not at the base, but at the proximal site of the diaphysis to prevent delayed union. A proximal dome-shaped osteotomy corrects the deformity and relieves the symptoms, but careful attention should be paid to the osteotomy site. 相似文献
84.
Hiroya Takeuchi Yoshiro Saikawa Takashi Oyama Soji Ozawa Koichi Suda Norihito Wada Tsunehiro Takahashi Rieko Nakamura Naoyuki Shigematsu Nobutoshi Ando Masaki Kitajima Yuko Kitagawa 《World journal of surgery》2010,34(2):277-284
Background
Salvage esophagectomy is potentially the only treatment available that can offer a chance of long-term survival when definitive chemoradiotherapy (CRT) fails to achieve local control for patients with esophageal squamous cell carcinoma (ESCC). However, salvage esophagectomy is a highly invasive procedure with various postoperative complications compared to planned esophagectomy after neoadjuvant chemoradiotherapy (CRT). We hypothesize that severe postoperative complications may affect not only surgical mortality but also tumor recurrence and long-term survival for patients with salvage esophagectomy after definitive CRT.Methods
For the present study we reviewed the surgical procedures, postoperative complications, and the prognosis of 65 consecutive patients with thoracic ESCC who underwent the esophagectomy after neoadjuvant (neoadjuvant group: n = 40) or definitive (salvage group: n = 25) CRT.Results
Most patients underwent right-transthoracic extended esophagectomy and reconstruction using gastric conduit by way of subcutaneous route with left cervical anastomosis. The incidence of postoperative pneumonia was found to be higher in the salvage group than in the neoadjuvant group. In both groups, the survival of patients with R0 resection was significantly better than those with R1/R2 resection. Moreover, in the salvage group, the postoperative survival rate of patients with pneumonia or bacteremia/sepsis was significantly lower than that for patients who did not suffer the same complications. In the neoadjuvant group, R0 resection was selected to be the only independent prognostic factor in univariate and multivariate analysis. In contrast, in the salvage group, R0 resection and bacteremia/sepsis remained significant and were independent of the other factors in multivariate analysis.Conclusions
This study reveals that postoperative morbidity affects not only the perioperative mortality but also the long-term survival of patients with ESCC who undergo salvage esophagectomy after definitive CRT. 相似文献85.
Acute subdural hematoma (ASDH) is a critical condition following the onset of traumatic brain injury, and it is essential to immediately reduce elevated intracranial pressure (ICP). Single burr hole surgery/twist drill craniostomy is commonly performed in patients with ASDH as an emergency surgical intervention, usually preceding decompressive craniotomy. A novel method using a cerebrospinal fluid (CSF) drainage catheter kit for rapid drainage of ASDH is described. Percutaneous twist drill craniostomy using a CAMINO(?) micro ventricular bolt pressure-temperature monitoring kit was performed in the emergency room in 12 patients with severe ASDH. The kit contained a closed-system CSF drainage and pressure-temperature monitoring catheter, which allowed aspiration of the hematoma and monitoring of the ICP. The tip of the catheter was inserted into the hematoma from the forehead. The mean initial ICP was 61 mmHg, with a range of 31 to 120 mmHg. The liquid hematoma was aspirated, and the ICP was temporarily controlled to the normal range. Pupil dilation recovered immediately after aspiration of the hematoma in 3 patients. No complications occurred either during or after the operation. This new method for craniostomy is easy, safe, and effective to monitor and rapidly control ICP in the emergency room. This technique also offers the possibility of evaluating the patient's prognosis and determining indications for further decompressive craniectomy by the continuation of ICP control under ICP monitoring and evaluation of the reversibility of pupillary findings in ASDH patients. 相似文献
86.
Isolated granulomatous inflammation of the appendix is extremely rare, and its etiology is still unknown. Thus, differentiating
between idiopathic granulomatous appendicitis and isolated appendiceal Crohn's disease is difficult. We report a case of idiopathic
granulomatous appendicitis with long-term follow-up after surgery. A 26-year-old woman was referred to our hospital for investigation
of persistent right lower abdominal pain. Abdominal computed tomography showed a mass, suggesting an inflammatory tumor around
the appendix; thus, we suspected subacute appendicitis and performed laparoscopically assisted ileocecal resection. Histological
examination of the resected specimen revealed several noncaseous epithelioid granulomas in the wall of the appendix, but no
foreign bodies, obstructing lesions, or parasites. Stains for acid-fast bacillus and fungi, and serology for yersinia were
all negative. The patient has been followed up for 9 years and remains asymptomatic. This clinical course suggests that her
isolated granulomatous appendicitis was idiopathic granulomatous appendicitis unrelated to Crohn's disease. 相似文献
87.
Hybrid repair of thoracoabdominal aortic aneurysm in high-risk patients using a quadrifurcated graft
Hirai H Sasaki Y Hosono M Sakaguchi M Nagashima F Nakahira A Seo H Morisaki A Okada Y Suehiro S 《Kyobu geka. The Japanese journal of thoracic surgery》2011,64(1):51-55
Surgical treatment for thoracoabdominal aortic aneurysm is still challenging and is associated with a high risk of paraplegia. Hybrid repair with stent graft insertion for the thoracoabdominal aorta excluding the branches of the lumbar and visceral arteries and bypass grafting to the visceral branches has been introduced as a less invasive treatment that reduces the risk of paraplegia. For hybrid repair, it is important to have appropriate management of the revascularized grafts to the 4 visceral arteries with sufficient inflow. We have recently adopted a knitted quadrifurcated graft applied inversely from the abdominal aorta or the iliac artery to the 4 visceral arteries; the celiac, superior mesenteric, and bilateral renal arteries. To date, we have used the graft in hybrid repair of thoracoabdominal aortic aneurysm in 2 high-risk elder patients who had disseminated intravascular coagulopathy and severe renal failure, respectively. We found that a knitted quadrifurcated graft was easy to handle and useful for reducing the number of anastomoses, which were expected to shorten the operation time. Postoperative courses were uneventful without paraplegia in either patient. Postoperative computed tomography showed excellent patency of the inversely applied quadrifurcated graft without any endoleak or migration in the thoracoabdominal stent. In conclusion, revascularization of 4 visceral arteries using a quadrifurcated graft should be considered a preferable option in hybrid treatment for thoracoabdominal aortic aneurysm. 相似文献
88.
Suga N Miura N Uemura Y Nakamura T Morita H Banno S Imai H 《Clinical and experimental nephrology》2011,15(6):970-975
We report an unusual pathological finding, a large-sized bubbling appearance of the glomerular basement membrane (GBM), in
a patient with pulmonary limited AL amyloidosis and a past history of lupus nephritis. The first renal biopsy specimen from
10 years ago, when systemic lupus erythematosus was diagnosed, demonstrated mild mesangial proliferation and subepithelial
deposits (WHO classification: III + V). Light microscopy of the current biopsy using periodic acid methenamine silver (PAMS)
stain demonstrated a large-sized bubbling appearance of the GBM; however, very weak immunoglobulin and complement deposition
was observed in immunofluorescence studies. Routine electron microscopy demonstrated partial subendothelial expansion with
electron-lucent materials, but no electron-dense deposits or amyloid fibrils. Electron microscopy with PAMS stain revealed
electron-lucent endothelial scalloping, including some cellular components and microspheres in the GBM; however, it is not
clear if these materials are derived from endothelial cells. One possibility is that these unique findings represent a recovery
phase of lupus membranous nephritis; another is that these findings correspond to a new disease entity. 相似文献
89.
Suda K Takeuchi H Seki H Yoshizu A Yasui N Matsumoto H Shimada A Ishikawa H Kitagawa Y 《Surgery today》2011,41(9):1238-1242
Primary cricopharyngeal dysfunction (PCD) is a rare idiopathic disorder of the upper esophageal sphincter (UES), characterized
by oropharyngeal dysphagia, frequent aspiration, and narrowing at the level of the UES. Cricopharyngeal myotomy (CPM) has
been used to treat oropharyngeal dysphagia of different causes including anatomic, neuromuscular, iatrogenic, inflammatory,
neoplastic, and idiopathic; however, the indications for CPM and predictors of its outcome are not clearly defined. We report
a case of PCD with hypertonic UES caused by a structural abnormality localized in the cricopharyngeus muscle, visualized as
a cricopharyngeal bar, which we treated successfully by CPM, achieving long-term relief. 相似文献
90.
Hashimoto Y Gotanda Y Ito T Ushijima K 《Masui. The Japanese journal of anesthesiology》2011,60(8):968-971
Motor evoked potential (MEP) monitoring has been employed to detect the spinal cord injury during spinal, neurosurgical and cardiovascular operations. Muscle relaxants diminish the amplitude of MEP because MEP is the picture of electromyogram. In 5 cases undergoing MEP monitoring, we examined the effect of rocuronium followed by the administration of sugammadex on MEP Anesthesia was induced with propofol (target controlled infusion 3.0-3.5 microg x ml(-1)) and remifentanil 0.15-0.3 microg x kg(-1) x min(-1), and the trachea was intubated with the use of rocuronium 0.6 mg x kg(-1) without any muscle rigidity, bucking and laryngospasm. General anesthesia was maintained by total intravenous anesthesia using propofol and remifentanil with no muscle relaxants. Immediately after the tracheal intubation, sugammadex 4 mg x kg(-1) was intravenously given. The amplitude of MEP was measured just before the administration of rocuronium, immediately after the tracheal intubation, and 1, 2, 3, 5 min following the administration of sugammadex. Sugammadex restored the MEP amplitude, deteriorated by rocuronium, in 3 to 5 min to the level of non-paralytic muscles. In one case, it took 8 min to restore the MEP of hemiparetic leg. Taking these findings into consideration, it is likely that rocuronium might not affect the MEP when reversed by sugammadex, and should be safe for smooth tracheal intubation in patients who need MEP monitoring. 相似文献