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81.
Roland O Swai Geofrey R Somi G Mecky IN Matee Japhet Killewo Eligius F Lyamuya Gideon Kwesigabo Tuhuma Tulli Titus K Kabalimu Lucy Ng'ang'a Raphael Isingo Joel Ndayongeje 《BMC public health》2006,6(1):1-10
Background
SPARCLE is a nine-centre European epidemiological research study examining the relationship of participation and quality of life to impairment and environment (physical, social and attitudinal) in 8–12 year old children with cerebral palsy. Concepts are adopted from the International Classification of Functioning, Disability and Health which bridges the medical and social models of disability.Methods/Design
A cross sectional study of children with cerebral palsy sampled from total population databases in 9 European regions. Children were visited by research associates in each country who had been trained together. The main instruments used were KIDSCREEN, Life-H, Strength and Difficulties Questionnaire, Parenting Stress Index. A measure of environment was developed within the study. All instruments were translated according to international guidelines. The potential for bias due to non response and missing data will be examined. After initial analysis using multivariate regression of how the data captured by each instrument relate to impairment and socio-economic characteristics, relationships between the latent traits captured by the instruments will then be analysed using structural equation modelling.Discussion
This study is original in its methods by directly engaging children themselves, ensuring those with learning or communication difficulty are not excluded, and by studying in quantitative terms the crucial outcomes of participation and quality of life. Specification and publication of this protocol prior to analysis, which is not common in epidemiology but well established for randomised controlled trials and systematic reviews, should avoid the pitfalls of data dredging and post hoc analyses. 相似文献82.
A. IIN DOAN EKICI T. KÜÇÜKALI† M. COKUN SALMAN‡ & A. AYHAN‡ 《International journal of gynecological cancer》2006,16(5):1947-1950
The occurrence of double simultaneous primary cancers is common. However, the occurrence of synchronous primary triple gynecological malignancies is an extremely rare event. In this report, the clinical and pathologic findings of a 56-year-old female patient with synchronous triple primary gynecological cancers including well-differentiated ovarian mucinous cystadenocarcinoma, well-differentiated endometrial endometrioid adenocarcinoma, and uterine leiomyosarcoma were presented. Synchronous primary, well-differentiated endometrial endometrioid adenocarcinoma and leiomyosarcoma of uterus without any ovarian neoplasm has only been once described in the English literature. To our knowledge, the presented patient is the first case in aspect of accompanying ovarian mucinous adenocarcinoma to endometrial endometrioid adenocarcinoma and leiomyosarcoma of uterus. 相似文献
83.
风湿热是一种全身性炎症性疾病,其也可引起多系统器官的血管炎。结论:有风湿性二尖瓣病变及接受二尖瓣置换的患儿因冠脉系统血管炎而发生了心肌缺血,其中1例有神经系统表现,可能是由于脑部的血管炎引起的。儿童的风湿性心脏病和冠脉系统血管炎@Gunal N.$Department of Paediatr 相似文献
84.
目的:调查女性青少年中潜在的可改变因素如安全套使用、性行为和并发的性传播性疾病与生殖器人乳头状瘤病毒(H PV)感染持续时间的关系。设计:纵向观察研究。机构:在印第安纳州的印第安纳波利斯的3所诊所进行的研究。入选者:49名H PV阳性青少年对H PV感染进行经常性测试并提供性行为日记。主要调查内容:安全套使用情况、性行为、性伴侣人数和伴发的淋病奈瑟菌、沙眼衣原体和阴道毛滴虫感染。主要观察指标:对特定类型H PV感染从发生到清除的时间应用比例风险模型进行分析,应用校正后的危险比(AH Rs)来评价危险因素对H PV感染时程的影… 相似文献
85.
Martin EA; Heydon RT; Brown K; Brown JE; Lim CK; White IN; Smith LL 《Carcinogenesis》1998,19(6):1061-1069
A novel HPLC system has been developed that has allowed the separation of
tamoxifen DNA adducts formed in the livers of rats and mice treated with
this drug. At least 13 different peaks have been separated from
32P-post-labelled DNA, with two major peaks jointly accounting for >60%
of the total adducts formed by tamoxifen in the livers of treated rats and
mice. This is a great improvement on the resolution obtained by thin layer
chromatography, which separates the adducts into one main product
consisting of a group of major adduct spots eluting together, plus several
other minor spots. Identification of the nature of some of the peaks has
been investigated. Comparisons of the products formed when
alpha-acetoxytamoxifen is reacted with DNA in vitro with 32P-post- labelled
liver DNA adducts from rats treated with tamoxifen or alpha-
hydroxytamoxifen in vivo, appear to confirm that a major route of
activation of tamoxifen in vivo is via alpha-hydroxylation. The resolving
power of this HPLC system has further extended this result to show that six
of the peaks, including the two major peaks, are formed by the reaction of
an activated alpha-hydroxytamoxifen with DNA. Activation of
4-hydroxytamoxifen by the peroxidase/H2O2 system in vitro gives a more
polar DNA adduct seen only at trace levels in liver DNA from
tamoxifen-treated rats and mice.
相似文献
86.
Psychopathology and psychosocial causes in adult deliberate self-poisoning in Plovdiv region, Bulgaria 总被引:1,自引:0,他引:1
INTRODUCTION: The percentage of deliberate self-poisoning among acute intoxications continues to be high in the medical practice worldwide; in Plovdiv region it reaches 64% of all acute poisoning cases. MATERIAL AND METHODS: A representative retrospective study of 311 acute deliberate self-poisoning cases over 14 years of age, treated in the Regional toxicological center of Plovdiv region between 01.01.1990 and 31.12.1998 was carried out. The following factors were studied: gender, age, type of poisoning, psychiatric diagnosis and psychosocial stressors. The classification criteria of Diagnostic and Statistical Manual--4th edition (DSM-IV) of the American Psychiatric Association were applied. RESULTS: We identified a first attempt of deliberate self-poisoning in 237 patients (71.6%) and a second consecutive attempt in 62 patients (18.7%). Thirty two (9.7%) of the attempts were committed in a state of alcohol intoxication. The percentage of women was statistically significantly higher. The age group of 14-19 years represented the highest percentage (27%). In 168 patients (50.8%) a psychiatric disorder was diagnosed. Adjustment disorder (53.57%) and depressive and schizophrenic disorders (26.79%) were the leading diagnoses among adults committing deliberate self-poisoning. The problems with primary support group (in 61.8% as a single stressor and in 13.71% in combination with other stressors) were the most common psychosocial factors for deliberate self-poisoning. CONCLUSIONS: To reduce the number of adult deliberate self-poisonings, measures including harmonization of the relationships in the primary support group and active treatment of patients with depressive and schizophrenic disorders are needed. 相似文献
87.
目的:通过检测湖北地区极重度感音神经性聋患儿常见耳聋基因突变情况,分析该人群的分子病因学特点,为临床耳聋防治和遗传咨询提供参考。方法:收集306例湖北地区极重度感音神经性聋患儿,抽取外周血,提取DNA,应用遗传性耳聋基因芯片检测GJB2、GJB3、SLC26A4和线粒体12SrRNA4个基因的9个突变热点。对所有携带SLC26A4基因突变患者进行颞骨CT扫描。结果:306名患儿中,132例(43.14%)检出携带不同基因突变,其中有2例携带双基因突变。GJB2基因突变检出率为29.41%(90/306),SLC26A4基因突变检出率为13.72%(42/306),线粒体12SrRNA基因突变检出率为O.65%(2/306)。本组患者未检出GJB3基因突变。36例携带SLC26A4基因突变者颞骨CT扫描显示前庭水管扩大。结论:GJB2基因和SLC26A4基因是本组患儿最主要的致聋基因,其中235delC突变为最常见的突变位点,其次为1VS7—2A〉G突变。筛查SLC26A4基因常见突变有助于大前庭水管综合征的诊断。 相似文献
88.
目的 观察超声引导下微波凝固治疗肝癌前后患者免疫指标的动态变化。方法 分别于微波治疗前1周及治疗后1、2、3、4周采集患者外周静脉血,用Cr51释放法检测自然杀伤细胞活性,放射免疫法测定白细胞介素-2水平,酶联免疫法测定可溶性白介素2受体水平。结果 肝癌患者存在严重免疫功能低下,与正常人比NK细胞活性与IL-2水平下降;SIL-2R水平上升,均有统计学意义(P<0.01)。微波凝固治疗肝癌后,NK细胞活性明显上升(P<0.05),SIL-2R水平明显降低(P<0.01)。结论 微波热疗后机体免疫功能增强,提高了抗肿瘤能力。 相似文献
89.
Soohyeon Cho Lina Gu Ik Joon IN Bo Wu Taehoon Lee Hakwon Kim Sangho Koo 《RSC advances》2021,11(50):31511
One-pot conversion of sustainable d-ribose with l-amino acid, methyl esters produced pyrrole-2-carbaldehydes 5 in reasonable yields (32–63%) under pressurized conditions of 2.5 atm at 80 °C. The value-added pyrraline compounds 5 as platform chemicals were utilized for quick installation of poly-heterocyclic cores for the development of pyrrole-motif natural and artificial therapeutic agents. A pyrrole-fused piperazin-2-one scaffold 6 was prepared by reductive amination of pyrralines 5 with benzylamine. While further cyclization of pyrralines 5 with ethane-1,2-diamine produced pyrrolo-piperazin-2-ones 7 with an extra imidazolidine ring, the reaction with 2-amino alcohols derived from natural l-amino acids, alanine, valine, and phenylalanine, respectively provided pyrrolo-piperazin-2-ones 8, 9, and 10 with oxazolidine as the third structural core. Cell viability and an anti-inflammatory effect of the synthesized compounds were briefly tested by the MTT method and the Griess assay, among which 8h and 10g exhibited significant anti-inflammatory effects with negligible cell toxicity.One-pot conversion of sustainable d-ribose with l-amino acid, methyl esters produced pyrrole-2-carbaldehydes 5 in reasonable yields (32–63%) under pressurized conditions of 2.5 atm at 80 °C. 相似文献
90.
Neutrophil chemotaxis in acutely infected and clinically stable cystic fibrosis patients* 总被引:1,自引:0,他引:1
BURÇIN ener Gülen Hasçelik Uur Özçelk AYFER Günalp & AYHAN Göçmen 《Pediatrics international》1999,41(5):514-518
Abstract Purpose : The aim of the present study was to evaluate the role of neutrophil chemotaxis in cystic fibrosis (CF) and to also determine whether an acute bacterial infection and the nutritional status of a child can affect neutrophil chemotaxis.
Methods : Twelve acutely infected and 12 clinically stable CF patients and 10 healthy age-matched controls were studied. Neutrophil chemotaxis and random migration were investigated in vitro in the peripheral blood of subjects by the Boyden chamber method and the results were expressed as chemotactic index (CI). The nutritional status of the cases was evaluated as body mass index (BMI).
Results : The CI values in the acutely infected group were found to be significantly lower than the clinically stable and healthy control groups ( P <0.05 and P <0.005, respectively). There was no significant difference between the clinically stable CF group and the healthy control group ( P >0.1). No significant correlation was detected between the CI and BMI of the two groups of CF patients ( P >0.05).
Conclusions : The present study confirms that neutrophil chemotaxis and random migration are normal in clinically stable CF patients. The decreased CI in the acutely infected patients indicates the possible role of infection itself on neutrophil chemotaxis. 相似文献
Methods : Twelve acutely infected and 12 clinically stable CF patients and 10 healthy age-matched controls were studied. Neutrophil chemotaxis and random migration were investigated in vitro in the peripheral blood of subjects by the Boyden chamber method and the results were expressed as chemotactic index (CI). The nutritional status of the cases was evaluated as body mass index (BMI).
Results : The CI values in the acutely infected group were found to be significantly lower than the clinically stable and healthy control groups ( P <0.05 and P <0.005, respectively). There was no significant difference between the clinically stable CF group and the healthy control group ( P >0.1). No significant correlation was detected between the CI and BMI of the two groups of CF patients ( P >0.05).
Conclusions : The present study confirms that neutrophil chemotaxis and random migration are normal in clinically stable CF patients. The decreased CI in the acutely infected patients indicates the possible role of infection itself on neutrophil chemotaxis. 相似文献