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131.
Prognostic value of chromogranin A in chronic heart failure: data from the GISSI‐Heart Failure trial
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134.
Johanna Galaski Christina Weiler-Normann Miriam Schakat Kalliopi Zachou Paolo Muratori Sibylle Lampalzer Friedrich Haag Christoph Schramm Marco Lenzi George N. Dalekos Ansgar W. Lohse 《Journal of hepatology》2021,74(2):312-320
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135.
Lifespan extension of Drosophila melanogaster through hormesis by repeated mild heat stress 总被引:3,自引:0,他引:3
We assessed the impact of repeated episodes of a mild heat stress on lifespan, fecundity, heat stress resistance and Hsp70
expression in Drosophila melanogaster. There was a significant increase in lifespan of females repeatedly exposed to a mild heat stress when measured in both a
pair and a group situation. There was no effect on fecundity when the flies were first exposed to the mild heat stress at
an age later than 3 days old, but when it did occur on day 3, there was a significant effect on cumulative fecundity levels
over 18 days. The negative fitness effect appears to be the result of a direct cessation or reduction of oviposition during
the first bout of stress exposure, and is influenced by the age at which this first exposure occurs. The mild heat stress
had no impacton egg viability. The mild heat stress exposures increased resistance to potentially lethal heat stress and levels
of Hsp70 expression in heat-exposed flies were higher than those in controls.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
136.
Dallago CM Abech DD Pereira-Lima JF Leães CG Batista RL Trarbach EB Oliveira Mda C 《Pituitary》2008,11(1):109-112
Kallmann syndrome (KS) is a developmental disease characterized by the association of isolated hypogonadotropic hypogonadism
and anosmia/hyposmia. We report an unusual presentation of two females with KS and empty sella. These females, aged at 20
and 29-year-old, presented primary amenorrhea with prepubertal estradiol and low gonadotropin levels. No other significant
clinical signs were observed. Empty sella was observed on MRI in both cases. Sequencing of FGFR1 gene, recently implicated in autosomal form of KS, was performed and one splicing mutation (IVS14 + 1G > A) was identified
in one patient. 相似文献
137.
Attainment of local drug delivery with paclitaxel-eluting balloon in porcine coronary arteries 总被引:1,自引:0,他引:1
Posa A Hemetsberger R Petnehazy O Petrasi Z Testor M Glogar D Gyöngyösi M 《Coronary artery disease》2008,19(4):243-247
OBJECTIVE: Our purpose was to confirm the local drug delivery of a paclitaxel-eluting balloon by percutaneous intervention of single arterial segments or bifurcations of porcine coronary arteries. METHODS: Eight domestic pigs were subjected to 2 x 30 s Dior balloon dilatation of the mid left anterior descending, left circumflex and proximal right coronary arteries. Bifurcation intervention was performed in six arteries. The dilated, and the distal and proximal reference segments were prepared for tissue paclitaxel concentration measurement. Tissue samples were harvested at mean 1.5, 12, 24 and 48 h after balloon dilatation and plasma samples were taken at various time points. RESULTS: The tissue paclitaxel concentration of the single dilated segment was at 1.5 h postdilatation 1.82+/-1.60 micromol/l, which decreased significantly to 0.73+/-0.27 (P=0.032), 0.62+/-0.34 and 0.44+/-0.31 micromol/l at 12, 24 and 48 h. The bifurcation intervention resulted in 5.10+/-1.80 micromol/l tissue paclitaxel amount in the main branch, which at 12 h had diminished to 1.41+/-1.23 micromol/l (P=0.004). The bifurcation side contained 7.00+/-4.80 micromol/l paclitaxel at 1.5 h postdilatation, which lowered to 2.72+/-0.40 micromol/l (P=0.034). The mean paclitaxel concentration of the reference segments decreased gradually from 0.84+/-0.99 to 0.34+/-0.36 micromol/l (P=0.09), 0.28+/-0.16 and 0.19+/-0.18 micromol/l tissue at 1.5, 12, 24 and 48 h postdilatation, respectively. No paclitaxel was found in the peripheral blood at any time point. CONCLUSION: Short exposure of the coronary artery to paclitaxel with a coated balloon is sufficient for the attainment of an adequate tissue concentration of paclitaxel, which is known to be efficient in inhibiting neointimal growth. 相似文献
138.
Pietrzyk M Krüger B Banas B Schlitt HJ Krämer BK 《Lancet》2004,363(9410):737; author reply 737-737; author reply 738
139.
140.
Global profiling of Shewanella oneidensis MR-1: expression of hypothetical genes and improved functional annotations 总被引:1,自引:0,他引:1
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Kolker E Picone AF Galperin MY Romine MF Higdon R Makarova KS Kolker N Anderson GA Qiu X Auberry KJ Babnigg G Beliaev AS Edlefsen P Elias DA Gorby YA Holzman T Klappenbach JA Konstantinidis KT Land ML Lipton MS McCue LA Monroe M Pasa-Tolic L Pinchuk G Purvine S Serres MH Tsapin S Zakrajsek BA Zhu W Zhou J Larimer FW Lawrence CE Riley M Collart FR Yates JR Smith RD Giometti CS Nealson KH Fredrickson JK Tiedje JM 《Proceedings of the National Academy of Sciences of the United States of America》2005,102(6):2099-2104