全文获取类型
收费全文 | 387篇 |
免费 | 19篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 3篇 |
妇产科学 | 7篇 |
基础医学 | 34篇 |
口腔科学 | 3篇 |
临床医学 | 18篇 |
内科学 | 54篇 |
皮肤病学 | 6篇 |
神经病学 | 11篇 |
特种医学 | 4篇 |
外科学 | 31篇 |
预防医学 | 104篇 |
药学 | 72篇 |
中国医学 | 5篇 |
肿瘤学 | 58篇 |
出版年
2023年 | 4篇 |
2022年 | 19篇 |
2021年 | 18篇 |
2020年 | 9篇 |
2019年 | 13篇 |
2018年 | 12篇 |
2017年 | 8篇 |
2016年 | 24篇 |
2015年 | 16篇 |
2014年 | 15篇 |
2013年 | 22篇 |
2012年 | 29篇 |
2011年 | 41篇 |
2010年 | 21篇 |
2009年 | 13篇 |
2008年 | 21篇 |
2007年 | 16篇 |
2006年 | 19篇 |
2005年 | 15篇 |
2004年 | 19篇 |
2003年 | 14篇 |
2002年 | 13篇 |
2001年 | 4篇 |
2000年 | 5篇 |
1999年 | 3篇 |
1998年 | 3篇 |
1997年 | 3篇 |
1996年 | 4篇 |
1995年 | 3篇 |
1994年 | 3篇 |
1992年 | 2篇 |
1987年 | 1篇 |
1982年 | 2篇 |
1981年 | 1篇 |
排序方式: 共有415条查询结果,搜索用时 15 毫秒
81.
Heinz Freisling Pedro T. Pisa Pietro Ferrari Graham Byrnes Aurelie Moskal Christina C. Dahm Anne-Claire Vergnaud Marie-Christine Boutron-Ruault Guy Fagherazzi Claire Cadeau Tilman Kühn Jasmine Neamat-Allah Brian Buijsse Heiner Boeing Jytte Halkjær Anne Tjonneland Camilla P. Hansen J. Ramón Quirós Noémie Travier Esther Molina-Montes Pilar Amiano José M. Huerta Aurelio Barricarte Kay-Tee Khaw Nicholas Wareham Tim J. Key Dora Romaguera Yunxia Lu Camille M. Lassale Androniki Naska Philippos Orfanos Antonia Trichopoulou Giovanna Masala Valeria Pala Franco Berrino Rosario Tumino Fulvio Ricceri Maria Santucci de Magistris H. Bas Bueno-de-Mesquita Marga C. Ocké Emily Sonestedt Ulrika Ericson Mattias Johansson Guri Skeie Elisabete Weiderpass Tonje Braaten Petra H. M. Peeters Nadia Slimani 《European journal of nutrition》2016,55(6):2093-2104
82.
83.
Byung Ock Choi Ihl Bohng Choi Hong Seok Jang Young Nam Kang Ji Sun Jang Si Hyun Bae Seung Kew Yoon Gyu Young Chai Ki Mun Kang 《BMC cancer》2008,8(1):351
Background
The objectives of this retrospective study was to evaluate the efficacy of stereotactic body radiation therapy (SBRT) for small non-resectable hepatocellular carcinoma (HCC) and SBRT combined with transarterial chemoembolization (TACE) for advanced HCC with portal vein tumor thrombosis (PVTT). 相似文献84.
85.
An Introduction to a Head and Neck Cancer‐Specific Frailty Index and Its Clinical Implications in Elderly Patients: A Prospective Observational Study Focusing on Respiratory and Swallowing Functions
下载免费PDF全文
![点击此处可从《The oncologist》网站下载免费的PDF全文](/ch/ext_images/free.gif)
86.
Jun Yup Kim Jihoon Kang Beom Joon Kim Seong-Eun Kim Do Yeon Kim Keon-Joo Lee Hong-Kyun Park Yong-Jin Cho Jong-Moo Park Kyung Bok Lee Jae-Kwan Cha Ji Sung Lee Juneyoung Lee Ki Hwa Yang Ock Ran Hong Ji Hyeon Shin Jung Hyun Park Philip B. Gorelick Hee-Joon Bae 《Journal of Korean medical science》2022,37(36)
BackgroundThe association between endovascular treatment (EVT) case volume per hospital and clinical outcomes has been reported, but the exact volume threshold has not been determined. This study aimed to examine the case volume threshold in this context.MethodsNational audit data on the quality of acute stroke care in patients admitted via emergency department, within 7 days of onset, in hospitals that treated ≥ 10 stroke cases during the audit period were analyzed. Ischemic stroke cases treated with EVT during the last three audits (2013, 2014, and 2016) were selected for the analysis. Annual EVT case volume per hospital was estimated and analyzed as a continuous and a categorical variable (in quartiles). The primary outcome measure was 1-year mortality as a surrogate of 3-month functional outcome. As post-hoc sensitivity analysis, replication of the study results was examined using the 2018 audit data.ResultsWe analyzed 1,746 ischemic stroke cases treated with EVT in 120 acute care hospitals. The median annual EVT case volume was 12.0 cases per hospital, and mortality rates at 1 month, 3 months, and 1 year were 12.7%, 16.6%, and 23.3%, respectively. Q3 and Q4 had 33% lower odds of 1-year mortality than Q1. Adjustments were made for predetermined confounders. Annual EVT case volume cut-off value for 1-year mortality was 15 cases per year (P < 0.02). The same cut-off value was replicated in the sensitivity analysis.ConclusionAnnual EVT case volume was associated with 1-year mortality. The volume threshold per hospital was 15 cases per year. 相似文献
87.
88.
Areum Jo Dasom Jeong Hye Hyeon Eum Nayoung Kim Minsu Na Huiram Kang Hae-Ock Lee 《International journal of cancer. Journal international du cancer》2023,152(9):1964-1976
Immune checkpoint inhibitors (ICIs) induce activation and expansion of cytotoxic T cells. To depict a comprehensive immune cell landscape reshaped by the CTLA-4 checkpoint inhibitor, we performed single-cell RNA sequencing in a mouse syngeneic tumor transplant model. After CTLA-4 inhibition, tumor regression was accompanied by massive immune cell expansion, especially in T and B cells. We found that B cells in tumor transplant represented follicular, germinal center and plasma B cells, some of which shared identical B cell receptor clonotypes and possessed tumor reactivity. Furthermore, the posttreatment tumor contained a tertiary lymphoid-like structure with intermingled T and B cells. These data suggest germinal center formation within the tumor mass and in situ differentiation of tumor-specific plasma cells. Taken together, our data provide a panoramic view of the immune microenvironment after CTLA-4 inhibition and suggest a role for tumor-specific B cells in antitumor immunity. 相似文献
89.
90.
Sang Un Choi Nam Young Kim Eun Jung Choi Kwang Hee Kim Chong Ock Lee 《Archives of pharmacal research》1996,19(5):342-347
Doxorubicin, one of the clinically most useful anticancer agents, is used alone or in combination with other drugs against a wide variety of tumors, recently. But cancer cells developed resistance to this agent in many ways. This resistance is an important limiting factor of doxorubicin for anticancer drug. We newly established doxorubicin-resistant HCT15/CL02 subline from parental HCT15 human adenocarcinoma colon cancer cells. HCT15/CL02 revealed resistance to doxorubicin about 85-fold of its parental cells, and it also revealed cross-vealed to actinomycin D, etoposide and vinblastine but not to cisplatin and tamoxifen. And verapamil, a reversal agent of multidrug-resistance (MDR) by P-glycoprotein, elevated the cytotoxicity of doxorubicin against both HCT15 and HCT15/CL02 cells. But the relative resistant rate was not reduced. Verapamil had no effects on the toxicity of cisplatin to the both cell lines. These results indicate that HCT15/CL02 cells have some functionally complex mechanisms for MDR. 相似文献