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61.
Noralane M. Lindor William A. Smithson Carlos A. Ahumada Virginia V. Michels John M. Opitz 《American journal of medical genetics. Part A》1995,56(1):10-11
We report on two father-son pairs with isolated nonsyndromal asplenia. This may represent autosomal dominant inheritance of a mutation in a gene involved with spleen development and determination of laterality. The incidence of hereditary isolated asplenia is unknown; therefore, screening for asplenia in first degree relatives of individuals with (poly)asplenia should be considered. © 1995 Wiley-Liss, Inc. 相似文献
62.
Jose Lopez-Sendon Peter Mills Heinz Weber Rolf Michels Carlo Di Mario Gerasimos S Filippatos Magda Heras Kevin Fox Jose Merino D J Pennell Heinz Sochor Joanna Ortoli Andras Szatmari Fausto Pinto Jan Peder Amlie Ali Oto Mitja Lainscak Kim Fox Peter Kearney Lino Gon?alves Heikki Huikuri Celine Carrera 《European heart journal》2007,28(17):2163-2171
63.
Manger B Michels H Nüsslein HG Schneider M Sieper J;Kommission Pharmakotherapie der DGRh 《Zeitschrift für Rheumatologie》2007,66(1):72-75
Zusammenfassung Entzündlich-rheumatische Erkrankungen sind mit eine Vielzahl von Schmerzen und Einschränkungen verbunden. Die zu ihrer Behandlung eingesetzten so genannten Basistherapeutika sind bei vielen Patienten nicht ausreichend wirksam oder werden wegen Nebenwirkungen abgesetzt.Hier liegt das Einsatzgebiet von Tumornekrosefaktor- (TNF-) Blockern. Sie führen in vielen Fällen zu einer deutlichen Besserung der Krankheitssymptome, einem Abfall der labormedizinischen Parameter der Krankheitsaktivität, zur Verbesserung der Lebensqualität bis hin zum Stillstand der Destruktionen bei raschem Wirkungseintritt. Häufigkeit und Schwere der Nebenwirkungen sind eher gering, allerdings gibt es noch wenige Daten zum Langezeitverlauf.Der folgende Beitrag gibt Empfehlungen, unter welchen Voraussetzungen bei welchem Krankheitsbild der Einsatz von TNF-Blockern erfolgen kann. 相似文献
64.
Hampl M Hantschmann P Michels W Hillemanns P;German Multicenter Study Group 《Gynecologic oncology》2008,111(2):282-288
ObjectiveTo investigate the diagnostic accuracy of the sentinel node procedure in patients with vulvar cancer, a multicenter study was launched in Germany in 2003 involving 7 oncology centers.Patients and methodsBetween 2003 and 2006, 127 women with primary T1–T3 vulvar cancer were entered in the study and treated with sentinel node removal after application of 99mTechnetium labeled nanocolloid and/or blue dye. Subsequently, in all women a complete inguinofemoral lymphadenectomy and the adequate vulvar operation were performed. Sentinel lymph nodes were examined by routine pathologic examination (H&;E), followed by step-sectioning and immunhistochemistry if negative.ResultsThe sentinel node procedure was successful in 125 out of 127 cases, in 2 cases no sentinel nodes were detected. 21 patients received unilateral lymphadenectomy, 103 women were operated on both groins. In 39 women out of 127, positive lymph nodes in one or both groins were identified (30.7%). In 36 women, the sentinel nodes were also positive (sensitivity 92.3%). We had three cases with a false negative sentinel node (false negative rate: 7.7%), all of these women presenting with tumors in midline position. One tumor was a T1 tumor (10 mm), 2 tumors being classified as T2 (40 and 56 mm, respectively). In one additional case (18 mm T1 tumor, midline position), the sentinel was positive in the right groin, but false negative on the left side.ConclusionsThis study shows that identification of SLN in squamous cell cancer of the vulva is feasible, however not highly accurate depending on tumor localization and size. The false negative rate seems to be acceptable if the procedure is restricted to stage 1 tumors with clinically negative lymph node status. Tumors situated in or close to the midline seem to be less suitable for this procedure. Implementation of SLNB into clinical practice should be performed with care and only by experienced teams as to avoid preventable groin relapses. 相似文献
65.
This year the American association for cancer research meeting was held in San Diego. “Harnessing breakthroughs and targeting cures” was the title of this meeting where the major recent scientific data on cancer research were discussed. This year was undoubtedly the year of immunotherapy and immunology of tumors. With the aim of sharing the data presented at this congress, AERIO (Association d’Enseignement et de Recherche des Internes d’Oncologie) and Oncologie joined to propose a digest of this outstanding congress. Of course, exhaustivity is not an objective of this type of digest which reflects the choices of young researchers and physicians, with the help of the editorial board, among the multiple themes and researches presented and discussed during this meeting. Tumor immunology and immunotherapy data from the congress are reported. Moreover, autophagy, microbiome, liquid biopsy, tumoral heterogeneity, and cancer stem cells data from this congress are reported, as a reflection of the diversity of this meeting and cancer research. From a clinical point of view, new targets and molecules and the new design of clinical trial are also reported. 相似文献
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Ingo Ilja Michels 《中国药物依赖性杂志》2007,16(2):150-155
Nearly 100 experts from all over China attended the Chinese National Conference on Drug Dependence in Sanya/Hainan. The participants came from drug abuse treatment centers, methadone clinics and drug research institutes. The conference's focus was on the question how drug abuse treatment shall and might be part of HIV prevention. CHINALi xiao(The Federal Drug Commissioner with the Federal Ministry of Health, Berlin) 相似文献
70.
To test the hypothesis that the frequency of biotinidase deficiency is greater in children with unexplained developmental delay or neurologic abnormalities than in the general population, we studied children seen at a large outpatient clinic over a four-year period who had one or more of these neurologic abnormalities and for whom no specific cause for their abnormalities could be found. The group totaled 274 children (163 boys; 111 girls) whose ages ranged from 2 weeks to 17 years. Characteristics were IQ/DQ, 30 to 70 in the 115 for whom scores were available; 41% had seizures; 15% had sensorineural hearing loss; 54% showed gross motor delay or ataxia; and 27% had decreased muscle tone. One patient with a classical clinical picture of biotinidase deficiency was diagnosed during the study period and was not included in the study. None of the patients with nonclassic findings had a deficiency of biotinidase activity. Our results suggest that biotinidase deficiency does not account for a large proportion of children with unexplained neurologic abnormalities or developmental delay. This does not negate the importance of biotinidase testing in children with clinical patterns specifically suggestive of the deficiency. 相似文献