全文获取类型
收费全文 | 2255篇 |
免费 | 171篇 |
国内免费 | 30篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 161篇 |
妇产科学 | 19篇 |
基础医学 | 245篇 |
口腔科学 | 98篇 |
临床医学 | 225篇 |
内科学 | 484篇 |
皮肤病学 | 113篇 |
神经病学 | 89篇 |
特种医学 | 348篇 |
外科学 | 198篇 |
综合类 | 25篇 |
一般理论 | 1篇 |
预防医学 | 109篇 |
眼科学 | 27篇 |
药学 | 180篇 |
1篇 | |
中国医学 | 1篇 |
肿瘤学 | 128篇 |
出版年
2022年 | 13篇 |
2021年 | 18篇 |
2020年 | 19篇 |
2019年 | 21篇 |
2018年 | 34篇 |
2017年 | 25篇 |
2016年 | 36篇 |
2015年 | 38篇 |
2014年 | 48篇 |
2013年 | 71篇 |
2012年 | 64篇 |
2011年 | 57篇 |
2010年 | 63篇 |
2009年 | 115篇 |
2008年 | 68篇 |
2007年 | 89篇 |
2006年 | 80篇 |
2005年 | 61篇 |
2004年 | 51篇 |
2003年 | 50篇 |
2002年 | 50篇 |
2001年 | 54篇 |
2000年 | 46篇 |
1999年 | 56篇 |
1998年 | 110篇 |
1997年 | 121篇 |
1996年 | 117篇 |
1995年 | 81篇 |
1994年 | 87篇 |
1993年 | 101篇 |
1992年 | 28篇 |
1991年 | 30篇 |
1990年 | 28篇 |
1989年 | 52篇 |
1988年 | 56篇 |
1987年 | 38篇 |
1986年 | 48篇 |
1985年 | 42篇 |
1984年 | 23篇 |
1983年 | 24篇 |
1982年 | 24篇 |
1981年 | 44篇 |
1980年 | 26篇 |
1979年 | 14篇 |
1978年 | 17篇 |
1977年 | 26篇 |
1976年 | 24篇 |
1975年 | 10篇 |
1972年 | 9篇 |
1970年 | 8篇 |
排序方式: 共有2456条查询结果,搜索用时 15 毫秒
41.
42.
43.
Kinetics of peptide uptake and tissue distribution following a single intranasal dose of peptide 总被引:2,自引:0,他引:2
Stimulation with the combination of PDB plus ionomycin induced LFA-l/ICAM-1-dependent homotypic adhesion of tonsil B cells. Adhesion of tonsil B cells in our system induced tyrosine phosphorylation of Pyk-2. Disruption of homotypic adhesion and concomitant inhibition of induction of protein tyrosine phosphorylation was achieved by physical separation of the cells and by treatment with methyl-2,5-dihydroxycinnamate (MDHC), an inhibitor of protein tyrosine phosphorylation. These results suggest that protein tyrosine phosphorylation that is associated with homotypic adhesion is mediated by LFA-l/ICAM-1 interactions. 相似文献
44.
Metzler M Strissel PL Strick R Niemeyer C Roettgers S Borkhardt A Harbott J Ludwig WD Stanulla M Schrappe M Reinhardt D Creutzig U Beck JD Rascher W Repp R Langer T 《Genes, chromosomes & cancer》2004,41(3):291-296
Therapy-related acute myeloid leukemia (t-AML) characterized by the t(9;11)(p22;q23) translocation is one of the most frequent secondary malignancies. The timing of the initiation of translocation and of development of the malignant t(9;11) clone during chemotherapy is presently unknown. In the present study, we backtracked bone marrow samples from three children during treatment for acute lymphoblastic leukemia (ALL). Two patients developed a t(9;11)-positive t-AML 19 and 30 months after therapy start, whereas the third patient, diagnosed with a rare t(9;11)-positive ALL, suffered from an ALL relapse 23 months after initial diagnosis. The genomic MLL-MLLT3 (MLL-AF9) fusion site was amplified by a multiplex, nested long-range PCR and used as a clonal marker for quantification of the MLL-MLLT3-positive cells during chemotherapy. The t(9;11)-positive clone was detectable 13 and 18 months after therapy start in both t-AML cases, which was 6-12 months before clinical diagnosis of the secondary malignancy. In the t(9;11)-positive ALL patient, the identical leukemic clone reoccurred during maintenance therapy after a short molecular remission, 8 months before clinically overt ALL relapse. The time course and characteristics of the genomic breakpoints in the present t-AML cases support the hypothesis of translocation formation as a result of defective breakage repair after topoisomerase II cleavage. 相似文献
45.
Rusby Julie C. Prinz Ronald J. Metzler Carol W. Crowley Ryann Sanders Matthew R. 《Child & youth care forum》2022,51(2):421-437
Child & Youth Care Forum - Parenting strategies such as communicating clear expectations, providing calm directions, and teaching specific skills can strengthen young children’s... 相似文献
46.
Guus MJ Bökkerink Maja Joosten Erik Leijte Maud YA Lindeboom Ivo de Blaauw Sanne MBI Botden 《Journal of pediatric surgery》2021,56(3):465-470
BackgroundMinimal invasive surgery (MIS) is increasingly used for the correction of congenital diaphragmatic hernia (CDH) and esophageal atresia (EA). It is important to master these complex procedures, preferably preclinically, to avoid complications. The aim of this study was to validate recently developed models to train these MIS procedures preclinically.MethodsTwo low cost, reproducible models (one for CDH and one for EA) were validated during several pediatric surgical conferences and training sessions (January 2017–December 2018), used in either the LaparoscopyBoxx or EoSim simulator. Participants used one or both models and completed a questionnaire regarding their opinion on realism (face validity) and didactic value (content validity), rated on a five-point-Likert scale.ResultsOf all 60 participants enrolled, 44 evaluated the EA model. All items were evaluated as significantly better than neutral, with means ranging from 3.7 to 4.1 (p < 0.001). The CDH model was evaluated by 48 participants. All items scored significantly better than neutral (means 3.5–3.9, p < 0.001), with exception of the haptics of the simulated diaphragm (mean 3.3, p = 0.054). Both models were considered a potent training tool (means 3.9).ConclusionThese readily available and low budget models are considered a valid and potent training tool by both experts and target group participants.Type of studyProspective study.Level of evidenceLevel II. 相似文献
47.
María Jesús Fernández Aceñero MD PhD Cristina Díaz del Arco CDdA MD Carme Dinarés CD MD PhD Tania Labiano TL MD Eva Tejerina ET MD PhD Mª José Bernabé MJ B MD Elena Forcen EF MD Melchor Saiz-Pardo MSP MD Pablo Pérez PP MD Maria D. Lozano MDL MD PhD 《Diagnostic cytopathology》2023,51(1):26-35
Lung carcinoma remains one of the most frequent and aggressive human neoplasms. Fortunately, in the last decades, the increasing knowledge of the molecular mechanisms leading to cancer development has allowed the use of targeted therapies with improvement of prognosis in many patients. Clinical management has also changed after the introduction of endobronchialultrasonographic bronchoscopy that allows a conservative staging of lung tumors, avoiding the need of mediastinoscopy for lymph node staging. Lung pathologists and cytopathologists are facing the challenge of giving the more comprehensive prognostic and predictive information with ever smaller tissue or cytological samples. The aim of this review is to summarize the molecular testing for non-small cell lung carcinoma and how pathologists can contribute to the patient's outcome with a conscious management of biological samples. 相似文献
48.
49.
Osteosarcomatosis 总被引:10,自引:0,他引:10
Hopper KD; Moser RP Jr; Haseman DB; Sweet DE; Madewell JE; Kransdorf MJ 《Radiology》1990,175(1):233-239
A review of the 690 cases of osteosarcoma in the radiographic file of the Armed Forces Institute of Pathology revealed 29 cases of "osteosarcomatosis" (multiple skeletal sites of osteosarcoma). Fifteen of these patients were 18 years old and under and manifested rapidly appearing, usually symmetric, sclerotic metaphyseal lesions. The remaining 14 patients were more than 18 years old and had fewer, asymmetric sclerotic lesions. In most patients (28 of 29), a radiographically dominant skeletal tumor was seen. Pulmonary metastases occurred in the majority of patients and were detected at the same time as the bone lesions. These 29 patients were studied with regard to demographic data and skeletal distribution and radiographic appearance of their lesions. As a result of the findings, a metastatic origin from a primary dominant osteosarcoma is favored over a multifocal origin as the basis for osteosarcomatosis. Osteosarcomatosis is more commonly encountered in the mature skeleton than has been previously recognized. 相似文献
50.
Pathways to care for alcohol use disorders 总被引:1,自引:0,他引:1