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51.
R. D. Baker R. J. Taylor G. Smurthwaite G. B. Kitchen I. Mehmood 《Journal of biopharmaceutical statistics》2013,23(4):619-634
The problem of comparing the deviation from a target of two or more treatments or procedures arises now and again in medicine. Practitioners usually carry out a t-test on a loss function such as absolute error. We have adapted and developed statistical methods to give a normative methodology for deviation-from-target problems and exemplify them by evaluating the performance of a tactile feedback device. Parametric and nonparametric analyses are compared and contrasted. We recommend nonparametric methods for inference about loss functions such as absolute error, with a permutation test for testing the hypothesis that the two methods perform identically, and the nonparametric bootstrap for deriving standard errors and confidence intervals on loss function ratios. We develop a new permutation test that can be used when the practitioner is unwilling to decide which loss function should be used. We recommend parametric analysis when more insight into how one method is superior is desired, or there are covariates, and discuss the complications. The results for our example are that the tactile sensing device reduces an upward bias in applied force, and more importantly reduces the spread (variance) of the applied force. It performs significantly better than manual force application. 相似文献
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Abdinasir Abubakar Nada Melhem Mamunur Malik Ghassan Dbaibo Wasiq Mehmood Khan Hassan Zaraket 《Vaccine》2019,37(12):1601-1607
Background
The World Health Organization recommends annual influenza vaccination, especially in high-risk groups. Little is known about the adoption and implementation of influenza vaccination policies in the Eastern Mediterranean Region.Methods
A survey was distributed to country representatives at the ministries of health of the 22 countries of the Region between December 2016 and February 2017 to capture data on influenza immunization policies, recommendations, and practices in place.Results
Of the 20 countries that responded to the survey, 14 reported having influenza immunization policies during the 2015/2016 influenza season. All countries with an influenza immunization policy recommended vaccination for people with chronic medical conditions, healthcare workers and pilgrims. Two of the 20 countries did not target pregnant women. Eight countries used the northern hemisphere formulation, one used the southern hemisphere formulation and nine used both. Vaccination coverage was not monitored by all countries and for all target groups. Where reported, coverage of a number of target groups (healthcare workers, children) was generally low. Data on the burden of influenza and vaccine protection are scarce in the Region.Conclusions
Despite widespread policy recommendations on influenza vaccination, attaining high coverage rates remains a challenge in the Eastern Mediterranean Region. Tackling disparities in influenza vaccine accessibility and strengthening surveillance systems may increase influenza vaccine introduction and use. 相似文献54.
55.
Sabba Mehmood M.Phil. Sayed Hajan Shah M.Phil. Abid Jan M.Phil. Muhammad Younus M.Phil. Farooq Ahmad M.Phil. Muhammad Ayub M.Phil. Wasim Ahmad Ph.D. 《Pediatric dermatology》2016,33(1):e40-e42
Hypotrichosis is a condition of abnormal hair pattern characterized by sparse to absent hair on different parts of the body, including the scalp. The condition is often characterized by tightly curled woolly hairs, discoloration of hair, and development of multiple keratin filled cysts or papules on the body. Sequence analysis of the lipase H (LIPH) gene, mapped on chromosome 3q27.3, led to the identification of a novel frameshift deletion variant (c.932delC, p.Pro311Leufs*3) in one family and previously reported 2‐bp deletion (c.659_660delTA) in five other families, inherited hypotrichosis, and woolly hair in an autosomal recessive pattern. The study further extends the body of evidence that sequence variants in the LIPH gene result in hypotrichosis and woolly hair phenotype. 相似文献
56.
Tahir Mehmood Khan Abdul Aziz Alhafez Syed Azhar Syed Sulaiman David Wu Bin Chia 《Saudi Pharmaceutical Journal》2015,23(6):614-620
Objectives: The aim of this study was to assess the safety and probability of adverse events associated with the use of 75 mg pregabalin post hemodialysis (pHD) among patients with UP. Methods: A cross-sectional study done among the hemodialysis patients suffering from uremic pruritus (UP) Aljaber Kidney Center (AJKC), Al-Ahsa, Eastern Province, Saudi Arabia. Assessment for the safety profile of pregabalin was done using Naranjo’s algorithm. A predictive model was developed using binary multiple logistic regression to explore association of patients’ demographics and risk factors with the occurrence of AEs. Throughout statistical significance level was considered significant at 0.05. Key findings: Assessment of safety of pregabalin revealed that somnolence and dizziness were the two frequent adverse events followed by constipation, weight gain and edema. However, it was noticed that female patients aged less than 50 years were found to be at a higher risk in comparison with men. Moreover, those patients having one comorbid complication (i.e. hypertension or diabetes mellitus alone) were at a higher risk of somnolence, weight gain and dry mouth. Conclusion: Naranjo’s quantification for the possibility and probability of adverse events reflect that all the events were probable. Age, gender and comorbid medical conditions are some of the factors that might have clinical association with the occurrence of the AEs. 相似文献
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Tahir Yaqub Muhammad Nawaz Muhammad Z. Shabbir Muhammad A. Ali Imran Altaf Sohail Raza Muhammad A. B. Shabbir Muhammad A. Ashraf Syed Z. Aziz Sohail Q. Cheema Muhammad B. Shah Saira Rafique Sohail Hassan Nageen Sardar Adnan Mehmood Muhammad W. Aziz Sehar Fazal Nadir Hussain Muhammad T. Khan Muhammad M. Atique Ali Asif Muhammad Anwar Nabeel A. Awan Muhammad U. Younis Muhammad A. Bhattee Zarfishan Tahir Nadia Mukhtar Huda Sarwar Maaz S. Rana Omair Farooq 《Biomedical and environmental sciences : BES》2021,34(9):729-733
In 2019, the newly emerged SARS-CoV-2 virus caused pneumonia-like illness. The disease rapidly spread globally, leading to a worldwide outbreak referred to as the COVID-19 pandemic. The affected patients show symptoms of fever, dry cough, respiratory distress, myalgia, and gastrointestinal disturbance. As of April 5, 2021, 132,083,022 people worldwide were affected by COVID-19, while 2,868,454 people died due to the disease[1]. SARS-CoV-2-positive patients may remain asymptomatic or start showing symptoms in 2?14 days after exposure to the virus[2]. The viral infection can be diagnosed from nasopharyngeal, throat, alveolar lavage, lacrimal, blood, and stool samples. The patient starts shedding the virus in stool regardless of being symptomatic or asymptomatic, which makes sewage-based detection of the virus to be more beneficial in the early infection stage. 相似文献
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Ayaz Ahmad Krzysztof Adam Ostrowski Mariusz Malak Furqan Farooq Imran Mehmood Afnan Nafees 《Materials》2021,14(15)
High temperature severely affects the nature of the ingredients used to produce concrete, which in turn reduces the strength properties of the concrete. It is a difficult and time-consuming task to achieve the desired compressive strength of concrete. However, the application of supervised machine learning (ML) approaches makes it possible to initially predict the targeted result with high accuracy. This study presents the use of a decision tree (DT), an artificial neural network (ANN), bagging, and gradient boosting (GB) to forecast the compressive strength of concrete at high temperatures on the basis of 207 data points. Python coding in Anaconda navigator software was used to run the selected models. The software requires information regarding both the input variables and the output parameter. A total of nine input parameters (water, cement, coarse aggregate, fine aggregate, fly ash, superplasticizers, silica fume, nano silica, and temperature) were incorporated as the input, while one variable (compressive strength) was selected as the output. The performance of the employed ML algorithms was evaluated with regards to statistical indicators, including the coefficient correlation (R2), mean absolute error (MAE), mean square error (MSE), and root mean square error (RMSE). Individual models using DT and ANN gave R2 equal to 0.83 and 0.82, respectively, while the use of the ensemble algorithm and gradient boosting gave R2 of 0.90 and 0.88, respectively. This indicates a strong correlation between the actual and predicted outcomes. The k-fold cross-validation, coefficient correlation (R2), and lesser errors (MAE, MSE, and RMSE) showed better performance than the ensemble algorithms. Sensitivity analyses were also conducted in order to check the contribution of each input variable. It has been shown that the use of the ensemble machine learning algorithm would enhance the performance level of the model. 相似文献